Category: pyridine-derivatives

Related Products of 7471-05-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7471-05-8, name is 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine, molecular formula is C8H9N3, molecular weight is 147.1772, as common compound, the synthetic route is as follows.

General procedure for dehydrogenation of imidazolines with NaIO4 catalyzed by [Mn(TPP)Cl]: All of the reactions were carried out at room temperature under air in a 25 mL flask equipped with a magnetic stirrer bar. A solution of NaIO4 (2 mmol) in H2O (10 mL) was added to a mixture of 2-imidazolines (1 mmol), [Mn(TPP)Cl] (0.05 mmol) in CH3CN (5 mL). The progress of reaction was monitored by TLC (eluent: EtOAc/MeOH 4:1). After the reaction was completed, water (30 mL) was added and the corresponding imidazoles were extracted with CH2Cl2 (2 x 20 mL). The imidazole derivatives were obtained after evaporation of solvent. IR and 1H NMR spectral data confirmed the identities of the products.

The chemical industry reduces the impact on the environment during synthesis 7471-05-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kargar, Hadi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Nameni, Iman; Bioorganic and Medicinal Chemistry Letters; vol. 21; 7; (2011); p. 2146 – 2148;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60186-13-2, 2,4,6-Trichloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 60186-13-2, blongs to pyridine-derivatives compound. Product Details of 60186-13-2

(7) (R)-1-(2,6-dichloro-3-nitropyridin-4-yl)piperidine-3-tert-butyl carbamate To 30 mL solution of 2,4,6-trichloro-3-nitropyridine (1.14 g, 5.0 mmol) in ethanol was added triethylamine (1.4 mL, 10 mmol) at -10C, and stirred in an ice bath. After 15 mL solution of (R)-tert-butylpiperidin-3-yl-carbamate (1 g, 5.0 mmol) in ethanol was slowly added dropwise with a constant pressure funnel, the reaction solution was stirred for 1 h at -10C, and concentrated. The resultant crude product was subjected to silica gel column chromatography (ethyl acetate : petroleum ether = 1:2) to afford 0.78 g titled product with a yield of 39.9%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60186-13-2, 2,4,6-Trichloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Xuanzhu Pharmaco., Ltd.; EP2524917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

The mixture of 234 mg of 2-chloro-4-iodo picoline, 17.6 mg of copper iodide, 33.3 mg of 1,10-phenanthroline, 601 mg of cesium carbonate, 230 muL of 4-methoxybenzyl alcohol, and 0.5 mL of toluene, was stirred at 110C for 4 hours. After adding water and a saturated aqueous solution of sodium hydrogen carbonate, the mixture was extracted with chloroform, and the organic layer was washed with saturated brine. The thus-obtained organic layer was dried over anhydrous sodium sulfate, insolubles were filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by preparative thin-layer chromatography, and 207 mg of 2-chloro-4-[(4-methoxybenzyl)oxy]-3-methylpyridine [64-1] as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1790650; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 849068-61-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 849068-61-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below.

A mixture of 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylic acid (480 mg, 2 mmol, 1.0 eq) and cone. H2S04 (0.5 mL, cat.) in methanol was refluxed for 24 h. After the reaction was complete, the solvent was concentrated. The resulting residue was dissolved with EA, washed with aq. NaHC03., dried over Na2S04, filtered and concentrated to provide methyl 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylate (450 mg, 85%) as a white solid. LCMS (M+H+) m/z calculated 256.1 found 256.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,849068-61-7, its application will become more common.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 144657-66-9, tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 144657-66-9, blongs to pyridine-derivatives compound. SDS of cas: 144657-66-9

To a solution of 1-(tert-butoxycarbonyl)-3-formyl-7-azaindole (2.5g, 10.2 mmol) in 16 mL EtOH was added NaBH4 (115mg, 3.05 mmol). The reaction was stirred at ambient temperature for 4h, concentrated and triturated with IN NaOH. The basic solution was extracted with ether and ethylacetate. The organics were washed with water and brine, then dried over Na2S04, filtered and concentrated. The filtrate was concentrated and purified by silica gel chromatography (50% ethylacetate/hexanes) to give tert-butyl 3-(hydroxymethyl)-lH- pyrrolo[2,3-b]pyridine-l-carboxylate (44%). LCMS [M-tert-Bu]+ = 191.1.

The synthetic route of 144657-66-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn, J.; EGBERTSON, Melissa; BRNARDIC, Edward; JONES, Kristen; SANDERS, John, M.; HENZE, Darrell, A.; WO2013/176970; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58483-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-amino-5-bromonicotinamide (100 mg, 0.46 mmol), 3- fluorobenzaldehyde (69 mg, 0.56 mmol), NaHSC>3 (40 mg, 0.38 mmol), 4-methylbenzene sulfonic acid (15 mg, 0.05 mmol) in DMAc (3 mL) was stirred at 115C for 1.5 h, then additional NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After 1.5 h, the third portion of NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After being stirred overnight at 115C, the reaction mixture was concentrated in vacuo, suspended in water and filtered to give the product of 6-bromo-2-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one (70 mg, yield: 47%), which was used for the next step without further purification. XH-NMR (DMSO-i, 400 MHz) delta 13.04 (br s, 1H), 9.07 (d, J= 2.8 Hz, 1H), 8.65 (d, J= 2.8 Hz, 1H), 8.08 (d, J= 8.0 Hz, 1H), 8.02 (dd, J= 9.6, 1.6 Hz, 1H), 7.60-7.68 (m, 1H), 7.45-7.54 (m, 1H). MS (M+H)+: 320/322.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58483-98-0, 2-Amino-5-bromonicotinamide.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 61494-55-1, Adding some certain compound to certain chemical reactions, such as: 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61494-55-1.

PREPARATIVE EXAMPLE 1 STR50 A stirred mixture of 5 grams(g) (0.029 mole) of 2-chloro-3-pyridineacetic acid, 9.4 g (0.058 mole) of 3-trifluoromethylaniline and 50 mg of p-toluenesulfonic acid in 15 mL of n-pentanol is heated for 24 hours from 130 to 140 C. After the solvent is removed at reduced pressure, the resulting solid residue is triturated with water, filtered, and recrystallized from isopropylacetate to afford 6 g of pure product of Formula A with melting point 133-134 C. (75% yield). By essentially the same method using aniline, 1,3-dihydro-1-phenyl-2H-pyrrolo[2,3-b]pyridine-2-one is prepared, m.p. 120-121 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61494-55-1, 2-(2-Chloropyridin-3-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schering Corporation; US5023265; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 59944-76-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59944-76-2, name is Thieno[2,3-b]pyridine-2-carboxylic acid, molecular formula is C8H5NO2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Thieno[2,3-b]pyridin-2-yl-carbamic acid tert-butyl ester (147-D) A solution of compound 147-C (0.36 g, 2.00 mmol), N,N-diisopropylethylamine (0.385 mL, 2.21 mmol) and diphenyl phosphoryl azide (0.536 mL, 2.41 mmol) in t-butanol (3.6 mL) was heated at reflux for 16 h. The solvent was evaporated in vacuo, the residue dissolved in dichloromethane, washed with 1 N NaOH, brine, dried with Na2SO4, filtered, and evaporated to afford a residue. Flash column chromatography (SiO2) eluting with dichloromethane afforded compound 147-D as a white solid (0.25 g, 50%). 1H-NMR (CDCl3): delta 1.55 (s, 9H), 6.60 (s, 1H), 7.20 (dd, 1H), 7.80 (d, 1H), 8.40 (d, 1H); MS: m/z 251.2 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59944-76-2, Thieno[2,3-b]pyridine-2-carboxylic acid.

Reference:
Patent; Branum, Shawn T.; Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher M.; Jetter, Michele C.; Liu, Yi; Ludovici, Donald; Macielag, Mark J.; Matthews, Jay M.; McNally, James J.; Reaney, Laura M.; Russell, Ronald K.; Qin, Ning; Teleha, Christopher; Wells, Kenneth M.; Youells, Scott C.; Youngman, Mark A.; US2012/190674; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 63071-12-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-12-5, name is (6-Methoxypyridin-2-yl)methanol, molecular formula is C7H9NO2, molecular weight is 139.15, as common compound, the synthetic route is as follows.

To a 100-mL round-bottomed flask was added 6-methoxy-2- pyridinyl)methanol (1.1 g, 7.91 mmol), triphenylphosphine (2.28 g, 8.70 mmol, Aldrich, St. Louis, MO) and tetrabromomethane (0.84 mL, 8.70 mmol, Aldrich, St. Louis, MO) in DCM (20 mL). The reaction mixture was stirred at 0 C for 2 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 10% EtOAc/hexanes to give 2-(bromomethyl)-6- methoxypyridine (1.33 g) as a colorless oil.

The chemical industry reduces the impact on the environment during synthesis 63071-12-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael David; BO, Yunxin; BRYAN, Marian C.; CROGHAN, Michael; FOTSCH, Christopher Harold; HALE, Clarence Henderson; KUNZ, Roxanne Kay; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis Dale; POON, Steve Fong; STEC, Markian Myroslaw; ST. JEAN, David, Joseph, Jr.; TAMAYO, Nuria A.; TEGLEY, Christopher Michael; YANG, Kevin Chao; WO2012/27261; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89978-52-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89978-52-9 as follows.

A-mixture of-[2′-{[(4-fluorophenyl)methyl]oxy}-5′-(trifluoromethyl)-2-biphenylyl]boronic acid (98mg, 0. 25MOL), ethyl 2-bromo-4-pyridinecarboxylate (58mg, 0. 25MOL), potassium carbonate (276mg, 2MMOL) and tetrakis (TRIPHENYLPHOSPHINE) PALLADIUM (0) (29mg, 0. 025MOL) in 1: 1 toluene/ethanol (4ml) was stirred and heated at 90C under nitrogen for 2 hours. After cooling and dilution with diethyl ether/water the organic phase was separated, dried (magnesium sulphate) and evaporated. The residue was chromatographed on silica eluting with ethyl acetate/iso-hexane (1: 9) to give 81 mg of colourless gum. LC/MS t=4. 10, [MH+] 496.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89978-52-9, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39753; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem