Category: 929022-76-4

Electric Literature of 929022-76-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 929022-76-4, name is 2-Chloro-4-fluoronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step B: Ethyl (2-chloro-4-fluoropyridin-3-yl)acetate (64-3)Intermediate 64^2 (19.9g, 108 mmol) was dissolved in CH2C12 (100 ml), added lml DMF and then added oxalyl chloride (17.2 g, 135 mmol) dropwise over 10 minutes. When gas evolution subsided (about an hour), the reaction was concentrated and azeotroped with THF (3 x 50 ml) to give the crude acid chloride. TMS-diazomethane solution (97 ml, 2.0 M, 195 mmol) was added to 300 ml 1 : 1 THF/CH3CN and then cooled to 0C. NEt3 (27.2 ml, 195 mmol) was added and then the acid chloride was added dropwise over 20 minutes. Stirred for 1 hour at 0C and then stored in freezer (-4C) overnight. Diluted with EtOAc and then washed with ¾0; added 0.5 N HCl to organic portion, stirred 5 minutes, basified with 1 N NaOH. Organic portion separated, washed with brine, dried (MgS04) and concentrated. Dissolved residue in EtOH (300 ml), added NEt3 (18.1 ml, 130 mmol) followed by portionwise addition of silver benzoate (3.72 g, 16.24 mmol, gas evolution). Heated to 80C for 10 minutes and then allowed to cool to ambient. The mixture was concentrated. Diluted with CH2Ci2, filtered and concentrated. The residue was purified by column chromatography on silica gel, eluting with hexanes to EtOAc to give 64-3 (8.05 g. 34.2%) as a colorless oil MS (ESI): m/z = 218.0 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929022-76-4, 2-Chloro-4-fluoronicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BUNGARD, Christopher, James; PERKINS, James, J.; MANIKOWSKI, Jesse, J.; DE LEON, Pablo; MEISSNER, Robert, S.; WO2011/53574; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 929022-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929022-76-4, name is 2-Chloro-4-fluoronicotinic acid, molecular formula is C6H3ClFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Example 75a (2.74 g, 15.6 mmol) in THF (50 mL), tBuOCOCl ( 3.2 g, 23.4 mmol) at 0C was added TEA (3.16 g, 31.2 mmol), the mixture was stirred at r.t. for 0.5 min, and then NaBD4 ( 1.31 g, 31.2 mmol) in EtOH (10 mL) was added at 0C, which was turned to r.t for another 30 min. The reaction was then quenched by adding water (10 mL), then concentrated, the residue was purified by flash column chromatography (eluted with EtOAc) to give the desired product (Example 75b, 1.05 g, yield 41 %) as yellow oil. LCMS [M+1]+= 164

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929022-76-4, 2-Chloro-4-fluoronicotinic acid.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem