Adding a certain compound to certain chemical reactions, such as: 917391-98-1, 5-Fluoro-2-oxo-1,2-dihydropyridine-3-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 917391-98-1, blongs to pyridine-derivatives compound. Recommanded Product: 917391-98-1
(b) 1 -Ethyl-5- fluoro-2-oxo-pyridine-3-carbaldehvde K2Ctheta3 (0.830 g, 6.00 mmol) was added to a solution of 5-Fluoro-2-oxo-pyridine- 3-carbaldehyde (0.424, 3.00 mmol) in dry DME (10 mL). Ethyl iodide (0.303 mL, 3.75 mmol) was added dropwise while the reaction was heated to reflux. After 8 hours the reaction was cooled to RT, filtered and evaporated. Purification using flash chromatography (heptane/EtOAc, 10-100%) gave 0.249 g (49 %) of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,917391-98-1, 5-Fluoro-2-oxo-1,2-dihydropyridine-3-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; WO2006/135323; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem