Category: 884494-69-3

Reference of 884494-69-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884494-69-3, name is 3-Fluoro-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-fluoro-2-methoxypyridine (20g, 157.48mmol), sodium acetate (25.74g, 314.0 mmol) inAcOH (6OmL) was added dropwise a solution of Br2 (20.32mL, 393.70mmol) in AcOH (40 mL) at 10Cand the RM stirred at RT for 16h.The RM was quenched into ice water (200mL) and then basified with 6N NaOH solution to pH 9 and filtered the solid. The solid was dissolved in Et2O (300mL), washed with brine, dried (Na2SO4), filtered, concentrated under reduced pressure to give 5-bromo-3-fluoro-2- methoxypyridine (20g, 61%) as white solid

According to the analysis of related databases, 884494-69-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 884494-69-3, Adding some certain compound to certain chemical reactions, such as: 884494-69-3, name is 3-Fluoro-2-methoxypyridine,molecular formula is C6H6FNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884494-69-3.

General procedure: A 3 mL glass vial was equipped with a rubber septum and magnetic stir bar. The vial was brought into a glove box and charged with methyl trifluoromethylsulfonate (MeOTf, 51 muL, 0.46 mmol) by micropipette with polypropylene tip. The vial was sealed and removed from the glove box. A separate 3 mL vial was charged with substrate (68 mg, 0.46 mmol) and was dissolved in PhMe (0.5 mL). The solution of pyridine was added via syringe onto the sealed vial of MeOTf at room temperature. The vial which contained the pyridine was rinsed with PhMe (0.2 mL) and the rinse solution was injected into the reaction vial. The reaction vial was kept at room temperature and stirring was maintained at ca. 400-600 rpm. Over the course of the reaction (2 hr), a precipitate formed. At the end of the reaction, PhMe (2 mL) was added after which stirring was stopped. Any solid or oil was allowed to settle and the solvent was removed by glass pipette. The residue was then rinsed with several portions of hexanes to remove any unreacted starting materials, again removing the solvent by pipette. Residual solvent was then removed in vacuo to provide the title compound (53 mg, 37%).

According to the analysis of related databases, 884494-69-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Topczewski, Joseph J.; Lodge, Alexander M.; Yasapala, Sumana N.; Payne, Maurice K.; Keshavarzi, Pedrom M.; Quinn, Daniel M.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 21; (2013); p. 5786 – 5789;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem