Category: 89026-78-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89026-78-8, name is 6-Chloro-N-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Chloro-N-methylpyridin-2-amine

6-Chloro-N-methylpyridin-2-mine (11.5 g, 0.081 mol) and phenylboronic acid (16 g, 0.131 mol) were mixed in 160 mL DME, after degassed by N2 for 10 min, 1,1-bis(diphenylphosphino)ferrocenedichloropalladium(II) (5 g, 6.12 mmol) was mixed, the heterogeneous solution was heated to reflux for 3 h. The mixture was concentrated under vacuum and the resulting oil was poured into saturated ammonium chloride and extracted (EtOAc, 2*). The combined organic layers were washed with saturated sodium bicarbonate, followed by brine. The resulting organic layers collected, dried over Na2SO4 and concentrated in vacuum. The crude product was purified with flash column chromatography (4:1 hexane/EtOAc) to give the title compound as an off-white solid. MS m/z 185 (MH)+.

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Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89026-78-8, name is 6-Chloro-N-methylpyridin-2-amine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.Formula: C6H7ClN2

2-Chloro-N-(6-chloropyridin-2-yl)-N-methyl-pyrimidin-4-amine used as starting material was made as follows: NaHMDS (1.5 ml, 1.5 mmol, IN in THF) was added dropwise to a mixture of 2-chloro-6- methylaminopyridine (142 mg, 1 mmol, German Patent, DE3318560, p 9) and 2,4- dichloropyrimidine (222 mg, 1.5 mmol) in THF (20 ml) cooled at -200C. The mixture was stirred at -200C for 2 hours. Acetic acid (a few drops) were added and the mixture was concentrated. The mixture was taken in DCM, filtered and concentrated. The residue was purified by chromatography on silica gel (eluant: 40% to 50% ethyl acetate in petroleum ether) to give 2-chloro-N-(6-chloropyridin-2-yl)-N-methyl-pyrimidin-4-amine (86 mg, 34%). NMR Spectrum: (CDCl3) 3.61 (s, 3H), 6.93 (d, IH), 7.18 (d, IH), 7.28 (m, IH), 7.72 (t, IH), 8.17 (d, IH); Mass spectrum: MH+ 255.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89026-78-8, 6-Chloro-N-methylpyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10794; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89026-78-8, name is 6-Chloro-N-methylpyridin-2-amine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.COA of Formula: C6H7ClN2

To a stirred solution of 6-chloro-N-methylpyridin-2-amine (0.3 g, 2.10 mmol) in toluene:EtOH:water (1:1:1; 3 ml) was added Cs2CO3 (1.37 g, 4.21 mmol) and phenylboronic acid (0.385 g, 3.16 mmol) at rt. The reaction mixture was degassed for 30 mm before adding Pd(PPh3)4 (0.121 g, 0.105 mmol) at a The reaction mixture was heated at 120C for 16 h. The resulting mixture was cooled to rt, diluted with water (20 ml) and extracted with EtOAc (3 x 25 ml). The combined organic phase was washed with water (20 ml). The organic phase was separated, dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting crude material was purified by flash chromatography (3-7% EtOAc in hexane) yielding N-methyl-6-phenylpyridin-2-amine (0.308 g, 1.67 mmol). LCMS:Method C, 1.48 mi MS: ES+ 185.14; ?H NMR (400 MHz, CDC13) (5ppm 7.97 – 8.02 (m, 2 H), 7.55 (t, J=8.0 Hz, 1 H), 7.44 – 7.52 (m, 2 H), 7.37 – 7.41 (m, 1 H), 7.06 (d, J=7.6 Hz, 1 H), 6.39 (d, J8.4 Hz, 1 H), 3.00 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89026-78-8, 6-Chloro-N-methylpyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; GIBSON, Karl Richard; JONES, Alison; KEMP, Mark Ian; MADIN, Andrew; STOCKLEY, Martin Lee; WHITLOCK, Gavin Alistair; WOODROW, Michael D.; (109 pag.)WO2017/141036; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem