Category: 91-02-1

I found the field of Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology very interesting. Saw the article Production of enantiomerically pure (S)-phenyl(pyridin-2-yl)methanol with Lactobacillus paracasei BD101 published in 2019.0. Name: Phenyl(pyridin-2-yl)methanone, Reprint Addresses Sahin, E (corresponding author), Bayburt Univ, Dept Food Engn, Fac Engn, TR-69000 Bayburt, Turkey.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Asymmetric reduction studies of heteroaryl ketones, including phenyl(pyridin-2-yl)methanone in enantioselective form with biocatalysts are very few, and chiral heteroaryl alcohols have been synthesized generally in the small scale. In this study, seven bacterial strains have been used to produce the (S)-phenyl(pyridin-2-yl)methanol in high enantiomeric excess and yield. Among the tested strains, Lactobacillus paracasei BD101, was found to be the best biocatalyst for the reducing phenyl(pyridin-2-yl)methanone to the (S)-phenyl(pyridin-2-yl)methanol at gram scale. The asymmetric bioreduction conditions were systematically optimized using L. paracasei BD101, which demonstrated excellent enantioselectivity and high level of conversion for the bioreduction reaction. (S)-phenyl(pyridin-2-yl)methanol, which is an analgesic, was produced enantiomerically pure form in the first time on gram scale using a biocatalyst. In total, 5.857 g of (S)-phenyl(pyridin-2-yl)methanol in enantiomerically pure form (>99% enantiomeric excess) was obtained in 52 h with 93% yield using whole cells of L. paracasei BD101. Enantiomerically pure (S)-phenyl (pyridin-2-yl)methanol, which is an analgesic, was first produced in the gram scale using a biocatalyst with excellent ee (>99%) and yield (93%). [GRAPHICS] .

Name: Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Sahin, E; Serencam, H; Dertli, E or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions? published in 2020.0. HPLC of Formula: C12H9NO, Reprint Addresses Usuki, T (corresponding author), Sophia Univ, Dept Mat & Life Sci, Fac Sci & Technol, Chiyoda Ku, 7-1 Kioicho, Tokyo 1028554, Japan.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1-100 mol%) with H-2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 mol% Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept (R)).

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Tanaka, N; Usuki, T or concate me.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Visible-light assisted of nano Ni/g-C3N4 with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation WOS:000588151800009 published article about GRAPHITIC CARBON NITRIDE; OXIDATION; ALKENES; NANOCOMPOSITE; EVOLUTION; CATALYSTS; STYRENE; DRIVEN; WATER; ZNO in [Hosseini-Sarvari, Mona; Akrami, Zahra] Shiraz Univ, Fac Sci, Dept Chem, Shiraz 7194684795, Iran in 2020.0, Cited 53.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

A selective, economical, and ecological protocol has been described for the oxidation of methyl arenes and their analogs to the corresponding carbonyl compounds and epoxidation reactions of alkenes with molecular oxygen (O-2) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C3N4 exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of methyl arenes, methylene arenes, and epoxidation of various alkenes under visible- light irradiation without the use of an oxidizing agent and under base free conditions. (C) 2020 Elsevier B.V. All rights reserved.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Hosseini-Sarvari, M; Akrami, Z or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Kim, JH; Mertens, RT; Agarwal, A; Parkin, S; Berger, G; Awuah, SG in [Kim, Jong Hyun; Mertens, R. Tyler; Agarwal, Amal; Parkin, Sean; Awuah, Samuel G.] Univ Kentucky, Dept Chem, 505 Rose St, Lexington, KY 40506 USA; [Berger, Gilles] Univ Libre Bruxelles, Fac Pharm, Microbiol Bioorgan & Macromol Chem, Brussels, Belgium published Direct intramolecular carbon(sp(2))-nitrogen(sp(2)) reductive elimination from gold(III) in 2019.0, Cited 54.0. Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

The reactivity of bidentate Au-III-Cl species, [(C<^>N)AuCl2], with a bisphosphine or carbon donor ligands results in reductive elimination. Combined experimental and computational investigations lead to the first evidence of a direct intramolecular C(sp(2))-N(sp(2)) bond formation from a monomeric [(C<^>N)AuCl2] gold(iii) complex. We show that bidentate ligated Au(iii) systems bypass transmetallation to form C(sp(2))-N(sp(2)) species and NHC-Au-Cl. Mechanistic investigations of the reported transformation reveal a ligand-induced reductive elimination via a key Au-III intermediate. Kinetic studies of the reaction support a second-order rate process.

Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Kim, JH; Mertens, RT; Agarwal, A; Parkin, S; Berger, G; Awuah, SG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Spectroscopy very interesting. Saw the article Imidazo[1,5-alpha]pyridine-based fluorescent probe with a large Stokes shift for specific recognition of sulfite published in 2020.0. Name: Phenyl(pyridin-2-yl)methanone, Reprint Addresses Chen, S (corresponding author), Qiqihar Med Univ, Coll Pharm, 333 Bukui St, Qiqihar 161006, Heilongjiang, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

By taking advantage of the intramolecular charge transfer (ICT) process, we presented a novel fluorescent probe IPY-SO2 based on imidazo[1,5-alpha]pyridine derivative for detecting SO32- with a low detection limit (70 nM). Combining its favorable turn-on fluorescence feature (75-fold), rapid response (5 min), high selectivity, large Stokes shift (174 nm) and low cytotoxicity, IPY-SO2 was successfully applied to imaging SO32 in living MCF-7 cells and zebrafish. (C) 2019 Elsevier B.V. All rights reserved.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Chen, S; Hou, P; Sun, JW; Wang, HJ; Liu, L or concate me.. Name: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 91-02-1. I found the field of Chemistry very interesting. Saw the article On/Off O-2 Switchable Photocatalytic Oxidative and Protodecarboxylation of Carboxylic Acids published in 2019, Reprint Addresses Hosseini-Sarvari, M (corresponding author), Shiraz Univ, Dept Chem, Shiraz 7194684795, Iran.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

Photoredox catalysis in recent years has manifested a powerful branch of science in organic synthesis. Although merging photoredox and metal catalysts has been a widely used method, switchable heterogeneous photoredox catalysis has rarely been considered. Herein, we open a new window to use a switchable heterogeneous photoredox catalyst which could be turned on/off by changing a simple stimulus (O-2) for two opponent reactions, namely, oxidative and protodecarboxylation. Using this strategy, we demonstrate that Au@ZnO core-shell nanoparticles could be used as a switchable photocatalyst which has good catalytic activity to absorb visible light due to the localized surface plasmon resonance effect of gold, can decarboxylate a wide range of aromatic and aliphatic carboxylic acids, have multiple reusability, and are a reasonable candidate for synthesizing both aldehydes/ketones and alkane/arenes in a large-scale set up. Some biologically active molecules are also shown via examples of the direct oxidative and protodecarboxylation which widely provided pharmaceutical agents.

SDS of cas: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Bazyar, Z; Hosseini-Sarvari, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: Phenyl(pyridin-2-yl)methanone. In 2021.0 ACS CATAL published article about C(SP(3))-H BORYLATION; BIPYRIDINE LIGAND; ARENES; ACTIVATION; COMPLEXES; CYCLOPROPANATION; C(SP(2))-H; FUNCTIONALIZATION; BONDS in [Song, Peidong; Yu, Tao; Li, Pengfei] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Peoples R China; [Hu, Linlin; He, Yangqing] Xian Univ Technol, Dept Appl Chem, Xian 710048, Peoples R China; [Jiao, Jiao] Xi An Jiao Tong Univ, Sch Chem, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China; [Xu, Liang] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China; [Li, Pengfei] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2021.0, Cited 104.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Although pyridine derivatives are versatile supporting ligands in catalysis, the development of their chiral versions has been relatively limited. Herein, we report the design, synthesis, and proof-of-concept application of a structurally tunable chiral pyridine framework featuring an annulated compact ring system. Using an N,B-bidentate ligand skeleton containing the chiral pyridine moiety, we have developed an enantioselective iridium-catalyzed desymmetrizing C-H borylation reaction of diaryl(2-pyridyl)methane compounds with up to 96% ee and 93% yield. The resulting borylation products could be readily transformed into various chiral tri(hetero)arylmethane compounds. Density functional theory investigations revealed that the two chair conformations of the flexible ketal motif both favored the enantiomer that was consistent with experimental results. This work has thus introduced an effective and tunable chiral pyridine ligand framework that may be used in many catalytic asymmetric transformations.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Song, PD; Hu, LL; Yu, T; Jiao, J; He, YQ; Xu, L; Li, PF or concate me.. Recommanded Product: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 BIOORG MED CHEM LETT published article about BIOLOGICAL EVALUATION; CYCLE ARREST; IN-VITRO; ANTIOXIDANT; DERIVATIVES; APOPTOSIS in [Gu, Xiaoke; Li, Xin; Guan, Mingyu; Jiang, Chunyu; Song, Qinghua; Sun, Nan; Qiu, Jingying] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China; [Zou, Yueting; Zhou, Qingqing; Chen, Jing; Qiu, Jingying] Xuzhou Med Univ, Sch Pharm, Dept Pharmaceut Anal, Xuzhou 221004, Jiangsu, Peoples R China in 2020.0, Cited 27.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Category: pyridine-derivatives

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Category: pyridine-derivatives. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. I found the field of Chemistry very interesting. Saw the article Electrochemical C-H oxygenation and alcohol dehydrogenation involving Fe-oxo species using water as the oxygen source published in 2019.0, Reprint Addresses Stahl, SS (corresponding author), Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

High-valent iron-oxo complexes are key intermediates in C-H functionalization reactions. Herein, we report the generation of a (TAML)Fe-oxo species (TAML = tetraamido macrocyclic ligand) via electrochemical proton-coupled oxidation of the corresponding (TAML)Fe-III-OH2 complex. Cyclic voltammetry (CV) and spectroelectrochemical studies are used to elucidate the relevant (TAML)Fe redox processes and determine the predominant (TAML)Fe species present in solution during bulk electrolysis. Evidence for iron(iv) and iron(v) species is presented, and these species are used in the electrochemical oxygenation of benzylic C-H bonds and dehydrogenation of alcohols to ketones.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Das, A; Nutting, JE; Stahl, SS or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. Recently I am researching about BIOLOGICAL EVALUATION; CYCLE ARREST; IN-VITRO; ANTIOXIDANT; DERIVATIVES; APOPTOSIS, Saw an article supported by the Natural Science Foundation of Jiangsu provinceNatural Science Foundation of Jiangsu Province [BK20171179, BK20181151]; Six Talent Peaks Project in Jiangsu Province [2017-YY-039]; Jiangsu Provincial 333 High-level Talents Cultivation Project [BRA201927]; Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_2506]; Jiangsu Training Programs of Innovation and Entrepreneurship for Undergraduates [201810313083X]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem