Synthetic Route of 955369-63-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.955369-63-8, name is Ethyl 2-(6-bromopyridin-2-yl)acetate, molecular formula is C9H10BrNO2, molecular weight is 244.09, as common compound, the synthetic route is as follows.
To a mixture of ethyl 2-(6-bromo-2-pyridyl)acetate (2.00 g, 8.19 mmol) in THF (10 mL), water (10 mL) and MeOH (20 mL) was added LiOH.H2O (1.03 g, 24.5 mmol). Then the reaction mixture was stirred at 20 C for 2 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was acidified by 1.0 N HCl to pH = 3.0, washed with water (150 mL) and extracted with ethyl acetate (3 X 150 mL). The organic layer was dried with Na2SO4, filtered and concentrated in vacuo to give the title compound (1.70 g, 96% yield) as a yellowish solid.1H NMR (400MHz, DMSO-d6) delta = 12.63 (br. s., 1H), 7.86 – 7.71 (m, 1H), 7.59 (d, J = 8.0 Hz, 1H), 7.46 (d, J = 7.6 Hz, 1H), 3.81 (s, 2H).
Statistics shows that 955369-63-8 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(6-bromopyridin-2-yl)acetate.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
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