Category: 84487-10-5

Application of 84487-10-5, Adding some certain compound to certain chemical reactions, such as: 84487-10-5, name is 2-Amino-4-bromo-3-nitropyridine,molecular formula is C5H4BrN3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84487-10-5.

Step 1 (0852) A solution of 4-bromo-3-nitropyridin-2-amine (LXVI) (5.00 g, 22.9 mmol, 1.00 eq), (2-fluorophenyl)boronic acid (LXVII) (3.82 g, 27.5 mmol, 1.20 eq), Pd(PPh3)4 (1.32 g, 1.14 mmol, 0.05 eq), and Na2CO3 (4.85 g, 45.8 mmol, 2 eq) in a mixture of toluene (25 mL), H2O (9 mL) and EtOH (6 mL) was stirred at 75 C. for 15 h under nitrogen atmosphere. The reaction mixture was the washed with brine (50 mL) and dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resultant residue was purified by chromatography on silica gel (PE:EtOAc=3:1) to give 4-(2-fluorophenyl)-3-nitropyridin-2-amine (LXVIII) (4.0 g, 17.15 mmol, 74.9%) as a yellow solid. 1H NMR (CDCl3, 400 MHz) delta ppm 6.29 (brs, 2H), 6.68 (d, J=4.8 Hz, 1H), 7.14 (t, J=5.2 Hz, 1H), 7.23-7.50 (m, 3H), 8.32 (d, J=4.8 Hz, 1H); ESIMS found C11H8FN3O2 m/z 234.2 (M+H).

According to the analysis of related databases, 84487-10-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Wallace, David Mark; Cao, Jianguo; Chiruta, Chandramouli; Hood, John; (264 pag.)US2016/68551; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84487-10-5, name is 2-Amino-4-bromo-3-nitropyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 84487-10-5

2-Amino-3-nitro-4-bromopyridine (1 g, 4.59 mmol)Dissolved in 20 ml of 95% ethanol, added stannous chloride(2.61 g, 13.76 mmol).The reaction solution was warmed to reflux and stirred at this temperature for 2-3 hours.Pour the reaction solution into 80 ml of 1N sodium hydroxide solution.Extracted with ethyl acetate (30 mL×3), and the extract was washed with brine.Dry over anhydrous sodium sulfate,Concentrated to a crude product.The crude product was subjected to silica gel column chromatography ( petroleum ether / ethyl acetate = 5:1)2,3-diamino-4-bromopyridine(322 mg, yield 37%)

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Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem