Category: pyridine-derivatives

Kim, Jong Hyun published the artcileAnticancer gold(III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition, Application In Synthesis of 91-02-1, the publication is Chemical Science (2021), 12(21), 7467-7479, database is CAplus and MEDLINE.

Expanding the chem. diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chem. of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiol. stability. Biol. evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of ATP (ATP). Mechanism-of-action efforts, RNA-Seq, quant. proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple neg. breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiol.

Chemical Science published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oda, Mitsunori published the artcileSynthesis and properties of 2-(2-pyridyl)-1-azaazulene, Formula: C5H6BNO2, the publication is Tetrahedron Letters (2007), 48(26), 4471-4475, database is CAplus.

The title azaazulene (I) was synthesized either by reaction of tropone with N-[(2-pyridyl)acetyl]pyridinium iodide in the presence of ammonium acetate or by palladium-catalyzed cross-coupling between 2-halo-1-azaazulene and 2-substituted pyridine. The compound shows relatively stronger basicity compared with 2,2′-bipyridyl. While I showed no emission from the S₁ state but from the S₂ state like azulene does, the protonated species of I exhibited emission from the S₁ state. Cationic metal-dependent absorption and emission relating to complexation were also studied.

Tetrahedron Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Adachi, Kenji published the artcileElectrophilic fluorination with N,N’-difluoro-2,2′-bipyridinium salt and elemental fluorine, Category: pyridine-derivatives, the publication is Journal of Fluorine Chemistry (2003), 120(2), 173-183, database is CAplus.

N,N’-Difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (MEC-31) was shown to be a highly reactive electrophilic fluorinating agent with the highest effective fluorine content in its class. We have developed the perfect recycled fluorination system with MEC-31 for the lower-cost industrial fluorination and for an environment. MEC-31 can be completely recycled including the counter-anion. We found the fluorination of 2-naphthol in liquid CO₂ with MEC-31 in the presence of catalytic amount of NaOTf proceeded quant. without the generation of byproduct. In the fluorination of 1,3-dicarbonyl compounds with elemental fluorine, we found the introduction method of fluorine gas would be very important in order to make a reaction efficient. As fluorination goes on, the quantity of 1,3-dicarbonyl compounds of the starting material is reduced gradually, and therefore the quantity of fluorine must be reduced by the method to control the flow rate or the concentration of fluorine gas diluted with nitrogen, together the fluorination to proceed efficiently.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ogino, Yoshio published the artcileSyntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists, Category: pyridine-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(18), 4997-5001, database is CAplus and MEDLINE.

Syntheses and structure-activity relationships of a novel class of 2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists are described. Optimization of the lead compound (I) by incorporating substituents into the 5-position or into both the 5- and 6-positions of the benzimidazole core part led to the identification of two potent, selective, and orally bioavailable Y5 receptor antagonists (II (IC₅₀ = 3.3 nM) and III (IC₅₀ = 5.9 nM)).

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileExtraction equilibria of nickel(II) with several heterocyclic substituted hydrazones, Quality Control of 2215-33-0, the publication is Analytical Sciences (1993), 9(6), 835-41, database is CAplus.

The extraction of nickel(II) with seven N,N,N-tridentate heterocyclic hydrazones, a neutral form of which is abbreviated as HL, using chloroform or benzene as an extraction solvent has been studied, the extraction equilibrium being analyzed on the basis of the data for the proton dissociation of H₃L²⁺, the formation of Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes and the proton dissociation of Ni(HL)₂²⁺ complexes in aqueous solution Nickel(II) is extracted as NiL₂ although it forms such complexing ions an Ni(HL)²⁺ or Ni(HL)₂²⁺ in the aqueous phase. The distribution constants of HL and NiL₂ (the abbreviations of which are K_d and K_dm, resp.) have been determined under the same condition as in aqueous solution The logarithmic plots of Kdm vs. K_d displayed two straight lines with slopes of 1.9; one is for hydrazones bearing one pyridyl or one quinolyl ring in the aldehyde moiety and the other for hydrazones bearing another pyridyl ring introduced to the aldehyde moiety. This is attributed to an intramol. hydrogen bond between the imino hydrogen and the nitrogen of pyridine of the latter hydrazones.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H16BFO4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileKinetic study of solvent extraction of nickel(II) from aqueous solution by some heterocyclic substituted-hydrazones, Application In Synthesis of 2215-33-0, the publication is Analytical Sciences (1991), 7(Suppl.), 21-4, database is CAplus.

Solvent extraction of nickel(II) complexes with five heterocyclic hydrazones (containing pyridine- or/ and quinoline-nitrogen atoms as the coordinating sites) into chloroform or benzene was studied kinetically at 25°C and μ = 0.1 by means of a spectrophotometric method. The kinetics of extraction of nickel(II) ion is first order in each of the aqueous nickel(II) concentration and the hydrazone concentration in the organic phase. The observed second-order rate constant, k_obs, -pH profiles suggest three rate-determining steps to be considered in the aqueous phase: Ni²⁺ + H₂L⁺ â†? Ni²⁺ + HL â†?and Ni(OH)⁺ + HL â†? The rate constant for the formation of 1:1 complexes with 2-pyridylmethanone 2-pyridylhydrazone (PAPH) was consistent with those for bipyridine and terpyridine. Replacement of pyridyl group by quinolyl group affects the distribution constant (K_d) of the ligand between the two phases rather than the rate constants The influence of the structure of ligands on the rate constants is also discussed.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C18H34N4O5S, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Morimoto, Nobuyuki published the artcileThe Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions, Name: 4-Amino-2-picoline, the publication is Macromolecular Chemistry and Physics (2020), 221(5), 1900429, database is CAplus.

Thermoresponsive polymers are attractive in terms of basics and applications because of the phase separation in aqueous solution Some sulfobetaine polymers are known for their antifouling biocompatibility and upper critical solution temperature (UCST) type thermoresponsiveness; however, thermoresponsiveness disappears in aliphatic sulfobetaine polymers in physiol. salt conditions. Aromatic cation-containing sulfobetaine polymers are not responded because of the strong intermol. interactions. In this study, new sulfobetaine methacrylamides with a pyridinium cation, 3-(4-(2-methacrylamido)alkyl pyridinio-1-yl)propane-1-sulfonates, (PySMAAm)s, are designed and then prepared the homopolymers using aqueous reversible addition-fragmentation chain transfer polymerization The P(PySMAAm)s exhibited UCST-type thermoresponsiveness that is induced by substitution of the dipole-dipole interaction between the interpolymer side chain to an ion-dipole interaction in physiol. salt conditions. The thermoresponsiveness is affected by the mol. weight and structure of the side chains. Such sulfobetaine polymers can be promising tools as biomaterials especially for drug delivery and regenerative medicine.

Macromolecular Chemistry and Physics published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Name: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Onduka, Toshimitsu published the artcileToxicity of Degradation Products of the Antifouling Biocide Pyridine Triphenylborane to Marine Organisms, Synthetic Route of 971-66-4, the publication is Archives of Environmental Contamination and Toxicology (2013), 65(4), 724-732, database is CAplus and MEDLINE.

We evaluated the acute toxicities of the main degradation products of pyridine triphenylborane (PTPB), namely, diphenylborane hydroxide (DPB), phenylborane dihydroxide (MPB), phenol, and biphenyl, to the alga Skeletonema costatum, the crustacean Tigriopus japonicus, and 2 teleosts, the red sea bream Pagrus major and the mummichog Fundulus heteroclitus. DPB was the most toxic of the degradation products to all four organisms. The acute toxicity values of DPB for S. costatum, T. japonicus, red sea bream, and mummichog were 55, 70, 100, and 200-310 μg/L, resp. The degradation products were less toxic than PTPB to S. costatum and T. japonicus; however, the toxicities of DPB and PTPB to the fish species were similar. We also examined changes in the inhibition of growth rate of S. costatum as well as the percentage of immobilization of T. japonicus as end points of toxicity of PTPB after irradiation of PTPB with 432 ± 45 W/m² of 290-700 nm wavelength light. After 7 days of irradiation with this light, the concentration of PTPB in the test solutions decreased markedly. A decrease in toxic effects closely coincided with the decrease in the concentration of PTPB caused by the irradiation PTPB probably accounted for most of the toxicity in the irradiation test solutions Because the concentrations of PTPB that were acutely toxic to S. costatum and T. japonicus were <10 % of the corresponding concentrations of its degradation products, PTPB probably accounted for most of the toxicity in the irradiation test solutions

Archives of Environmental Contamination and Toxicology published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Synthetic Route of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kobayashi, Naomasa published the artcileEffects of new antifouling compounds on the development of sea urchin, Quality Control of 971-66-4, the publication is Marine Pollution Bulletin (2002), 44(8), 748-751, database is CAplus and MEDLINE.

Tributyltin oxide (TBTO) was used worldwide in marine antifouling paints as a biocide for some time. However, it produced toxic effects, especially in marine water/sediment ecosystems. Consequently, its use in antifouling paints was prohibited in many countries. In this study, the toxicity of alternative and/or new antifouling biocides compared with TBTO is assessed by a biol. method. The effects of these chems. on marine species were not well studied. This paper assesses, comparatively, the effects of 8 biocides on sea urchin eggs and embryos. The chems. assessed were TBTO, Irgarol 1051, M1 (the persistent degradation product of Irgarol), Diuron, Zn pyrithione, KH101, Sea-Nine 211, and Cu pyrithione. For these chems., toxicity appears to be in the order Zn pyrithione>Sea-Nine 211>KH101>Cu pyrithione>TBTO>Diuron∼Irgarol 1051>M1. Here, the authors show that zinc pyrithione, Sea-Nine 211, KH101, and copper pyrithione are much more toxic to sea urchins than TBTO or the other chems.

Marine Pollution Bulletin published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Quality Control of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mieno, Hirohisa published the artcileToxic effects of alternative antifouling biocides on marine zooplankton and phytoplankton, COA of Formula: C23H20BN, the publication is Yosui to Haisui (2004), 46(12), 1031-1036, database is CAplus.

The toxic effects of antifouling biocides as alternatives of TBT, TBTO and the like on marine zooplankton and phytoplankton were assessed; the used biocides were Irgarol 1051, Diuron, Sea-Nine 211, Zinc pyrithione, Copper pyrithione, Tri-Ph borane pyridine (KH101). Zinc di-Me dithiocarbamate and N-(2,4,6-trichlorophenyl)maleimide (TCPM); in addition, Cu²⁺, Cr⁶⁺, Zn²⁺, Cd²⁺ and DMSO were examd; the used phytoplankton were Skeletonema costatum (NIES-323) and the used zooplankton were Artemia saline. The bioassay examination for the phytoplankton were performed based on the ISO 10253 (1995) method; for the zooplankton, Artoxkit M (Microbiotest corporation) with a microplate was used. Values of NOEC and 72-h EC₅₀ for S. costatum, and 48-h LC₁₀ and 48-h LC₅₀ for A. salina were determined for each of the biocides, and metals also. The values of 72-h EC₅₀ were 0.85-21 μg/L; the ones of 48-h LC₅₀ were 28-7400 μg/L. The biocides showed higher sensitivities than the metals. The risk assessment in the maline environment also was tried based on the obtained data and published data for the highest concentrations of the residual biocides in maline water (HCRB) in references; the assessment were relied on risk coefficients determined in an equation: risk coefficient = (HCRB)/(NOEC or LOEC). The values of NOEC and LOEC were discussed of many countries.

Yosui to Haisui published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, COA of Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem