Category: 874302-76-8

Related Products of 874302-76-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.874302-76-8, name is 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, molecular formula is C14H12N2O5S2, molecular weight is 352.39, as common compound, the synthetic route is as follows.

EXAMPLE 1 : Synthesis of Conjugate 1To a solution of cabazitaxel (2.00 g, 2.40 mmol) and 2-(2- pyridinyldithio)ethanol -nitrophenyl carbonate (915 mg, 2.60 mmol) in dichloromethane (48 mL) was added DMAP (439 mg, 3.60 mmol). The solution was stirred at room temperature overnight, then washed with 0.1N HC1 (3 x 20 mL), saturated aqueous NaCl (50 mL), and dried with sodium sulfate. The solvent was removed in vacuo, the the remaining residue purified by silica gel chromatography (2: 1 petroleum ethenethyl acetate) to give cabazitaxel 2-(2- pyridyldithio)ethylcarbonate (2.50 g, 2.38 mmol, 99% yield). LCMS m/z: 1049 (M + H).

The chemical industry reduces the impact on the environment during synthesis 874302-76-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BLEND THERAPEUTICS, INC.; ALARGOVA, Rossitza G.; BILODEAU, Mark T.; DUNBAR, Craig A.; KADIYALA, Sudhakar; SHINDE, Rajesh R.; LIM SOO, Patrick; SWERYDA-KRAWIEC, Beata; WHITE, Brian H.; BAZINET, Patrick Rosaire; WOOSTER, Richard; (194 pag.)WO2016/4048; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 874302-76-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.874302-76-8, name is 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, molecular formula is C14H12N2O5S2, molecular weight is 352.39, as common compound, the synthetic route is as follows.

To a solution of compound 2 (10 mg, 0.028 mmol) and doxorubicin hydrochloride (12 mg, 0.020 mmol) in DMF (1 mL) under N2, DIPEA (8 jiL, 0.028 mmol) is added at room temperature and stirred for 16 h. Then, the solvent is evaporated and the residue is purified by flash chromatography (eluent: CH2C12/MeOH 20:1) to obtain compound 3(Figure 3) as red solid in 90% yield; 1H NMR (500 MHz, CDC13) oe 13.94 (s, 1H), 13.18(s, 1H), 8.40 (d, J= 3.8 Hz, 1H), 8.00 (d, J 7.6 Hz, 1H), 7.76 (t, J 8.0 Hz, 1H), 7.70(d, J 7.5 Hz, 1H), 7.63 (t, J 7.4 Hz, 1H), 7.37 (d, J= 8.5 Hz, 1H), 7.07 (t, J= 1H),5.50 b(s, 1H), 5.26 (dd, J= 3.7, 2.0 Hz, 1H), 5.15 (d, J= 8.8 Hz, 1H), 4.74 b(s, J 21.4Hz, 2H), 4.56 (bs, 1H), 4.42 – 4.34 (m, 1H), 4.21 – 4.08 (m, 2H), 4.06 (s, 3H), 3.81 (m,1H), 3.62 (bs, 1H), 3.22 (dd, J= 18.8, 1.5 Hz, 1H), 3.14-2.86 (m, 5H), 2.33 (d, J14.6 Hz, 1H), 2.15 (dd, J= 15.0, 3.6 Hz, 1H), 1.81 (m, 2H), 1.48 – 1.42 (m, 2H), 1.29(d, J 6.5 Hz, 3H); 13C NMR (126 MHz, CDC13) oe 213.9, 187.0, 186.6, 161.0, 160.1,156.2, 155.6, 155.2, 149.8, 149.4, 137.3, 135.7, 135.4, 133.6, 133.6, 120.9, 120.8,119.9, 119.8, 118.4, 111.5, 111.4, 100.9, 69.7, 69.0, 67.4, 65.6, 63.5, 56.7, 53.4, 47.0,37.5, 35.6, 33.9, 30.0, 29.7, 28.3, 17.0; MS (ESI): mlz (%)757(100), (figures 13 and14).

Statistics shows that 874302-76-8 is playing an increasingly important role. we look forward to future research findings about 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate.

Reference:
Patent; FUNDACION IMDEA NANOCIENCIA; LOPEZ CORTAJARENA, Aitziber; SOMOZA CALATRAVA, Alvaro; COULEAUD, Pierre; OCAMPO GARCIA, Sandra; AIRES TRAPOTE, Antonio; LATORRE LOZANO, Alfonso; (66 pag.)WO2016/150521; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 874302-76-8, name is 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate. A new synthetic method of this compound is introduced below., Quality Control of 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate

To a solution of compound 3 (230.52 mg, 654.17 umol) in DMF (2 mL) was added Motohmod (0.15 g, 327.09 umol), DIEA (126.82 mg, 981.26 umol, 170.92 uL) and HOBt (53.04 mg, 392.50 umol). The mixture was stirred at 25 C for 16 hr. LC-MS indicated compound 3 was consumed completely and a peak with desired mass (m/z: 672.1([M+H+])) was detected. The reaction mixture was purified by prep-HPLC (A: H20, B: ACN). Compound 4 (0.11 g, 163.72 umol, 50.05% yield) was obtained as a white solid. Calculated MW: 671.8 observed m/z: 672.1([M+H+])

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 874302-76-8, 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate.

Reference:
Patent; BICYCLERD LIMITED; KEEN, Nick; MCDONNELL, Kevin; PARK, Peter U.; MUDD, Gemma Elizabeth; IVANOVA-BERNDT, Gabriela; (274 pag.)WO2019/34868; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 874302-76-8, 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, blongs to pyridine-derivatives compound. Quality Control of 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate

To a solution of cabazitaxel (2.00 g, 2.40 mmol) and 2-(2- pyridinyldithio)ethanol p-nitrophenyl carbonate (915 mg, 2.60 mmol) in dichloromethane (48 mL) was added DMAP (439 mg, 3.60 mmol). The solution was stirred at room temperature overnight, then washed with 0.1N HCl (3 x 20 mL), brine (50 mL), and dried with sodium sulfate. The solvent was removed in vacuo, the the remaining residue purified by silica gel chromatography (2:1 petroleum ether:ethyl acetate) to give 4? (2.50 g, 2.38 mmol, 99% yield). LCMS m/z: 1049 (M + 1).

The synthetic route of 874302-76-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARVEDA THERAPEUTICS, INC.; BILODEAU, Mark T.; SIMCOX, Mary; WHITE, Brian H.; KADIYALA, Sudhakar; WOOSTER, Richard; (178 pag.)WO2017/180834; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 874302-76-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 874302-76-8 as follows.

Weigh 61.2mg (0.06mmol) compound 39,64.3mg (0.18mmol) compound 37,9.8mg (0.08mmol) DMAP, was added to a 25ml eggplant-shaped flask, add 5ml DCM was dissolved under argon atmosphere, stirred at room temperature 48h, DCM was evaporated to dryness under reduced pressure and, add acetonitrile dissolved, purified by preparative liquid phase to give product 51.3mg

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,874302-76-8, its application will become more common.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Liu Keliang; Feng Siliang; Chen Kuncheng; Guo Xiaopeng; Meng Qingbin; Zhou Ning; (23 pag.)CN104370862; (2019); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem