Category: pyridine-derivatives

Reference of 5467-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5467-69-6, name is 6-Methoxy-2-methyl-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of intermediate 74 (2 g, 0.012 mol) in H20/MEOH 1: 1 (40 mL), were added NH4CI (2.2 g, 3.5 eq. ) and Fe powder (2.3 g, 3.5 eq. ). The reaction mixture was stirred at 80C for 16 hr. Fe was then filtered and washed with MeOH. The MeOH was evaporated, H20 was added and the aqueous solution was extracted with EtOAc (3X50 mL). The combined organic extracts were dried over anh. NA2SO4, the solids were filtered and the solvent evaporated to dryness to give the title compound (1.35 g, 81 %) as a brown oil. NMR (‘H, CDCI3) : 8 6.9 (d, 1 H), 6.4 (d, 1 H), 3.8 (s, 3H), 2.33 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine.

Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED; WO2004/62665; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60032-57-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60032-57-7, name is 2-Methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

(b) methyl 2-Q -(hydroxy(2-methyipyridin-3-yl)mnethyi)bcnzofuran-5-yl)acctate: To asohLtion of methyl 2-(Z-bromobenzofuran-5-yi)acctate (0.35 g, 1.3 mmol) in dry THE (5 niL) wasadded i-PrMgCI-iithium chloride (1.3 M solution in THF, 1.3 mL, 1.6 nnol) dropwise at 0 C andthe reaction mixture was stilTed for 30 mm maintaining the same temperature. ?To the reaction mixture was added a solution of 2-methylnicotinaldehyde (157 rng, 1.3 mniol) in dry TF1F (5 mL) and the reaction mixture was further stirred for 2 h at 0 C. The reaction mixture was quenched with saturated NH4C1 solution and the organic product was extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under vacuum. The crudeproduct was purified by column chromatography (neutral alumina, eluent 5-10% MeOI-f in CH2C12) to afford the title compound (160 mg, yield 40%) as a yellow viscous liquid. ?H NMR (300 MHz, MeOH-d,) 6 ppm 8.36 – 8.34 (dd, J= 4.9 Hz, 1.6 Hz, IH), 8.01 – 7.97 (dd, J= 7.9 Hz, 1.5 Hz, 1H), 7.447.43 (d,J 1.3 Ffz, 1Ff), 7.37-7.30 (in, 2Ff), 7.18 -7.14 (dd,J 8.4 Ffz, 1.6 Ffz, 1Ff), 6.56 (s, 1ff), 6.08 (s, 1Ff), 3.69 (s, 2Ff), 3.65 (s, 3Ff), 2.52 (s, 3Ff).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60032-57-7, 2-Methylnicotinaldehyde.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1594-58-7, name is N-Hydroxynicotinimidamide, molecular formula is C6H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of N-Hydroxynicotinimidamide

Add 0.05 mol (6.85 g) to a 250 mL three-necked flaskN-hydroxynicotinamide,100mL acetonitrile as solvent,0.055 mol (5.5 g) of triethylamine as an acid binding agent, and stirring, 0.05 mol (16.5 g) of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride Diluted with 50 mL of ethyl acetate and added dropwise to the reaction flask.The reaction was carried out for 2 h after the completion of the dropwise addition.TLC monitoring until the reaction is complete,Add an appropriate amount of saturated sodium bicarbonate solution,Filtering,Made a brown solid,Rinse with methanol to obtain 18.1 g of a yellow solid.The yield was 96.02%.

With the rapid development of chemical substances, we look forward to future research findings about 1594-58-7.

Reference:
Patent; Qingdao University of Science and Technology; Wang Minghui; Xu Liangzhong; Liu Liancai; Sun Jianxin; Cui Huanqi; (7 pag.)CN109336879; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 66572-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66572-56-3, name is 2-Bromoisonicotinic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 3-iodo-4-methylbenzoic acid 5-1 (262mg, 1.0mmol) in dry DCM (10mL) at 0C was added oxalyl chloride (0.13mL, 1.5mmol) and 3 drops of dry DMF. The resulting reaction mixture was stirred at room temperature for 3h, and then the solvent was removed under reduced pressure. The crude product was used directly for the next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66572-56-3, 2-Bromoisonicotinic acid.

Reference:
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13466-41-6, Adding some certain compound to certain chemical reactions, such as: 13466-41-6, name is 4-Methylpyridin-2-ol,molecular formula is C6H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13466-41-6.

Step 1 3-(4-Methyl-2-oxo-2H-pyridin-1-yl)-5-nitro-benzoic acid methyl ester To a 25 ml round-bottomed flask was added 2-Hydroxy-4-methylpyridine (17.9 mg, 0.164 mmol), 3-Iodo-5-nitro-benzoic acid methyl ester (40 mg, 0.137 mmol), CuI (5.2 mg, 0.027 mmol) and 1,4-dioxane (10 ml). The reaction mixture was stirred for 5 minutes to the dissolve 2-Hydroxy-4-methylpyridine and 3-iodo-5-nitro-benzoic acid methyl ester, after which 1,10-phenanthroline (9.84 mg, 0.055 mmol) was added, followed by K3PO4 (174 mg, 0.082 mmol). The reaction mixture was flushed with N2, and heated to 110 C. for 24 hours. After cooling to room temperature, the mixture was diluted with H2O, and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography to give 3-(4-Methyl-2-oxo-2H-pyridin-1-yl)-5-nitro-benzoic acid methyl ester (39.45 mg, 61%) as light yellow solid. MS (M+H)=289.

According to the analysis of related databases, 13466-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dillon, Michael Patrick; Hawley, Ronald Charles; Chen, Li; Feng, Lichun; Yang, Minmin; US2008/4442; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 118650-08-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 118650-08-1, name is Methyl 2-(5-bromopyridin-3-yl)acetate. This compound has unique chemical properties. The synthetic route is as follows.

A solution of palladium acetate (1.4 mg, 0.00623 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (5.3 mg, 0.0124 mmol) and potassium phosphate (27.6 mg, 0.1246 mmol) in water (0.020 mL) and toluene (0.100 mL) was stirred for three minutes. Then, a solution of (5-bromo-pyridin-3-yl)acetic acid methyl ester (Example 24-(2); 15.2 mg, 0.0659 mmol) and (E)-4-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl) – phenyl]-propyl}-2-methyl-phenyl)-1,1,1-trifluoro-2-trifluoromethyl-3-buten-2-ol (Example 26-(5); 26.9 mg, 0.0471 mmol) in toluene (0.12 mL) was added, and the mixture was stirred in a nitrogen atmosphere at 100C for one hour. After filtration through cotton plug, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate = 3/2) to give the title compound (5.0 mg, 17%). 1H-NMR (chloroform-d): 0.65 (t, 6H, J=7.2Hz), 1.60 (brs, 1H), 2.12 (q, 4H, J=7.2Hz), 2.24 (s, 6H), 3.69 (s, 2H), 3.73 (s, 3H), 6.16 (d, 1H, J=15.6Hz), 6.97-7.05 (m, 5H), 7.36-7.43 (m, 2H), 7.66 (s, 1H), 8.43 (d, 1H, J=6.9Hz).

According to the analysis of related databases, 118650-08-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1894911; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1239363-36-0, tert-Butyl 2′,6′-dichloro-5,6-dihydro-[4,4′-bipyridine]-1(2H)-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: tert-Butyl 2′,6′-dichloro-5,6-dihydro-[4,4′-bipyridine]-1(2H)-carboxylate, blongs to pyridine-derivatives compound. Recommanded Product: tert-Butyl 2′,6′-dichloro-5,6-dihydro-[4,4′-bipyridine]-1(2H)-carboxylate

18-1 (1.62 g, 4.9 mmol) was treated with PtO2 (0.16 g) under a H2 atmosphere for 1 h. The catalyst was removed by filtration, and 18-2 (1.46 g, 90%) was used without further purification. LC/MS: m/z 331.10 [M+H]+.

The synthetic route of 1239363-36-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alios BioPharma, Inc.; Wang, Guangyi; Beigelman, Leonid; Truong, Anh; Stein, Karin Ann; (234 pag.)US2016/244460; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1003-73-2, Adding some certain compound to certain chemical reactions, such as: 1003-73-2, name is 3-Methylpyridine 1-oxide,molecular formula is C6H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1003-73-2.

PREPARATION EXAMPLE 3 2-Chloro-5-methyl-pyridine A solution of 20 g (0.1 mol) of N,N-dipropylsulphamoyl chloride in 60 ml of chlorobenzene is added dropwise under nitrogen to a solution of 5.5 g (50 mmol) of 3-methylpyridine-1-oxide and 10.1 g (0.1 mol) of triethylamine in 40 mol of chlorobenzene. The mixture is then heated to 70 C. for a further 3 hours, the solid is then filtered off with suction, the filter cake is washed with chlorobenzene and the liquid phase is extracted using conc. hydrochloric acid.

According to the analysis of related databases, 1003-73-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Aktiengesellschaft; US5099025; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19798-80-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19798-80-2, name is 4-Chloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-amino-4-chloropyridine (150 g, 0.78 mol) in DMF (1.5 L) was added NIS (341 g, 1.52 mol) and the reaction mixture stirred at RT for 18 h before being concentrated in vacuo to 300 mL volume. The resultant residue was poured into 10% aqueous sodium thiosulfate solution (1.2 L), stirred for 15 min and the precipitate formed collected by filtration, washed with water then dried at 35 C. in vacuo to give the title compound as a pale brown solid (185 g, 62%). 1H NMR 400 MHz (CDCl3) delta: 8.33 (1H, s), 6.68 (1H, s), 4.52 (2H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; Genentech, Inc.; US2012/245144; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 372-48-5 , The common heterocyclic compound, 372-48-5, name is 2-Fluoropyridine, molecular formula is C5H4FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of diisopropylamine (104 g, 1 .03 mol) in dry THF (2.6 L) was added dropwise 2.5 M solution of pi-BuLi in hexane (392 mL, 0.98 mol) at -30 to -40C under N2. The resulting mixture was stirred at 0C for 35 min. The mixture was cooled to -70C and a solution of 2-fluoropyridine (I-25) (100 g, 1 .03 mol) in dry THF (800 mL) was added. After stirring at -70C for 2 hr, the mixture was added to a solution of l2 (261 .6 g, 1 .03 mol) in dry THF (800 mL) at -20C under N2. After the reaction was complete, the mixture was quenched with ice water (4 L). The mixture was diluted with EtOAc (4 L) and washed with aq. Na2S203 (500 mL) and brine (500 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The residue was purified by distillation in vacuum to afford 2-fluoro-3-iodopyridine (I-26) (140 g, 61 %) as a yellow solid.

The synthetic route of 372-48-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem