Category: 91-02-1

Recently I am researching about C-H FUNCTIONALIZATION; TERMINAL ALKYNES; HIGHLY EFFICIENT; OXIDATIVE AMINATION; MCM-41; COMPLEXES; ALDEHYDES; IMMOBILIZATION; BONDS; TRANSANNULATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21462021]; Key Laboratory of Functional Small Organic Molecule, Ministry of Education [KLFS-KF-201704]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Liao, Y; Yan, CY; Zhang, RL; Cai, MZ. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Safety of Phenyl(pyridin-2-yl)methanone

The heterogeneous decarboxylative cyclization reaction between 2-benzoylpyridines and alpha-amino acids was achieved in toluene at 120 degrees C in the presence of 15 mol% of L-proline-functionalized MCM-41-supported copper(II) complex [L-Proline-MCM-41-Cu(OTf)(2)] and iodine with di-tert-butyl peroxide (DTBP) as oxidant, yielding a variety of 1,3-disubstituted imidazo[1,5-a]pyridines in good to excellent yields. The new supported copper catalyst can be prepared from commercially available and inexpensive reagents, and recovered from the reaction mixture by a simple filtration and recycled up to eight times with almost consistent activity. (c) 2018 Elsevier B.V. All rights reserved.

Safety of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ORG LETT published article about C-H AMINATION; HETEROCYCLIC CARBENE COMPLEXES; BOND FUNCTIONALIZATION; EFFICIENT SYNTHESIS; NATURAL-PRODUCTS; ALKYNES; N-SULFONYL-1,2,3-TRIAZOLES; THERMOCHEMISTRY; CYCLOADDITION; CONSTRUCTION in [Rawat, Deepa; Ravi, Chitrakar; Joshi, Abhisek; Suresh, Eringathodi; Jana, Kalyanashis; Ganguly, Bishwajit; Adimurthy, Subbarayappa] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res, GB Marg, Bhavnagar 364002, Gujarat, India in 2019.0, Cited 63.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. SDS of cas: 91-02-1

Pyrido[1,2-a]indoles are known for medicinally and pharmaceutically important compounds; however, the efficient synthetic routes are scarce in the literature. We report herein a convenient and efficient route to synthesize these molecules through indium-catalyzed transannulation of pyridotriazoles with arenes. A library of compounds have been synthesized employing the method developed with various substituted pyrido[1,2-a]indole derivatives in moderate to good yields. The density functional theory study using SMDDCB-M06/6-31++G(d,p)/LANL2DZ//B3LYP/6-31G(d)/LANL2DZ method suggests that the reactions proceed via indium-carbenoid complex.

SDS of cas: 91-02-1. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 POLYHEDRON published article about COBALT(III) COMPLEX; CATECHOLASE; OXIDATION; DIOXYGEN; LIGAND; EXAMPLE in [Chatterjee, Arnab; Ghosh, Rajarshi] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India; [Khan, Sumitava] Burdwan Raj Coll, Dept Chem, Burdwan 713104, W Bengal, India in 2019.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: Phenyl(pyridin-2-yl)methanone

Three new mononuclear complexes of the type [M(L)(2)](ClO4)(2), with Ni(II) (1), Cu(II) (2) and Zn(II) (3) ions, have been synthesized and structurally characterized, using the N,N,O donor Schiff base ligand 2-[(phenyl-pyridine-2-yl-methylene)-amino]-ethanol]. An X-ray diffraction study reveals identical crystallization patterns for each of the complexes, in the monoclinic crystal system with the C2/c space group. Interestingly, the synthesized complexes are isostructural in nature. The complexes showed biomimetic phenoxazinone synthase-like activity for the aerial oxidation of o-aminophenol to phenoxazine-2-one, separately in methanol (MeOH) and acetonitrile (ACN) solutions. For each of the complexes, the turnover numbers were found to be higher in MeOH than in ACN. The highest catalytic activity between among the three complexes was found to be for complex 2. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Tanaka, N; Usuki, T in [Tanaka, Nao; Usuki, Toyonobu] Sophia Univ, Dept Mat & Life Sci, Fac Sci & Technol, Chiyoda Ku, 7-1 Kioicho, Tokyo 1028554, Japan published Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions? in 2020.0, Cited 79.0. Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1-100 mol%) with H-2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 mol% Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept (R)).

Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Mravec, B; Filo, J; Csicsai, K; Garaj, V; Kemka, M; Marini, A; Mantero, M; Bianco, A; Cigan, M in ROYAL SOC CHEMISTRY published article about ISOMERIZATION MECHANISM; LIGHT; SWITCHES; RELEASE; PHOTOCHEMISTRY; PHOTOCHROMISM; ASSEMBLIES; SYSTEMS; PYRIDYL in [Mravec, Bernard; Filo, Juraj; Csicsai, Klaudia; Cigan, Marek] Camenius Univ, Fac Nat Sci, Inst Chem, Ilkavicova 6, SK-84215 Bratislava, Slovakia; [Garaj, Vladimir; Kemka, Miroslav] Comenius Univ, Fac Pharm, Dept Pharmaceut Chem, Odbojarov 10, SK-83232 Bratislava, Slovakia; [Marini, Anna; Mantero, Mariachiara; Bianco, Andrea] INAF Osservatoria Astron Brera, Via Bianchi 46, I-23807 Merate, Italy in 2019.0, Cited 61.0. Safety of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

The photoswitching properties of three readily accesible benzoylpyridine hydrazones were investigated. Interestingly, replacing classical stirring with ultrasound wave activation results in pure thermodynamically less stable E isomer crystallization at room temperature. The studied benzoylpyridine hydrazones exhibit both P- and T-photochromic behaviour, depending on the benzoyl substituent, and improved addressability compared to most of the previously published pyridyl based hydrazones and 2-pyridylcarboxaldehyde acylhydrazones. Low activation entropy and calculated transition state geometry favour the inversion mechanism of their thermal isomerization rather than tautomerization followed by rotation recently found for pyridyl-hydrazone ester or nitrile rotary switches. The association behaviour of the nitro derivative during its thermal E-to-Z isomerization in highly polar DMSO indicates an important role of intermolecular hydrogen bonding in the thermal kinetics of benzoylpyridine-based hydrazone photoswitches. Moreover, the addition of triethylamine significantly accelerates the rate of Z-isomer thermal isomerization from days to seconds and could thus pave the way to fast pyridyl hydrazone T-type photochromic compounds in polar solvents. This study could therefore contribute to general knowledge related to the photochromic behaviour of hydrazones as an important class of modern photoswitches.

Safety of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Mravec, B; Filo, J; Csicsai, K; Garaj, V; Kemka, M; Marini, A; Mantero, M; Bianco, A; Cigan, M or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. Authors Hou, CF; Sun, SE; Liu, ZQ; Zhang, H; Liu, Y; An, Q; Zhao, J; Ma, JJ; Sun, ZZ; Chu, WY in WILEY-V C H VERLAG GMBH published article about in [Hou, Chuanfu; Sun, Shouneng; Liu, Ziqi; Zhang, Hui; Liu, Yue; An, Qi; Zhao, Jian; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Peoples R China in 2021.0, Cited 80.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Herein, the development of a visible-light-induced catalytic system to achieve the decarboxylative acylation of pyridine N-oxides with alpha-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst, is reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium has been used to catalyze the Minisci-type C-H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene to confirm a radical mechanism. The disclosed catalytic system provides a green synthetic strategy for decarboxylative acylation without the use of additional oxidants or metal catalysts.

Welcome to talk about 91-02-1, If you have any questions, you can contact Hou, CF; Sun, SE; Liu, ZQ; Zhang, H; Liu, Y; An, Q; Zhao, J; Ma, JJ; Sun, ZZ; Chu, WY or send Email.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019 ADV SYNTH CATAL published article about THERMOANAEROBACTER-ETHANOLICUS; SATURATION MUTAGENESIS; MOLECULAR-DYNAMICS; DIRECTED EVOLUTION; SUBSTRATE-SPECIFICITY; ASYMMETRIC REDUCTION; BIOCATALYSIS; KETOREDUCTASE; MUTATION; ENZYME in [Liu, Beibei; Xu, Yan; Nie, Yao] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Liu, Beibei; Qu, Ge; Li, Jun-Kuan; Fan, Wenchao; Sun, Zhoutong] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin Airport Econ Area, 32 West 7th Ave, Tianjin 300308, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China in 2019, Cited 82. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: Phenyl(pyridin-2-yl)methanone

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce enantio-pure secondary alcohols is particularly attractive in organic synthesis. Loops located at the active pocket of enzymes often participate in conformational changes required to fine-tune residues for substrate binding and catalysis. It is therefore of great interest to control the substrate specificity and stereochemistry of enzymatic reactions by manipulating the conformational dynamics. Herein, a secondary alcohol dehydrogenase was chosen to enantioselectively catalyze the transformation of difficult-to-reduce bulky ketones, which are not accepted by the wildtype enzyme. Guided by previous work and particularly by structural analysis and molecular dynamics (MD) simulations, two key residues alanine 85 (A85) and isoleucine 86 (I86) situated at the binding pocket were thought to increase the fluctuation of a loop region, thereby yielding a larger volume of the binding pocket to accommodate bulky substrates. Subsequently, site-directed saturation mutagenesis was performed at the two sites. The best mutant, where residue alanine 85 was mutated to glycine and isoleucine 86 to leucine (A85G/I86L), can efficiently reduce bulky ketones to the corresponding pharmaceutically interesting alcohols with high enantioselectivities (similar to 99% ee). Taken together, this study demonstrates that introducing appropriate mutations at key residues can induce a higher flexibility of the active site loop, resulting in the improvement of substrate specificity and enantioselectivity.

Welcome to talk about 91-02-1, If you have any questions, you can contact Liu, BB; Qu, G; Li, JK; Fan, WC; Ma, JA; Xu, Y; Nie, Y; Sun, ZT or send Email.. Recommanded Product: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 CHEM COMMUN published article about C-H OXIDATION; AEROBIC OXIDATION; POLYOXOMETALATE; OXYGEN; ACTIVATION; REMOTE in [Yu, Han; Zhao, Qixin; Wei, Zheyu; Wu, Zhikang; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Yu, Han; Li, Qi; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China; [Yu, Han; Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China in 2019.0, Cited 48.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Quality Control of Phenyl(pyridin-2-yl)methanone

An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6 center dot 2Br), which can effectively catalyze the reaction.

Quality Control of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Yu, H; Zhao, QX; Wei, ZY; Wu, ZK; Li, Q; Han, S; Wei, YG or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2020.0 DALTON T published article about NI-II COMPLEXES; MOLECULAR-STRUCTURE; HYDROLYSIS; MECHANISM; LIGANDS; ESTERS; DRUGS; COBALT(III); DERIVATIVES; KINETICS in [Dasgupta, Sanchari; Karim, Suhana; Das, Debasis] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India; [Banerjee, Saswati; Saha, Moumita; Saha, Krishna Das] CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India in 2020.0, Cited 48.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl-2]2H(2)O (1), [Zn(L2)Cl-2] (2) and [Zn(L3)Cl-2] (3) were synthesized by treatment of zinc(ii) chloride with the corresponding Schiff base ligands and characterised by the usual physicochemical techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal X-ray analysis. All complexes were able to hydrolyse the P-O bond of the phosphate monoester in 90% (v/v) DMSO-water medium using 4-nitrophenylphosphate (4-NPP) as the model substrate and the trend in their activity is 1 approximate to 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1-3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human non-small lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Dasgupta, S; Karim, S; Banerjee, S; Saha, M; Saha, KD; Das, D or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C12H9NO. Zhang, Y; Hatami, N; Lange, NS; Ronge, E; Schilling, W; Jooss, C; Das, S in [Zhang, Yu; Das, Shoubhik] Univ Antwerp, Dept Chem, ORSY Div, Gronenborgerlaan 171, B-2020 Antwerp, Belgium; [Zhang, Yu; Hatami, Nareh; Lange, Niklas Simon; Schilling, Waldemar] Georg August Univ Gottingen, Inst Biomol & Organ Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Ronge, Emanuel; Jooss, Christian] Georg August Univ Gottingen, Inst Materialphys, Friedrich Hund Pl 1, D-37077 Gottingen, Germany published A metal-free heterogeneous photocatalyst for the selective oxidative cleavage of C = C bonds in aryl olefins via harvesting direct solar energy in 2020, Cited 68. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Selective cleavage of C & xe001;C bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reactionetc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries! To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.

Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem