Category: pyridine-derivatives

Application of 1008-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The crude material (1.15 g, 7.06 mmol) from Step B was dissolved in dichloromethane (50 mL). After addition of diisopropylethylamine (4.7 mL, 42.4 mmol), 3-nitrosalicylic acid (1.94 g, 10.6 mmol), and PyBrOP (5.78 g, 12.3 mmol), the resulting mixture was stirred over night at room temperature before being put into 1 N sodium hydroxide (300 mL). Extraction with dichloromethane (2?100 mL) removed all PyBrOP products. The aqueous phase was carefully acidified to pH 5-6 with 3N HCl and extracted with dichloromethane (3?100 mL). The combined organic layers of the neutral extraction were dried over sodium sulfate, concentrated, and finally purified by column chromatography (dichloromethane/methanol/NH4OH=10/1/0.1) to yield the desired product (850 mg, 37% for 2 steps).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1008-91-9, 1-(Pyridin-4-yl)piperazine.

Reference:
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 31181-53-0, 5-Fluoro-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 31181-53-0, blongs to pyridine-derivatives compound. Computed Properties of C6H6FN

1 5-Fluoro-2-pyridinecarboxylic acid To water (100 ml) were added 5-fluoro-2-methylpyridine (J. Med. Chem., 32, 1970(1989): 2.2 g, 20 mmol) and potassium permanganate (19.1 g, 120 mmol), and heated under reflux for 4 hours. The reaction mixture was filtrated and the filtrate was concentrated, acidified with KHSO4, extracted with ethyl acetate and the extract was dried over Na2SO4. The sol vent was evaporated to give the title compound (0.80 g; 28%). 1H-NMR(270 MHz, DMSO-d6) 8.70 (d, J=2.8 Hz, 1H), 8.14 (dd, J=8.7, 4.6 Hz, 1H), 7.89 (td, J=8.7, 2.8 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,31181-53-0, its application will become more common.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; US6384033; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 53014-84-9 , The common heterocyclic compound, 53014-84-9, name is 2-Methyl-5-formylpyridine, molecular formula is C7H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 15 Preparation of 2-methyl-5-(oxiran-2-yl)py?dme [0380] The title compound was prepared by following general procedure 3 DMSO (4mL) was added to NaH 60% dispersion in oil (0 314 g, 7 8 mmol, 1 3 equiv ) and heated to 65 0C for 1 h THF (1OmL) was added at the same temperature and heated for another 10 mm After 10 mm , the reaction mixture was cooled to 00C T?methylsulfomum iodide (1 2 g, 5 9 mmol, 1 equiv ) was added and stirred for 10 mm and then a solution of 6-methylmcotmaldehyde (0 720 g, 5 9 mmol, 1 equiv ) in THF was added dropwise After complete addition, the reaction mixture was stirred at RT for 2 h, the product was detected by LCMS The reaction mixture was poured into ice water and the product was extracted in diethyl ether (4 x 5OmL), dried over Na2SO4 and concentrated at 25 0C to get the crude product 2-methyl-5-(oxiran-2-yl)py?dme (1 1 g crude)

The synthetic route of 53014-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 7598-35-8 ,Some common heterocyclic compound, 7598-35-8, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-bromopyridin-4-amine (LVIII) (584 g, 3.38 mol, 1 eq) and sodium acetate (554 g, 6.75 mol, 2 eq) in HOAc (2000 mL) was added a solution of iodine monochloride (559 g, 3.44 mol, 176 mL, 1.02 eq) in HOAc (1000 mL) drop-wise at 70 C., the resulting mixture was stirred at 70 C. for 3 h. The mixture was concentrated to remove HOAc and poured into water (20 L). The aqueous solution was extracted with EtOAc (10 L*3). The combined organic layers were washed with saturated aq. Na2CO3 (20 L), saturated aq. Na2S2O3 (10 L), brine (10 L), dried over Na2SO4, filtered and concentrated to give a yellow residue, which was purified by column chromatography (1:1?1:0 petroleum ether:DCM) to obtain 2-bromo-5-iodopyridin-4-amine (II) as a yellow solid (340 g, 1.14 mol, 33.7% yield). H NMR (400 MHz, DMSO-d6) delta ppm 6.56-6.53 (3H, m), 7.73-7.72 (1H, d, J=5.2 Hz); ESIMS found for C5H4BrIN2 m/z 299.9 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7598-35-8, 2-Bromopyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Cao, Jianguo; Bollu, Venkataiah; Chiruta, Chandramouli; Mittapalli, Gopi Kumar; Eastman, Brian Walter; Hofilena, Brian Joseph; (960 pag.)US2019/127370; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 573762-62-6, Adding some certain compound to certain chemical reactions, such as: 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile,molecular formula is C7H4F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 573762-62-6.

Alternative syntheis of A52hr 2 hr [0090] Thiophosgene (1.23 niL, 16.0 mmol) is added dropwise to a solution of 5- amino-2-cyano-3-trifluoromethylpyridine (3.0 g, 16.0 mmol) and N-methyl-4-(l- cyanocyclobutylamino)-2-fluorobenzamide (3.96 g, 16.0 mmol) in dry DMA (35 mL) under Argon. The solution is stirred overnight at 6O0C. To this mixture were added MeOH (60 mL) and aq. 2M HCl (30 mL), then it was brought to reflux temperature for 2 h. After cooling down to the ambiant, the mixture was poured into ice water (100 mL) and extracted with EtOAc (3 x 60 mL). The organic layer was dried over Mg2SO4, filtered over celite, and concentrated under reduced pressure. Silica gel chromatography using DCM/-acetone 19-1 (v-v) yielded the desired product (5.78 g, 76%).Scale up.[0091] Thiophosgene (5.48 mL, 1.05 eq, 70.9 mmol) is added dropwise to a solution of 5-amino-2-cyano-3-trifluoromethylpyridine (13.27 g, 1.05 eq, 70.9 mmol) and N-methyl- 4-(l-cyanocyclobutylamino)-2-fluorobenzamide (16.7 g, 67.5 mmol) in dry DMA (110 mL) under Argon at 0 0C. After 10 min, the solution was heated up to 60 0C and allowed to stir at that temperature for an overnight period. This was then diluted with MeOH (200 mL) and treated with aq. 2M HCl (140 mL), then the mixture was refluxed for 2 h. After cooling down to RT, the mixture was poured into ice water (500 mL), and filtered over buchner. The solid was recrystallized from DCM/EtOH to get desired product (20.6g, 64%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2008/119015; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13509-13-2, Adding some certain compound to certain chemical reactions, such as: 13509-13-2, name is Methyl 4-methylpicolinate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13509-13-2.

1-(3-Benzyl-5-pyrazin-2-yl-phenyl)-3-(4-methyl-pyridin-2-yl)-propane-1,3-dione (25B). In an oven dried flask equipped with a rubber septum with bubbling argon was dissolved 25A (0.15 g, 0.00052 mole) and 3H (0.078 g, 0.00052 mole) in 1 mL of anhydrous THF. NaOMe (56 mg, 0.00104 mole) was added and the reaction turned a brown color. After 0.5 hour the reaction was poured into 8 mL of a saturated NH4Cl solution. The mixture was extracted 3 times with EtOAc, dried NaSO4, filtered and evaporated to give a crude product. The oily solids were crystallized with and hot petroleum ether in a sonicator. Solids were collected by vacuum filtration to give pure light yellow powder, (25B). 1H NMR (400 MHz, CDCl3) delta 9.05 (s, 1H), 8.65 (s, 1H), 8.58 (d, j=5.0 Hz, 1H), 8.4 (m, 2H), 8.04 (s, 2H), 8.02 (s, 1H), 7.62 (s, 1H), 7.33-7.21 (m, 6H), 4.17 (s, 2H), 2.47 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13509-13-2, Methyl 4-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 866319-00-8 ,Some common heterocyclic compound, 866319-00-8, molecular formula is C7H5FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Fluoro-1H-pyrrolo[2,3-b]pyridine (1 g, 7.34 mmol) was dissolved in DMF (10 mL)Then, bromine (0.75 mL, 14.5 mmol) was added dropwise thereto, and the reaction was stirred at room temperature for 4 hours.Quenched with saturated aqueous sodium thiosulfate solution (100 mL)The reaction mixture was extracted with ethyl acetate (100 mL×2).The combined organic phases were washed with brine (100 mL×3)Filtered, concentrated under reduced pressure,The residue was subjected to silica gel column chromatography(PE/EtOAc (v/v) = 4/1) purified,The title compound was obtained as a yellow powder (0.6 g, 40%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 866319-00-8, 5-Fluoro-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; Nie Biao; Xu Juan; Yan Huan; Chen Jianping; (90 pag.)CN108727369; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 55-22-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55-22-1, name is Isonicotinic acid. A new synthetic method of this compound is introduced below.

General procedure: A mixture of 1 (166 mg, 0.4 mmol), the corresponding acids RCO2H (0.48 mmol), DMAP(10 mg, 0.08 mmol), and DCC (99 mg, 0.48 mmol) in dry CH2Cl2 (10 ml) was stirred at ambient temperature. When the reaction was completed for 2-3 h according to TLC analysis,the mixture was filtered, and the filtrate was diluted by CH2Cl2 (60 ml). The mixture was washed by 0.1 N HCl (30 ml), saturated Na2CO3 (30 ml) and saturated NaCl (30 ml),dried over anhydrous Na2SO4, concentrated in vacuo, and purified by PTLC to give the pure 4alpha-acyloxypodophyllotoxin derivatives 5a, b, e, f in 84-90% yields. The data for 5a,b, e, f are shown as follows.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55-22-1, Isonicotinic acid, and friends who are interested can also refer to it.

Reference:
Article; Che, Zhi-Ping; Tian, Yue-E; Liu, Sheng-Ming; Jiang, Jia; Hu, Mei; Chen, Gen-Qiang; Journal of Asian Natural Products Research; vol. 21; 10; (2019); p. 1028 – 1041;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 94446-97-6, name is 2-Bromo-3-(bromomethyl)pyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 94446-97-6

Step 2: To a solution of the product of Step 1 (595 mg, 2.36 mmol) in DMF was added piperidine (205 mg, 2.4 mmol) and K2CO3 (979 mg, 7.08 mmol), sequentially. The mixture was stirred at rt overnight, quenched with ice-water and then partitioned with ether. The organic layer was dried over Na2SO4, filtered, and concentrated. Purification of the residue by SiO2 chromatography (0-50% EtOAc/hexane) gave the desired compound (-450 mg). CnH15BrN2, LC/ESI-MS: m/z 255 and 257 (C11H15BrN2 H+)

The synthetic route of 94446-97-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2007/53435; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1122-54-9, Adding some certain compound to certain chemical reactions, such as: 1122-54-9, name is 4-Acetylpyridine,molecular formula is C7H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1122-54-9.

4-Bromoacetyl-pyridine, HBr salt; Dibromine (17.2g, 108 mmol) was added dropwise to a cold (0C) solution of 4-acetyl- pyridine (12 g, 99 mmol) in acetic acid containing 33% of HBr (165 mL) under vigourous stirring. The vigorously stirred mixture was warmed to 40C for 2h and then to 75C. After 2h at 75C, the mixture was cooled and diluted with ether (400 mL) to precipitate the product. which was recovered by filtration and washed with ether and acetone to give white crystals (100%). This material may be recrystallised from methanol and ether.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AB SCIENCE; WO2005/73225; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem