Category: 91-02-1

Formula: C12H9NO. I found the field of Chemistry very interesting. Saw the article Development of Bronsted Base-Photocatalyst Hybrid Systems for Highly Efficient C-C Bond Formation Reactions of Malonates with Styrenes published in 2020, Reprint Addresses Yamashita, Y; Kobayashi, S (corresponding author), Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

Bronsted base-photocatalyst hybrid systems have been developed for reactions of malonates with styrene derivatives. The concept of this process lies in the photo-oxidation of catalytic amounts of the enolate to form reactive radicals that react with alkene double bonds under mild reaction conditions. This is an example of visible-light-activated C-C bond formation reactions of malonates with alkenes to realize high atom economy under very mild reaction conditions without using any transition-metal catalysts.

Welcome to talk about 91-02-1, If you have any questions, you can contact Bas, S; Yamashita, Y; Kobayashi, S or send Email.. Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. In 2021 J FLOW CHEM published article about ASYMMETRIC HYDROGENATION; NITRIC-ACID; CHEMISTRY; SYSTEM; GENERATION; CONVERSION; NITRATION; ARYL in [Sun, Maolin; Li, Jianchang; Liang, Chaoming; Shan, Chao; Shen, Xinyuan; Ma, Yueyue; Ye, Jinxing] East China Univ Sci & Technol, Minist Educ, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China; [Cheng, Ruihua] East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China in 2021, Cited 59. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

2-Pyridyl ketones widely appear in bioactive molecules, natural products, and are employed as precursors of chiral 2-pyridine alky/aryl alcohols or 2-aminoalkyl pyridine ligands for asymmetric catalysis. Herein, a practical method for the rapid synthesis of 2-pyridyl ketone library in continuous flow is reported, in which the 2-lithiopyridine formed by Br/Li exchange reacts with commercially available esters to obtain 2-pyridyl ketones in a good yield at short reaction time. This protocol functions broadly on a variety of esters and has been applied to the synthesis of TGF-beta type 1 receptor inhibitor LY580276 intermediate in an environmentally friendly method. It is rapid, reliable, and cost-efficient to afford diverse kinds of 2-pyridyl ketones in the compound library.

Welcome to talk about 91-02-1, If you have any questions, you can contact Sun, ML; Li, JC; Liang, CM; Shan, C; Shen, XY; Cheng, RH; Ma, YY; Ye, JX or send Email.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Transition-Metal-Free Oxidation of Benzylic C-H Bonds of Six Membered N-Heteroaromatic Compounds WOS:000464250800029 published article about SELECTIVE OXIDATION; AEROBIC OXIDATION; DIRECT AMIDATION; BRONSTED ACID; METHYL-GROUP; COPPER; PYRIDINE; FUNCTIONALIZATION; OXYGENATION; KETONES in [Gao, Xianying; Han, Shuaijun; Zheng, Maolin; Liang, Apeng; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie] Zhengzhou Univ, Henan Key Lab Chem Biol & Organ Chem, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China; [Li, Jingya; Wu, Yusheng] Tetranov Biopharm LLC, Zhengzhou 450052, Henan, Peoples R China; [Li, Jingya; Wu, Yusheng] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450052, Henan, Peoples R China; [Wu, Yusheng] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA in 2019.0, Cited 77.0. Recommanded Product: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A novel oxidation of benzylic C H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.

Welcome to talk about 91-02-1, If you have any questions, you can contact Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ or send Email.. Recommanded Product: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Zhu, NB; Su, M; Wan, WM; Li, YJ; Bao, HL in [Zhu, Nengbo; Su, Min; Wan, Wen-Ming; Li, Yajun; Bao, Hongli] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem,Key Lab Coal Ethylene G, Fuzhou 350002, Peoples R China published Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O in 2020.0, Cited 59.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

alpha-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords alpha-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Zhu, NB; Su, M; Wan, WM; Li, YJ; Bao, HL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Suman, S; Singh, R in [Suman, Shankar; Singh, Ram] Delhi Technol Univ, Dept Appl Chem, Delhi 110042, India published Zn(II)-selective poly (vinyl chloride) (PVC) membrane electrode based on Schiff base ligand 2-benzoylpyridine semicarbazone as an ionophore in 2020.0, Cited 35.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A new poly (vinyl chloride) (PVC) membrane electrode using 2-benzoylpyridine semicarbazone as membrane carrier with dioctylphthalate as plasticizer and sodium tetraphenylborate (NaTBP) as anion excluder has been fabricated and investigated as Zn(II)-selective electrode. Best potential response is observed for the composition PVC 30%, plasticizer 58%, NaTBP 8% and ionophore 4% (w/w). The sensor showed a linear stable response over a concentration range of 1.0 x 10(-2)-4.56 x 10(-6) M with a detection limit of 2.28 x 10(-6) M and a response time <10 s. The electrode can be used for at least six months without any divergence in potential. Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Carbonylative Suzuki coupling reactions catalyzed by ONO pincer-type Pd(II) complexes using chloroform as a carbon monoxide surrogate WOS:000505315200001 published article about DIRECT AEROBIC CARBONYLATION; EX-SITU GENERATION; PALLADIUM(II) COMPLEXES; SYNERGISTIC CATALYSIS; EFFICIENT; HYDRAZONE; BONDS; ACIDS; CO; C(SP(2))-H in [Layek, Samaresh; Agrahari, Bhumika; Das, Parthasarathi; Pathak, Devendra D.] Indian Sch Mines, Indian Inst Technol, Dept Chem, Dhanbad 826004, Jharkhand, India; [Ganguly, Rakesh] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 639798, Singapore in 2020.0, Cited 69.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

Benzoylhydrazone Schiff base-ligated three new ONO pincer-type palladium(II) complexes, [(PdL1(PPh3)] (1), [(PdL2(PPh3)] (2), and [(PdL3(PPh3)] (3), were synthesized by the reaction of the respective ligand, N-(2-hydroxybenzylidene)benzohydrazide (HL1), N-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (HL2), or N-(5-bromo-2-hydroxybenzylidene) benzohydrazide (HL3), with Pd(OAc)(2) and PPh3 in methanol and isolated as air-stable reddish-orange crystalline solids in high yields (78%-83%). All three complexes were fully characterized by elemental analysis, Fourier-transform infrared spectroscopy, UV-Visible, H-1 nuclear magnetic resonance (NMR), C-13{H-1} NMR, and P-31{H-1} NMR spectroscopic studies. The molecular structure of all three complexes was established unambiguously by single-crystal X-ray diffraction studies which revealed a distorted square planar geometry of all three complexes. The ONO pincer-type ligands occupied three coordination sites at the palladium, while the fourth site is occupied by the monodentate triphenylphosphine ligand. The catalytic potential of all three complexes was explored in the carbonylative Suzuki coupling of aryl bromides and iodides with arylboronic acids to yield biaryl ketones, using CHCl3 as the source of carbonyl. The reported protocol is convenient and safe as it obviates the use of carbon monoxide (CO) balloons or pressured CO reactors which are otherwise needed for the carbonylation reactions. The methodology has been successfully applied to the synthesis of two antineoplastic drugs, namely, phenstatin and naphthylphenstatin, in good yields (81% and 85%, respectively). Under the optimized reaction conditions, complex 2 exhibited the best catalytic activity in the carbonylative Suzuki couplings. The reported catalysts have wide reaction scope with good functional group tolerance. All catalysts could be retrieved from the reaction after completion and recycled up to three times with insignificant loss in the catalytic activity.

Welcome to talk about 91-02-1, If you have any questions, you can contact Layek, S; Agrahari, B; Ganguly, R; Das, P; Pathak, DD or send Email.. Computed Properties of C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C12H9NO. Kondo, Y; Kadota, T; Hirazawa, Y; Morisaki, K; Morimoto, H; Ohshima, T in [Kondo, Yuta; Kadota, Tetsuya; Hirazawa, Yoshinobu; Morisaki, Kazuhiro; Morimoto, Hiroyuki; Ohshima, Takashi] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan; [Morisaki, Kazuhiro] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan published Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines in 2020.0, Cited 67.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using commercially available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described.

Computed Properties of C12H9NO. Welcome to talk about 91-02-1, If you have any questions, you can contact Kondo, Y; Kadota, T; Hirazawa, Y; Morisaki, K; Morimoto, H; Ohshima, T or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 91-02-1. Recently I am researching about DEUTERIUM; ACTIVATION; HYDROGEN; TRITIATION; REDUCTION; CARBON; DRUG, Saw an article supported by the . Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Nan, XL; Wang, Y; Li, XB; Tung, CH; Wu, LZ. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Owing to the high synthetic value of deuteration in the pharmaceutical industry, we describe herein the conversion of a range of aromatic ketones to deuterium-labeled products in good to excellent yields. Efficient and site-selective deuteration of benzyl alcohols by D2O with visible light irradiation of quantum dots (QDs), together with gram-scale synthesis and photocatalyst recycling experiments indicated the potential of the developed method in practical organic synthesis.

Welcome to talk about 91-02-1, If you have any questions, you can contact Nan, XL; Wang, Y; Li, XB; Tung, CH; Wu, LZ or send Email.. SDS of cas: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. In 2019.0 J ORGANOMET CHEM published article about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY in [Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin] Monash Univ Malaysia, Sch Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia in 2019.0, Cited 74.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

Product Details of 91-02-1. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity published in 2020.0. Recommanded Product: Phenyl(pyridin-2-yl)methanone, Reprint Addresses Reid, RC; Fairlie, DP (corresponding author), Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, Brisbane, Qld 4072, Australia.; Reid, RC; Fairlie, DP (corresponding author), Univ Queensland, Inst Mol Biosci, Australian Res Council, Ctr Excellence Adv Mol Imaging, Brisbane, Qld 4072, Australia.; Reid, RC; Fairlie, DP (corresponding author), Univ Queensland, Inst Mol Biosci, Ctr Inflammat & Dis Res, Brisbane, Qld 4072, Australia.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound JR14a was among the most potent of the new antagonists in vitro, assessed by (a) inhibition of intracellular calcium release (IC50 10 nM) induced in human monocyte-derived macrophages by 100 nM C3a, (b) inhibition of beta-hexosaminidase secretion (IC50 8 nM) from human LAD2 mast cells degranulated by 100 nM C3a, and (c) selectivity for human C3aR over C5aR JR14a was metabolically stable in rat plasma and in rat liver microsomes and efficacious in rats when given orally to suppress rat paw inflammation, macrophage and mast cell activation, and histopathology induced by intraplantar paw administration of a C3aR agonist. Potent C3aR antagonists are now available for interrogating C3a receptor activation and suppressing C3aR-mediated inflammation in mammalian physiology and disease.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Rowley, JA; Reid, RC; Poon, EKY; Wu, KC; Lim, JX; Lohman, RJ; Hamidon, JK; Yau, MK; Halili, MA; Durek, T; Iyer, A; Fairlie, DP or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem