Category: pyridine-derivatives

Related Products of 607373-83-1 , The common heterocyclic compound, 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of 2-chloro-4-methoxy-5-nitropyridine (300 mg, 1.59 mmol), prepared according to a literature procedure (PCT Int. Appl. (2003), WO 2003080610 Al 20031002) in EtOH (3 mL) was added SnCl2.2H20 (1.44g, 6.36 mmol) and the the mixture heated at 90C for lhr. The solvents were evaporated and the residue partitioned between 3M NaOH (50 mL) and DCM (lOOmL). The phases were separated and the organic phase was washed with brine (20 mL), dried (Na2SC>4), the mixture filtered and the filtrate evaporated to dryness to afford the title compound as a yellow oil (174 mg, 69%); m z=158.9, 160.8 (MH)+.

The synthetic route of 607373-83-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 677728-92-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 677728-92-6, name is 2-Fluoropyridine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

General procedure: A solution containing the corresponding 4-fluoro aryl aldehyde (20.0mmol) and 4-hydroxy aryl aldehyde (20.0mmol) in DMAC (20 mL) was added to K2CO3(24.0mmol) and stirred at 100 C for 4 h under N2. The progress of the reaction was monitored by TLC (eluent: petroleum ether /ethyl acetate 5:1). Following the disappearance of the starting material, the mixture was washed with 1mol/LHCl(30 mL), 5% solution of NaHCO3(30 mL), and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated to yield the crude material used for the subsequent reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,677728-92-6, its application will become more common.

Reference:
Article; Bian, Cong; Chen, Xiaofang; Hu, Laixing; Hu, Xinxin; Liu, Yonghua; Wang, Chong; Wu, Yanbin; You, Xuefu; Zhang, Yongzhong; Bioorganic and medicinal chemistry letters; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 103-74-2, blongs to pyridine-derivatives compound. Recommanded Product: 103-74-2

To a solution of 2-(2-hydroxyethyl)pyridine (3 ml, 26.6 mmol) was added 30 ml of 33% HBr in acetic acid. The yellow solution was heated in the capped vial at 78 C. for 2 days. The reaction was evaporated under high vacuum to produce a brown solid. The solid was re-crystallized from hot isopropanol to produce a light tan solid (73%). 1H NMR (500 MHz, dMSO): delta 3.62-3.65 (t, 2H), 3.95-3.98 (t, 2H), 7.95 (t, 1H), 8.09-8.10 (d, 1H), 8.58 (t, 1H), 8.90 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,103-74-2, its application will become more common.

Reference:
Patent; Tachdjian, Catherine; Lebl-Rinnova, Marketa; Wallace, David; US2006/263411; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 799293-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine. A new synthetic method of this compound is introduced below.

To a solution of 3-bromo-thieno[2,3-c]pyridine-4-yl-amine (1.00 g, 4.38 mmol) in DMF (15 mL) was added NIS (1.08 g, 4.81 mmol). The resulting solution was stirred at room temperature overnight. Approximately half of the solvent was removed in vacuo and the resulting slurry was poured into sodium thiosulfate (5% solution in water, 100 mL). The resulting precipitate was collected and washed with water (2 x 30 mL) to afford 4-amino-7- biphenyl-3-yl-thieno[3,2-c]pyridine carboxylic acid as a tan solid (1.55 g, 4.38 mmol); RP- HPLC (Table 1, Method i) Rt 2.72 min; m/z: (M + H) + 357.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-85-9, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 100367-39-3, 4-Bromo-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H6BrNO, blongs to pyridine-derivatives compound. COA of Formula: C6H6BrNO

EXAMPLE 22: Synthesis of N1-(7-chloroquinolin-4-vn-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane- 1 ,2-diamine. Pd(OAc)2, BINAP, K3PO4, dioxane [00257] A mixture of 4-bromo-2-methoxypyridine (0.188 g, 0.997 mmol), Nx-(2- aminoethyl)-N2-(7-chloroquinolin-4-yl)-N1-methylethane-l,2-diamine (0.278 g, 0.997 mmol), Pd(OAc)2 (24.5 mg), BINAP (0.135 g), and K3PO4 (1.14 g) in 1,4-dioxane (10 mL) was degassed with argon for 5 min and then stirred at 100 C for 20 h in a sealed tube. The reaction mixture was cooled to room temperature, filtered through Celite, and concentrated in vacuo. Purification by silica gel chromatography using CH2CI2/CH3OH/NH4OH (270:9: 1, and 180:9: 1) afforded N1-(7-chloroquinolin-4-yl)-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane-l,2-diamine (0.26 g, 67%) as a pale-yellow solid after lyophilization with CH3CN/H20. 1H NMR (300 MHz, DMSO-d6) delta 2.31 (s,3H); 2.60 (t, J = 6.3, 2H); 2.69 (t, J = 6.6, 2H); 3.12 (q, J = 5.9, 2H); 3.38 (q, J = 6.0, 2H); 3.72 (s, 3H); 5.78 (d, J = 2.1, 1H); 6.20 (dd, J = 2.0, 5.9, 1H); 6.26 (t, J = 5.0, 1H); 6.50 (d, J = 5.4, 1H); 7.14 (br t, 1H); 7.41 (dd, J = 2.1, 9.0, 1H); 7.62 (d, J = 5.7, 1H); 7.78 (d, J = 2.4, 1H); 8.17 (d, J = 9.0, 1H); 8.39 (d, J = 5.4, 1H). Mass spectrum (ESI) m/e = 386.6 (M+l).

The synthetic route of 100367-39-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRESAGE BIOSCIENCES, INC.; DECKWERTH, Thomas; KLEINMAN, Edward; RUAN, Fuqiang; BAKER, William; KLINGHOFFER, Richard; (126 pag.)WO2016/196393; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1136-52-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of alpha4,3-O-isopropylidene pyridoxine (1, 0.10 g, 0.48 mmol, 1.00 eq.), 2,3,4,6-tetra-O-acetyl-[13C6]-alpha-d-glucopyranosyl bromide (24, 0.23 g, 0.57 mmol, 1.20 eq.) and molecular sieves (4 A) in dry dichloromethane (5 mL) was stirred under argon atmosphere at rt for 1 h. The reaction was cooled to 0 C, AgOTf (0.36 g, 1.43 mmol, 3.00 eq.) and NIS (0.32 g, 1.43 mmol, 3.00 eq.) were added and the reaction mixture was allowed to reach rt overnight. The mixture was diluted with dichloromethane (25 mL) and filtered through a pad of celite. Afterwards, the filtrate was washed with Na2S2O3 (10 % v/v in water, 30 mL) and the aqueous phase extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with distilled water (1 x 50 mL), brine (1 x 50 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product subjected to column chromatography using SiO2 (pentane/ethyl acetate 1/1 to 1/4, gradient elution) followed by Sephadex (methanol, isocratic) to afford the glycoside (25, 85.8 mg, 0.15 mmol, 33 %).

According to the analysis of related databases, 1136-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael; Carbohydrate Research; vol. 489; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 30683-23-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30683-23-9, name is 3-Bromopyridine-2-carboxylic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 5.45 g of 3-bromo-2-pyridine carboxylic acid (27.0 mmol, 1 eq.), obtained in example 3b), in 100 ml of methanol is reflux heated in the presence of 8 ml of sulfuric acid. The reaction mixture is allowed to return to ambient temperature and poured into water. It is extracted 3 times with ethyl acetate, the organic phase is dried on Na2SO4 and vacuum evaporated. 2.48 g (42%) of esterified product is obtained. NMR (1H, CDCl3): 4.02 (s; 3H), 7.34 (dd, J=8.2, 2.8 Hz; 1H), 8.04 (d, J=8.2 Hz; 1H), 8.64 (d, J=2.8 Hz; 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30683-23-9, 3-Bromopyridine-2-carboxylic acid.

Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1008-91-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1008-91-9, name is 1-(Pyridin-4-yl)piperazine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of compound 4-6 (1 mmol) in 5 ml of dry DCM and piperazine derivative (1 mmol) was cooled in an ice bath. Then, 1.1 mmol of DCC in 5 ml of dry dichloromethane was added tothe mixture under nitrogen (N2) atmosphere. Reaction mixture was stirred for 0.5 hour in an ice bath, then 10-16 hours at room temperature. Reaction solvent was evaporated to the dryness. Residue was dissolved in hot acetonitrile then cooled in refrigerator to get the DCU precipitated. White crystalline DCU was removed by filtration. Liquid part was evaporated and crystallized from appropriate solvents to give compound 7-34

According to the analysis of related databases, 1008-91-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Akgun, Hulya; Yilmaz, Demet Us; Atalay, Rengul Cetin; Gozen, Damla; Letters in drug design and discovery; vol. 13; 1; (2016); p. 64 – 76;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 462-08-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 462-08-8, name is Pyridin-3-amine. A new synthetic method of this compound is introduced below.

To an ice-cooled solution of 3-aminopyridine (6 g, 63.8 mmol) and triethylamine (9.72 ml_, 70.2 mmol) in 124 ml. of dichloromethane under argon, was carefully added pivaloyl chloride (7.92 mL, 64.4 mmol) in 16 mL of dichloromethane. After the addition was completed, the reaction mixture was stirred at 0 0C for 15 minutes and then at room temperature for 18 hours. The mixture was washed with water, 4% aqueous sodium bicarbonate, brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane/ethyl acetate (85:15) as eluent, to yield the title compound (8.5 g, 75%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,462-08-8, Pyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2008/131922; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

A mixture of la (0.35 g, 1.76 mmol), 3-methoxybenzenesulfonyl chloride (0.37 mL, 2.64 mmol), and pyridine (3 mL) was refluxed overnight. The reaction was quenched with water and the mixture was extracted with ethyl acetate (30 ml x 3). The organic layer was collected, dried over anhydrous MgS04, and concentrated in vacuo to yield a brown residue, which was purified by a flash column over silica gel (ethyl acetate : n-hexane = 1 : 1 , Rf = 0.73) to afford 2c (0.56g, 86.17%) as a yellow solid. ‘H-NMR (500MHZ, CDCI3): delta 3.04 (t, /= 8.5 Hz, 2H), 3.84 (s, 3H), 4.07 (t, /= 8.5 Hz, 2H), 7.11 (dd, /= 2.5, 9.0 Hz, 1H), 7.38 (t, /= 8.0 Hz, 1H), 7.46 (s, 1H), 7.62 (dd, /= 1.5, 8.0 Hz, 1H), 7.65 (s, 1H), 8.19 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 115170-40-6.

Reference:
Patent; YEN, Yun; TAIPEI MEDICAL UNIVERSITY; NATIONAL HEALTH RESEARCH INSTITUTES; LIOU, Jing-Ping; CHANG, Jang-Yang; WANG, Jia-Yi; WO2015/157504; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem