Category: pyridine-derivatives

Safety of Ethyl nicotinate. Authors Chen, ZP; Tang, HQ; Ou, CR; Xie, C; Cao, JX; Zhang, X in WILEY published article about in [Chen, Zhipeng; Ou, Changrong; Xie, Cheng; Cao, Jinxuan; Zhang, Xin] Ningbo Univ, Coll Food & Pharmaceut Sci, Dept Food Sci & Engn, Ningbo, Peoples R China; [Tang, Haiqing] Zhejiang Pharmaceut Coll, Fac Food Sci, Dept Food Nutr & Testing, Ningbo, Peoples R China in 2021, Cited 153. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

Volatiles of four zaoyu (Chinese traditional fermented fish) products prepared from different species of marine fish were analyzed by headspace solid-phase micro-extraction (HS-SPME) and comprehensive two-dimensional gas chromatography in combination with time-of-flight mass spectrometry (GC x GC/TOFMS). First, a 50/30 mu m DVB/CAR/PDMS was used and the influence of several parameters on the efficiency of HS-SPME such as extraction temperature, time, salting-out effect, and stirring were optimized, odor activity values (OAVs) of volatile compounds were computed based on the threshold values of aroma constituents; the characteristic volatiles and their odor characteristics of the four zaoyu were investigated. The results demonstrated that the most effective extraction of the analytes was obtained with a 40 min extraction at 50 degrees C with the addition of 20% NaCl and stirring at 300 r/min. Under these conditions, a total of 288 volatile components were tentatively identified based on mass spectra and comparison of linear retention indices in the four zaoyu products. Authenticated compounds included aldehydes, esters, alcohols, ketones, furans, lactones, nitrogen compounds, sulfur compounds, terpenes, phenols, etc. Among the identified types of volatile compounds, the number of esters is the largest, whereas the content of aldehydes is the highest. The results of OAVs comparisons proved that both aldehydes and esters provided the most significant contribution to the aromas of zaoyu, and each zaoyu product had its own unique active flavor components. Moreover, the OAVs of active flavor compounds common to the four examined zaoyu varied significantly. Our results substantiated that GC x GC/TOFMS could provide a robust technical means to understand the flavor characteristics of zaoyu and allow us to better evaluate and improve the flavor quality of the products with complex food matrix like zaoyu. Practical applications The method present in this research is suitable to characterize the volatile constituents of aquatic products, and could also be used for component characterization of similar complex samples such as fermented fish and foods. Understanding the key aroma compounds of fermented fish and its formation mechanism could provide a guide of process optimization and flavor regulation, contributing to further studies related to volatile compounds in the field of food flavor analysis.

About Ethyl nicotinate, If you have any questions, you can contact Chen, ZP; Tang, HQ; Ou, CR; Xie, C; Cao, JX; Zhang, X or concate me.. Safety of Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Neutral 4-phenyl-1-[phenyl(pyridin-2-yl)methylidene]semicarbazide and its salt forms with inorganic anions WOS:000454742800001 published article about SUPEROXIDE-DISMUTASE ACTIVITY; DOT-N INTERACTIONS; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE in [Araujo, Vinicius Oliveira; Schwade, Vania Denise] Fundacao Univ Fed Grande Dourados, Fac Ciencias Exatas & Tecnol, Rodovia Dourados Itahum,Km 12, BR-79804970 Dourados, MS, Brazil; [Tirloni, Brbara] Univ Fed Santa Maria, Dept Quim, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil; [Streit, Livia] Univ North Georgia, Dept Chem & Biochem, 3820 Mundy Mill Rd, Oakwood, GA 30566 USA in 2019.0, Cited 22.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. HPLC of Formula: C12H9NO

Semicarbazones can exist in two tautomeric forms. In the solid state, they are found in the keto form. This work presents the synthesis, structures and spectroscopic characterization (IR and NMR spectroscopy) of four such compounds, namely the neutral molecule 4-phenyl-1-[phenyl(pyridin-2-yl)methylidene] semicarbazide, C19H16N4O, (I), abbreviated as HBzPyS, and three different hydrated salts, namely the chloride dihydrate, C19H17N4O+center dot Cl-center dot 2H(2)O, (II), the nitrate dihydrate, C19H17N4O+center dot NO3-center dot 2H(2)O, (III), and the thiocyanate 2.5-hydrate, C19H17N4O+center dot SCN-center dot 2.5H(2)O, (IV), of 2-[phenyl({[(phenylcarbamoyl) amino]imino})methyl]pyridinium, abbreviated as [H(2)BzPyS](+)center dot X-center dot nH(2)O, with X = Cl- and n = 2 for (II), X= NO3- and n = 2 for (III), and X = SCN- and n = 2.5 for (IV), showing the influence of the anionic form in the intermolecular interactions. Water molecules and counter-ions (chloride or nitrate) are involved in the formation of a two-dimensional arrangement by the establishment of hydrogen bonds with the N-H groups of the cation, stabilizing the E isomers in the solid state. The neutral HBzPyS molecule crystallized as the E isomer due to the existence of weak pi-pi interactions between pairs of molecules. The calculated IR spectrum of the hydrated [H(2)BzPyS](+) cation is in good agreement with the experimental results.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Araujo, VO; Tirloni, B; Streit, L; Schwade, VD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Hou, P; Sun, JW; Wang, HJ; Liu, L; Zou, LW; Chen, S in [Hou, Peng; Sun, Jingwen; Wang, Haijun; Liu, Lei; Chen, Song] Qiqihar Med Univ, Coll Pharm, 333 Bukui St, Qiqihar 161006, Heilongjiang, Peoples R China; [Zou, Liwei] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China published TCF-imidazo[1,5-alpha]pyridine: A potential robust ratiometric fluorescent probe for glutathione detection with high selectivity in 2020.0, Cited 41.0. Category: pyridine-derivatives. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A novel fluorescent probe, TCF-IPY, has been designed and developed for highly selective and ratiometric detection of GSH based on the extend of the pi-conjugation system of imidazo[1,5-alpha]pyridine IPY-CHO. Upon addition of GSH, TCF-IPY displayed remarkable fluorescence variations (approximate 949-fold ratio changes) from 603 nm to 475 nm, thereby enabling GSH detection in a fine ratiometric manner. Moreover, TCF-IPY exhibited excellent selectivity toward GSH over other biologically related species including Cys and Hcy. The huge blue shifts both in absorption (259 nm) and emission spectra (128 nm), low cytotoxicity, high sensitivity (97 nM) and rapid response (240 s) of TCF-IPY make it a robust molecular tool for endogenous GSH investigation. Furthermore, TCF-IPY was also successfully used for ratiometric imaging of endogenous GSH in living MCF-7 cells and zebrafish.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Hou, P; Sun, JW; Wang, HJ; Liu, L; Zou, LW; Chen, S or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS, Saw an article supported by the Royal SocietyRoyal Society of LondonEuropean Commission; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/I000992/1]; University of Surrey, U.K.; Sultanate of Oman; Erasmus+ scheme. Formula: C6H5NO. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and Evaluation of Pyridoxal Hydrazone and Acylhydrazone Compounds as Potential Angiogenesis Inhibitors published in 2019.0, Reprint Addresses Luo, WH (corresponding author), Shantou Univ, Coll Med, Bioanalyt Lab, Xinling Rd 22, Shantou, Guangdong, Peoples R China.. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride.

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or concate me.. Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C12H9NO. In 2019.0 CHEMISTRYSELECT published article about METAL-ORGANIC FRAMEWORK; O-IODOXYBENZOIC ACID; TERT-BUTYL HYDROPEROXIDE; LIQUID-PHASE OXIDATION; CATALYZED OXIDATION; SECONDARY ALCOHOLS; ALLYLIC ALCOHOLS; ALDEHYDES; H2O2; COMPOSITE in [Tan, Jin; Chen, Wei Feng; Hu, Yu Lin] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmetall Crystalline & Energy Co, Yichang 443002, Hubei, Peoples R China; [Liu, Xiao Bing] Jinggangshan Univ, Coll Chem & Chem Engn, Jian 343009, Jiangxi, Peoples R China in 2019.0, Cited 56.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A new methodology for the highly efficient and atom-economic oxidation of alcohols and benzylic compounds to the corresponding aldehydes and ketones with environmental-friendly hydrogen peroxide using a magnetic MOF nanocatalyst has been developed. We demonstrated that the resulting magnetic nanocomposite CoFe2O4@SiO2@MIL-53(Fe) can show excellent catalytic performances in the highly selective oxidation at room temperature, based on a synergetic effect between iron sites and CoFe2O4@SiO2. The nanocatalyst offers simple operation for recovery and the recycling test showed that it could be reused for successive runs without significant degradation in catalytic activity.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Tan, J; Liu, XB; Chen, WF; Hu, YL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C8H10ClNO3. Ramilo-Gomes, F; Addis, Y; Tekamo, I; Cavaco, I; Campos, DL; Pavan, FR; Gomes, CSB; Brito, V; Santos, AO; Domingues, F; Luis, A; Marques, MM; Pessoa, JC; Ferreira, S; Silvestre, S; Correia, I in [Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Matilde Marques, M.; Pessoa, Joao Costa; Correia, Isabel] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Av Rovisco Pais, P-1049001 Lisbon, Portugal; [Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Matilde Marques, M.; Pessoa, Joao Costa; Correia, Isabel] Univ Lisbon, Inst Super Tecn, Dept Engn Quim, Av Rovisco Pais, P-1049001 Lisbon, Portugal; [Ramilo-Gomes, Filipa] Univ Lisbon, Inst Invest Medicamento IMed ULisboa, Fac Farm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal; [Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel] Univ Algarve, Dept Quim & Farm, Campus Gambelas, P-8005139 Faro, Portugal; [Campos, Debora L.; Pavan, Fernando R.] UNESP, Fac Ciencias Farmaceut, CP 582, BR-14801902 Araraquara, SP, Brazil; [Gomes, Clara S. B.] Univ NOVA Lisboa, Dept Quim, LAQV REQUIMTE Lab Associado Quim Verde, Fac Ciencias & Tecnol, P-2829516 Monte De Caparica, Portugal; [Gomes, Clara S. B.] Univ NOVA Lisboa, Appl Mol Biosci Unit UCIBIO, Fac Ciencias & Tecnol, P-2829516 Monte De Caparica, Portugal; [Brito, Vanessa; Santos, Adriana O.; Domingues, Fernanda; Luis, Angelo; Ferreira, Susana; Silvestre, Samuel] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, Av Infante D Henrique, P-6200506 Covilha, Portugal published Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes in 2021.0, Cited 80.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), ovanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)complexes (1-4), are synthesized. All compounds are characterized by elemental analyses, infrared, UV-Vis, nuclear magnetic resonance spectroscopy and mass spectrometry. The structures of H2L2 and [Zn-2(L-1)(2)(H2O) (DMF)] (1a) (DMF = dimethylformamide) are solved by single crystal X-ray diffraction. The SB coordinates the metal center through the Ophenolate, Nimine and Sthiolate atoms. The radical scavenging activity is tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with all ligand precursors showing IC50 values similar to 40 mu M. Cytotoxicity studies with several tumor cell lines (PC-3, MCF-7 and Caco-2) as well as a non-tumoral cell line (NHDF) are reported. Interestingly, 1 has relevant and selective antiproliferative effect against Caco-2 cells (IC50 = 9.1 mu M). Their antimicrobial activity is evaluated in five bacterial strains (Klebsiella pneumoniae, Acinetobacter baumannii, Listeria monocytogenes, Pseudomonas aeruginosa and Staphylococcus aureus) and two yeast strains (Candida albicans and Candida tropicalis) with some compounds showing bacteriostatic and fungicidal activity. The minimal inhibitory concentration (MIC90) of HnL against Mycobacterium tuberculosis is also reported, with H2L2 and H3L4 showing very high activity (MIC90 < 0.6 mu g/mL). The ability of the compounds to bind bovine serum albumin (BSA) and DNA is evaluated for H3L4 and [Zn-2(L-4)(CH3COO)] (4), both showing high binding constants to BSA (ca. 106 M 1) and ability to bind DNA. Overall, the reported compounds show relevant antitumor and antimicrobial properties, our data indicating they may be promising compounds in several fields of medicinal chemistry. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Ramilo-Gomes, F; Addis, Y; Tekamo, I; Cavaco, I; Campos, DL; Pavan, FR; Gomes, CSB; Brito, V; Santos, AO; Domingues, F; Luis, A; Marques, MM; Pessoa, JC; Ferreira, S; Silvestre, S; Correia, I or concate me.. HPLC of Formula: C8H10ClNO3

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Li, FZ; Geng, JS; Hu, KQ; Yu, JP; Liu, N; Chai, ZF; Mei, L; Shi, WQ in [Li, Fei-Ze; Liu, Ning] Sichuan Univ, Inst Nucl Sci & Technol, Minist Educ, Key Lab Radiat Phys & Technol, Chengdu 610064, Peoples R China; [Li, Fei-Ze; Geng, Jun-Shan; Hu, Kong-Qiu; Yu, Ji-Pan; Chai, Zhi-Fang; Mei, Lei; Shi, Wei-Qun] Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Energy Chem, Beijing 100049, Peoples R China; [Chai, Zhi-Fang] Chinese Acad Sci, Ningbo Inst Ind Technol, Engn Lab Adv Energy Mat, Ningbo 315201, Zhejiang, Peoples R China published Proximity Effect in Uranyl Coordination of the Cucurbit[6]uril-Bipyridinium Pseudorotaxane Ligand for Promoting Host-Guest Synergistic Chelating in 2021, Cited 43. Formula: C8H9NO2. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

behavior of cucurbituril-bipyridinium pseudorotaxane ligand by utilizing meta-functionalized bipyridinium dicarboxylate guest. A tailored pseudorotaxane precursor involving 1,1′-(hexane-1,6-diyl)bis(3-cyanopyridin-1-ium) bromide (C6BPCN3) and cucurbit[6]uril (CB[6]) has designed and synthesized. Through in situ hydrolysis of the pseudorotaxane ligands and their coordination assembly with uranyl cations, seven new uranyl-rotaxane coordination polymers URCP1-URCP7 have been obtained under hydrothermal conditions in the presence of different anions. It is demonstrated that the variation of carboxylate groups from para- to meta-position greatly affected the coordination behaviors of the metafunctionalized pseudorotaxane linkers, which are enriched from simple guest-only binding to host-guest simultaneous coordination and synergistic chelating. This effective regulation on uranyl coordination of supramolecular pseudorotaxane can be attributed to the proximity effect, which refers to the meta-position carboxyl group being spatially closer to the portal carbonyl group of CB[6]. Moreover, by combining other regulation methods such as introducing competing counterions and modulating solution acidity, the nuclearity of the uranyl center and the coordination patterns of the pseudorotaxane ligand can be diversely tuned, which subsequently exert great influence on the final dimensionality of resultant uranyl compounds. This work presents a large diversity of uranyl-based coordination polyrotaxane compounds with fascinating mechanically interlocked components and, most importantly, provides a feasible approach to adjust and control the metal coordination behavior of the pseudorotaxane ligand that might expand the scope of application of such supramolecular ligands.

Formula: C8H9NO2. About Ethyl nicotinate, If you have any questions, you can contact Li, FZ; Geng, JS; Hu, KQ; Yu, JP; Liu, N; Chai, ZF; Mei, L; Shi, WQ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about DUAL-CHANNEL RECOGNITION; MOLECULAR LOGIC GATES; TURN-ON SENSOR; FLUORESCENT SENSOR; AQUEOUS-MEDIA; COLORIMETRIC SENSOR; SCHIFF-BASE; CYANIDE; CHEMOSENSOR; MAGNESIUM, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41867053]; Nanchang normal university Doctoral Research Startup fund [NSBSJJ2015035]; Open Project Program of 311 high level engineering center Jiangxi Science &Technology Normal University [KFGJ19004]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Yuwen, ZY; Mei, HX; Li, H; Pu, SZ. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. HPLC of Formula: C8H10ClNO3

A chemical sensor composed of pyridoxal hydrochloride schiff base based on diarylethene (1O) was synthesized. Its photochemical properties and selectivity to ions were further studied. The chemosensor could detect cyanide effectively and is almost undisturbed by other ions. When titrating CN-, the reaction aroused a distinct change in the absorption spectrum with the color change from transparent to yellow, and the fluorescence intensity centered at 562 nm was increased 68 folds. It also exhibited a good fluorescence sensing of Mg(2+ )with high selectivity and sensitivity. Upon addition of Mg2+, its emission intensity enhanced 110 folds, with the color change from dark to bright blue. Its good spectral response could be applied to molecular logic circuit. Moreover, the chemosensor could be made into test paper strips for the qualitative and quantitative detection of CN- and Mg2+.

HPLC of Formula: C8H10ClNO3. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Yuwen, ZY; Mei, HX; Li, H; Pu, SZ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. I found the field of Chemistry very interesting. Saw the article Crystal structure, spectroscopic, DNA binding studies and DFT calculations of a Zn(II) complex published in 2019.0, Reprint Addresses Chattopadhyay, SK (corresponding author), Indian Inst Engn Sci & Technol, Dept Chem, Sibpur 711103, Howrah, India.. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride.

Herein we report, a mononuclear, highly fluorescent zinc(ii) complex Zn(L)(N-3)(H2O) (1) that was prepared by an easy one pot method, in which the tridentate Schiff base ligand (E)-4-((2-(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (HL) was generated in situ. The compound is characterized by various spectroscopic techniques, and its structure was determined by single crystal X-ray diffraction studies. DFT calculations were used to understand the electronic structures of the ligand and the complex, and TD-DFT calculations were performed to interpret the nature of the electronic transitions observed in their UV-vis spectra. In the complex, Zn(II) is found to be penta-coordinated with one azide ligand, an aqua ligand and a monoanionic tridentate N,N,O-donor ligand. In an aqueous methanol (1:9 by volume) solution, at the physiological pH (0.01 M Tris-HCl buffer, pH 7.4), compound 1 exhibits an intense greenish blue fluorescence (lambda(ex) 390 nm, lambda(em) 462 nm), whose intensity is about 17-fold stronger than that of the free ligand. Compound 1 is found to show significant DNA binding activity. The pyridoxal appended tridentate ligand can be used for the bio-imaging of Zn(II).

Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Mondal, S; Chakraborty, M; Mondal, A; Pakhira, B; Mukhopadhyay, SK; Banik, A; Sengupta, S; Chattopadhyay, SK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem