Category: 91-02-1

Recently I am researching about ONE-POT SYNTHESIS; N-TOSYLHYDRAZONES; CATALYZED TRANSANNULATION; ASYMMETRIC HYDROGENATION; ETHYL DIAZOACETATE; C(SP(3))-H BONDS; DIAZO-COMPOUNDS; ARYLATION; DISCOVERY; NITRILES, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [21302095]; Jiangsu Provincial NSF [BK20130924]; Nanjing Tech University. Name: Phenyl(pyridin-2-yl)methanone. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dong, C; Wang, X; Pei, ZB; Sheno, RW. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Pyridotriazoles are utilized as robust building blocks to access alpha-secondary and alpha-tertiary pyridines via the development of a simple yet practically useful metal-free denitrogenative C-C cross-coupling with boronic acids. The reaction shows a high level of functional tolerance, broad substrate scope, and facile scalability. The synthetic potential of the method is demonstrated by the strurctural modification of a bioactive molecule and concise synthesis of pheniramine analogs.

Name: Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Dong, C; Wang, X; Pei, ZB; Sheno, RW or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2021.0 ACTA PHARMACOL SIN B published article about CELL-DEATH; IN-VITRO; CLASSIFICATION; ORGANIZATION; ANTIFUNGAL in [Zhao, Bing; Zhang, Xinhui; Yu, Tingting; Liu, Ying; Zhang, Xiaoling; Yao, Yongfang; Feng, Xuejian; Liu, Hongmin; Ma, Liying; Qin, Shangshang] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treament, Key Lab Technol Drug Preparat,Inst Pharmaceut Res, Minist Educ China,Key Lab Henan Prov Drug Qual &, Zhengzhou 450001, Henan, Peoples R China; [Zhao, Bing; Zhang, Xinhui; Yu, Tingting; Liu, Ying; Zhang, Xiaoling; Yao, Yongfang; Feng, Xuejian; Liu, Hongmin; Ma, Liying; Qin, Shangshang] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Yu, Dequan] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China in 2021.0, Cited 44.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

New Delhi metallo-beta-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all beta-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive superbug, and no promising NDM-1 inhibitors were used in clinical practice. In this study, structure-activity relationship based on thiosemicarbazone derivatives was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds 19bg and 19bh exhibited excellent activity against 10 NDM-positive isolate clinical isolates in reversing MEM resistance. Further studies demonstrated compounds 19bg and 19bh were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44 mu mol/L, respectively. Molecular docking speculated that compounds 19bg and 19bh were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities even at concentrations of 1000 mg/mL against red blood cells. In vivo experimental results showed combination of MEM and compound 19bh was markedly effective in treating infections caused by NDM-1 positive strain and prolonging the survival time of sepsis mice. Our finding showed that compound 19bh might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Zhao, B; Zhang, XH; Yu, TT; Liu, Y; Zhang, XL; Yao, YF; Feng, XJ; Liu, HM; Yu, DQ; Ma, LY; Qin, SS or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 DALTON T published article about NI-II COMPLEXES; MOLECULAR-STRUCTURE; HYDROLYSIS; MECHANISM; LIGANDS; ESTERS; DRUGS; COBALT(III); DERIVATIVES; KINETICS in [Dasgupta, Sanchari; Karim, Suhana; Das, Debasis] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India; [Banerjee, Saswati; Saha, Moumita; Saha, Krishna Das] CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India in 2020.0, Cited 48.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Formula: C12H9NO

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl-2]2H(2)O (1), [Zn(L2)Cl-2] (2) and [Zn(L3)Cl-2] (3) were synthesized by treatment of zinc(ii) chloride with the corresponding Schiff base ligands and characterised by the usual physicochemical techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal X-ray analysis. All complexes were able to hydrolyse the P-O bond of the phosphate monoester in 90% (v/v) DMSO-water medium using 4-nitrophenylphosphate (4-NPP) as the model substrate and the trend in their activity is 1 approximate to 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1-3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human non-small lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time.

Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Dasgupta, S; Karim, S; Banerjee, S; Saha, M; Saha, KD; Das, D or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Iron-catalyzed oxidative functionalization of C(sp(3))-H bonds under bromide-synergized mild conditions WOS:000474265200024 published article about C-H OXIDATION; AEROBIC OXIDATION; POLYOXOMETALATE; OXYGEN; ACTIVATION; REMOTE in [Yu, Han; Zhao, Qixin; Wei, Zheyu; Wu, Zhikang; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Yu, Han; Li, Qi; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China; [Yu, Han; Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China in 2019.0, Cited 48.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. SDS of cas: 91-02-1

An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6 center dot 2Br), which can effectively catalyze the reaction.

SDS of cas: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Yu, H; Zhao, QX; Wei, ZY; Wu, ZK; Li, Q; Han, S; Wei, YG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Direct intramolecular carbon(sp(2))-nitrogen(sp(2)) reductive elimination from gold(III) WOS:000472449300036 published article about ORGANOGOLD COMPLEXES; CARBON-CARBON; BASIS-SETS; GOLD; MECHANISMS; CATALYSTS; IODIDE; ISOMERIZATION; DESIGN; AMINES in [Kim, Jong Hyun; Mertens, R. Tyler; Agarwal, Amal; Parkin, Sean; Awuah, Samuel G.] Univ Kentucky, Dept Chem, 505 Rose St, Lexington, KY 40506 USA; [Berger, Gilles] Univ Libre Bruxelles, Fac Pharm, Microbiol Bioorgan & Macromol Chem, Brussels, Belgium in 2019.0, Cited 54.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: Phenyl(pyridin-2-yl)methanone

The reactivity of bidentate Au-III-Cl species, [(C<^>N)AuCl2], with a bisphosphine or carbon donor ligands results in reductive elimination. Combined experimental and computational investigations lead to the first evidence of a direct intramolecular C(sp(2))-N(sp(2)) bond formation from a monomeric [(C<^>N)AuCl2] gold(iii) complex. We show that bidentate ligated Au(iii) systems bypass transmetallation to form C(sp(2))-N(sp(2)) species and NHC-Au-Cl. Mechanistic investigations of the reported transformation reveal a ligand-induced reductive elimination via a key Au-III intermediate. Kinetic studies of the reaction support a second-order rate process.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Kim, JH; Mertens, RT; Agarwal, A; Parkin, S; Berger, G; Awuah, SG or concate me.. COA of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C12H9NO. Recently I am researching about STRUCTURAL-ANALYSIS; STRESS; BONDS, Saw an article supported by the Fonds der chemischen IndustrieFonds der Chemischen IndustrieEuropean Commission; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [HE 8521/1-1]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Waldchen, F; Mohr, F; Wagner, AH; Heiles, S. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Local lipid variations in tissues are readily revealed with mass spectrometry imaging (MSI) methods, and the resulting lipid distributions serve as bioanalytical signatures to reveal cell- or tissue-specific lipids. Comprehensive MSI lipid mapping requires measurements in both ion polarities. Additionally, structural lipid characterization is necessary to link the lipid structure to lipid function. Whereas some structural elements of lipids are readily derived from high-resolution mass spectrometry (MS) and tandem-MS (MSn), the localization of C=C double bonds (DBs) requires specialized fragmentation and/or functionalization methods. In this work, we identify a multifunctional matrix-assisted laser desorption/ionization (MALDI) matrix for spatially resolved lipidomics investigations that reacts with lipids in Paterno-Biichi (PB) reactions during laser irradiation facilitating DB-position assignment and allows dual-polarity high-resolution MALDI-MSI and MALDI (MSI)-I-2 studies. By screening 12 compounds for improved ionization efficiency in positive-/negative-ion mode and the functionalization yield compared to the previously introduced reactive MALDI matrix benzophenone, 2-benzoylpyridine (BzPy) is identified as the best candidate. The new matrix enables DB localization of authentic standards belonging to 12 lipid classes and helps to assign 133/58 lipid features in positive-/negative-ion mode from mouse cerebellum tissue. The analytical capabilities of BzPy as a multifunctional MALDI-MSI matrix are demonstrated by imaging endogenous and PB-functionalized lipids in mouse kidney sections with 7 mu m lateral resolution in both ion modes. Tracking diagnostic lipid DB-position fragment ions in mouse pancreatic tissue with down to 10 mu m pixel size allows us to identify the islets of Langerhans associated with lipid isomer upregulation and depletion.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Waldchen, F; Mohr, F; Wagner, AH; Heiles, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Transition-Metal-Free Oxidation of Benzylic C-H Bonds of Six Membered N-Heteroaromatic Compounds WOS:000464250800029 published article about SELECTIVE OXIDATION; AEROBIC OXIDATION; DIRECT AMIDATION; BRONSTED ACID; METHYL-GROUP; COPPER; PYRIDINE; FUNCTIONALIZATION; OXYGENATION; KETONES in [Gao, Xianying; Han, Shuaijun; Zheng, Maolin; Liang, Apeng; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie] Zhengzhou Univ, Henan Key Lab Chem Biol & Organ Chem, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China; [Li, Jingya; Wu, Yusheng] Tetranov Biopharm LLC, Zhengzhou 450052, Henan, Peoples R China; [Li, Jingya; Wu, Yusheng] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450052, Henan, Peoples R China; [Wu, Yusheng] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA in 2019.0, Cited 77.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

A novel oxidation of benzylic C H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ or concate me.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Emami, M; Shahroosvand, H; Bikas, R; Lis, T; Daneluik, C; Pilkington, M in AMER CHEMICAL SOC published article about TRANSITION-METAL-COMPLEXES; CATIONIC IRIDIUM COMPLEXES; ELECTROLUMINESCENT DEVICES; PALLADIUM(II) COMPLEXES; HIGH-BRIGHTNESS; SOLID-STATE; WHITE-LIGHT; LOW-VOLTAGE; CYCLOMETALATED PALLADIUM(II); QUANTUM EFFICIENCY in [Emami, Marzieh; Shahroosvand, Hashem] Univ Zanjan, Chem Dept, Grp Mol Engn Adv Funct Mat GMA, Zanjan 4537138791, Iran; [Bikas, Rahman] Imam Khomeini Int Univ, Fac Sci, Dept Chem, Qazvin 3414896818, Iran; [Lis, Tadeusz] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland; [Daneluik, Cody; Pilkington, Melanie] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada in 2021.0, Cited 129.0. Safety of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

For the first time, square planar Pd(II) complexes of hydrazone ligands have been investigated as the emissive components of light-emitting electrochemical cells (LECs). The neutral transition metal complex, [Pd(L-1)(2)]center dot 2CH(3)OH (1), (HL1 = (E)-N’-(phenyl(pyridin-2-yl) methylene)isonicotinhydrazide), was prepared and structurally characterized. Complex 1 displays quasireversible redox properties and is emissive at room temperature in solution with a lambda(max) of 590 nm. As a result, it was subsequently employed as the emissive material of a single-layer LEC with configuration FTO/1/Ga/In, where studies reveal that it has a yellow color with CIE(x, y) = (0.33, 0.55), a luminance of 134 cd cm(-2), and a turn-on voltage of 3.5 V. Protonation of the pendant pyridine nitrogen atoms of L-1 afforded a second ionic complex [Pd((LH)-H-1)(2)](ClO4)(2) (2) which is also emissive at room temperature with a lambda(max) of 611 nm, resulting in an orange LEC with CIE(x, y) = (0.43, 0.53). The presence of mobile anions and cations in the second inorganic transition metal complex resulted in more efficient charge injection and transport which significantly improved the luminance and turn-on voltage of the device to 188.6 cd cm(-2) and 3 V, respectively. This study establishes Pd(II) hydrazone complexes as a new class of materials whose emissive properties can be chemically tuned and provides proof-of-concept for their use in LECs, opening up exciting new avenues for potential applications in the field of solid state lighting.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Emami, M; Shahroosvand, H; Bikas, R; Lis, T; Daneluik, C; Pilkington, M or concate me.. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: Phenyl(pyridin-2-yl)methanone. Recently I am researching about C-C BOND; CARBON-CARBON BONDS; CONJUGATED YNONES; ARYL KETONES; CLEAVAGE; PALLADIUM; DECARBONYLATION; REARRANGEMENT; FUNCTIONALIZATION; CARBOACYLATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472128]; Sichuan Science and Technology Program [2018JY560]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhong, J; Long, Y; Yan, XF; He, SY; Ye, RY; Xiang, HF; Zhou, XG. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp(2)) and C(O)-C(sp(3)) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Zhong, J; Long, Y; Yan, XF; He, SY; Ye, RY; Xiang, HF; Zhou, XG or concate me.. Safety of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. Shao, TJ; Li, YJ; Ma, NN; Li, CY; Chai, GB; Zhao, XW; Qiao, BK; Jiang, ZY in [Shao, Tianju; Li, Yajuan; Li, Chunyang; Zhao, Xiaowei; Qiao, Baokun; Jiang, Zhiyong] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China; [Ma, Nana; Jiang, Zhiyong] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China; [Chai, Guobi] Zhengzhou Tobacco Res CNTC, Zhengzhou 450001, Henan, Peoples R China published Photoredox-Catalyzed Enantioselective alpha-Deuteration of Azaarenes with D2O in 2019.0, Cited 61.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantioselective manner, which could slow the metabolism and improve the bioavailability of bioactive molecules, remains challenging owing to the lack of established catalytic methods. Here, we report an asymmetric alpha-deuteration strategy for azaarenes with inexpensive D2O as the deuterium source. A cooperative visible light-driven photoredox and chiral Bronsted acid-catalyzed system using a Hantzsch ester as the terminal reductant has been developed, which enables racemic alpha-chloro-azaarenes and prochiral azaarene-substituted ketones to experience a single-electron reduction-enantioselective deuteration process. The transition metal-free method provides important chiral alpha-deuterated azaarenes in satisfactory yields with good to excellent enantioselectivities (up to 99% ee) and substantial deuterium incorporation.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Shao, TJ; Li, YJ; Ma, NN; Li, CY; Chai, GB; Zhao, XW; Qiao, BK; Jiang, ZY or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem