Category: 80827-67-4

Related Products of 80827-67-4 , The common heterocyclic compound, 80827-67-4, name is 1-(3-Methoxypyridin-2-yl)piperazine, molecular formula is C10H15N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 9 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(3-methoxy-pyridin-2-yl)-piperazin-1-yl]-2-phenyl-butan-1-one The title compound was prepared from 4-(3-methoxy-pyridin-2-yl)-piperazine (1.0 g, 5.0 mmole) 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-bromo-2-phenyl-butan-1-one (1.6 g, 4.76 mmole), diisopropylethylamine (0.9 g, 7.0 mmole) and potassium iodide (0.8 g, 5.0 mmole) in dimethylformamide (30 mL) in the manner described in example 2 to yield 0.87 g of title product as the hydrochloride hydrate, m.p. 140-147 C. Elemental Analysis For: C27 H36 N4 O2. HCl H2O Calcd: C, 64.46; H, 7.81; N, 11.14. Found: C, 64.32; H, 7.91; N, 10.64.

The synthetic route of 80827-67-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; John Wyeth & Brother, Ltd.; American Home Products Corp.; US5610154; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.80827-67-4, name is 1-(3-Methoxypyridin-2-yl)piperazine, molecular formula is C10H15N3O, molecular weight is 193.2456, as common compound, the synthetic route is as follows.Formula: C10H15N3O

Example 5d 3-[3-[(3-Methoxy-2-pyridinyl)-1-piperazinyl]propyl]-5-nitro-1H-indole. (5) A mixture of 3-(3-bromopropyl)-5-nitro-1H-indole (4) (0.88 g, 3.11 mmol), potassium carbonate (0.43 g, 3.11 mmol), potassium iodide (0.52 g, 3.11 mmol) and 1-(3-methoxy-2-pyridinyl)piperazine (1) (0.60 g, 3.11 mmol) in 50 mL of acetonitrile was heated to reflux for 5 h. The mixture was cooled, filtered and concentrated. The residue was purified by flash column chromatography with 5% methanol in dichloromethane as eluant to give the title compound (1.2 g, 99%) as a yellow foam; 1 H NMR (DMSO-d6, 300 MHZ) delta 8.54 (d, J=2.2 Hz, 1H), 7.97 (dd, J=2.2, 9.9 Hz, 1H), 7.77(m, 1H), 7.50 (d, J=9.0 Hz, 1H), 7.44 (s, 1H), 7.24 (d, J=7.75 Hz, 1H), 6.90 (m, 1H), 3.78 (s, 3H), 3.33 (br s, 2H), 2.80 (t, J=7.3 Hz, 2H), 1.93 (m, 2H); IR(KBr) 3300, 1520, 1330, 1240 cm-1; MS (m/e) 395 (M+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,80827-67-4, 1-(3-Methoxypyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; US5521188; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem