Reference of 73672-37-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73672-37-4, name is Ethyl 2-oxo-2-(pyridin-3-yl)acetate. A new synthetic method of this compound is introduced below.
Reference Example 36 A mixture of ethyl 3-pyridylglyoxylate (6.00 g), hydroxylamine hydrochloride (2.79 g), sodium acetate (4.13 g) and ethanol (80 ml) was heated to reflux for 15 hours. The reaction mixture was concentrated, water was added to the residue, and extracted with ethyl acetate. The ethyl acetate layer was washed with an aqueous saturated solution of sodium chloride, dried (MgSO4) and concentrated. The remaining crystals were recrystallized from ethyl acetate to obtain ethyl E-2-hydroxyimino-2-(3-pyridyl)-acetate (3.30 g, yield 51%) as colorless crystals. m.p. 172-173 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73672-37-4, its application will become more common.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6251926; (2001); B1;,
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