Category: 97986-08-8

Electric Literature of 97986-08-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97986-08-8, name is N,6-dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.

Example 110 4′-Cyano-biphenyl-4-sulfonic acid methyl-(6-methyl-pyridin-2-yl)-amide To a solution of N,6-dimethylpyridin-2-amine (0.15 g, 1.24 mmol) in THF (5 ml) was added NaHMDS (1.56 mL, 1.56 mmol) at R.T. After 15 min, 4′-cyanobiphenyl-4-sulfonyl chloride (0.28 g, 1.03 mmol) was added to the reaction mixture and stirred for 1 hour. The reaction mixture was diluted with ethyl acetate (30 mL) and washed with saturated aqueous sodium bicarbonate (2*30 mL). The collected organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The resulting residue was purified with radial chromatography (2 mm silica plate, 2:1 hexanes/ethyl acetate) to yield a clear oil. The product was converted to a HCl salt by dissolving in 5 mL diethyl ether and adding 1 N HCl in diethyl ether dropwise.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,97986-08-8, its application will become more common.

Reference:
Patent; AGOURON PHARMACEUTICALS, INC.; US2005/148631; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 97986-08-8, N,6-dimethylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 97986-08-8, blongs to pyridine-derivatives compound. Safety of N,6-dimethylpyridin-2-amine

Example 11N-[3,5-difmorpholin-4-yl)phenyll-N>-methyl-N>-f6-methylpyridin-2-yl)pyrimidine-2.,4- diamine4-Chloro-N-(3,5-dimorpholin-4-ylphenyl)pyrimidin-2-amine (described in Example 1, 200 mg, 0.53 mmol), 6-methyl-2-methylaminopyridine (98 mg, 0.8 mmol), potassium carbonate (736 mg, 5.3 mmol), Pd2dba3 (16 mg, 0.027 mmol) and Xantphos (31 mg, 0.053 mmol) were mixed in toluene (5 ml). The mixture was degassed with nitrogen and heated in a sealed tube at 1200C for 3 hours. After filtration, the toluene was evaporated and the residue purified on a preparative HPLC-MS system (Column: C18, 5 microns, 19 mm diameter, 100 mm length, elution with a gradient of water and acetonitrile containing 2g/l of ammonium carbonate) to give 55 mg of the title compound (22% yield). NMR Spectrum (500 MHz, DMSOd) 2.45 (s, 3H), 3.01 (m, 8H), 3.51 (s, 3H), 3.70 (m, 8H), 6.10 (s, IH), 6.30 (d, IH), 6.93 (d, 2H), 7.07 (d, IH), 7.23 (d, IH), 7.70 (t, IH), 8.00 (d, IH), 8.92 (s, IH). Mass Spectrum MH+ 462

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,97986-08-8, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10794; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem