Category: 91-02-1

Recommanded Product: 91-02-1. In 2019.0 ORG LETT published article about ASYMMETRIC HYDROGENATION; ABSOLUTE-CONFIGURATION; PHOSPHORUS LIGANDS; HETEROARYL KETONES; HYDROSILYLATION; BEPOTASTINE; DERIVATIVES; HISTAMINE; EFFICIENT; DIARYL in [Nian, Sanfei; Ling, Fei; Chen, Jiachen; Wang, Ze; Shen, Haiwei; Yi, Xiao; Zhong, Weihui] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Green Pharmaceut Technol & Related Equipm, Hangzhou 310014, Zhejiang, Peoples R China; [Yang, Yun-Fang; She, Yuanbin] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China; [Yang, Yun-Fang] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA in 2019.0, Cited 44.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

This work disclosed a highly enantioselective hydrogenation of non-ortho-substituted 2-pyridyl aryl ketones via Ir/f-diaphos catalysis. This catalytic system allows for full control over the configuration of the stereocenter, affording two enantiomers of the desired products with extremely high enantioselectivity (up to >99% ee in most cases) and excellent reactivity (TON of up to 19600, TOF of 1633 h(-1)) under mild conditions. Density functional theory calculations and control experiments revealed that the relay hydrogen bonding among the solvent isopropanol, substrate, and ligand is crucial for high ee’s.

Recommanded Product: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Nian, SF; Ling, F; Chen, JC; Wang, Z; Shen, HW; Yi, X; Yang, YF; She, YB; Zhong, WH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Reductive Activation and Hydrofunctionalization of Olefins by Multiphoton Tandem Photoredox Catalysis WOS:000649106200047 published article about TRANSFER HYDROGENATION; RADICAL IONS; LIGHT; ALKENES; MARKOVNIKOV; FUNCTIONALIZATION; PHOTOCHEMISTRY; PHOTOCATALYSIS; GENERATION; COMPLEXES in [Czyz, Milena L.; Taylor, Mitchell S.; Horngren, Tyra H.; Polyzos, Anastasios] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia in 2021.0, Cited 86.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: 91-02-1

The conversion of olefin feedstocks to architecturally complex alkanes represents an important strategy in the expedient generation of valuable molecules for the chemical and life sciences. Synthetic approaches are reliant on the electrophilic activation of unactivated olefins, necessitating functionalization with nucleophiles. However, the reductive functionalization of unactivated and less activated olefins with electrophiles remains an ongoing challenge in synthetic chemistry. Here, we report the nucleophilic activation of inert styrenes through a photoinduced direct single electron reduction to the corresponding nucleophilic radical anion. Central to this approach is the multiphoton tandem photoredox cycle of the iridium photocatalyst [Ir(ppy)(2)(dtb-bpy)]PF6, which triggers in situ formation of a high-energy photoreductant that selectively reduces styrene olefinic it bonds to radical anions without stoichiometric reductants or dissolving metals. This mild strategy enables the chemoselective reduction and hydrofunctionalization of styrenes to furnish valuable alkane and tertiary alcohol derivatives. Mechanistic studies support the formation of a styrene olefinic radical anion intermediate and a Birch-type reduction involving two sequential single electron transfers. Overall, this complementary mode of olefin activation achieves the hydrofunctionalization of less activated alkenes with electrophiles, adding value to abundant olefins as valuable building blocks in modern synthetic protocols.

Recommanded Product: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Czyz, ML; Taylor, MS; Horngren, TH; Polyzos, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 ORG PROCESS RES DEV published article about HIGHLY EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; SUBSTITUTED INDOLIZINES; PROPARGYLIC ALCOHOLS; ONE-POT; CYCLOISOMERIZATION; S(N)2′-SUBSTITUTION; 2-ALKYLAZAARENES; DERIVATIVES; ACTIVATION in [Martinez, Thibaut; Alahyen, Ismail; Lemiere, Gilles; Mouries-Mansuy, Virginie; Fensterbank, Louis] Sorbonne Univ, Paris, France in 2020.0, Cited 43.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

A metal-free access to 2-iodo-1,3-disubstituted indolizines has been developed. The proposed synthesis is relatively simple and efficient and involves the iodine-triggered 5-endo-trig cyclization of 2-pyridylallene precursors. While it can be conducted on a gram scale, the preparation of the precursors is straightforward and does not always require intermediate purifications. The obtained 2-iodoindolizines can be further functionalized through cross-coupling reactions.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Martinez, T; Alahyen, I; Lemiere, G; Mouries-Mansuy, V; Fensterbank, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Designing of novel zinc(ii) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities WOS:000527529300029 published article about NI-II COMPLEXES; MOLECULAR-STRUCTURE; HYDROLYSIS; MECHANISM; LIGANDS; ESTERS; DRUGS; COBALT(III); DERIVATIVES; KINETICS in [Dasgupta, Sanchari; Karim, Suhana; Das, Debasis] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India; [Banerjee, Saswati; Saha, Moumita; Saha, Krishna Das] CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India in 2020.0, Cited 48.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl-2]2H(2)O (1), [Zn(L2)Cl-2] (2) and [Zn(L3)Cl-2] (3) were synthesized by treatment of zinc(ii) chloride with the corresponding Schiff base ligands and characterised by the usual physicochemical techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal X-ray analysis. All complexes were able to hydrolyse the P-O bond of the phosphate monoester in 90% (v/v) DMSO-water medium using 4-nitrophenylphosphate (4-NPP) as the model substrate and the trend in their activity is 1 approximate to 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1-3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human non-small lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Dasgupta, S; Karim, S; Banerjee, S; Saha, M; Saha, KD; Das, D or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, characterization, in vitro antimicrobial and anticancer studies of new platinum N-heterocyclic carbene (NHC) complexes and unexpected nickel complexes WOS:000485103500021 published article about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY in [Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin] Monash Univ Malaysia, Sch Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia in 2019.0, Cited 74.0. HPLC of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Choo, KB; Lee, SM; Lee, WL; Cheow, YL or concate me.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Triazole-based ligands functionalized silica: Effects of ligand denticity and donors on catalytic oxidation activity of Pd nanoparticles published in 2019.0. Product Details of 91-02-1, Reprint Addresses Sangtrirutnugul, P (corresponding author), Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about AEROBIC ALCOHOL OXIDATION; PALLADIUM NANOPARTICLES; COUPLING REACTIONS; HIGHLY EFFICIENT; SELECTIVITY; SURFACE; SUZUKI, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Quality Control of Phenyl(pyridin-2-yl)methanone

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Krishna; Kumari, S; Yadav, D; Sharma, SK in [Krishna; Kumari, Shweta; Yadav, Deepak; Sharma, Sunil K.] Univ Delhi, Dept Chem, Delhi 110007, India; [Yadav, Deepak] Cent Univ Haryana, Dept Chem, Mahendergarh 123031, India published Cu (II) Schiff base complex grafted guar gum: Catalyst for benzophenone derivatives synthesis in 2020.0, Cited 79.0. Computed Properties of C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

In this study Guar gum based Cu(II) Schiff’s base complex (GG-Cu) has been synthesized and characterized by FTIR, PXRD, UV-vis, TGA, XPS, FESEM, TEM, EDAX, solid-state NMR, Elemental mapping, CHNS and AAS analysis. This moiety has been found to be an efficient heterogeneous catalyst for selective oxidation reactions. Fifteen model reactions have been carried to establish the catalytic behavior of GG-Cu, and five of these yield novel products. The ease of separation of catalyst from the reaction mixture simply by filtration is an added advantage; furthermore the catalyst can be reused up to five times without significant loss of catalytic activity. The overall concept of developing newer, efficient and environmental benign catalysts with ease of separation and recycling ability has been successfully demonstrated. All of the isolated products were fully characterized on the basis of their physical and spectral data.

Computed Properties of C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Krishna; Kumari, S; Yadav, D; Sharma, SK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ADV SYNTH CATAL published article about ACTIVE ALPHA-PHENYLPYRIDYLMETHANOLS; ARYL HETEROARYL KETONES; ENANTIOSELECTIVE REDUCTION; ASYMMETRIC-SYNTHESIS; KLUYVEROMYCES-MARXIANUS; BIOCATALYTIC SYNTHESIS; CARBONYL REDUCTASE; CELL-CULTURES; SUBSTRATE; BIOREDUCTION in [Li, Zhining; Wang, Zexu; Wang, Yuhan; Huang, Zedu; Chen, Fener] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China; [Li, Zhining; Wang, Zexu; Huang, Zedu; Chen, Fener] Shanghai Engn Res Ctr Ind Asymmetr Catalysis Chir, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wu, Xiaofan] Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350100, Fujian, Peoples R China; [Lu, Hong] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Lu, Hong] Shanghai Engn Res Ctr Ind Microorganisms, 2005 Songhu Rd, Shanghai 200438, Peoples R China in 2019.0, Cited 63.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Formula: C12H9NO

We report here the discovery of a novel ketoreductase (KRED), named KmCR2, with a broad substrate spectrum on bioreduction of sterically bulky diaryl- and aryl(heteroaryl)methanones. The position of the substituent on aromatic rings (meta versus para or ortho) was revealed to control the stereospecificity of KmCR2. The stereoselective preparation of both enantiomers of diaryl- or aryl(heteroaryl)methanols using strategically engineered substrates with a traceless directing group (bromo group) showcased the potential application of this substrate-controlled bioreduction reaction. The combined use of substrate engineering and protein engineering, was demonstrated to be a useful strategy in efficiently improving stereoselectivity or switching stereopreference of enzymatic processes.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Li, ZN; Wang, ZX; Wang, YH; Wu, XF; Lu, H; Huang, ZD; Chen, F or concate me.. Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 DYES PIGMENTS published article about AGGREGATION-INDUCED EMISSION; POLYMERIC NANOPARTICLES; ORGANIC NANOPARTICLES; LIQUID-CHROMATOGRAPHY; HYDROGEN-SULFIDE; CLICK REACTION; HUMAN PLASMA; AIE; HOMOCYSTEINE; THIOLS in [Sheng, Huace; Hu, Yonghong; Zhao, Xinxin; Yang, Wenge] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China; [Hu, Yonghong; Fan, Shimin] Nanjing Tech Univ, Synerget Innovat Ctr Adv Mat, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China; [Zhou, Yi] Nanjing Tech Univ, Coll Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China; [Cao, Yang] Jiangsu Prov Hosp, Nanjing 210000, Jiangsu, Peoples R China in 2019.0, Cited 58.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

A new imidazo [1,5-alpha]pyridine-based fluorescent probe, named MZC-AC, is developed for the detection of cysteine (Cys) based on an excited state intramolecular proton transfer (ESIPT) mechanism. The probe MZC-AC uses an acrylate moiety as the ESIPT blocking group as well as the recognition site. Upon the treatment with Cys, MZC-AC exhibits a dramatic fluorescence enhancement (85-fold) and a large Stokes shift (166 nm). The limit of detection obtained from fluorescent titration was as low as 0.07 mu M. MZC-AC displays highly sensitive and selective response to Cys over homocysteine (Hcy) and glutathione (GSH). Significantly, MZC-AC could be used to detect Cys in living cells.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Sheng, HC; Hu, YH; Zhou, Y; Fan, SM; Cao, Y; Zhao, XX; Yang, WG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem