Category: 7579-20-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7579-20-6, name is 3-Aminoisonicotinic acid. A new synthetic method of this compound is introduced below., name: 3-Aminoisonicotinic acid

3- Aminoisonicotinic acid (1 g, 7.24 mmol) was carefully added in 3 aliquots to a slurry of UAIH4 (0.99 g, 26.1 mmol) in dry tetrahydrofuran (40 ml). The resulting mixture was stirred at 15°C overnight. After cooling in an ice bath, the reaction mixture was quenched with careful addition of water (1 ml) dropwise, followed by 15percent aqueous NaOH (1 ml), and then water (3 ml). The resulting solid was filtered, and washed several times with tetrahydrofuran. The filtrate was concentrated to give oil, which was purified by flash chromatography on silica gel using 5percent CH3OH Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7579-20-6, name is 3-Aminoisonicotinic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

Preparation 19 2-Methyl-3-oxa-1,7-diaza-naphthalen-4-one A mixture of 3-aminopyridine-4-carboxylic acid (3.38 g, 24.5 mmol), acetic anhydride (15 mL), and sulfuric acid (3 drops) was refluxed 4 hours. The reaction was cooled and carefully quenched with solid sodium bicarbonate. The mixture was filtered through Celite.(R). (trademark). The filtrate was extracted with ethyl acetate. This organic phase was washed with brine, dried over magnesium sulfate and concentrated to give 2-methyl-3-oxa-1,7-diaza-naphthalen-4-one (1.95 g, 49percent) as a brown crystalline material. 1H NMR delta9.00 (s, 1 H), 8.78 (d, J=5 Hz, 1 H), 7.96 (d, J=5 Hz, 1 H), 2.52 (s, 3 H). The product was suitable for use without further purification.

The synthetic route of 7579-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc; US6323208; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem