Category: pyridine-derivatives

Todeschini, A.R. published the artcile2-Pyridylarylhydrazone derivatives, a new class of platelet aggregation inhibitors, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Brazilian Journal of Medical and Biological Research (1996), 29(3), 389-93, database is CAplus and MEDLINE.

A series of 2-pyridylarylhydrazone derivatives was synthesized and compared with a previously reported pyrazole series, i.e., 4-acylpyrazolylarylhydrazone and 5-pyrazolylarylhydrazone, which present antiplatelet aggregation activity. The structures of these pyridylarylhydrazone derivatives were designed on the basis of the known bioisosteric relation of the heteroaromatic ring. The antiplatelet aggregation activity was measured in vitro on citrated platelet-rich rabbit plasma in which aggregation was induced with 5 μM ADP, 5 μg/mL collagen and 200 μM arachidonic acid. Eighteen compounds belonging to the pyridine series were tested at 1 mM concentration and none inhibited ADP-induced rabbit platelet aggregation. 2-(2-Formylfurane)pyridylhydrazone exhibited a highly potent inhibitory activity on arachidonic acid-induced aggregation, with an IC₅₀ of 0.35 μM. These results suggest that the hydrazone unit and the 2-furyl moiety of the arylhydrazone framework are important pharmacophores for antiplatelet activity.

Brazilian Journal of Medical and Biological Research published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C15H20O6, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Palav, Amey published the artcileRapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide, Synthetic Route of 91-02-1, the publication is Tetrahedron Letters (2021), 153094, database is CAplus.

A sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcs. as well as their sym. and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcs. and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quant. and can be reused for synthesizing NCBSI.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Katakis, D. published the artcilePhotocatalytic splitting of water: increase in conversion and energy storage efficiency, Computed Properties of 47369-00-6, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (1994), 81(2), 103-6, database is CAplus.

The yield of the photocatalytic splitting of water using tris-[1-(4-methoxyphenyl)-2-phenyl-1,2-ethylenodithiolenic-S,S’]tungsten as a photocatalyst-catalyst increases by more than three fold on going from 20 to 70°, and there is no indication that the effect levels off at this temperature The intensity of light (within the error limits of our experiments) does not have an appreciable effect. The nature of the reversible electron acceptor also influences the energy storage efficiency, e.g. 1,1-dibenzyl-4,4′-bipyridinium dichloride gives an energy storage efficiency approx. 10% higher than methylviologen. The energy storage efficiency also depends on the presence of electron donors; if Ph₃N is added, the energy storage efficiency increases by 20%. With EDTA the results are even more spectacular; there is a two-fold increase, but only initially. At longer times the system is unstable. Overall light energy storage efficiencies can be as high as 7%, and the expectations for further improvement are very good.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Computed Properties of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishida, Naoki published the artcileStereoselective synthesis of trisubstituted alkenylboranes by palladium-catalysed reaction of alkynyltriarylborates with aryl halides, Name: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Chemical Communications (Cambridge, United Kingdom) (2007), 4381-4383, database is CAplus and MEDLINE.

The palladium-catalyzed reaction of alkynyltriarylborates with aryl halides afforded trisubstituted alkenylboranes, in which two different aryl groups were installed across the carbon-carbon double bond in a cis arrangement.

Chemical Communications (Cambridge, United Kingdom) published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Name: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arashiba, Kazuya published the artcileA molybdenum complex bearing PNP-type pincer ligands leads to the catalytic reduction of dinitrogen into ammonia, Application In Synthesis of 338800-13-8, the publication is Nature Chemistry (2011), 3(2), 120-125, database is CAplus and MEDLINE.

The synthesis of transition metal-dinitrogen complexes and the stoichiometric transformation of their coordinated dinitrogen into ammonia and hydrazine have been the subject of considerable research, with a view to achieving nitrogen fixation under ambient conditions. Since a single example in 2003, no examples have been reported of the catalytic conversion of dinitrogen into ammonia under ambient conditions. The dimolybdenum-dinitrogen complex bearing PNP pincer ligands was found to work as an effective catalyst for the formation of ammonia from dinitrogen, with 23 equivalent of ammonia being produced with the catalyst (12 equivalent of ammonia are produced based on the molybdenum atom of the catalyst). This is another successful example of the catalytic and direct conversion of dinitrogen into ammonia under ambient reaction conditions. We believe that the results described in this Article provide valuable information with which to develop a more effective nitrogen-fixation system under mild reaction conditions.

Nature Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Application In Synthesis of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Okazaki, Shiho published the artcileIdentification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold, Safety of 2-Pyridinylboronic acid, the publication is Bioorganic & Medicinal Chemistry (2015), 23(7), 1447-1452, database is CAplus and MEDLINE.

3,4-Dihydro-2H-benzo[4,5]isothiazolo[2,3-a]pyrimidine is a newly identified antiviral agent against human immunodeficiency virus type 1 (HIV-1) infection, derived from 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182). The introduction of the hydrophobic 8-aryl substituent on the benzene substructure improved its anti-HIV activity, resulting in the identification of 6-fold more potent analogs. In addition, it was demonstrated that these isothiazolopyrimidine derivatives exert anti-HIV effects at an early stage of viral infection.

Bioorganic & Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arnold, Eric P. published the artcileOxidative Cyclization Approach to Benzimidazole Libraries, COA of Formula: C6H8N2, the publication is ACS Combinatorial Science (2020), 22(1), 1-5, database is CAplus and MEDLINE.

An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-dianiline building blocks, providing limited chem. space coverage. We have developed an amidine formation/oxidative cyclization sequence that enables anilines as a diversity set for benzimidazole C4-C7 SAR generation in parallel format. The amidine annulation was achieved using PIDA or Cu-mediated oxidation to access both N-H and N-alkyl benzimidazoles. This library protocol has now been utilized for analog production in four medicinal chem. projects. Addnl., the synthesis of aza-benzimidazoles from aminopyridines was achieved via an analogous sequence.

ACS Combinatorial Science published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Iribarren, Inigo published the artcileCations brought together by hydrogen bonds: the protonated pyridine-boronic acid dimer explained, Name: 2-Pyridinylboronic acid, the publication is Physical Chemistry Chemical Physics (2019), 21(10), 5796-5802, database is CAplus and MEDLINE.

According to the Cambridge Structural Database, protonated pyridine-boronic acid dimers exist in the solid phase, apparently defying repulsive coulombic forces. In order to understand why these cation-cation systems are stable, we carried out M06-2X/6-311++G(3df,2pd) electronic structure calculations and used a set of computational tools (energy partitioning, topol. of the electron d. and elec. field maps). The behavior of the charged dimers was compared with the corresponding neutral systems, and the effect of counterions (Br^– and BF₄^–) and the solvent (PCM model) on the binding energies has been considered. In the gas-phase, the charged dimers present pos. binding energies but are local min., with a barrier (16-19 kJ mol^-1) preventing dissociation Once the environment is included via solvent effects or counterions, the binding energies become neg.; remarkably, the strength of the interaction is very similar in both neutral and charged systems when a polar solvent is considered. Essentially, all methods used evidence that the intermol. region where the HBs take place is very similar for both neutral and charged dimers. The energy partitioning explains that repulsion and electrostatic terms are compensated by the desolvation and exchange terms in polar solvents, thus giving stability to the charged dimer.

Physical Chemistry Chemical Physics published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Name: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hidalgo, M. published the artcileSurface-enhanced resonance Raman spectroscopy of 2-pyridylhydrazone and 1,10-phenanthroline chelate complexes with metal ions on colloidal silver, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1996), 318(2), 229-37, database is CAplus.

Surface-enhanced resonance Raman spectra (SERRS) of the complexes PAPH-Co(II), PAPH-Ni(II), PAPH-Fe(II), and PHEN-Fe(II) (PAPH = 2-pyridine carboxyaldehyde 2-pyridylhydrazone and PHEN = 1,10-phenanthroline) adsorbed on silver colloid have been studied. Differences among SERS spectra of ligands and SERRS spectra of complexes have been investigated. Ultra-sensitive methods for metal determination with limits of detection at the ng mL^-1 level are presented.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Laserna, J. J. published the artcileKinetic determination of cobalt by complexation with pyridine-2-aldehyde 2-pyridylhydrazone and ligand oxidation with bromate, Category: pyridine-derivatives, the publication is Mikrochimica Acta (1985), 2(5-6), 457-67, database is CAplus.

Optimum conditions are outlined for the kinetic determination of Co. The rate of disappearance of pyridine-2-aldehyde 2-pyridylhydrazone (PAPH) in acidic medium is monitored spectrophotometrically at 372 nm. The method is based on the modification of the oxidation rate by complexation of PAPH with Co ions. The detection limit was 0.25 μg/mL. Beer’s law was obeyed for 0.40-1.50 μg/mL.

Mikrochimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem