Category: pyridine-derivatives

Adding a certain compound to certain chemical reactions, such as: 128071-98-7, 4-Bromo-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3BrFN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3BrFN

4-bromo-2-fluoropyridine (1.55 g, 8.81 mmol), tert-butyl piperazine-1-carboxylate (2.46 g, 13.22 mmol) and potassium carbonate (3.65 g, 26.41 mmol) in dimethylsulphoxide (10 mL) was heated in a sealed tube at 100 ºC with stirring. After stirring overnight the mixture was cooled and ethyl acetate and water were added. The organic layer was washed with brine, dried (MgSO4) and evaporated. Purification of the residue by flash chromatography (100% hexanes to 1:4 hexanes /ethyl acetate) gave the title compound (2.33 g, 78%) as a white solid. LRMS (m/z): 342/344 (M+1)+. 1H NMR (300 MHz, , CDCl3) delta ppm 1.49 (s, 9 H), 2.49 (bs, 2 H), 3.63 (t, J=5.77 Hz, 2 H), 4.08 (d, J=2.75 Hz, 2 H), 6.05 (br s, 1 H), 7.21 (t, J=7.69 Hz, 1 H), 7.27 – 7.31 (m, 1 H), 7.36 – 7.40 (m, 1 H), 7.51 (t, J=1.79 Hz, 1 H)

The synthetic route of 128071-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Ines; EP2489663; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7584-05-6, name is 3-Methylisonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

1-Amino-3-(3-methyl-4-pyridyl)2,6-naphthyridine To 5.9 g. of 4-cyano-3-methylpyridine dissolved in 30 ml. of dimethylformamide, gradually add 6.7 g. of potassium t-butoxide at about 5 C. Maintain the mixture at 5 C for 4 – t hours and quench the reaction in ice water. Collect the crystalline precipitate and recrystallize from toluene to yield 1-amino-3-(3-methyl-4-pyridyl)-2,6-naphthyridine.

With the rapid development of chemical substances, we look forward to future research findings about 7584-05-6.

Reference:
Patent; Schering Corporation; US4017500; (1977); A;,
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Pyridine | C5H5N – PubChem

Electric Literature of 73257-49-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73257-49-5, name is Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 1,4-DHPs (1 mmol, dissolved in 10 mL acetonitrile), TEMPO(0.05 mmol), FeCl3·6H2O (0.05 mmol), NaNO2 (0.05 mmol) and CH3COOH (1 mL) were added successively to a 25 mL three-neckedround-bottom flask equipped with a magnetic stirrer and a thermometer. The resulting mixture was stirred at room temperature and ambient pressure with an oxygen balloon until the reaction was completed as monitored by TLC (5:1 ethyl acetate/petroleum ether as eluent). Saturated aqueous NaHCO3 solution was added to make it neutral. The mixture was extracted with ethyl acetate three times. The combined organic extracts were washed with saturated aqueous NaCl solution, dried over MgSO4 and filtered. After removal of the solvent under reduced pressure, the residue was purified by columnchromatography (10:1 ethyl acetate/petroleum ether as eluent). Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate(2l): Pale yellow solid, m.p. 138-140 C (lit.[24] 137-139 C). 1H NMR (500 MHz, CDCl3): delta 7.37 (d, J = 8 Hz, 2H), 7.19 (d, J = 8 Hz, 2H), 3.58 (s, 3H), 2.60 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 73257-49-5, Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Reference:
Article; Lou, Bin-Hui; Chen, Shu-Bin; Wang, Jian; Chen, Ying; Li, Jing-Hua; Journal of Chemical Research; vol. 37; 7; (2013); p. 409 – 412;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 884494-54-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884494-54-6 as follows.

Step A N-r(2-chloro-5-fluoropyridin-4-yl’)methylidenel-2-methylpropane-2-sulfinamide (1-8); A solution of 2-cMoro-5-fluoroisonicotinaldehyde (1-7, 5.0 g, 31.34 mmol), 2-methyl-2- propanesulfmamide (4.18 g, 34.47 mmol) and Ti(OEt)4 in THF (50 ml) was heated at 60 0C for 18 h. The reaction mixture was cooled to -20 0C and then 60 ml MeOH was added. The cooling bath was removed. CELITE was then added followed by a 200 ml brine wash. The resulting solids were filtered through a fritted glass funnel and washed with EtOAc. The organic portion was separated, dried (MgSO4) and concentrated in vacuo. Chromatography (hexanes to 50% EtOAc/hexanes) afforded 1-8.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-54-6, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2007/16358; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 67443-38-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 7: Synthesis of 2-{[5-(3-aminopropyl)-2-methylpyridin-3-yl]amino}-9-(trifluoromethyl)-5,7-dihydro-6Eta-pyrimido[5,4-d][l]benzazepin-6-one; Step 1 : Diethyl (5-bromo-3-nitropyridin-2-yl)malonate; To a suspension of NaH (60% in mineral oil, 27.9 g, 0.69 mol) in DMF (300 mL) at 5-10 0C was slowly added ethyl malonate (125 mL, 0.69 mol) over 30 min. The mixture was allowed to stir for 20 min at rt, during which time the suspension became a solution. A solution of 5-bromo-2-chloro-3- nitropyridine (75 g, 0.32 mol) in DMF (75 mL) was added slowly at 5-10 0C. The resulting dark red mixture was allowed to stir at 40 0C for 2 h. The reaction mixture was then poured into IM AcOH (0.75 L) and extracted with DCM (3 x 250 mL). The organic solutions were combined, washed with water and brine, dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography to give diethyl (5-bromo-3-nitropyridin-2-yl)malonate (260 g, 99%) as a yellow oil.

According to the analysis of related databases, 67443-38-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; BHARATHAN, Indu, T.; DUFFEY, Matthew, O.; ELDER, Amy, M.; GUO, Jianping; LI, Gang; REYNOLDS, Dominic; SOUCY, Francois; VOS, Tricia, J.; WO2010/65134; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 18437-58-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18437-58-6, name is 4-Amino-2-picoline, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Amino-2-methylpyridine (0.522 g, 4.8 mmol) and CuCl2 (0.324 g, 2.1 mmol) were added to a solution of 4 ml of conc. aq. HCl in 20 ml of 1-propanol to give a green solution. Slow evaporation at room temperature over the course of 3 weeks yielded yellow crystals which were isolated by filtration, washed with a small amount to cold 1-propanol, and air-dried to give 0.61 g (58%). IR (KBr) nu 3383m, 3319m, 3244m, 3212m, 3121m, 2984m, 1659s, 1614s, 1522m, 1239 m cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18437-58-6, 4-Amino-2-picoline.

Reference:
Article; Wikaira, Jan L.; Landee, Christopher P.; Ludy, Sarah J.; Turnbull, Mark M.; Polyhedron; vol. 52; (2013); p. 770 – 780;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6602-32-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6602-32-0 as follows.

Example 33; K2CO3 Part A; Compound 936A (5.00 g, 28.7 mmol) and potassium carbonate (7.90 g, 57.5 mmol) were dissolved in water (66 ml_) and iodine (7.51 g, 29.6 mmol) was added. The reaction was allowed to proceed at rt for 3 d. Excess iodine was quenched by addition of solid sodium bisulfite. The pH of the solution was adjusted to -5-6 using glacial acetic acid. A solid formed during the process and was collected by filtration and dried in vacuo. The desired product, Compound 936B, was obtained as a light gray solid (8.25 g, 96% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6602-32-0, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; KOZLOWSKI, Joseph, A.; YU, Wensheng; WONG, Michael, K.C.; KIM, Seong-Heon; TONG, Ling; LAVEY, Brian, J.; SHANKAR, Bandarpalle, B.; YANG, De-Yi; FELTZ, Robert; KOSINSKI, Aneta, Maria; ZHOU, Guowei; RIZVI, Razia, K.; DAI, Chaoyang; FIRE, Luke; GIRIJAVALLABHAN, Vinay, M.; LI, Dansu; POPOVICI-MULLER, Janeta; RICHARD, Judson, E.; ROSNER, Kristin, E.; SIDDIQUI, M., Arshad; YANG, Liping; WO2010/54279; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1452-63-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1452-63-7, name is Picolinohydrazide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of appropriate carboxylic acid hydrazide 1a-1h(0.01 mol) and allylisocyanate (0.01 mol) in 15 ml diethyl ether waskept for 48 h at room temperature. Obtained product was filteredoff and washed with diethyl ether and water. After drying semicarbazidederivatives were crystallized from ethanol.

According to the analysis of related databases, 1452-63-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Drozd, Monika; Ginalska, Grazyna; Karczmarzyk, Zbigniew; Kowalczuk, Dorota; Morawiak, Maja; Pitucha, Monika; Swatko-Ossor, Marta; Urbanczyk-Lipkowska, Zofia; Wysocki, Waldemar; Journal of Molecular Structure; vol. 1219; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 74784-70-6

Phenyl chloroformate (620mg, 3.96 mmol) was added to a solution of 5-(trifluoromethyl)pyridin-2-amine (615 mg, 3.79 mmol) and pyridine (323 mg, 4.08 mmol) in ACN (50 mL) at 0C. After stirring the solution overnight at room temperature, the reaction was quenched with H20. The resulting precipitate was filtered, dried and used without further purification. The product was a white solid (905mg, 3.21 mmol, 84% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74784-70-6, 5-(Trifluoromethyl)pyridin-2-amine.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce; KODANI, Sean; (110 pag.)WO2017/160861; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 145100-50-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, molecular formula is C7H4F6N2O4S2, molecular weight is 358.24, as common compound, the synthetic route is as follows.

General procedure: To a mixture of bis(3,5-bis(trifluoromethyl)phenyl)(2,5-dihydroxyphenyl)phosphineoxide (25) (291 mg, 0.500 mmol) and N-(2-pyridyl)bis(trifluoromethanesulfonimide)(358 mg, 1.00 mmol) dissolved in CH2Cl2 (5.0 mL) was added triethylamine (0.174 mL,1.25 mmol) at room temperature. After stirring for 16 h at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (5 mL). The mixture was extracted with CH2Cl2 (10 mL × 3), and the combined organic extract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel 30 g, n-hexane/EtOAc= 8/2) to give bis(3,5-bis(trifluoromethyl)phenyl)(2,5-bis(triflyloxy)phenyl)phosphineoxide (1g) (399 mg, 0.471 mmol, 94.3%) as a colorless solid.

The chemical industry reduces the impact on the environment during synthesis 145100-50-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem