Category: 91-02-1

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. I found the field of Chemistry very interesting. Saw the article Rhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation published in 2019, Reprint Addresses Zhou, XG (corresponding author), Sichuan Univ, Coll Chem, 29 Wangjiang Rd, Chengdu 610064, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp(2)) and C(O)-C(sp(3)) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Zhong, J; Long, Y; Yan, XF; He, SY; Ye, RY; Xiang, HF; Zhou, XG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Science & Technology – Other Topics very interesting. Saw the article Photoredox-Catalyzed Enantioselective alpha-Deuteration of Azaarenes with D2O published in 2019.0. Category: pyridine-derivatives, Reprint Addresses Qiao, BK; Jiang, ZY (corresponding author), Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China.; Jiang, ZY (corresponding author), Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantioselective manner, which could slow the metabolism and improve the bioavailability of bioactive molecules, remains challenging owing to the lack of established catalytic methods. Here, we report an asymmetric alpha-deuteration strategy for azaarenes with inexpensive D2O as the deuterium source. A cooperative visible light-driven photoredox and chiral Bronsted acid-catalyzed system using a Hantzsch ester as the terminal reductant has been developed, which enables racemic alpha-chloro-azaarenes and prochiral azaarene-substituted ketones to experience a single-electron reduction-enantioselective deuteration process. The transition metal-free method provides important chiral alpha-deuterated azaarenes in satisfactory yields with good to excellent enantioselectivities (up to 99% ee) and substantial deuterium incorporation.

Welcome to talk about 91-02-1, If you have any questions, you can contact Shao, TJ; Li, YJ; Ma, NN; Li, CY; Chai, GB; Zhao, XW; Qiao, BK; Jiang, ZY or send Email.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2021.0 ACTA PHARMACOL SIN B published article about CELL-DEATH; IN-VITRO; CLASSIFICATION; ORGANIZATION; ANTIFUNGAL in [Zhao, Bing; Zhang, Xinhui; Yu, Tingting; Liu, Ying; Zhang, Xiaoling; Yao, Yongfang; Feng, Xuejian; Liu, Hongmin; Ma, Liying; Qin, Shangshang] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treament, Key Lab Technol Drug Preparat,Inst Pharmaceut Res, Minist Educ China,Key Lab Henan Prov Drug Qual &, Zhengzhou 450001, Henan, Peoples R China; [Zhao, Bing; Zhang, Xinhui; Yu, Tingting; Liu, Ying; Zhang, Xiaoling; Yao, Yongfang; Feng, Xuejian; Liu, Hongmin; Ma, Liying; Qin, Shangshang] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Yu, Dequan] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China in 2021.0, Cited 44.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: 91-02-1

New Delhi metallo-beta-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all beta-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive superbug, and no promising NDM-1 inhibitors were used in clinical practice. In this study, structure-activity relationship based on thiosemicarbazone derivatives was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds 19bg and 19bh exhibited excellent activity against 10 NDM-positive isolate clinical isolates in reversing MEM resistance. Further studies demonstrated compounds 19bg and 19bh were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44 mu mol/L, respectively. Molecular docking speculated that compounds 19bg and 19bh were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities even at concentrations of 1000 mg/mL against red blood cells. In vivo experimental results showed combination of MEM and compound 19bh was markedly effective in treating infections caused by NDM-1 positive strain and prolonging the survival time of sepsis mice. Our finding showed that compound 19bh might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Zhao, B; Zhang, XH; Yu, TT; Liu, Y; Zhang, XL; Yao, YF; Feng, XJ; Liu, HM; Yu, DQ; Ma, LY; Qin, SS or concate me.. Recommanded Product: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Zhang, Y; Hatami, N; Lange, NS; Ronge, E; Schilling, W; Jooss, C; Das, S in [Zhang, Yu; Das, Shoubhik] Univ Antwerp, Dept Chem, ORSY Div, Gronenborgerlaan 171, B-2020 Antwerp, Belgium; [Zhang, Yu; Hatami, Nareh; Lange, Niklas Simon; Schilling, Waldemar] Georg August Univ Gottingen, Inst Biomol & Organ Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Ronge, Emanuel; Jooss, Christian] Georg August Univ Gottingen, Inst Materialphys, Friedrich Hund Pl 1, D-37077 Gottingen, Germany published A metal-free heterogeneous photocatalyst for the selective oxidative cleavage of C = C bonds in aryl olefins via harvesting direct solar energy in 2020, Cited 68. COA of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Selective cleavage of C & xe001;C bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reactionetc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries! To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Recently I am researching about NUCLEOPHILIC FLUOROMETHYLATION; STRAIGHTFORWARD ACCESS; EFFICIENT SYNTHESIS; FLUORINE; HOMOLOGATION; CARBENOIDS; STABILITY; MONOFLUOROMETHYLATION; FLUOROALKYLATION; EPOXIDATION, Saw an article supported by the University of Vienna; project Laboratorio Sistema – MIURMinistry of Education, Universities and Research (MIUR) [PONa300369]; MISEMinistry of Economic Development, Italy; Horizon 2020 – PON 2014/2020 FARMIDIAB [338]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Monticelli, S; Colella, M; Pillari, V; Tota, A; Langer, T; Holzer, W; Degennaro, L; Luisi, R; Pace, V. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

An expeditious, high-yielding synthesis of rare alpha-fluoroepoxides and alpha-fluoroaziridines through the addition of the unkown fluoroiodomethyllithium (LiCHIF)-formed via deprotonation the commercially available fluoroiodomethane with a lithium amide base-to carbonyl-like compounds is documented. The ring-closure reactions, leading to alpha-fluorinated three-membered heterocycles, rely on the diversely reactive C-I and C-F bonds. Excellent chemoselectivity was observed in the presence of highly sensitive functionalities-aldehyde, ketone, nitrile, alkene-which remained untouched during the homologation sequence.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. Yuan, Q; Chen, LL; Zhu, XH; Yuan, ZH; Duan, YT; Yang, YS; Wang, BZ; Wang, XM; Zhu, HL in [Yuan, Qing; Chen, Li-Li; Zhu, Xiao-Hua; Yuan, Zeng-Hui; Yang, Yu-Shun; Wang, Bao-Zhong; Wang, Xiao-Ming; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Duan, Yong-Tao] Zhengzhou Univ, Childrens Hosp, Henan Prov Key Lab Childrens Genet & Metab Dis, Zhengzhou 450018, Peoples R China published An imidazo[1,5-alpha]pyridine-derivated fluorescence sensor for rapid and selective detection of sulfite in 2020.0, Cited 55.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Sulfur-containing species are essential in the composition and the metabolism of the organisms, thus developing a full set of implements to cover all of them is still a favorable choice. Herein, we chose imidazo [1,5-alpha] pyridine moiety as the basic fluorophore for the detection of sulfite, and preliminarily completed the toolset since biothiols (GSH, Cys, Hcy), H2S, and PhSH could be detected by sensors based on the same backbone. The designed sensor, IPD-SFT, with structural novelty and large Stokes shift (130 nm), indicated the most attractive advantages of remarkably rapid response period (within 1 min) and high selectivity for sulfite from all the sulfurcontaining species. Other practical properties included high sensitivity (LOD = 50 nM) and wide pH adaptability (5.0-11.0). Furthermore, IPD-SFT could monitor both exogenous and endogenous sulfite. It not only raised a potential tool for sulfite detection, but also preliminarily completed the toolset for all the sulfur-containing species. The development of such toolsets might reveal the sulfur-containing metabolism and corresponding physiology and pathological procedures.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2020.0 DALTON T published article about NI-II COMPLEXES; MOLECULAR-STRUCTURE; HYDROLYSIS; MECHANISM; LIGANDS; ESTERS; DRUGS; COBALT(III); DERIVATIVES; KINETICS in [Dasgupta, Sanchari; Karim, Suhana; Das, Debasis] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India; [Banerjee, Saswati; Saha, Moumita; Saha, Krishna Das] CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India in 2020.0, Cited 48.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl-2]2H(2)O (1), [Zn(L2)Cl-2] (2) and [Zn(L3)Cl-2] (3) were synthesized by treatment of zinc(ii) chloride with the corresponding Schiff base ligands and characterised by the usual physicochemical techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal X-ray analysis. All complexes were able to hydrolyse the P-O bond of the phosphate monoester in 90% (v/v) DMSO-water medium using 4-nitrophenylphosphate (4-NPP) as the model substrate and the trend in their activity is 1 approximate to 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1-3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human non-small lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. Recently I am researching about GEM-DISUBSTITUTED ALKENES; C=C BOND-CLEAVAGE; C DOUBLE-BOND; SELECTIVE OXIDATION; EFFICIENT; HYDROGENATION; OZONOLYSIS; QUINOLINES; CATALYSTS; COMPLEX, Saw an article supported by the 111 ProjectMinistry of Education, China – 111 Project [D20015]; Natural Science Foundation of Hubei Province of ChinaNatural Science Foundation of Hubei Province [2018CFB241]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Yu, T; Guo, MQ; Wen, SMM; Zhao, RR; Wang, JL; Sun, YL; Liu, QX; Zhou, HF. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

A simple, and practical oxidative scission of aromatic olefins to carbonyl compounds using O-2 as the sole oxidant with poly(ethylene glycol) dimethyl ether as a benign solvent has been developed. A wide range of monosubstituted, gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

Welcome to talk about 91-02-1, If you have any questions, you can contact Yu, T; Guo, MQ; Wen, SMM; Zhao, RR; Wang, JL; Sun, YL; Liu, QX; Zhou, HF or send Email.. Product Details of 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Visible-light assisted of nano Ni/g-C3N4 with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation published in 2020.0. Name: Phenyl(pyridin-2-yl)methanone, Reprint Addresses Hosseini-Sarvari, M (corresponding author), Shiraz Univ, Fac Sci, Dept Chem, Shiraz 7194684795, Iran.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

A selective, economical, and ecological protocol has been described for the oxidation of methyl arenes and their analogs to the corresponding carbonyl compounds and epoxidation reactions of alkenes with molecular oxygen (O-2) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C3N4 exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of methyl arenes, methylene arenes, and epoxidation of various alkenes under visible- light irradiation without the use of an oxidizing agent and under base free conditions. (C) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 91-02-1, If you have any questions, you can contact Hosseini-Sarvari, M; Akrami, Z or send Email.. Name: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Oxyfunctionalization of Alkanes Based on a Tricobalt(II)-Substituted Dawson-Type Rhenium Carbonyl Derivative as Catalyst published in 2020.0. Safety of Phenyl(pyridin-2-yl)methanone, Reprint Addresses Niu, JY; Wang, JP (corresponding author), Henan Univ, Henan Key Lab Polyoxometalate Chem, Coll Chem & Chem Engn, Kaifeng 475004, Henan, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

POM-supported metal carbonyl derivatives (PMCDs) represent a family of tremendous potential catalysts owing to their peculiar physical and chemical properties. Yet low-valence transition metal-substituted Dawson-type PMCD catalysts are uncommon. Hence, we synthesized a tricobalt-substituted PMCDs by conventional aqueous solution method, [Na(H2O)(5)](NH4)(7)[P2W15O56Co3(H2O)(3)(OH)(3)Re(CO)(3)]center dot 13H(2)O (1), and characterized by single crystal X-ray diffraction crystallography, IR, and thermogravimetric analyses (TGA), etc. The obtained compound 1 was employed as a catalyst for the oxidation of diphenylmethane (DPM) to benzophenone, giving 96.8% yield in the presence of tert-butyl hydroperoxide (TBHP) and pyridine. The control experiments indicate that Co metal ion plays an important role in the catalytic reactions. As a side note, the electrospray ionization mass spectrometry (ESI-MS) and UV spectroscopy showed that 1 can retain its integrity in solution, and magnetic measurements indicated that 1 exhibited a weaker ferromagnetic interaction at low temperature.

Welcome to talk about 91-02-1, If you have any questions, you can contact Ma, XY; Wang, P; Liu, ZH; Xin, CH; Wang, SY; Jia, JG; Ma, PT; Niu, JY; Wang, JP or send Email.. Safety of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem