Application of 85333-26-2, Adding some certain compound to certain chemical reactions, such as: 85333-26-2, name is 2-Amino-4-benzyloxypyridine,molecular formula is C12H12N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85333-26-2.
A mixture of 2-amino-4-benzyloxypyridine (2.00 g, 9.49 mmol), copper (I) bromide (70 mg, 0.05 mmol), 1,10-phenanthroline monohydrate (95 mg, 0.05 mmol) and benzonitrile (25 mL) was heated in a 50-mL 3-necked flask to 130 C. During 23 h a gentle flow of (O2/N2 5:95) was bubbled through the reaction mixture (>99% conversion, HPLC method see below). The dark brown solution was then evaporated at 60 C./0.1 mbar to dryness and the dark brown residue dissolved in DCM (30 mL). The organic solution was washed with water (30 mL), dried over sodium sulphate, filtered and evaporated to yield an dark oil containing crude 7-benzyloxy-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine and residual benzonitrile. [0099] Charcoal treatment of the crude product with Norit SA II (0.90 g) in EtOAc (120 mL) at reflux, filtration and subsequent crystallization (via partial evaporation of EtOAc and addition of heptane) afforded 7-benzyloxy-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine (1.78 g, 62%) as an off-white solid with >99.9% purity (HPLC area-%, HPLC method: Onyx monolithic C18 column, 100×4.6 mm; mobile phase, A: water/NCMe (95:5), B: NCMe; flow: 2.0 ml/min; gradient from 95/5 (A/B) to 15/85 (A/B) within 3 min, isocratic 15/85 (A/B) for 2.5 min. Retention time: 3.40 min (2-amino-4-benzyloxypyridine), 3.60 min 7-benzyloxy-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine)). [0100] EI-MS: m/z=302.13 (M+H)+.
According to the analysis of related databases, 85333-26-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HOFFMANN-LA ROCHE INC.; Bartels, Bjoern; Fantasia, Serena Maria; Flohr, Alexander; Puentener, Kurt; Wang, Shaoning; US2014/350259; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem