Category: 91-02-1

COA of Formula: C12H9NO. I found the field of Chemistry very interesting. Saw the article Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O published in 2020.0, Reprint Addresses Bao, HL (corresponding author), Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem,Key Lab Coal Ethylene G, Fuzhou 350002, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

alpha-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords alpha-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.

Welcome to talk about 91-02-1, If you have any questions, you can contact Zhu, NB; Su, M; Wan, WM; Li, YJ; Bao, HL or send Email.. COA of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY, Saw an article supported by the Ministry of Higher Education (MOHE), Malaysia via Fundamental Research Grant Scheme (FRGS) [FRGS/1/2014/ST01/MUSM/03/1]; School of Science, Monash University Malaysia. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Choo, KB; Lee, SM; Lee, WL; Cheow, YL. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Quality Control of Phenyl(pyridin-2-yl)methanone

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Metal-free photocatalysts for the oxidation of non-activated alcohols and the oxygenation of tertiary amines performed in air or oxygen WOS:000513109400004 published article about SELECTIVE OXIDATION; ALPHA-OXYGENATION; FREE CATALYST; AMIDES in [Zhang, Yu; Schilling, Waldemar; Riemer, Daniel; Das, Shoubhik] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Gottingen, Germany in 2020, Cited 25. Product Details of 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

This protocol describes the use of 9-fluorenone as a cheap and non-toxic photocatalyst for the oxidation of non-activated alcohols performed under the irradiation of a blue light-emitting diode. It also describes the use of the similarly cheap and non-toxic photocatalyst rose bengal for the selective alpha-oxygenation of tertiary amines to produce the corresponding amides in a selective way using the same light source. We have provided detailed instructions on how to assemble the light-emitting diode equipment and set up the photocatalytic reaction, where an oxygen atmosphere is created with an O-2-filled balloon. Further details are provided using four example reactions that illustrate how this system works: alcohol oxidation to prepare terephthlalaldehyde and androstanedione, and amine oxidation to make 2-phenyl-3,4-dihydroisoquinolin-1(2H)-one and (4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)m-tolyl)methanone. The times needed to perform these photocatalytic reactions are 18, 76, 22 and 54 h, respectively. We believe that this protocol represents a robust methodology for the late-stage modification of amines and the selective oxidation of steroids. Cheap and non-toxic photocatalysts 9-fluorenone or rose bengal are used to oxidize non-activated alcohols or oxygenate tertiary amines, respectively, under irradiation from a blue light-emitting diode.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Liang, L; Li, WQ; Zheng, JR; Li, RX; Chen, HY; Yuan, ZW in ROYAL SOC CHEMISTRY published article about SULFANE SULFURS; SULFIDE; H2S; MITOCHONDRIA; METABOLISM; EMISSION in [Liang, Li; Li, Weiqing; Zheng, Jinrong; Li, Ruixi; Chen, Haiyan; Yuan, Zhenwei] China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, 24 Tongjia Lane, Nanjing 210009, Peoples R China in 2020.0, Cited 36.0. HPLC of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Hydrogen polysulfides (H2Sn, n > 1) belong to sulfane sulfur in the reactive sulfur species (RSS) family and play significant roles in maintaining biological homeostasis in organisms. The detection of H2Sn in living systems is essential, but further understanding of its intact function in living cells has been limited, owing to the lack of appropriate analytical tools. In this work, a new fluorescent probe PP-PS was designed for the detection of endogenous H2Sn. The probe has a large Stokes shift (178 nm), low detection limit (1 nM), and short response time (1 minute). Besides, PP-PS was successfully applied in the imaging of endogenous H2Sn in lysosomes of living cancer cells, xenograft mouse tumor tissues, and LPS-induced mouse inflammation tissues. These results revealed that the probe PP-PS could act as a new fluorescence imaging tool to study the function of intracellular hydropolysulfides.

HPLC of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation WOS:000510109900013 published article about RUTHENIUM(II) ARENE COMPLEXES; VITRO ANTICANCER ACTIVITY; IN-VITRO; RIBONUCLEOTIDE REDUCTASE; ZN(II) COMPLEXES; DNA CLEAVAGE; PHASE-II; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; SPECTRAL CHARACTERIZATION; CYTOTOXIC ACTIVITIES in [Saswati; Mohanty, Monalisa; Banerjee, Atanu; Biswal, Sonaleen; Dinda, Rupam] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India; [Horn, Adolfo, Jr.] Univ Estadual Norte Fluminense, Lab Ciencias Quim, Campos Dos Goytacaces, RJ, Brazil; [Schenk, Gerhard] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia; [Brzezinski, Krzysztof] Univ Bialystok, Inst Chem, Ciolkowskiego 1K, PL-15245 Bialystok, Poland; [Sinn, Ekkehard] Western Michigan Univ, Dept Chem, Kalamazoo, MI 49008 USA; [Reuter, Hans] Univ Osnabruck, Inst Chem New Mat, Barbarastr 6, D-49069 Osnabrucks, Germany in 2020.0, Cited 98.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Two new dimeric Zn(II) ([{ZnL1(DMSO2)}(2)]center dot DMSO (1), [{(ZnLCl)-Cl-2}(2)] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)(2)(mu-OAc)(2)(mu(3)-O)(2)] (3)), where H2L1 = 4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2 = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3 = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10(12)M(-1)), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10(3) to 10(4) M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Saswati; Mohanty, M; Banerjee, A; Biswal, S; Horn, A; Schenk, G; Brzezinski, K; Sinn, E; Reuter, H; Dinda, R or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Solvent-free microwave-assisted synthesis of imidazo[1,5-a]pyridine and -quinoline derivatives WOS:000481164400001 published article about RATIOMETRIC FLUORESCENT-PROBE; COMPLEXES; EFFICIENT; LIGHT; TRANSANNULATION; ALDEHYDES; EMISSION; LIGANDS; IMIDAZO; SHIFT in [Herr, Jasmin Martha; Roessiger, Carina; Goettlich, Richard] Justus Liebig Univ Giessen, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany; [Herr, Jasmin Martha; Roessiger, Carina; Albrecht, Georg; Goettlich, Richard] Justus Liebig Univ Giessen, Ctr Mat Res LaMa, Giessen, Germany; [Albrecht, Georg] Justus Liebig Univ Giessen, Inst Appl Phys, Giessen, Germany; [Yanagi, Hisao] NAIST, Dept Mat Sci, Nara, Japan in 2019.0, Cited 39.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A quick and highly efficient microwave-assisted preparation of imidazopyridines and -quinolines is described, starting from the corresponding ketones and amines. The method requires no solvent and uses activated MnO2 as an oxidant. A mechanism for the cyclization is proposed and discussed.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. In 2020 GREEN CHEM published article about C DOUBLE-BOND; MOLECULAR-OXYGEN; FREE CATALYST; PHOTOOXIDATIVE CLEAVAGE; ALPHA-METHYLSTYRENE; SINGLET-OXYGEN; ALCOHOLS; GREEN; CO2; TRANSFORMATION in [Zhang, Yu; Das, Shoubhik] Univ Antwerp, Dept Chem, ORSY Div, Gronenborgerlaan 171, B-2020 Antwerp, Belgium; [Zhang, Yu; Hatami, Nareh; Lange, Niklas Simon; Schilling, Waldemar] Georg August Univ Gottingen, Inst Biomol & Organ Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Ronge, Emanuel; Jooss, Christian] Georg August Univ Gottingen, Inst Materialphys, Friedrich Hund Pl 1, D-37077 Gottingen, Germany in 2020, Cited 68. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Selective cleavage of C & xe001;C bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reactionetc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries! To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.

COA of Formula: C12H9NO. Welcome to talk about 91-02-1, If you have any questions, you can contact Zhang, Y; Hatami, N; Lange, NS; Ronge, E; Schilling, W; Jooss, C; Das, S or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, characterization, in vitro antimicrobial and anticancer studies of new platinum N-heterocyclic carbene (NHC) complexes and unexpected nickel complexes WOS:000485103500021 published article about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY in [Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin] Monash Univ Malaysia, Sch Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia in 2019.0, Cited 74.0. Recommanded Product: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Oxyfunctionalization of Alkanes Based on a Tricobalt(II)-Substituted Dawson-Type Rhenium Carbonyl Derivative as Catalyst WOS:000548456300009 published article about HETEROPOLYTUNGSTATE DERIVATIVES; HETEROGENEOUS CATALYSTS; CYCLOHEXANE OXIDATION; W-183 NMR; METAL; KEGGIN; PERFORMANCE; FUNCTIONALIZATION; HYDROCARBONS; OXYGENATION in [Ma, Xinyi; Wang, Ping; Liu, Zhihao; Xin, Changhui; Wang, Siyu; Jia, Jiage; Ma, Pengtao; Niu, Jingyang; Wang, Jingping] Henan Univ, Henan Key Lab Polyoxometalate Chem, Coll Chem & Chem Engn, Kaifeng 475004, Henan, Peoples R China in 2020.0, Cited 61.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Category: pyridine-derivatives

POM-supported metal carbonyl derivatives (PMCDs) represent a family of tremendous potential catalysts owing to their peculiar physical and chemical properties. Yet low-valence transition metal-substituted Dawson-type PMCD catalysts are uncommon. Hence, we synthesized a tricobalt-substituted PMCDs by conventional aqueous solution method, [Na(H2O)(5)](NH4)(7)[P2W15O56Co3(H2O)(3)(OH)(3)Re(CO)(3)]center dot 13H(2)O (1), and characterized by single crystal X-ray diffraction crystallography, IR, and thermogravimetric analyses (TGA), etc. The obtained compound 1 was employed as a catalyst for the oxidation of diphenylmethane (DPM) to benzophenone, giving 96.8% yield in the presence of tert-butyl hydroperoxide (TBHP) and pyridine. The control experiments indicate that Co metal ion plays an important role in the catalytic reactions. As a side note, the electrospray ionization mass spectrometry (ESI-MS) and UV spectroscopy showed that 1 can retain its integrity in solution, and magnetic measurements indicated that 1 exhibited a weaker ferromagnetic interaction at low temperature.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C12H9NO. In 2019.0 ISCIENCE published article about 1,2-ASYMMETRIC INDUCTION; ALLYLATION REACTIONS; RADICAL REACTIONS; REDUCTION; CHEMISTRY; DISCOVERY; EXCHANGE; KETONES in [Shao, Tianju; Li, Yajuan; Li, Chunyang; Zhao, Xiaowei; Qiao, Baokun; Jiang, Zhiyong] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China; [Ma, Nana; Jiang, Zhiyong] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China; [Chai, Guobi] Zhengzhou Tobacco Res CNTC, Zhengzhou 450001, Henan, Peoples R China in 2019.0, Cited 61.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantioselective manner, which could slow the metabolism and improve the bioavailability of bioactive molecules, remains challenging owing to the lack of established catalytic methods. Here, we report an asymmetric alpha-deuteration strategy for azaarenes with inexpensive D2O as the deuterium source. A cooperative visible light-driven photoredox and chiral Bronsted acid-catalyzed system using a Hantzsch ester as the terminal reductant has been developed, which enables racemic alpha-chloro-azaarenes and prochiral azaarene-substituted ketones to experience a single-electron reduction-enantioselective deuteration process. The transition metal-free method provides important chiral alpha-deuterated azaarenes in satisfactory yields with good to excellent enantioselectivities (up to 99% ee) and substantial deuterium incorporation.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem