Category: pyridine-derivatives

Synthetic Route of 170886-13-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol. A new synthetic method of this compound is introduced below.

A mixture of 2-(trifluoromethyl)pyridin-4-ol (100 mg, 0.613 mmol) and Lawesson?s reagent (123.99 mg, 0.307 mmol) in toluene (10 mL) was refluxed for 2 hours. Excess solvent was evaporated under reduced pressure. The residue was purified by automate column chromatography to give the desired product (75 mg, 68% yield). LC-MS: m/z: 180 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,170886-13-2, 2-(Trifluoromethyl)pyridin-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 69045-79-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-79-0, name is 2-Chloro-5-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of (S)-1-(phenyl-3-boronic acid)-ethyl]-carbamic acid tert-butyl ester (1.29 g, 4.86 mmol) and 2-chloro-5-Iodo-pyridine (1.4 g, 11.4 mmol) in ethyleneglycoldimethylether (25 mL) in a sealed tube were added cesium carbonate (4.75 g, 14.6 mmol) and water (5 mL). Argon was bubbled in to the above mixture for 10 min, and Pd(PPh3)4 (280 mg, 0.24 mmol) was added. The reaction mixture was stirred at 100 C. for 18 hand then cooled down to room temperature. Ethyl acetate (100 mL) was added, the resulting solution was washed with NH4Cl (sat.) (2¡Á100 mL), and the organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated in vacuo and the crude product was diluted in CH2Cl2 (30 mL) and trifluoroacetic acid (10 mL). The reaction mixture was agitated for 1 h and concentrated in vacuo. The residue was purified by solid phase extraction (SCX cartridge, silca gel benzene sulfonic acid linked) to give the title product (785 mg, 69%) as yellow oil. [0147] 1H NMR (DMSO d6, 400 MHz): delta 1.28 (d, 3 H, J=6.8 Hz), 4.04 (q, 1 H, J=6.8 Hz), 7.4-7.45 (m, 2H), 7.5-7.55 (m, 1H), 7.61 (d, 1H J =7.8 Hz,), 7.72 (s, 1H), 8.15 (dd, 1H, J=8.3, 2.5 Hz,), 8.73 (d, 1H, J=3.3 Hz).

According to the analysis of related databases, 69045-79-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wu, Yong-Jin; Sun, Li-Qiang; L’Heureux, Alexandre; US2004/110754; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 849020-87-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.849020-87-7, name is 6-Hydroxy-4-(trifluoromethyl)nicotinic acid, molecular formula is C7H4F3NO3, molecular weight is 207.1068, as common compound, the synthetic route is as follows.

Diethyl chlorophosphate (0.045 ml, 0.312 mmol) was added to a solution of 6-hydroxy-4-(trifluoromethyl)nicotinic acid (0.065 g, 0.312 mmol) in pyridine, anhydrous (0.945 ml, 11.70 mmol) at room temperature under nitrogen. After stirring for lh, this solution was added to a vial containing 6-fluoro-4-(4- methylpiperazin-1-yl)-3′-(mo holinomethyl)-[l, -biphenyl]-3-amine (step 3 from (a): 0.030 g, 0.078 mmol) under nitrogen and the reaction was heated to 70C for 3 hours. The pyridine was removed under reduced pressure and LCMS of the residue (dissolved in DCM, MeCN and MeOH) indicated complete conversion to the desired product. The mixture was loaded onto celite purified by flash chromatography [0.5-10% DCM/MeOH + 1% NH4OH] to methylpiperazin-1-yl)-3′-(mo holinomethyl)-[l,Gamma- biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-l,6-dihydropyridine-3-carboxarnide (0.024 g, 0.042 mmol, 53.6% yield) as a clear film. NMR (500 MHz, DMSO-d6) delta = 9.53 (s, 1H), 7.94 (s, 1H), 7.76 (d, J=8.4 Hz, 1H), 7.46 – 7.42 (m, 2H), 7.40 – 7.38 (m, 1H), 7.32 (d, J=7.3 Hz, 1H), 7.08 (d, J=12.5 Hz, 1H), 6.81 (s, 1H), 3.60 – 3.57 (m, 4H), 3.53 (s, 2H), 2.93 (br. s., 4H), 2.38 (br. s., 4H), 2.24 (s, 3H); LCMS [M+H]+ 574 g/mol.

The chemical industry reduces the impact on the environment during synthesis 849020-87-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ZEPEDA-VELAZQUEZ, Carlos Armando; PODA, Gennady; ISAAC, Methvin; UEHLING, David; WILSON, Brian; JOSEPH, Babu; LIU, Yong; SUBRAMANIAN, Pandiaraju; MAMAI, Ahmed; PRAKESCH, Michael; STILLE, Julia Kathleen; (1053 pag.)WO2017/147700; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89937-77-9, Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89937-77-9, blongs to pyridine-derivatives compound. Recommanded Product: 89937-77-9

LiH (78 mg) was suspended in DMF (5 ml), and a suspension of methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (500 mg) in DMF (5 ml) was added dropwise thereto at room temperature. The suspension was stirred as it was, and a solution of 1-indo-2-methylpropane (506 mul) in DMF (5 ml) was added dropwise thereto over 10 min, followed by stirring at 50C for 15 hours. To the reaction solution was added 1M HCl at 0C, followed by extraction with EtOAc, and the organic layer was washed with saturated brine, dried over anhydrous MgSO4, and filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (n-hexane:EtOAc=90:10 to 50:50) to obtain methyl-1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylate (440 mg) as white powders.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89937-77-9, its application will become more common.

Reference:
Patent; Astellas Pharma Inc.; EP2003132; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In an article, author is Mala, Ramanjaneyulu, once mentioned the application of 586-95-8, Name is 4-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, MDL number is MFCD00006442, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 586-95-8.

An Imidazo[1,2-a]pyridine Derivative That Enables Selective and Sequential Sensing of Cu2(+) and CN- Ions in Aqueous and Biological Samples

We report a triazole appended imidazopyridine based chemosensor (probe 1) for sequential detection of Cu2+ and CN- ions using fluorometry. Probe 1 is fluorescent in aqueous acetonitrile (H2O-CH3CN, 1:1, v/v) when common metal ions are present, but the fluorescence is quenched when Cu2+ is present. The binding mechanism, quantitative determination and the mode of interaction of Cu2+ with probe 1 are explained using fluorescence spectroscopy, electrospray ionization mass spectrometry and Density Functional Theory (DFT) calculations. The observed detection limit for Cu2+ is found to be (18.17 x 10(-6) M) and it is comparable with those reported for other Cu2+ chemosensors. Further, the 1-Cu2+ complex formation is found to be reversible, and this property has been successfully exploited for the quantitative determination of CN- ions in aqueous acetonitrile. Addition of CN- leads to a complete recovery of fluorescence from 1-Cu2+ complex, permitting the real time detection with the lower limit of detection of CN being 33.57 x 10(-6) M. The observed experimental results are supported by DFT calculations. A possible application of 1-Cu2+ in fluorescence imaging of Rhizoctonia solani mycelia cells, contaminated with CN ions, is also represented.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 586-95-8, Recommanded Product: 586-95-8.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 99368-66-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 99368-66-8, Name is 5-Nitro-3-(trifluoromethyl)pyridin-2-ol, SMILES is FC(C1=CC([N+]([O-])=O)=CN=C1O)(F)F, belongs to pyridine-derivatives compound. In a article, author is Roozifar, Majid, introduce new discover of the category.

Application of salicylic acid as an eco-friendly and efficient catalyst for the synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives

In this study, three eco-friendly, efficient, and convenient protocols have been reported for one-pot synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives using salicylic acid as a catalyst under solvent-free condition. The reported protocols offer several significant advantages such as the application of a nontoxic, neutral, and cheap catalyst, environmentally friendly conditions, the easy isolation of products by filtering, short reaction times, simple methodology, and good yields.

Electric Literature of 99368-66-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 99368-66-8 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 614-18-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 614-18-6, Name is Ethyl nicotinate, SMILES is O=C(OCC)C1=CN=CC=C1, belongs to pyridine-derivatives compound. In a article, author is Kuo, Yi-Min, introduce new discover of the category.

Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis

Astrocytes play pivotal roles in regulating glutamate homeostasis at tripartite synapses. Inhibition of soluble epoxide hydrolase (sEHi) provides neuroprotection by blocking the degradation of 14,15-epoxyeicosatrienoic acid (14,15-EET), a lipid mediator whose synthesis can be activated downstream from group 1 metabotropic glutamate receptor (mGluR) signaling in astrocytes. However, it is unclear how sEHi regulates glutamate excitotoxicity. Here, we used three primary rat cortical culture systems, neuron-enriched (NE), astrocyte-enriched glia-neuron mix (GN), and purified astrocytes, to delineate the underlying mechanism by which sEHi and 14,15-EET attenuate excitotoxicity. We found that sEH inhibitor 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) and 14,15-EET both attenuated N-methyl-D-aspartate (NMDA)-induced neurite damage and cell death in GN, not NE, cortical cultures. The anti-excitotoxic effects of 14,15-EET and AUDA were both blocked by the group 1 mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), as were their protective effects against NMDA-disrupted perineuronal astrocyte processes expressing glutamate transporter-1 (GLT-1) and subsequent glutamate uptake. Knockdown of sEH expression also attenuated NMDA neurotoxicity in mGluR5- and GLT-1-dependent manners. The 14,15-EET/AUDA-preserved astroglial integrity was confirmed in glutamate-stimulated primary astrocytes along with the reduction of the c-Jun N-terminal kinase 1 phosphorylation, in which the 14,15-EET effect is mGluR5-dependent. In vivo studies validated that sEHi and genetic deletion of sEH (Ephx2-KO) ameliorated excitotoxic kainic acid-induced seizure, memory impairment, and neuronal loss while preserving GLT-1-expressing perineuronal astrocytes in hippocampal CA3 subregions. These results suggest that 14,15-EET mediates mGluR5-dependent anti-excitotoxicity by protecting astrocytes to maintain glutamate homeostasis, which may account for the beneficial effect of sEH inhibition in excitotoxic brain injury and diseases.

Related Products of 614-18-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 614-18-6.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hu, Xiao-Lu, once mentioned the application of 31251-41-9, Name is 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, molecular formula is C14H10ClNO, molecular weight is 243.69, MDL number is MFCD00800222, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/31251-41-9.html.

Homochiral coordination architectures based on a series of pyridyl-alanine derivatives with varied configurations: Structural diversity, photoluminescence and magnetic properties

Six homochiral coordination polymers based on a series of designed pyridyl-alanine derivatives ligands (x,y-H(2)PDBAla, x, y = 2, 6; 2, 5; 3, 5) and different divalent cations in the absence/presence of ancillary ligands, including [Zn (2,6-PDBAla)]center dot 3H(2)O (1), [Cd (2,6-PDBAla)] (2), [Cd (2,5-PDBAla) (H2O)(3)]center dot 2H(2)O (3), [Cu-3(2,5-PDBAla)(2) (bipy)(2)(H2O)(2)]center dot 10H(2)O (4), [Co(3,5-PDBAla) (bpea) (H2O)] ( 5 ), [Ni(3,5-PDBAla) (bpee) (H2O)(2)]center dot 5H(2)O (6) (H(2)PDBAla = pyridine-dicarbonyl-bis(L-alanine), bipy = 4,4′-bipyridine, bpea = 1,2-bis(4-pyridyl)ethane, bpee = 1,2-bis(4-pyridyl)ethylene), were prepared and characterized. Three kinds of pyridyl-alanine derivatives ligands with versatile coordination modes bridge metal ions to generate the diverse structures. In the absence of ancillary ligand, the 2,6-H(2)PDBAla ligands and Zn(II)/Cd(II) ions react to get the compounds 1 and 2.1 exhibits a one-dimensional (1D) loop chain structure with the 14-membered rings, whereas a 3D framework with the qtz topology was observed in 2, in which the right-handed single-stranded and the left-handed double-stranded helical chains coexist. The 2,5-H(2)PDBAla ligands coordinate with Cd(II)/Cu(II) ions to yield the compounds 3 and 4.3 shows 1D right-handed single-stranded helical chain, and 4 shows a 2D layer constructed from right-handed single-stranded helical chain. The integration of 3,5-H(2)PDBAla ligands and Co(II)/Ni(II) ions leads to the compounds 5 and 6.5 displays a 2D wavy layer, consisting of the [Co(3,5-PDBAla)] right-handed single-stranded helical chain and the [Co(bpea)](2+) zigzag chain, and 6 displays a 2D layer with sql topology. The photoluminescence spectra of 1, 2 and 3 reveal the corresponding emissions of organic ligands, their maximum emission peaks appear at 402, 401 and 433 nm, respectively. Magnetic susceptibility mensuration of 5 gives the J of -12.35 cm(-1), indicating strong antiferromagnetic interactions between the Co(II) ions.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 626-60-8, Name is 3-Chloropyridine, molecular formula is C5H4ClN. In an article, author is Mannava, Vennela,once mentioned of 626-60-8, Quality Control of 3-Chloropyridine.

Nickel-Mediated Dehydrogenative Aryl-Aryl Homocoupling of a Bulky Phosphino-Pyridine

Aryl-aryl bond formation through dehydrogenative coupling is an attractive transformation due to the atom and step economy of working with unfunctionalized C-H bonds. Pd catalysts are most common for this process, but Ni complexes have also been targeted as less expensive and more abundant alternatives. Here we report the ability of Ni-0 to activate a sterically encumbered phosphino-pyridine ligand with resulting dehydrogenative aryl-aryl homocoupling. The net H-2 equivalent is transferred to the coligand, resulting in hydrogenation of an olefin unit. We have investigated the mechanism of this process by stirring Ni(1,5-COD)(2) (COD = cyclooctadiene) and the PNPh ligand (PNPh = 2-((di-tert-butylphosphino)methyl)-6-phenylpyridine) at mild temperatures to afford a Ni-II complex. Isolation and characterization shows a PNPh ligand coordinated to Ni-II through an activated pyridine carbon and the directing phosphine. The coligand is an activated allylic cyclooctenyl fragment resulting from partial hydrogenation of 1,5-COD. We propose that this intermediate reacts intermolecularly with 1 equiv of itself, enabling the isolation of a bi-PNPh compound (bi-PNPh = 2,2′-bis((di-tert-butylphosphino)methyl)-6,6′-dipheny1-3,3′-bipyridine), coupled through the activated pyridyl position. This dehydrogenative coupling, although stoichiometric, demonstrates the potential of Ni-0-mediated C(sp(2))-H activation and homocoupling for synthetic applications.

Interested yet? Keep reading other articles of 626-60-8, you can contact me at any time and look forward to more communication. Quality Control of 3-Chloropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Wang, Jin, once mentioned the application of 93-60-7, Name is Methyl nicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, MDL number is MFCD00006388, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Quality Control of Methyl nicotinate.

One-pot synthesis of imidazo[1,2-alpha]pyridine thioethers using imidazo[1,2-alpha]pyridines, arylsulfonyl chlorides and hydrazine

A one-pot reaction of making RS-substituted imidazo[1,2-alpha]pyridine derivatives by directly using aryl or alkylsulfonyl chloride and hydrazine was developed, selectively giving good yields of the expected products. Compared with previously reported methods of using ArSO2NHNH2 as a sulfur source, this method is much cheaper, more practical and convenient and enriches current methods to make thioether-containing compounds, providing a good example of green chemistry.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem