Category: pyridine-derivatives

Related Products of 886371-28-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.886371-28-4, name is 3-Bromo-6-chloroimidazo[1,2-a]pyridine, molecular formula is C7H4BrClN2, molecular weight is 231.48, as common compound, the synthetic route is as follows.

General procedure: To an oven dried 5 mL microwave vessel was addedPd(dppf)Cl2·CH2Cl2 (4 mol%), halide/pseudohalide (1 equiv),boron coupling partner (1 equiv), and Cs2CO3 (3 equiv). Thevessel was then capped and purged with N2 before addition ofCyrene (1 mL, 0.25 M) and H2O (1.8 mL). The reaction mixturewas heated to 50 C and maintained at this temperature withstirring for 5 h before the vessel was vented and decapped. Thesolution was then diluted with Et2O (10 mL) and washed withwater (2 × 20 mL) and brine (2 × 20 mL). The organics were thenpassed through a hydrophobic frit and concentrated underreduced pressure to give a residue, which was purified by flashchromatography (silica gel) to afford the title compound.

The chemical industry reduces the impact on the environment during synthesis 886371-28-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Wilson, Kirsty L.; Murray, Jane; Jamieson, Craig; Watson, Allan J. B.; Synlett; vol. 29; 5; (2018); p. 650 – 654;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53554-20-4, name is 6-Amino-2-chloronicotinonitrile, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 6-Amino-2-chloronicotinonitrile

[00227j Step 1: 6-Amino-2-chloronicotinonitrile (0.100 g, 0.65 1 mmol) was taken in a sealed tube and dissolved in dioxane (3 mL) and NMP (0.2 mL). To that was added (R)pyrrolidin-3-ol (0.05 7 g, 0.651 mmol) and NMP (0.2 mL) and the set up was heated at 150 C for 18 h. The solvents were evaporated from the reaction mixture and the crudewas dissolved in water and made basic by adding NaHCO3 and was extracted with DCM(3 x 15 mL). The combined organic layer were dried and evaporated to get the product(80 mg, 42% yield) which was directly in the next reaction. LCMS 205.2 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 53554-20-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong; WO2014/74675; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, blongs to pyridine-derivatives compound. Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole

A solution of CoCl2¢6H2O (0.25 g, 1.05 mmol), 3-PBIM(0.2 g, 1.03 mmol), 1,3-H2BDC (0.2 g, 1.2 mmol), and H2O(15 mL) was stirred under ambient condition. The mixturewas then sealed in a Teflon-lined steel vessel and heated at170C for three days. After slow cooling to room temperature, the resulting product was obtained (yield: 55%). Anal.Calcd. for C64H56Co2N12O14: C, 57.58; N, 12.59; H, 4.23%.Found: C, 58.13; N, 12.87; H, 4.54%. IR (KBr pellet, cm1):3450 s, 3050 s, 1870 m, 1615 s, 1565 w, 1535 m, 1500 m, 1478m, 1448 m, 1371 m, 1270 s, 1145 m, 1130 m, 1060 s, 1018 s,970 s, 880 m, 840 s, 770 m, 745 s, 705 m, 695 m, 593 m, 565 m.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Quanzheng; Xia, Changkun; Lu, Hongdian; Jiang, Rui; Zhang, Xueke; Wang, Xinghan; He, Longzhong; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 46; 4; (2016); p. 543 – 547;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 942189-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine, molecular formula is C9H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine 76 (100mg, 0.425mmol), potassium carbonate (100mg,0.724mmol), and piperazine (100mg,1.16mmol) in DMF’ (5ml), were stirred at 1000C for 1 hour. The reaction was cooled, solvent evaporated^/ – under reduced pressure, and the residue dissolved in MeCI2 (150ml), washed with H2O (50ml),dried over MgSO4,filtered and evaporated solvent yielding title product 77 as a white solid (100mg,98%). ESMS (MH, 242).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 942189-65-3, 2-(6-Bromopyridin-3-yl)pyrimidine.

Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 851607-27-7, name is 5-Bromo-4-chloro-2-methoxypyridine, the common compound, a new synthetic route is introduced below. Product Details of 851607-27-7

A mixture of 5-bromo-4-chloro-2-methoxypyridine (416 mg),ethyl (6-(piperidin-4-ylmethoxy)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)acetate (938 mg), potassium carbonate (775 mg)and DMSO (10 mL) was stirred at 100C for 40 hr. The reactionmixture was added to water, and the mixture was extracted with ethyl acetate. The organic layer was separated, washedsuccessively with water and saturated brine, dried overanhydrous magnesium sulfate and concentrated under reducedpressure. The residue was purified by silica gel columnchromatography (ethyl acetate/hexane) to give the title35 compound ( 396.0 mg) . MS: [M+H] + 520. 1.

The synthetic route of 851607-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; SCOHIA PHARMA, INC.; MIWATASHI, Seiji; MIYAMOTO, Yasufumi; WATANABE, Koji; YOSHITOMI, Yayoi; HITOMI, Yuko; AIDA, Jumpei; TAKAKURA, Nobuyuki; FURUKAWA, Hideki; NOGUCHI, Naoyoshi; HIRATA, Yasuhiro; KASAI, Shizuo; KOBAYASHI, Toshitake; MAEKAWA, Tsuyoshi; SASAKI, Satoshi; MATSUMOTO, Shigemitsu; (190 pag.)WO2018/182050; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 90395-45-2, name is 1-(4-(Pyridin-3-yl)phenyl)ethanone. A new synthetic method of this compound is introduced below., Recommanded Product: 1-(4-(Pyridin-3-yl)phenyl)ethanone

1-(4-Pyridin-3-ylphenyl)-ethanone (75 g, 380.26 mmole), 3-bromobenzaldehyde (3-bromo) -benzaldehyde) (67g, 362.16mmole), add 1340 ml of ethanol to the reaction flask, and finally add sodium tert-butoxide (52.7 g, 543.23 mmole) at room temperature. After the reaction is complete, add 200 ml. The mixture was filtered with deionized water, and the solid was filtered, washed with deionized water and methanol. The solid was then stirred with 100 ml of deionized water and 200 ml of methanol for 30 minutes. The solid was dried twice to obtain 78 g of pale yellow solid. 3-(3-Bromophenyl)-1-(4-pyridin-3-ylphenyl)-propanone (3-(3-Bromo-phenyl)-1-(4-pyridin-3-yl-phenyl)- Propanone), yield 88.7%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 90395-45-2, 1-(4-(Pyridin-3-yl)phenyl)ethanone.

Reference:
Patent; E-ray Optoelectronics Technology Co Ltd; Huang, Heh Lung; Guo, Huang Ming; Chao, Teng Chih; Lin, Chi Jen; Chang, Min Jong; (53 pag.)TW2019/30287; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 84539-34-4, 4-Amino-3,5-dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-Amino-3,5-dibromopyridine, blongs to pyridine-derivatives compound. Quality Control of 4-Amino-3,5-dibromopyridine

A sealed reaction vessel charged with 4-amino-3,5-dibromopyridine (643 mg, (0490) 2.55 mmol, 1 equiv) and potassium ethyl xanthogenate (495 mg, 3.09 mmol, 1.21 equiv) in N,N-dimethylacetamide (8.0 mL) was heated with microwave irradiation at 160 C for 20 min. Additional potassium ethyl xanthogenate (0.490 g, 3.06 mmol, 1.20 equiv) was added to the mixture, and the resulting solution was heated with microwave irradiation at 160 C for a further 20 min. The reaction mixture was cooled to 0 C before the addition of iodomethane (382 mu^, 6.13 mmol, 2.40 equiv). After 20 min, the reaction was concentrated in vacuo and the resultant residue purified by flash column chromatography (solvent: 2: 1 heptane / ethyl acetate). Appropriate fractions were combined and evaporated to afford 7-bromo-2-(methylthio)thiazolo[5,4-c]pyridine (505 mg, 75.7%) as a tan solid. 1H NMR (500 MHz, CDC13): delta: 8.88 (s, 1H), 8.66 (s, 1H), 2.85 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,84539-34-4, 4-Amino-3,5-dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ZAK, Mark; ROMERO, F. Anthony; YUEN, Po-wai; HANAN, Emily J.; (139 pag.)WO2018/166993; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 597532-36-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 597532-36-0, name is Ethyl 6-(trifluoromethyl)nicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of ethyl 6-(trifluoromethyl)nicotinate (2.2 g, 10 mmol), Pd/C (10 wt.%, 100 mg) and platinum(IV) oxide (150 mg, 0.661 mmol) in acetic acid (30 mL) was stirred in a steel bomb under hydrogen atmosphere (200 psi) at 25 C for 24 hrs. The reaction mixture was filtered through a pad of celites and washed with MeOH (150 mL). The filtrate was concentrated under reduced pressure providing crude ethyl 6- (trifluoromethyl)piperidine-3-carboxylate (776 mg; mixture of cis and trans isomers) as a colorless oil, which was directly used in the next step without further purification.LCMS (m/z): 226.1 [M+H]+; Rt = 0.36 min.

According to the analysis of related databases, 597532-36-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BARSANTI, Paul A.; HU, Cheng; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WO2011/26904; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 856851-48-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.856851-48-4, name is 2-Chloro-5-ethoxypyridine, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

2-Chloro-5-ethoxy-pyridine (23 mg, 0.134 mmol) was dissolved in 2 ml dioxane. To this solution was added under argon 1,3-bis-(2,6-diisopropylphenyl)-imidazolinium chloride (12 mg,0.028 mmol), Pd2dba3 (12 mg, 0.013 mmol), compound (II) (56 mg, 0.143 mmol) and NaOtBu (20 mg, 0.21 mmol). The mixture was heated under argon at 100 C. for 6 hours. After cooling, the reaction was diluted with ethylacetate, washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by Prep TLC using 5% methanol in dichloromethylene to afford 23 mg of 6-Dimethylamino-2-{3-[5-(5-ethoxymethyl-pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-hydroxymethyl-phenyl}-3,4-dihydro-2H-isoquinolin-1-one (31% yield).

The chemical industry reduces the impact on the environment during synthesis 856851-48-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Berthel, Steven; Firooznia, Fariborz; Fishlock, Daniel; Hong, Jun-Bae; Lou, Yan; Lucas, Matthew; Owens, Timothy D.; Sarma, Keshab; Sweeney, Zachary Kevin; Taygerly, Joshua Paul Gergely; US2010/222325; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 832715-99-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 832715-99-8 as follows.

A mixture of [6-(3-amino-2-methyl-phenyl)-imidazo[l,2-a]pyrazin-8- yl]-(4-morpholin-4-ylmethyl-phenyl)-amine (150mg; 0.36mmol), benzotriazol-1- yloxytris(dimethylamino)phosphonium hexafluorophosphate (450mg; l.Ommol), and diisopropylethylamine (0.3mL; 1.7mmol) is dissolved in dimethylacetamide (ImL) and stirred at room temperature for 20min. 6-te/t-butyl-nicotinic acid (200mg; l.lmmol) is added and the mixture is stirred at room temperature for 16hr.[00297] Water (1OmL) is added and the mixture is filtered to give 6-?err-Butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[l,2-a]pyrazin-6- yl] -phenyl} -nicotinamide as a crude tan solid (120mg). The crude solid is purified by flash chromatography over silica gel to provide the final compound as a pale cream solid (lOOmg)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,832715-99-8, its application will become more common.

Reference:
Patent; CGI PHARMACEUTICALS, INC.; WHITNEY, James A.; DI PAOLO, Julie; VALLECA, Mark A.; BRITELLI, David R.; CURRIE, Kevin S.; DARROW, James W.; KROPF, Jeffrey E.; LEE, Tony; GALLION, Steven L.; MITCHELL, Scott A.; PIPPEN, Douglas A.I.; BLOMGREN, Peter A.; STAFFORD, Douglas Gregory; WO2008/33858; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem