Category: 74134-42-2

Synthetic Route of 74134-42-2 , The common heterocyclic compound, 74134-42-2, name is 2-Bromo-6-(methylthio)pyridine, molecular formula is C6H6BrNS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Bromo-6-(methylthio)pyridine (1.00 g, 4.90 mmol) and trifluoroacetamide (0.831 g, 7.35 mmol) in THF (10 mL) was added dropwise to a pre-cooled suspension of sodium hydride (60% in mineral oil) (0.176 g, 4.41 mmol) in THF (5 mL) at 0 00 under nitrogen. After 5 mm, a solution of 1,3-dibromo-5,5- dimethylhydantoin (2.10 g, 7.35 mmol) in THF (7.5 mL) was added dropwise. After 1 h, the reaction mixture was partitioned between EtOAc and 25% sodium sulfite (aq) solution, separated, extracted (EtOAc x 2), dried (Phase Separator), and the solvents were removed in vacuo to give the title compound as a colourless oil that turned into a white solid on standing. The material was carried through to the next step without further purification.LCMS (Method A): RT = 1.02 mi mlz = 315, 317 [M+H]

The synthetic route of 74134-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BURKAMP, Frank; ROUNTREE, James Samuel Shane; TREDER, Adam Piotr; (155 pag.)WO2018/11569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74134-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74134-42-2 as follows.

NBS (131 mg, 0.735 mmol) was added to a stirred solution of 2-bromo-6- (methylthio)pyridine (100 mg, 0.490 mmol), cyanamide (26.8 mg, 0.637 mmol) and potassium teit-butoxide (66.0 mg, 0.588 mmol) in methanol (3.0 mL) at RT under nitrogen. After 20 h, the reaction mixture was concentrated in vacuo, partitioned between DCM and satd. sodium thiosulfate (aq) solution, separated, extracted using DCM (x 2), dried (Phase Separator), and the solvents were removed in vacuo to give the title compound (crude, 124 mg) as a pale yellow oil that was used directly in the next step without purification.LCMS (Method A): RT = 0.65 mi mlz = 244, 246 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74134-42-2, its application will become more common.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BURKAMP, Frank; ROUNTREE, James Samuel Shane; TREDER, Adam Piotr; (155 pag.)WO2018/11569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74134-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74134-42-2 as follows.

NBS (131 mg, 0.735 mmol) was added to a stirred solution of 2-bromo-6- (methylthio)pyridine (100 mg, 0.490 mmol), cyanamide (26.8 mg, 0.637 mmol) and potassium teit-butoxide (66.0 mg, 0.588 mmol) in methanol (3.0 mL) at RT under nitrogen. After 20 h, the reaction mixture was concentrated in vacuo, partitioned between DCM and satd. sodium thiosulfate (aq) solution, separated, extracted using DCM (x 2), dried (Phase Separator), and the solvents were removed in vacuo to give the title compound (crude, 124 mg) as a pale yellow oil that was used directly in the next step without purification.LCMS (Method A): RT = 0.65 mi mlz = 244, 246 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74134-42-2, its application will become more common.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BURKAMP, Frank; ROUNTREE, James Samuel Shane; TREDER, Adam Piotr; (155 pag.)WO2018/11569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74134-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74134-42-2 as follows.

NBS (131 mg, 0.735 mmol) was added to a stirred solution of 2-bromo-6- (methylthio)pyridine (100 mg, 0.490 mmol), cyanamide (26.8 mg, 0.637 mmol) and potassium teit-butoxide (66.0 mg, 0.588 mmol) in methanol (3.0 mL) at RT under nitrogen. After 20 h, the reaction mixture was concentrated in vacuo, partitioned between DCM and satd. sodium thiosulfate (aq) solution, separated, extracted using DCM (x 2), dried (Phase Separator), and the solvents were removed in vacuo to give the title compound (crude, 124 mg) as a pale yellow oil that was used directly in the next step without purification.LCMS (Method A): RT = 0.65 mi mlz = 244, 246 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74134-42-2, its application will become more common.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BURKAMP, Frank; ROUNTREE, James Samuel Shane; TREDER, Adam Piotr; (155 pag.)WO2018/11569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem