Category: pyridine-derivatives

Application of 585-48-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 585-48-8, name is 2,6-Di-tert-butylpyridine. A new synthetic method of this compound is introduced below.

c Trifluoromethanesulfonic acid 2-amino-5-fluoro-6-furan-2-yl-pyrimidin-4-yl ester To a stirred suspension of 0.5 g (2.58 mmol) 2-amino-5-fluoro-6-furan-2-yl-3H-pyrimidin-4-one in 5 ml dichloromethane was added 1.16 ml (5.17 mmol) 2,6-di-tert-butylpyridine and the mixture was ultrasonicated for 30 minutes. 0.42 ml (2.55 mmol) triflic anhydride was then added dropwise at 0 C. with stirring and stirring continued at room temperature for 16 hours. The reaction mixture was then partitioned between water and dichloromethane and the organic phase was dried over sodium sulfate and concentrated in vacuo. The residue was recrystallized from ether/hexane and the resulting crystals (2,6-di-tert-butylpyridinium triflate) were removed by filtration. The mother liquor was concentrated in vacuo to afford 0.84 g (99%) trifluoromethanesulfonic acid 2-amino-5-fluoro-6-furan-2-yl-pyrimidin-4-yl ester as a brown crystalline solid. ES-MS m/e (%): 326 ([M-H]-, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,585-48-8, its application will become more common.

Reference:
Patent; Borroni, Edilio Maurizio; Huber-Trottmann, Gerda; Kilpatrick, Gavin John; Norcross, Roger David; US2001/27196; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 193537-14-3 ,Some common heterocyclic compound, 193537-14-3, molecular formula is C15H22N2O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Oxo-3,5,6,8-tetrahydro-4H-9-thia-1,3,7-triaza-fluorene-7-carboxylic acid tert-butyl ester (step b). A mixture of 2-amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3,6-dicarboxylic acid 6-tert-butyl ester 3-ethyl ester (18.5 g) and formamidine acetate (8.85 g) in DMF (100 mL) were heated at 100 C. for 16 h. The reaction mixture was cooled and concentrated. The residues was partitioned between water and ethyl acetate. The organic layer was washed with water 3 times and concentrated to give the title compound (15.8 g, 90%). 1H NMR (400 MHz, CDCl3): delta 7.88 (s, 1H), 4.56-4.62 (brs, 2H), 3.62-3.70 (brs, 2H), 3.02-3.08 (brs, 2H), 1.42 (s, 9H). LC-MS (ESI) m/z 308.1 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,193537-14-3, its application will become more common.

Reference:
Patent; National Health Research Institutes; US2010/120805; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14667-47-1 ,Some common heterocyclic compound, 14667-47-1, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 2-amino-3-nicotinic acid methyl ester (4 g, 26 mmol) in a mixture of concentrated HN03 (2.8 mL) and H2S04 (10 mL) was stirred for 45 min at 0 C, followed by room temperature for 19 h, and at 70 C for 4 h. The reaction mixture was cooled to 0 C and a saturated aqueous solution of NaHC03 (40 mL) was added till basic (pH 8). Extraction with EtOAc (3X40 mL), filtered and concentration of the combined organics afforded the title compound (3.5 g, 68%) which was used in the next step without further purification. 1H NMR (DMSO-cfe, 400 MHz): delta 9.05 (1 H, d, J = 2.8 Hz), 8.69 (1 H, d, J = 2.8 Hz), 8.64 (1 H brs), 8.15 (1 H, brs), 3.88 (3H, s). MS: mlz 198 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14667-47-1, its application will become more common.

Reference:
Patent; UNIVERSITY OF DUNDEE; MEDIVIR AB; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS; SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE; SYNGENE INTERNATIONAL LIMITED PLC; KAHNBERG, Pia; JOHANSSON, Nils-Gunnar; GILBERT, Ian; HAMPTON, Shahienaz; HARRISON, Justin; SARKAR, Sandipan; GONZALES, Dolores; WO2015/189595; (2015); A1;,
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Pyridine | C5H5N – PubChem

Application of 2402-77-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2402-77-9 as follows.

2,3-Dichloro-isonicotinic acid[00195] To a solution of diisopropylamine (7.0 niL, 50 mmol) in anhydrous THF (100 rnL) at -25C was added a 1.6M solution of nBuLi in hexanes (31 rnL, 50 mmol) dropwise under an inert atmosphere. The reaction mixture was then cooled to -78C and 2,3- dichloropyridine was added. The reaction mixture was stirred at -78C for 3 hours, then poured onto solid carbon dioxide and aged for 18 hours at room temperature. The mixture was diluted with water (100 mL) and washed with diethyl ether (3 x 40 mL) then cooled to 00C, acidified with concentrated HCl (ca. 5 mL) and extracted with diethyl ether (3 x 50 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated to give the title compound as a white solid (7.7 g, 80%). 1H NMR (d6-DMSO, 400MHz) 8.49 (d, J = 5.0 Hz, IH), 7.72 (d, J = 5.0 Hz, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2402-77-9, its application will become more common.

Reference:
Patent; GENENTECH, INC.; WO2009/85980; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16063-70-0, name is 2,3,5-Trichloropyridine, the common compound, a new synthetic route is introduced below. Formula: C5H2Cl3N

To a solution of tert- butyl N-(2-amino-5-fluoro-phenyl)-N-methyl-carbamate (80 g, 333 mmol, compound A 1.4) and 2,3,5 -trichloropyridine (66.8 g, 366 mmol, CAS: 16063-70-0) in dioxane (2 L) were added cesium carbonate (217 g, 666 mmol), palladium(II) acetate (3.74 g, 16.7 mmol), and BINAP ( 20.7 g, 33.3 mmol, CAS: 98327-87-8). The reaction mixture was stirred at 120 C for 16 h under nitrogen atmosphere. After the reaction mixture was cooled back to room temperature, it was diluted with EtOAc (800 mL). The precipitate was removed by filtration and the filtrate was concentrated in vacuo, and the crude product was purified by silica gel flash chromatography (0.2% to 5% EtOAc in petroleum ether) to give intermediate fe/7-butyl N-[2-[(3,5-dichloro-2-pyridyl)amino]-5-fluoro-phenyl]-N-methyl-carbamate (75 g, 58% yield) as a white solid. MS (ESI): 390.1 ([{37C1}M+H]+), 388.1 ([{37C1+35C1 }M+H]+), 386.1 (0192) ([{35C1}M+H]+).

The synthetic route of 16063-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; SHEN, Hong; TAN, Xuefei; ZHOU, Chengang; ZHOU, Mingwei; HU, Yimin; SHI, Houguang; DEY, Fabian; LIU, Yongqiang; DING, Xiao; (86 pag.)WO2020/104436; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55676-21-6, blongs to pyridine-derivatives compound. Product Details of 55676-21-6

KOH (0.5 N MeOH, 6.0 mL, 3.0 mmol) was added to a solution of the compound 6 (467 mg, 3.0 mmol) prepared in Example 1 and 2-methoxybenzaldehyde (408 mg, 3.0 mmol) in THF The reaction was stopped by adding 0.5 N HCl (6 mL) to the mixed light yellow solution at 0 ° C and mixing at 0 ° C to room temperature for 3 hours. After evaporation of the solvent from this solution, the mixture was taken up in saturated NaHCO3 solution (30 mL) and extracted three times with dichloromethane (20 mL). The concentrated residue was purified by silica gel column chromatography using 30percent EtOAc / n-hexane as the extraction solvent to give compound 7l (673 mg, 82percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55676-21-6, its application will become more common.

Reference:
Patent; Duksung Women’s University Industry-Academic Cooperation Foundation; Jae, In Lee; (15 pag.)KR101766414; (2017); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13534-89-9, name is 2,3-Dibromopyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2,3-Dibromopyridine

General procedure: A mixture of MeCN and MeOH (2:1, 15 ml) wasadded to a mixture of 2,3-dibromopyridine (1) (474 mg,2.0 mmol), arylboronic acid (2.1 mmol), K2CO3 (560 mg,4.0 mmol), PPh3 (52 mg, 10 mol %) and Pd(OAc)2 (23 mg,5 mol %) in a screw-cap vial. Reaction mixture was flushedwith argon, sealed, and stirred at 50C for 24 h in an oilbath. Then the reaction mixture was cooled to room temperature and filtered through Celite. Filtrate was concentratedunder reduced pressure, the residue was dissolved in CH2Cl2(20 ml), washed with water (3×10 ml) and dried overNa2SO4. Solvent was evaporated under reduced pressure,and the residue was purified by column chromatography on silica (hexane-EtOAc, 30:1) to provide pure pyridines 2a-j. 3-Bromo-2-phenylpyridine (2a).53 Yield 387 mg(83%), colorless oil.

The synthetic route of 13534-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shestakov, Aleksandr N.; Pankova, Alena S.; Kuznetsov, Mikhail A.; Chemistry of Heterocyclic Compounds; vol. 53; 10; (2017); p. 1103 – 1113; Khim. Geterotsikl. Soedin.; vol. 53; 10; (2017); p. 1103 – 1113,11;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 69008-70-4, N,N-Dipropylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 69008-70-4, blongs to pyridine-derivatives compound. SDS of cas: 69008-70-4

To a solution of 4-dipropylaminopyridine (1.16 g, 6.50 mmol) in benzonitrile (2.0 mL) was added 1-iodoadamantane (2.04 g, 7.80 mmol).Was added and stirred at 145 C. for 60 hours. After cooling to room temperature,The reaction solution was purified by silica column chromatography (chloroform / methanol),Brown solid 1- (1-adamantyl) -4-dipropylaminopyridinium iodide(0.717 g, yield 25%) was obtained.

The synthetic route of 69008-70-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ???????????????; ???????; Araki Keisuke; Nakamura Maki Tsukasa; Yoshioka Masato; Naranoki Yuusuke; (35 pag.)JP2019/210213; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 959616-64-9, name is Methyl 2-chloro-5-fluoro-6-methoxynicotinate, molecular formula is C8H7ClFNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-chloro-5-fluoro-6-methoxynicotinate

A mixture of methyl 2-chloro-5-fluoro-6-methoxy-pyridine-3-carboxylate (200 mg, 0.911 mmol), 4-fluoro-2-methoxyphenol (114 pL, 1.00 mmol) and cesium carbonate (742 mg, 2.28 mmol) in MeCN (8 mL) was stirred at 80 C for 3 h, then allowed to cool to room temperature with stirring. Water (30 mL) and methanol (5 mL) were added and the resulting mixture was sonicated briefly then stirred for 4 h. The precipitate was collected by filtration, washed with water and dried under vacuum to give methyl 5-fluoro-2-(4-fluoro-2-methoxy-phenoxy)-6-methoxy- pyridine-3-carboxylate (237 mg, 0.727 mmol, 79.9% yield) as a beige solid. MS, ES+m/z 326.0 [M+H]+. -NMR (400 MHz, DMSO-rie) d 8.12 (d, J=l0.11 Hz, 1 H), 7.18 (dd, J=8.72, 5.94 Hz, 1 H), 7.09 (dd, J=l0.74, 2.91 Hz, 1 H), 6.81 (td, J=8.46, 2.78 Hz, 1 H), 3.83 (s, 3 H), 3.72 (s, 3 H), 3.57 (s, 3 H).

With the rapid development of chemical substances, we look forward to future research findings about 959616-64-9.

Reference:
Patent; LIEBER INSTITUTE, INC.; HUANG, Yifang; POSLUSNEY, Michael; ERNST, Glen; BARROW, James; (0 pag.)WO2020/14246; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 108-99-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-99-6, name is 3-Methylpyridine, molecular formula is C6H7N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Catalyst (0.03 mmol), H2O (3 ml), substrate (4 mmol), and H2O2 (20 mmol, 30% aq.) were charged in the reaction flask, which was first bathed in cold water (about 283 K). The mixture was then stirred at room temperature for 16-24 h. The reaction was detected by thin-layer chromatography (TLC). After the reaction, the system was concentrated by evaporation, and the catalyst precipitated from the mixture after the addition of anhydrous ethyl alcohol. The recovered catalyst, obtained by filtration, was washed with anhydrous ethyl alcohol and diethyl ether and then used for the next oxidation after drying. The filtrate was extracted with dichloromethane. The combined organic layers were dried over anhydrous Na2SO4, and the pure products were obtained by evaporation or column chromatography. The products were analyzed by 1H NMR and 13C NMR.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-99-6, 3-Methylpyridine.

Reference:
Article; Zhao, Wei; Wang, Xing; Yang, Chunxia; Synthetic Communications; vol. 44; 1; (2014); p. 150 – 160;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem