Category: pyridine-derivatives

Taya, Toshiki published the artcileComplexation behavior of heterocyclic hydrazones. II. Effects of steric factors on formation constants for nickel(II) complexes with heterocyclic hydrazones, Related Products of pyridine-derivatives, the publication is Bulletin of the Chemical Society of Japan (1994), 67(3), 710-19, database is CAplus.

The equilibrium of nickel(II) ion with thirteen nitrogen-heterocyclic hydrazones (neutral form: HL) with and without blocking group(s) have been investigated spectrophotometrically in 28% aqueous dioxane solution at 25°C and an ionic strength of 0.2 (KCl). For a series of 2-pyridinecarbaldehyde 5-substituted-2-pyridylhydrazones, the following linear free energy relationships (LFER) were derived between the overall formation constants, β₁, β₁‘, and β₂, of Ni(HL)²⁺, NiL⁺, and Ni(HL)₂²⁺ complexes, resp., and the dissociation constants, K_a1 and K_a2, of H₃L²⁺ and H₂L⁺, resp.: log β₁ = 0.95 (pK_a1 + pK_a2)/2 + 4.60, 1/2 log β₂ = 0.95 × (pK_a1 + pK_a2)/2 + 4.82, and log β₁‘ = 1.40 (pK_a1 + pK_a2)/2 + 9.73. The steric effects of the 6-Me group in pyridine and the quinolyl ring in place of pyridyl group on the complex formation were evaluated on the basis of LFER. The complex stabilization effect of the pyridyl group substituted for formyl hydrogen was also evaluated for Ni(HL)₂²⁺, Ni(HL)²⁺, and NiL⁺ complexes. These results together with LFER were discussed in conjunction with the thermodn. parameters for the formation of Ni(HL)²⁺ complex and the ligand field parameters, D_q, for Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes.

Bulletin of the Chemical Society of Japan published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C7H8BBrO3, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nogawa, Hisashi published the artcilePharmacological characterisation of electrocardiogram J-T_peak interval in conscious Guinea pigs, Product Details of C17H18N2O6, the publication is European Journal of Pharmacology (2022), 175065, database is CAplus and MEDLINE.

Drug-induced human ether-a-́go-go-related gene (hERG) channel block and QT interval prolongation increase torsade de pointes (TdP) risk. However, some drugs block hERG channels and prolong QT interval with low TdP risk, likely because they block addnl. inward currents. We investigated the utility of J-T_peak interval, a novel biomarker of inward current block and TdP risk, in conscious telemetered guinea pigs. ECG parameters were analyzed in Hartley guinea pigs orally administered one of eight test compounds (dofetilide, flecainide, nifedipine, quinidine, quinine, ranolazine, sotalol, verapamil) or vehicle alone as controls. Heart rate-corrected QT (QTcX) and J-T_peak (J-T_peakcX) were calculated to evaluate the relations of QT-RR and J-T_peak-RR. Dofetilide and sotalol significantly increased ΔQTcX and ΔJ-T_peakcX intervals to similar degrees. Quinidine, quinine and flecainide also increased ΔQTcX and ΔJ-T_peakcX intervals, but the degrees of ΔJ-T_peakcX interval prolongation were shorter than those of ΔQTcX interval prolongation. Ranolazine showed slight increasing trends in ΔQTcX and ΔJ-T_peakcX intervals, but the differences were not significant. Verapamil and nifedipine did not increase the ΔQTcX or ΔJ-T_peakcX intervals. Based on the relations of ΔΔJ-T_peakcX and ΔΔQTcX intervals, dofetilide, sotalol and quinidine were classified as high risk for TdP, quinine, flecainide and ranolazine were classified as intermediate risk and verapamil and nifedipine were classified as low risk. These results supported the usefulness of J-T_peak interval assessment in conscious guinea pigs for predicting drug-induced balanced block of inward currents and TdP risk in early-stage preclin. studies.

European Journal of Pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Prakash, Sekar published the artcileCobalt-Catalyzed Oxidative Annulation of Nitrogen-Containing Arenes with Alkynes: An Atom-Economical Route to Heterocyclic Quaternary Ammonium Salts, Quality Control of 85237-71-4, the publication is Angewandte Chemie, International Edition (2016), 55(5), 1844-1848, database is CAplus and MEDLINE.

Four cobalt-catalyzed oxidative annulation reactions of nitrogen-containing arenes with alkynes proceeds by C-H activation, thus leading to biol. useful quaternary ammonium salts, including pyridoisoquinolinium, cinnolinium, isoquinolinium, and quinolizinium salts, in high yields. The results are comparable to those reactions catalyzed by rhodium and ruthenium complexes. The transformation of the salts into various N-heterocycles has also been demonstrated.

Angewandte Chemie, International Edition published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Yiding published the artcileDirect Copper-Catalyzed Three-Component Synthesis of Sulfonamides, Formula: C5H6BNO2, the publication is Journal of the American Chemical Society (2018), 140(28), 8781-8787, database is CAplus and MEDLINE.

Sulfonamides such as N-(phenylsulfonyl)morpholine were prepared in one step by coupling of aryl-, heteroaryl-, and alkenylboronic acids such as phenylboronic acid with cyclic and acyclic alkyl secondary amines such as morpholine and primary anilines and the bis(sulfur dioxide) complex of DABCO (DABSO) in the presence of Cu(OTf)₂ and 4,4′-dimethoxy-2,2′-bipyridine in DMSO. The method was used on gram scale and was used to prepare sulfonamides from drugs and drug fragments.

Journal of the American Chemical Society published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nirmalram, Jeyaraman Selvaraj published the artcileHydrogen-bonding patterns in pyrimethaminium pyridine-3-sulfonate, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Acta Crystallographica, Section E: Structure Reports Online (2010), 66(8), o2121-o2122, database is CAplus and MEDLINE.

In the asym. unit of the title salt [systematic name: 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidin-1-ium pyridine-3-sulfonate], C₁₂H₁₄N₄Cl⁺·C₅H₄NSO₃^–, there are two independent pyrimethaminium cations and two 3-pyridine sulfonate anions. Each sulfonate group interacts with the corresponding protonated pyrimidine ring through two N-H…O hydrogen bonds, forming a cyclic hydrogen-bonded bimol. R₂²(8) motif. Even though the primary mode of association is the same, the next higher level of supramol. architectures are different due to different hydrogen-bonded networks. In one of the independent mols. in the asym. unit, the pyrimethamine cation is paired centrosym. through N-H…N hydrogen bonds, generating an R₂²(8) ring motif. In the other mol., the pyrimethamine cation does not form any base pairs; instead it forms hydrogen bonds with the 3-pyridine sulfonate anion. The structure is further stabilized by C-H…O, C-H…N and π-π stacking [centroid-centroid distance = 3.9465 (13) Å] interactions. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Jong-Woo published the artcileFlexible and transparent electrochromic displays with simultaneously implementable subpixelated ion gel-based viologens by multiple patterning, HPLC of Formula: 47369-00-6, the publication is Advanced Functional Materials (2019), 29(13), n/a, database is CAplus.

Electrochromic materials reversibly change colors by redox reactions depending on the oxidation states. To utilize electrochromic materials for active-matrix display applications, an electrochromic display (ECD) requires simultaneous implementation of various colors and a fine-pixelation process. Herein, flexible and transparent ECDs with simultaneously implementable subpixelated EC gels by sequential multiple patterning are successfully demonstrated. Ionic liquid-based EC gels of monoheptyl-viologen, diheptyl-viologen (DHV), and diphenyl-viologen (DPV) are used to create the colors of ECDs: magenta, blue, and green, resp. Especially, to realize an improved green color, DHV-DPV composite gels are synthesized. Three EC gels exhibit stable properties without degradation during repetitive operation. Moreover, a transmittance greater than 90% is maintained in a bleached state, which is sufficient for application as a transparent display. The subpixelation process for multicolored-flexible ECDs is designed to facilitate both easy fabrication and rapid operation with various patterns at low cost. The subpixelated EC gels using a film mask can be implemented to a min. size of 200 μm. Furthermore, the subpixelated flexible ECDs exhibit high durability even after 1000 cycles of mech. bending tests at a bending radius of 10 mm. Therefore, these EC materials can be used directly for flexible and transparent active-matrix displays.

Advanced Functional Materials published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, HPLC of Formula: 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hamukwaya, Eunike published the artcileA multi-colorimetric probe to discriminate between heavy metal cations and anions in DMSO-H₂O with high selectivity for Cu²⁺ and CN^–: study of logic functions and its application in real samples, Quality Control of 91-02-1, the publication is RSC Advances (2021), 11(47), 29466-29485, database is CAplus and MEDLINE.

A ditopic multi-colorimetric probe based on the phenylpridyl-thioic moiety (EN) was synthesized via a Schiff base reaction mechanism and characterized using ¹H NMR and UV-vis spectroscopy. The colorimetric analyses carried out revealed that EN was capable of discriminating between a number of heavy metal cations via coordination induced charge transfer, as well as between anions through hydrogen bonding induced charge transfer, in DMSO-H₂O (9 : 1). In particular, the ditopic probe could spectrally and colorimetrically recognize the most toxic heavy metal cations of Cd²⁺, Pb²⁺ and Hg²⁺, among others, in DMSO-H₂O. Addnl., EN was selective and sensitive to the presence of CN^–, F^–, AcO^– and H₂PO₄^– in the same solvent system as cations. The reversibility and reproducibility studies showed that EN exhibited complementary IMP/INH logic functions, based on color and spectral switching (ON/OFF), modulated by F^–/Al³⁺. The real time application of the probe was tested on food grade products to detect the presence of F^– in toothpastes and mouthwash dissolved in water, as well as cations in underground water (normally saline), which displayed substantial responses. Thus, EN displayed an excellent scope of response and can thus be developed for real time sensing kits, which could be used instantly in on-field anal. Theor. studies were conducted to complement the exptl. work.

RSC Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Murugan, Karthik published the artcileGreen-Synthesized Nickel Nanoparticles on Reduced Graphene Oxide as an Active and Selective Catalyst for Suzuki and Glaser-Hay Coupling Reactions, Computed Properties of 197958-29-5, the publication is Applied Organometallic Chemistry (2020), 34(9), e5778, database is CAplus.

The present work disclosed the potential catalytic application of the as-prepared RGO-Ni nanocomposite in Csp²-Csp² Suzuki type homocoupling and Csp-Csp Glaser-Hay coupling reactions. A mild and benign methodol. to synthesize biaryls Ar-Ar [Ar = Ph, 3-MeOC₆H₄, 2-pyridyl, etc.] and 1,3-diynes R-CC-CC-R [R = t-Bu, 3-FC₆H₄, 4-EtC₆H₄, etc.] was demonstrated using the nickel nanoparticles supported on reduced graphene oxide (RGO-Ni) as a heterogeneous catalyst which was prepared using green reagents. A series of substituted biaryls Ar-Ar and 1,3-diynes R-CC-CC-R was synthesized in good to excellent yields via reduced graphene oxide supported nickel nanoparticles catalyzed Suzuki coupling of arylboronic acids and Glaser-Hay coupling of terminal alkynes resp. using 1,4-dioxane as a benign solvent. The present ligand-free catalytic system proceeded smoothly under mild conditions, avoided noble and stoichiometric metal reagents and tolerated sensitive functional groups such as nitrogen and sulfur containing heteroaryl boronic acids. Hot filtration test unambiguously proved the true heterogeneity of the catalyst and which supported for the further reusability of the catalyst for several times without any change in the activity. The easy preparation and simple magnetic separation, stability and reusability revealed that as-prepared RGO-Ni as a versatile catalyst for the synthesis of polyaromatic compounds both in academia and industries.

Applied Organometallic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kamata, Ryo published the artcileAgonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay, Computed Properties of 971-66-4, the publication is Toxicology In Vitro (2018), 335-349, database is CAplus and MEDLINE.

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism.

Toxicology In Vitro published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Computed Properties of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Papillon, Julien P. N. published the artcileDiscovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers, Synthetic Route of 18437-58-6, the publication is Journal of Medicinal Chemistry (2018), 61(22), 10155-10172, database is CAplus and MEDLINE.

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homolog (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homolog Brahma-related gene 1 (BRG1), also known as SMARCA4, are mutually exclusive ATPases of the large ATP-dependent SWI/SNF chromatin-remodeling complexes involved in transcriptional regulation of gene expression. No small mols. have been reported that modulate SWI/SNF chromatin-remodeling activity via inhibition of its ATPase activity, an important goal given the well-established dependence of BRG1-deficient cancers on BRM. Here, the authors describe allosteric dual BRM and BRG1 inhibitors that downregulate BRM-dependent gene expression and show antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model upon oral administration. These compounds represent useful tools for understanding the functions of BRM in BRG1-loss-of-function settings and should enable probing the role of SWI/SNF functions more broadly in different cancer contexts and those of other diseases.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem