Category: 883107-62-8

New downstream synthetic route of Methyl 3-amino-2,6-dichloroisonicotinate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 883107-62-8, Methyl 3-amino-2,6-dichloroisonicotinate.

Electric Literature of 883107-62-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 883107-62-8, name is Methyl 3-amino-2,6-dichloroisonicotinate, molecular formula is C7H6Cl2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 8: Preparation of 3-amino-2, 6-dichloroisonicotinic acid; 3-Amino-2, 6-dichloroisonicotinic acid methyl ester (460 mg) was dissolved in ethanol (8 mL) , water (2 mL) and potassium hydroxide (234 mg) was added. The solution was stirred for 20 minutes at room temperature and for 1.5 hours under reflux. After cooling to room temperature, 2N hydrochloric acid was added to adjust the pH-value to ~3 and the so- formed yellow precipitate was extracted 3x with ethyl acetate. The combined organic layer was washed with brine, dried over MgSO4 and concentrated in vacuum to afford 420 mg of the title compound of the formulaas a yellow solid. The compound was used in the following reaction step without further purification1H-NMR (CDCl3, TMS) delta (ppm) : 6.21 (2 H, br s), 7.69 (1 H, s) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 883107-62-8, Methyl 3-amino-2,6-dichloroisonicotinate.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2008/130021; (2008); A2;,
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