Category: pyridine-derivatives

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, the common compound, a new synthetic route is introduced below. Recommanded Product: 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

EXAMPLE 14B 1-tert-butyl-3-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}-5,6-dihydropyridine-1,3(2H)-dicarboxylate A solution of Example 14A (958 mg, 3.73 mmol) in dichloromethane (10 mL) at 0 C. was treated with diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), warmed to room tempeature overnight, treated with additional diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), stirred for 5 days, and partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5 to 10% ethyl acetate/hexanes to provide the desired product (1.02 g, 70%). MS (DCI/NH3) m/e 407 (M+NH4)+; 1H NMR (300 MHz, CDCl3) delta4.27 (m, 2H), 3.84 (s, 3H), 3.63 (t, J=5.8 Hz, 2H), 2.52 (m, 2H), 1.48 (s, 9H).

The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gwaltney II, Stephen L.; Nelson, Lissa T.J.; O’Connor, Stephen J.; Sham, Hing L.; Sullivan, Gerard M.; Wang, Weibo; US2003/216441; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6221-01-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6221-01-8, name is Pyridine-2,5-dicarbaldehyde. A new synthetic method of this compound is introduced below.

General procedure: To a stirred solution of 2,5-pyridinedicarboxaldehyde(0.37 mmol) in 5 mL EtOH was added the indole (1.85 mmol) andI2 (0.15 mmol). The resulting mixture was stirred at reflux for 6 hcooled and treated with aqueous Na2S2O3. The combined organiclayers obtained by extraction with EA (3 30 mL) were washedwith H2O (2 10 mL) and brine (2 10 mL), dried over MgSO4 and concentrated under reduced pressure to give a residue, which wassubjected to flash column chromatography, followed by normalphaseHPLC to afford the pure product. 4.3.2 3,3′,3″,3?-(Pyridine-2,5-diylbis(methanetriyl))tetrakis(1H-indole) (3a) Yield 50% (white powder), mp 164-165 C, 1H NMR (400 MHz, DMSO-d6): delta 10.85 (s, 2H, NH), 10.81 (s, 2H, NH), 8.51 (s, 1H, ArH), 7.59 (d, J = 8.4 Hz, 1H, ArH), 7.35-7.25 (m, 9H, ArH), 7.05-7.00 (m, 4H, ArH), 6.90 (s, 2H, ArH), 6.87-6.83 (m, 6H, ArH), 5.89 (s, 1H, CH), 5.86 (s, 1H, CH). 13C NMR (100 MHz, DMSO-d6): delta 162.48, 149.53, 138.42, 137.51, 137.36, 136.97, 127.65, 127.36, 124.49, 124.42, 122.88, 121.90, 121.74, 119.92, 119.20, 119.12, 118.32, 118.05, 112.45, 112.35, 43.21, 37.74. HRMS calcd for C39H30N5 (M + H)+, 568.2501; found, 568.2500.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6221-01-8, its application will become more common.

Reference:
Article; Fu, Chih-Wei; Hsieh, Yun-Jung; Chang, Tzu Ting; Chen, Chia-Ling; Yang, Cheng-Yu; Liao, Anne; Hsiao, Pei-Wen; Li, Wen-Shan; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 165 – 176;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56129-55-6, Adding some certain compound to certain chemical reactions, such as: 56129-55-6, name is 1-(Pyridin-3-yl)ethanamine,molecular formula is C7H10N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56129-55-6.

A sealed tube is charged with 7-chloro-5-(1 -methyl- 7 – -indol-6-yl)-quinoxaline (60.00 mg; 0.20 mmol; 1.0 eqr.) (Intermediate 4), 1-pyridin-3-yl-ethylamine (0.05 ml0.41 mmol; 2.0 eqf.), NaOtBu (58.77 mg; 0.61 mmol; 3.00 eqf.) and toluene (2.0 ml_). RM is purged with argon and then BINAP (25.39 mg; 0.04 mmol; 0.20 eqf.) and Pd2(dba)3 (18.67 mg; 0.02 mmol; 0.10 eq.) are added. RM is sealed and heated at 1 10C for 16 h. After this time, the mixture is filtered through a Celite pad and the filtrate is diluted with EtOAc and extracted with water. Combined organic phases are washed with brine, dried over Na2S04. Solvent is evaporated and the residue is purified by FCC (hexane/EtOAc; gradient). [8-(1 -Methyl- 7H-indol-6-yl)-quinoxalin-6-yl]-(1 – pyridin-3-yl-ethyl)-amine is obtained as a yellow powder (60.00 mg; yield 79%; 97% by HPLC).

According to the analysis of related databases, 56129-55-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19355-04-5, Adding some certain compound to certain chemical reactions, such as: 19355-04-5, name is 3-Methoxy-4-nitropyridine 1-oxide,molecular formula is C6H6N2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19355-04-5.

EXAMPLE a) Preparation of 2-cyano-3-methoxy-4-nitropyridine A mixture of 12.5 g (12.5 moles) of the N-oxide of 3-methoxy-4-nitropyridine, 7.72 mL (1.1 eq.) of methyl sulphate and 70 mL of 1,2-dichloroethane is heated at 70 C. for 2.5 hours. It is allowed to cool and 70 mL of water are added. It is cooled in a salt and ice bath and, in portions, 7.55 g (2.1 moles) of sodium cyanide are added, controlling the temperature so as not to exceed 10 C. After 4 hours stirring, the reaction mixture is extracted with ethyl ether, the organic phase is washed with water, concentrated and the residue chromatographed (ethyl acetate/dichloromethane). There is obtained 7.06 g of a yellow oil (yield 53%).

According to the analysis of related databases, 19355-04-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nieto-Roman, Francisco; Vors, Jean-Pierre; Villier, Alain; Lachaise, Helene; Mousques, Adeline; Hartmann, Benoit; Hutin, Pierre; Molina, Jose Lorenzo; Muller, Benoit; US2003/191113; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 669066-91-5, Adding some certain compound to certain chemical reactions, such as: 669066-91-5, name is 5-Bromo-3-fluoropicolinic acid,molecular formula is C6H3BrFNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 669066-91-5.

N,N-Diisopropylethylamine (200 mu, 1 mmol) was added to a mixture of 2- methylbiphenyl-3-amine (70 mg, 0.4 mmol), 5-(methoxycarbonyl)pyridine-2-carboxylic acid (Oakwood Chemical, cat017196, 75 mg, 0.42 mmol), and N,N,N’,N’-tetramethyl-0-(7- azabenzotriazol-l -yl)uronium hexafluorophosphate (220 mg, 0.57 mmol) in N,N- dimethylformamide (2 mL, 20 mmol). The reaction mixture was allowed to stir at room temperature (rt) overnight. The reaction mixture was quenched with saturated aqueous NaHCC , and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with brine, dried over MgSCn, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-35%) to afford the desired product. LC-MS calculated for C21H19N2O3 (M+H)+: m/z = 347.1 ; found 347.1. This compound was prepared using a similar procedure as described for Example 1, Step 2, with 5-bromo-3-fluoropyridine-2-carboxylic acid (Aldrich, cat753483) replacing 5- (methoxycarbonyl)pyridine-2-carboxylic acid and prolong the reaction time to 3 days. LC-MS calculated for C19H15BrFN2O (M+H)+: m/z = 385.0; found 385.0.

According to the analysis of related databases, 669066-91-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; YU, Zhiyong; ZHANG, Fenglei; YAO, Wenqing; (173 pag.)WO2017/106634; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1209459-88-0, name is 4-Bromo-N-methylpicolinamide, the common compound, a new synthetic route is introduced below. COA of Formula: C7H7BrN2O

Step 2. Methyl l-(4-(2-(methylcarbamoyl)pyridin-4-yl)phenyl)cyclobutane-l- carboxylate: Into a 20 mL microwave vial equipped with a magnetic stir bar and under N2 were added 4-bromo-N-methyl-pyridine-2-carboxamide (204mg, 948.77 muiotatauiotaomicron), methyl l-[4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]cyclobutanecarboxylate (300 mg, 948.77 mupiiotaomicron), tetrakis(triphenylphosphine)palladium(0) (109mg, 94.88 mupiiotaomicron), potassium carbonate (393 mg, 2.85 mmol), MeOH (3 mL) and DMF (6 mL). The vial was sealed and the suspension degassed with nitrogen for 10 minutes and the mixture was heated to 150 C for 10 minutes. The mixture was purified by column chromatography through silica gel eluting with 100:0 to 0: 100 hexanes:EtOAc as a gradient over 25 minutes. The desired fractions were combined, concentrated and further dried under high vacuum O/N to provide a yellow solid (250 mg). LCMS (ESI+) m/z = 325 (M+l).

The synthetic route of 1209459-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEMPEST THERAPEUTICS, INC.; POWELL, David Andrew; ROPPE, Jeffrey Roger; SEIDERS, Thomas Jon; DING, Jinyue; SHENG, Tao; JACINTHO, Jason Duarte; (65 pag.)WO2019/79614; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 126954-66-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126954-66-3, name is 2,5-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.

To a solution of 2,5-dichloronicotinonitrile (160 mg, 0.92 mmol) in n-butanol (15.0 mL) was added hydrazine hydrate (0.4 mL, 15 mmol). The mixture was stirred at 120 C for 7 h. The reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 4/1) to give the title compound as a white solid (86 mg, 55 %).MS (ESI, pos. ion) m/z: 169.0 [M+H]?H NIVIR (400 MHz, CDC13) (ppm): 8.33 (s, 1H), 8.29 (s, 1H), 5.69 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,126954-66-3, 2,5-Dichloronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (215 pag.)WO2018/127096; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89570-82-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89570-82-1, name is 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

Formula () 3- chloro-2-hydrazino-5-trifluoromethyl-pyridine (211mg, 1mmol) shown in ethanol (10ml), acetic acid (0.1mmol), 2- fluorobenzaldehyde (1 mmol of) mixing, Join CEM pressure tank, and then in the microwave synthesizer (150W, 85 , 200psi, 15minutes) under the conditions of work, after the completion of the microwave instrument through which compressed air is cooled to room temperature, filtration, and recrystallized from ethanol to obtain the objective compound of formula (-1) shown chloro-2- (2- (2-fluorophenyl) hydrazine-yl) -5-trifluoromethyl-pyridine, yield 71%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89570-82-1, its application will become more common.

Reference:
Patent; Zhejiang University Of Technology; Zhao, Wen; Di, Zhiwen; Yang, Mingyan; Sun, Zhaohui; Liu, Xinghai; Min, Lijing; Shi, Yanxian; Weng, Jianquan; Tan, Chengxia; Li, Baoju; (12 pag.)CN105541706; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 17228-69-2 ,Some common heterocyclic compound, 17228-69-2, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Under an N2 atmosphere, KOtBu (1.3 mmol), complex 1 (1 mol %), dioxane (2 ml), amines (1.3 mmol) and aryl chlorides (1.0 mmol) were successively added into a Schlenk tube. The mixture was stirred vigorously at 90 C for 4 h. Then the solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EA = 15:1) to give the pure products. The reported yields are the average of two runs.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17228-69-2, 2-Chloro-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nirmala, Muthukumaran; Saranya, Gandhi; Viswanathamurthi, Periasamy; Bertani, Roberta; Sgarbossa, Paolo; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 831; (2017); p. 1 – 10;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116632-24-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116632-24-7, name is 2-Amino-4,6-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dichloro-6-hydroxypyridine; Sodium nitrite (64 mg, 0.93 mmol) dissolved in water (0.6 mL), was added dropwise to a stirred solution of 2-amino-4,6-dichloropyridine (prepared according to the method described in Recl. Trav. Chim. Pays-Bas, 1950, 69, 673) (126 mg, 0.77 mmol) in 5% sulphuric acid (aq) (5 mL) at 0 C., over 5 min. The mixture was stirred at 0 C. for 1 h and then diluted with water (20 mL) and extracted with DCM (3×20 mL). The combined extracts were washed with brine (20 mL), dried over MgSO4 and concentrated in vacuo to afford the 2,4-dichloro-6-hydroxypyridine (116 mg, 0.71 mmol, 92%) M.S. (ESI) (m/z) 164,166 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 116632-24-7, 2-Amino-4,6-dichloropyridine.

Reference:
Patent; N.V. Organon; US2007/185156; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem