Category: 72716-86-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72716-86-0, name is 2-Methoxyisonicotinonitrile. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

Example 2; Synthesis of l-(2-methoxy-pyridin-4-yl)-propan-l-one; A stirred suspension of 25.44 g of 2-methoxy-isonicotinonitrile as obtained in Example 1 (189.7 rnmol) in 380 niL TBME was cooled to 0 C and 114 mL ethyl magnesium chloride in THF(2.0 M, 228.0 mmol, 1.20 eq) were added within 45 min. Stirring was continued at O0 C. After 3 h 40 min, additional 5 mL ethyl magnesium chloride in THF(2.0 M, 10.0 mmol, 0.05 eq) were added at 0 C. The reaction was monitored by HPLC. After 4.5 h (< 3 % area 2-methoxy-isonicotinonitrile), the reaction was quenched at 0 C by addition of 300 mL water. The resulting suspension was stirred for 16 h at room temperature and was then diluted with 200 mL toluene. The aqueous phase was extracted with 400 mL toluene and the combined organic phases were washed with 500 mL saturated aqueous NH4Cl and 500 mL brine, dried over 50 g Na2SO4 (30 min) and filtered. The filter cake was washed with 100 mL toluene. After evaporation of solvent in a rotary evaporator (40C/10 mbar), the title compound (28.64 g, 91 % by weight) was obtained as an orange solid. M^: 38C;1R NMR (300 MHz, CDCl3): delta 8.30 (d, IH5 J= 5.3 Hz), 7.30 (dd, IH5 J= 5.3 Hz5 J= 1.3), 7.18 (br. s, IH), 3.98 (s, 3H)5 2.96 (q, 2H, J= 7.2 Hz), 1.22 (t, 3H, J- 7.2 Hz) ppm If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 72716-86-0, 2-Methoxyisonicotinonitrile. Reference:
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.); WO2006/33011; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72716-86-0, 2-Methoxyisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 72716-86-0, blongs to pyridine-derivatives compound. SDS of cas: 72716-86-0

(ii) A mixture of 2-methoxy-4-cyanopyridine (57.2 g), semicarbazide hydrochloride (71.24 g), sodium acetate (69.86 g), ethanol (1200 ml) and water (370 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g). The mixture was evaporated to a volume of 450 ml, water (900 ml) was added and the mixture was allowed to stand at 0 overnight. The mixture was filtered and the solid was washed with water and was dissolved in 10% hydrochloric acid (950 ml). Formaldehyde solution (36% w/v, 420 ml) was added and the mixture was warmed for 30 minutes, allowed to cool and was cooled to a solution of sodium acetate (280 g) in water (840 ml). The mixture was extracted with ether (3*500 ml) and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 2-methoxypyridine-4-carboxyaldehyde (20.53 g, 35%) m.p. 33-35. A sample recrystallized from petroleum ether had m.p. 33-36.

The synthetic route of 72716-86-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4234588; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72716-86-0, 2-Methoxyisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 72716-86-0, blongs to pyridine-derivatives compound. SDS of cas: 72716-86-0

(ii) A mixture of 2-methoxy-4-cyanopyridine (57.2 g), semicarbazide hydrochloride (71.24 g), sodium acetate (69.86 g), ethanol (1200 ml) and water (370 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g). The mixture was evaporated to a volume of 450 ml, water (900 ml) was added and the mixture was allowed to stand at 0 overnight. The mixture was filtered and the solid was washed with water and was dissolved in 10% hydrochloric acid (950 ml). Formaldehyde solution (36% w/v, 420 ml) was added and the mixture was warmed for 30 minutes, allowed to cool and was cooled to a solution of sodium acetate (280 g) in water (840 ml). The mixture was extracted with ether (3*500 ml) and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 2-methoxypyridine-4-carboxyaldehyde (20.53 g, 35%) m.p. 33-35. A sample recrystallized from petroleum ether had m.p. 33-36.

The synthetic route of 72716-86-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4234588; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem