Category: pyridine-derivatives

Extended knowledge of 848498-98-6

The synthetic route of 848498-98-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 848498-98-6, name is 2,6-Dichloro-N-methoxy-N-methylisonicotinamide, the common compound, a new synthetic route is introduced below. Product Details of 848498-98-6

A mixture of 88-1 (20.0 g, 85.1 mmol), boronic acid (13.1 g, 93.6 mmol), Pd(dppf)Cl2 (3.1 g, 4.25 mmol) and TBAF (1 M, 127.6 mL) in DCM (400 mL) was stirred at 25 C. for 12 h under N2. The solution was concentrated, and the residue was diluted with H2O (1 L) and extracted with EA (800 mL). The organic phase was washed with brine, dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography using 520% EA in PE as eluent to give 88-2 (17.2 g, 68.6%) as a yellow oil. MS: m/z 295.7 [M+H]+.

The synthetic route of 848498-98-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alios BioPharma, Inc.; Wang, Guangyi; Beigelman, Leonid; Truong, Anh; Stein, Karin Ann; (234 pag.)US2016/244460; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on (4,6-Dichloropyridin-3-yl)methanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73998-95-5, its application will become more common.

Synthetic Route of 73998-95-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 73998-95-5 as follows.

A solution of oxalyl chloride (2.32 mL, 26.963 mmol) in DCM (30 mL) was cooled down to -78 C. To this solution was added DMSO (3.83 mL, 53.922 mmol) dropwise under nitrogen atmosphere. The reaction mixture was stirred at the same temperature for another 30 min. To this reaction mixture was added a solution of (4,6-dichloro-3- pyridyl)methanol (1.6 g, 8.987 mmol) in DCM (10 mL), and then the reaction mixture was stirred for 30 min. Then, to this stirred reaction mixture was added triethylamine (11.2 mL, 80.883 mmol). The reaction mixture was stirred at the same temperature for another 30 min. The progress of reaction was monitored by TLC. After completion of reaction, the mixture was quenched with saturated sodium bicarbonate solution (30 mL). The product was extracted using DCM (2×50 mL). The combined organic layer was again washed with water (3×30 mL) and finally with brine solution (30 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4,6-dichloropyridine-3-carbaldehyde (1.53 g) as a light yellow solid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73998-95-5, its application will become more common.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; PUJALA, Brahmam; SHINDE, Bharat Uttam; NAYAK, Anjan Kumar; CHAKLAN, Naveen; AGARWAL, Anil Kumar; RAMACHANDRAN, Sreekanth A.; PHAM, Son; WO2015/103355; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2002-04-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2002-04-2, its application will become more common.

Related Products of 2002-04-2 ,Some common heterocyclic compound, 2002-04-2, molecular formula is C7H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of (Patent; GENKYOTEX SA; MACHIN, Peter; SHARPE, Andrew; LOCK, Christopher James; CHAMBERS, Mark S; HODGES, Alastair; ALLEN, Vivienne; ELLARD, John M; (189 pag.)WO2016/98005; (2016); A1;,
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Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 504-29-0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 1-2-1 2,2-Dimethyl-N-pyridin-2-yl-propionamide To a methylene chloride solution (500 mL) of 2-aminopyridine (50.0 g, 531 mmol) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Potassium carbonate (73.4 g, 531 mmol) was added to 300 mL of thus obtained residue methanol solution at 0 C., which was stirred at room temperature for 90 minutes. This reaction solution was partitioned into water and ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, the precipitated solids were collected by filtering, which gave the titled compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1), which gave the titled compound (12.2 g, 13%). 1H-NMR spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference:
Patent; MATSUKURA, Masayuki; US2010/331282; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 2-Bromo-5-(difluoromethoxy)pyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,845827-14-7, 2-Bromo-5-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

Related Products of 845827-14-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 845827-14-7, name is 2-Bromo-5-(difluoromethoxy)pyridine. A new synthetic method of this compound is introduced below.

Production Example 23 4-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid Operations similar to those of Production Example 14 were conducted using 4-carboxyphenylboronic acid and 2-bromo-5-(difluoromethoxy)pyridine, to provide the title compound as white solid. ESI-MS Found:m/z 266[M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,845827-14-7, 2-Bromo-5-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1657242; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 2-Methoxy-6-methylpyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-03-4, its application will become more common.

Application of 63071-03-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 63071-03-4 as follows.

BuLi (2.5 M, 49.0 ml, 122 mmol) was added to a solution of 2-methoxy-6-methylpyridine in THF (300 ml) at -78 C. over a period of 30 min. After warming the mixture to 0 C. over a period of 1 h, the reaction was re-cooled to -78 C. and acetaldehyde (22.3 ml, 407 mmol) was slowly added. The mixture was stirred for 1 h at -78 C. and allowed to warm to ambient temperature. Addition of sat. aq. NH4Cl and extraction with EtOAc was followed by a wash of the organic layer with sat. aq. NaHCO3 and brine. Concentration of the organic layer in vacuo and chromatographic purification of the resulting residue gave 8.96 g (66%) of 1-(6-methoxypyridin-2-yl)propan-2-ol. 1H-NMR (CDCl3) delta 7.51 (dd, 1H), 6.71 (d, 1H), 6.63 (d, 1H), 5.18 (br s, 1H), 4.21 (qdd, 1H), 3.91 (s, 3H), 2.84 (dd, 1H), 2.77 (dd, 1H), 1.28 (d, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-03-4, its application will become more common.

Reference:
Patent; Forest Laboratories Holdings Limited; US2007/281918; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 18614-51-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18614-51-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 18614-51-2, 4-Amino-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18614-51-2, blongs to pyridine-derivatives compound. Recommanded Product: 18614-51-2

Method A) CuCl2 (0.0680 g, 0.513 mmol) was dissolved in 3 mL of water to yield a blue,opaque solution. 2-F-4-AP (0.111 g, 0.991 mmol) in 5 mL of water was added to the CuCl2solution. The aquamarine, opaque solution was left to evaporate at room temperature forthree weeks. Dark green prisms were recovered by vacuum filtration, washed with cold waterand allowed to air dry to give 0.0612 g (13.7%). Single crystals (dark green needles) weregrown through recrystallization of the prisms from water over the course of a month. IR (KBr)nu – 3413 m, 3327 m, 3220 m, 3071w, 1639s, 1560 m, 1510 m, 1475 m, 1375s, 1267s, 1195 m,1026 m, 994 m, 834 m, 777 m, and 656w cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18614-51-2, its application will become more common.

Reference:
Article; Krasinski, Claire A.; Solomon, Benjamin L.; Awwadi, Firas F.; Landee, Christopher P.; Turnbull, Mark M.; Wikaira, Jan L.; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 914 – 935;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 2-Fluoro-3-iodopyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113975-22-7, 2-Fluoro-3-iodopyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 113975-22-7, 2-Fluoro-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3FIN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3FIN

General procedure: 1-(Indol-3-yl)-N-Boc-THIQ 4a (100 mg, 0.287 mmol, 1.0 equiv.), iron(III)-chloride (4.7 mg, 28.7 mumol, 0.1 equiv.), and K3PO4 (122 mg, 0.574 mmol, 2.0 equiv.) were placed in a 2 mL glass vial, and aryliodide (0.431 mmol, 1.5 equiv.) and DMEDA (5.6 muL, 57.4 mumol, 0.20 equiv.) were added followed by dry toluene (300 muL). The reaction mixture was purged with argon for 30 seconds, the vial sealed and heated to 135 C and stirred at this temperature for 24 hours. The black slurry was cooled down to rt, diluted with DCM and filtered through a plug of celite. The solvent of the filtrate was evaporated and the crude product directly subjected to column chromatography using gradient elution with PE_EtOAc=100:0 0:40 (50 minutes) to afford the desired products 7a-e,g.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113975-22-7, 2-Fluoro-3-iodopyridine, and friends who are interested can also refer to it.

Reference:
Article; Ghobrial, Michael; Mihovilovic, Marko D.; Schnuerch, Michael; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2186 – 2199;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 4-Amino-3-bromopyridine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13534-98-0, 4-Amino-3-bromopyridine.

Related Products of 13534-98-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13534-98-0, name is 4-Amino-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Ethyl (3-bromopyridin-4-yl)carbamate (S7).3-Bromopyridin-4-amine (100 mol%) was dissolved in CH2Cl2 (0.2 M), and cooled to 0 C. Ethyl chloroformate (110 mol%) was added at 0 C, then diisopropylethylamine (150 mol%) was added. The mixture was stirred at 0 C for 30 min, warmed to ambient temperature, and stirredor additional 2-3 h. After completion, the mixture was diluted with CH2Cl2, and washed withwater and brine. The combined aqueous layer was washed with CH2Cl2. The combined organiclayer was dried over anhydrous Na2SO4, and concentrated in vacuo. The title compound S7 was obtained as an off white solid in 86% yield (610.6 mg, 2.49 mmol) after flash column chromatography (hexanes/EtOAc = 1:1). 1H NMR (asterisk denotes minor rotamer peaks, 400 MHz, CDCl3) delta 8.82* (d, J = 0.5 Hz, 1H), 8.59* (d, J = 5.6 Hz, 1H), 8.59 (d, J = 0.4 Hz, 1H), 8.40 (dd, J = 5.6, 0.6 Hz, 1H), 8.15 (d, J =5.6 Hz, 1H), 7.30 (br s, 1H), 7.22* (dd, J = 5.1, 0.5 Hz, 1H), 4.28 (q, J = 7.1 Hz, 2H), 4.24* (q, J= 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H), 1.23* (t, J = 7.1 Hz, 3H). 13C NMR (asterisk denotes minor rotamer peaks, 100 MHz, CDCl3) delta 153.0*, 152.4*, 151.6,149.5, 142.8, 124.7*, 113.2, 109.7, 63.8*, 62.2, 14.4, 14.0*. IR (neat) 3405, 2980, 1739, 1582, 1506, 1236, 1205 cm-1.HRMS (ESI+) calcd. for C8H10BrN2O2 [M+H]+ 244.9920, found 244.9920.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13534-98-0, 4-Amino-3-bromopyridine.

Reference:
Article; Shin, Inji; Ramgren, Stephen D.; Krische, Michael J.; Tetrahedron; vol. 71; 35; (2015); p. 5776 – 5780;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 1211534-25-6

According to the analysis of related databases, 1211534-25-6, the application of this compound in the production field has become more and more popular.

Reference of 1211534-25-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211534-25-6, name is 4-Bromo-5-chloro-2-methoxypyridine, molecular formula is C6H5BrClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00257j 27F. 4-((3 ,4-cis)-4-((tert-Butyldimethylsilyl)oxy)-3 -methylpiperidin- l-yl)-5 – chloro-2-methoxypyridine: A mixture of 27B (9.70 g, 43.6 mmol), 27E (10.0 g, 43.6mmol), and K2C03 (12.0 g, 87.0 mmol) in DMSO (14.5 mL) was vigorously stirred at110 C overnight. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried (MgSO4), and concentrated. Purification via silica chromatography gave 27F as an oil (14.3 g, 77% yield). LC-MS Anal. Calc?d for C18H31C1N2O2Si: 370.18, found [M+H] 371.2.

According to the analysis of related databases, 1211534-25-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing; WO2014/78609; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem