Category: 91-02-1

Recommanded Product: Phenyl(pyridin-2-yl)methanone. I found the field of Chemistry; Crystallography very interesting. Saw the article Copper(II) hydrazone complexes with different nuclearities and geometries: Synthesis, structural characterization, antioxidant SOD activity and antiproliferative properties published in 2020.0, Reprint Addresses Jadeja, RN (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

New copper(II) hydrazone complexes with (Z)-2-(phenyl(2-(pyridin-2-yl)hydrazono)methyl)pyridine (L) were synthesized and characterized using various physicochemical methods. The geometries of the complexes can be classified as mononuclear and binuclear. The complex 1, [Cu(L)(Cl)(2)], is mononuclear whereas the solid-state structure of complex 2 contain a mixture of co-crystals of the mono- and binuclear complexes 2a, [Cu(L)(H2O)(SO4)], and 2b, [Cu-2(L)(2)(mu-SO4)(2)]. The unit cell of 2 contains two units of the mononuclear complex 2a and one units of the binuclear complex 2b. The copper atoms contained in all the mono- and binuclear complexes are in a distorted square pyramidal geometry. The present study indicates that complexes having different nuclearities and geometries can be achieved by changing the synthetic conditions and methods. Variable temperature magnetic susceptibility measurements of the complexes have shown the presence of weak anti-ferromagnetic interactions. These interactions are mediated by intermolecular hydrogen bonding in 1 and through a symmetric sulfate bridge in 2. The EPR spectra in the polycrystalline state for 1 and 2 exhibited a broad signal at similar to 2.149 due to spin-spin interactions between two copper(II) ions. The cyclic voltammograms of complexes 1 and 2 in DMSO gave two irreversible redox waves. Density functional theory (DFT) calculations were evaluated in the study, involving the molecular specification with the use of B3LYP/LANL2DZ formalism for the copper atoms and B3LYP/6-31G for the remaining atoms. Both complexes catalyzed the dismutation of superoxide (O-2(center dot-)). Furthermore, the copper complexes and the ligand were tested to explore their anticancer properties. Promising cytotoxicity of the synthesized compounds was observed against the selected cancerous cell lines of neuroblastoma, lung carcinoma, hepatocellular carcinoma and breast cancer. (C) 2020 Elsevier Ltd. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about SELECTIVE OXIDATION; AEROBIC OXIDATION; DIRECT AMIDATION; BRONSTED ACID; METHYL-GROUP; COPPER; PYRIDINE; FUNCTIONALIZATION; OXYGENATION; KETONES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21172200, 21702191]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Category: pyridine-derivatives

A novel oxidation of benzylic C H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Non-covalent interactions governing the supramolecular assembly of copper(II) complexes with hydrazone-type ligand: Experimental and quantum chemical study WOS:000640386000003 published article about SUPEROXIDE-DISMUTASE ACTIVITY; PARAMAGNETIC-RESONANCE SPECTRA; DENSITY-FUNCTIONAL THEORY; AB-INITIO HF; CRYSTAL-STRUCTURES; X-RAY; ACTIVE-SITE; SPECTROSCOPIC CHARACTERIZATION; INTERMOLECULAR INTERACTIONS; NICKEL(II) COMPLEXES in [Singh, Y.; Patel, Ram N.; Patel, Satish K.] APS Univ, Dept Chem, Rewa 486003, MP, India; [Jadeja, R. N.; Patel, Abhay K.; Patel, Neetu] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India; [Roy, H.] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Zool, Vadodara 390002, India; [Kumar, P.] VBS Purvanchal Univ, Rajju Bhaiya Inst Phys Sci Study & Res, Dept Chem, Jaunpur 222203, UP, India; [Butcher, R. J.] Howard Univ, Dept Inorgan & Struct Chem, Washington, DC 22031 USA; [Jasinski, Jerry P.] Keene State Coll, Dept Chem, 229 Main St, Keene, NH 03435 USA; [Cortijo, M.; Herrero, S.] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Inorgan, Madrid 28040, Spain in 2021.0, Cited 133.0. COA of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of two new mono- and one binuclear m-nitrato bridged copper(II) complexes [Cu(L)(HL)]ClO4 (1), [Cu(HL)(NO3)(H2O)](2)NO3 center dot H2O (2) and [Cu-2(L-2)(mu-NO3)(2)] (3), with an unsymmetrical NNO donor Schiff base (HL) have been synthesized and characterized by elemental analysis, FTIR, CV, UV-vis and EPR spectroscopy. Their molecular structures were also determined by single crystal X-ray crystallography. In the binuclear complex 3, the Cu center dot center dot center dot Cu distance is 3.494 angstrom. In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (tau(5) = 0.05-0.17). Evidence of weak pi center dot center dot center dot pi stacking intermolecular interactions along with other non-covalent interactions (hydrogen bonding) was observed by analyzing the respective crystal structures of the complexes. Thus, these hydrogen bonds, pi center dot center dot center dot pi stacking interactions and other weak intermolecular interactions establish in the form of supramolecular architectures a crystalline network environment. The non-covalent interactions were also investigated by employing Hirshfeld Analysis. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear copper(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit copper(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In complexes 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chemical calculations (DFT) were carried out on complexes 1-3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of kMcCF is in the range 4.94-12.31 (mol L)(-1)s(-1))x 10(4). (C) 2021 Elsevier Ltd. All rights reserved.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Zn(II)-selective poly (vinyl chloride) (PVC) membrane electrode based on Schiff base ligand 2-benzoylpyridine semicarbazone as an ionophore WOS:000591188400006 published article about HEAVY-METAL IONS; SENSOR; CONSTRUCTION; CARRIER in [Suman, Shankar; Singh, Ram] Delhi Technol Univ, Dept Appl Chem, Delhi 110042, India in 2020.0, Cited 35.0. Recommanded Product: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A new poly (vinyl chloride) (PVC) membrane electrode using 2-benzoylpyridine semicarbazone as membrane carrier with dioctylphthalate as plasticizer and sodium tetraphenylborate (NaTBP) as anion excluder has been fabricated and investigated as Zn(II)-selective electrode. Best potential response is observed for the composition PVC 30%, plasticizer 58%, NaTBP 8% and ionophore 4% (w/w). The sensor showed a linear stable response over a concentration range of 1.0 x 10(-2)-4.56 x 10(-6) M with a detection limit of 2.28 x 10(-6) M and a response time <10 s. The electrode can be used for at least six months without any divergence in potential. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Authors Kim, JH; Ofori, S; Parkin, S; Vekaria, H; Sullivan, PG; Awuah, SG in ROYAL SOC CHEMISTRY published article about in [Kim, Jong Hyun; Ofori, Samuel; Parkin, Sean; Awuah, Samuel G.] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA; [Awuah, Samuel G.] Univ Kentucky, Coll Pharm, Ctr Pharmaceut Res & Innovat, Lexington, KY 40536 USA; [Awuah, Samuel G.] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA; [Vekaria, Hemendra; Sullivan, Patrick G.] Univ Kentucky, Spinal Cord & Brain Injury Res Ctr, Lexington, KY USA; [Sullivan, Patrick G.] Univ Kentucky, Dept Neurosci, Lexington, KY USA; [Sullivan, Patrick G.] Lexington Vet Affairs Healthcare Syst, Lexington, KY USA in 2021.0, Cited 75.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Expanding the chemical diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chemistry of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiological stability. Biological evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of adenosine triphosphate (ATP). Mechanism-of-action efforts, RNA-Seq, quantitative proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple negative breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiology.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Kim, JH; Ofori, S; Parkin, S; Vekaria, H; Sullivan, PG; Awuah, SG or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach WOS:000539603800001 published article about VISIBLE-LIGHT; ELECTRON; PHOTOEXCITATION; ENERGY; STATE; ACIDS in [Cardinale, Luana; Konev, Mikhail O.; Jacobi von Wangelin, Axel] Univ Hamburg, Dept Chem, Martin Luther King Pl 6, D-20146 Hamburg, Germany in 2020.0, Cited 57.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C-1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Cardinale, L; Konev, MO; von Wangelin, AJ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article AIBN for Ru-catalyzed meta-C-Ar-H alkylation published in 2020.0. Product Details of 91-02-1, Reprint Addresses Li, G (corresponding author), Anyang Normal Univ, Coll Chem & Chem Engn, Henan Prov Key Lab New Optoelect Funct Mat, Anyang 455002, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Themeta-C-Ar-H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl(3)catalyst is presented. This development not only confirmed that ruthenium-catalyzedmeta-C-Ar-H bond functionalization is a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which are prevalent in a diverse range of biologically active molecules and other functional materials.

Product Details of 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Yang, SL; Yan, BX; Zhong, L; Jia, CQ; Yao, D; Yang, CL; Sun, K; Li, G or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Discovery of thiosemicarbazone-containing compounds with potent anti- proliferation activity against drug-resistant K562/A02 cells WOS:000595378800015 published article about BIOLOGICAL EVALUATION; CYCLE ARREST; IN-VITRO; ANTIOXIDANT; DERIVATIVES; APOPTOSIS in [Gu, Xiaoke; Li, Xin; Guan, Mingyu; Jiang, Chunyu; Song, Qinghua; Sun, Nan; Qiu, Jingying] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China; [Zou, Yueting; Zhou, Qingqing; Chen, Jing; Qiu, Jingying] Xuzhou Med Univ, Sch Pharm, Dept Pharmaceut Anal, Xuzhou 221004, Jiangsu, Peoples R China in 2020.0, Cited 27.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. In 2020.0 ANTI-CANCER AGENT ME published article about CELL-CYCLE ARREST; G-QUADRUPLEX DNA; METAL-COMPLEXES; CISPLATIN-DNA; TUMOR; INHIBITION; BINDING; RECOGNITION; P53; PROLIFERATION in [Li, Yu-Lan; Gan, Xin-Li; Zhu, Rong-Ping; Jin, Junfei] Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China; [Li, Yu-Lan; Jin, Junfei] Guilin Med Univ, Guangxi Key Lab Mol Med Liver Injury & Repair, Guilin 541001, Guangxi, Peoples R China; [Li, Yu-Lan; Jin, Junfei] Guilin Med Univ, China USA Lipids Hlth & Dis Res Ctr, Guilin 541001, Guangxi, Peoples R China; [Wang, Xuehong; Huang, Zhaoquan] Guilin Med Univ, Dept Pathol, Affiliated Hosp, 15 Lequn Rd, Guilin 541001, Guangxi, Peoples R China; [Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China; [Li, Yu-Lan] Guangxi Normal Univ, Sch Chem & Pharm, Key Lab Chem & Mol Engn Med Resources, 15 Yucai Rd, Guilin 541004, Peoples R China; [Zhu, Rong-Ping] Nanchang Univ, Ganzhou Peoples Hosp, Dept Emergency Traumat Surg, Affiliated Ganzhou Hosp, Ganzhou 341000, Jiangxi, Peoples R China in 2020.0, Cited 54.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Objective: To overcome the disadvantages of cisplatin, numerous platinum (Pt) complexes have been prepared. However, the anticancer activity and mechanism of Pt(II) complexed with 2-benzoylpyridine [Pt(II)-Bpy]: [PtCl2(DMSO)L] (DMSO = dimethyl sulfoxide, L = 2-benzoylpyridine) in cancer cells remain unknown. Methods: Pt(II)-Bpy was synthesized and characterized by spectrum analysis. Its anticancer activity and underlying mechanisms were demonstrated at the cellular, molecular, and in vivo levels. Results: Pt(II)-Bpy inhibited tumor cell growth, especially HepG2 human liver cancer cells, with a half-maximal inhibitory concentration of 9.8 +/- 0.5 mu M, but with low toxicity in HL-7702 normal liver cells. Pt(H)Bpy induced DNA damage, which was demonstrated through a marked increase in the expression of cleaved-poly (ADP ribose) polymerase (PARP) and gamma-H2A histone family member X and a decrease in PARP expression. The interaction of Pt(II)-Bpy with DNA at the molecular level was most likely through an intercalation mechanism, which might be evidence of DNA damage. Pt(II)-Bpy initiated cell cycle arrest at the S phase in HepG2 cells. It also caused severe loss of the mitochondria( membrane potential; a decrease in the expression of caspase-9 and caspase-3; an increase in reactive oxygen species levels; the release of cytochrome c and apoptotic protease activation factor; and the activation of caspase-9 and caspase-3 in HepG2 cells, which in turn resulted in apoptosis. Meanwhile, changes in p53 and related proteins were observed including the upregulation of p53, the phosphorylation of p53, p21, B-cell lymphoma-2-associated X protein, and NOXA; and the down-regulation of B-cell lymphoma 2. Moreover, Pt(II)-Bpy displayed marked inhibitory effects on tumor growth in the HepG2 nude mouse model. Conclusion: Pt(II)-Bpy is a potential candidate for cancer chemotherapy.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Li, YL; Gan, XL; Zhu, RP; Wang, XH; Liao, DF; Jin, JF; Huang, ZQ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Yuan, Q; Chen, LL; Zhu, XH; Yuan, ZH; Duan, YT; Yang, YS; Wang, BZ; Wang, XM; Zhu, HL in ELSEVIER published article about LARGE STOKES SHIFT; SULFUR-DIOXIDE DERIVATIVES; HYDROGEN-SULFIDE; RATIOMETRIC FLUORESCENT; SO2 DERIVATIVES; LIVING CELLS; PROBE; CYSTEINE; H2S; GASOTRANSMITTERS in [Yuan, Qing; Chen, Li-Li; Zhu, Xiao-Hua; Yuan, Zeng-Hui; Yang, Yu-Shun; Wang, Bao-Zhong; Wang, Xiao-Ming; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Duan, Yong-Tao] Zhengzhou Univ, Childrens Hosp, Henan Prov Key Lab Childrens Genet & Metab Dis, Zhengzhou 450018, Peoples R China in 2020.0, Cited 55.0. HPLC of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Sulfur-containing species are essential in the composition and the metabolism of the organisms, thus developing a full set of implements to cover all of them is still a favorable choice. Herein, we chose imidazo [1,5-alpha] pyridine moiety as the basic fluorophore for the detection of sulfite, and preliminarily completed the toolset since biothiols (GSH, Cys, Hcy), H2S, and PhSH could be detected by sensors based on the same backbone. The designed sensor, IPD-SFT, with structural novelty and large Stokes shift (130 nm), indicated the most attractive advantages of remarkably rapid response period (within 1 min) and high selectivity for sulfite from all the sulfurcontaining species. Other practical properties included high sensitivity (LOD = 50 nM) and wide pH adaptability (5.0-11.0). Furthermore, IPD-SFT could monitor both exogenous and endogenous sulfite. It not only raised a potential tool for sulfite detection, but also preliminarily completed the toolset for all the sulfur-containing species. The development of such toolsets might reveal the sulfur-containing metabolism and corresponding physiology and pathological procedures.

HPLC of Formula: C12H9NO. Welcome to talk about 91-02-1, If you have any questions, you can contact Yuan, Q; Chen, LL; Zhu, XH; Yuan, ZH; Duan, YT; Yang, YS; Wang, BZ; Wang, XM; Zhu, HL or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem