Category: 89856-44-0

Synthetic Route of 89856-44-0 ,Some common heterocyclic compound, 89856-44-0, molecular formula is C7H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of aromatic aldehyde (1mmol), amidine (1mmol) and isocyanide (1mmol) was taken in 2 mL acetonitrile. Then, the catalyst bromodimethylsulfonium bromide (0.022 g, 0.1mmol) was added into it and the reaction mixture was kept for stirring at room temperature till the completion of the reaction as indicated by TLC. The solid product came out slowly which was filtered through a Buchner funnel and the solid precipitate was washed with acetonitrile. Finally it was dried under reduced pressure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89856-44-0, 5-Bromo-4,6-dimethylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Khan, Abu T.; Sidick Basha; Lal, Mohan; Tetrahedron Letters; vol. 53; 17; (2012); p. 2211 – 2217;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89856-44-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89856-44-0, name is 5-Bromo-4,6-dimethylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Preparation Example 38 Synthesis of 3-bromo-6-fluoro-2,4-dimethylpyridine 2-amino-5-bromo-4,6-dimethylpyridine (2 g) was suspended in fluoroboric acid (48% aqueous solution, 7.5 mL). Sodium nitrite (890 mg) dissolved in water (3 mL) was added to the solution at 0 C. The reaction mixture was stirred at 0 C. for 10 minutes. The precipitated solid was collected by filtration and suspended in n-heptane (100 mL). The solution was stirred with heating under reflux for two hours. After cooling to room temperature, the precipitated solid was collected by filtration. The resulting solid was dried under reduced pressure to give the title compound (500 mg). 1H-NMR (400 MHz, CDCl3) delta (ppm): 2.43 (s, 3H), 2.62 (s, 3H), 6.67 (s, 1H).

According to the analysis of related databases, 89856-44-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki; US2013/143907; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem