In 2016,ChemMedChem included an article by Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Kuruvilla, Dana S.; Novick, Scott J.; Lin, Li; Cameron, Michael D.; Griffin, Patrick R.; Kamenecka, Theodore M.. Formula: C7H8BrNO. The article was titled 《N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists》. The information in the text is summarized as follows:
The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-mol. repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein the authors describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure-activity studies reveal a critical linker region in these mols. as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) anal. of RORγ-ligand complexes help rationalize the observed results. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3Formula: C7H8BrNO)
2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C7H8BrNO