Category: pyridine-derivatives

Wang, Qingqing published the artcilePreparation of 2-pyridylboronic acid, Computed Properties of 197958-29-5, the publication is Bengbu Yixueyuan Xuebao (2010), 35(10), 1043-1045, database is CAplus.

The means of preparing 2-pyridylboronic acid was investigated. The product was synthesized with 2-bromopyridine, tris-trimethylsilylborate and iPrMgCl as Grignard reagents under N₂, and identified by 1H-NMR. 2-Pyridylboronic acid was synthesized with the yield of 67.7% on conditions of n(tris-trimethylsilylborate): n(2-bromopyridine)=2:1; the reaction temperature was 0 degree, the reaction time 3 h and the hydrolysis temperature 0 degree. 2-Pyridylboronic acid can be synthesized by Grignard reaction on moderate conditions with high yield, which may contribute to the study of pyridine drugs.

Bengbu Yixueyuan Xuebao published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C19H14Cl2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yakun published the artcileSuper-structural 2D ultrathin carbon nitride/acrylate boron silane polymer with multi-function for enhancing antifouling performance, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Coatings Technology and Research (2021), 18(4), 1051-1064, database is CAplus.

Haunted by marine biofouling and the ecol. crisis caused by toxic antifouling paints, the demand for environmental coatings has become more and more pressing. In this work, a series of super-structural 2D ultrathin carbon nitride/acrylate boron silane polymers (CNPs) was prepared by incorporating C₃N₄ into a self-polishing acrylate boron silane polymer (ABSP). The antifouling, environmental performances were evaluated, and the antifouling mechanism was investigated. The results showed that when the content of C₃N₄ was 3-7 wt%, the coatings showed the best resistance to diatoms, Staphylococcus aureus and Escherichia coli in visible light. It was noted that the coatings showed weak antibacterial properties in the dark. In addition, the CNPs and ABSP were shown to expel mussels by photocatalytic active species, self-renewal and amphiphilic surfaces. The COD (COD) values showed that the addition of C₃N₄ made the CNPs become environmental coatings.

Journal of Coatings Technology and Research published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Popov, V. I. published the artcileNovel syntheses of fluoroferrocene and pentafluoroanisole, Application of 1-Fluoropyridiniumtriflate, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1990), 56(10), 1115-16, database is CAplus.

Treating mercurated ferrocene (I; R = HgOAc) (II) or (CF₃CO₂Hg)₅C₆OMe with AcOF in CFCl₃/HOAc gave 42, 29% I (R = F) or C₆F₅OMe, resp. II was also fluorinated in 37% yield by using N-fluoropyridinium trifluoromethanesulfonate.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Application of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lian, Lingxiang published the artcilePhosphine oxide-directed palladium-catalyzed B(3)-H arylation of o-carboranes, Safety of 2-Pyridinylboronic acid, the publication is Tetrahedron Letters (2020), 61(51), 152625, database is CAplus.

The selective functionalization of carboranes has received increasing research interests due to their wild applications in chem., life, and material sciences. Among various structurally diverse carboranes, the development of selective functionalization of the com. available o-carborane (1,2-C₂B₁₀H₁₂) has largely focused on the two acidic C-H bonds. By contrast, research on the activation of the other ten hydridic cage B-H vertexes is relatively less explored. Of particularly challenging, the most electron-deficient nature of B(3,6)-H bonds render very few synthetic methods available for their functionalization. Herein, the authors develop a phosphine oxide-directed Pd-catalyzed highly B(3)-H selective arylation of o-carboranes under very mild reaction conditions in short reaction time.

Tetrahedron Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tung, Ying-Chang published the artcileComparative effectiveness of generic nifedipine versus Adalat long-acting nifedipine for hypertension treatment: A multi-institutional cohort study, Product Details of C17H18N2O6, the publication is Journal of Clinical Hypertension (Hoboken, NJ, United States) (2022), 24(5), 621-629, database is CAplus and MEDLINE.

This retrospective multi-institutional database anal. aimed to evaluate the blood-pressure-lowering efficacy and clin. outcomes of a generic vs. brand-name nifedipine for hypertension management. A total of 12 693 patients who were prescribed a generic or brand-name nifedipine between Jan. 1, 2011, and Dec. 31, 2018, were identified from the Chang Gung Research Database of Chang Gung Memorial Hospitals, Taiwan. Among them, 2112 (21.4%) were prescribed generic nifedipine. After propensity score matching, both the generic and brand-name groups consisted of 2102 patients. At a mean follow-up of 3 years, the changes in office systolic (p for interaction = .791) and diastolic blood pressure (p for interaction = .689) did not differ significantly between the patients who received the generic and the brand-name nifedipine. There was no significant difference between the two study groups regarding the composite of all-cause mortality, acute myocardial infarction, stroke, coronary revascularization, or hospitalization for heart failure (hazard ratio 0.98, 95% confidence interval 0.85-1.13; p = .774). In conclusion, the generic nifedipine was comparable to its brand-name counterpart regarding office blood pressure reduction and the composite cardiovascular outcome for the treatment of patients with hypertension.

Journal of Clinical Hypertension (Hoboken, NJ, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C6H6BClO3, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Bingyang published the artcilePorous organic polymer-supported manganese catalysts with tunable wettability for efficient oxidation of secondary alcohols, Application of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Catalysis (2022), 87-95, database is CAplus.

Porous organic polymers (POPs) feature high surface areas, tunable components, and designable hierarchical pores, thus showing versatile applications including catalysis, separation, gas storage and so on. However, the inherently hydrophobic property may be unfavorable for the catalytic reaction that involves hydrophilic reactants. By using the hydrophilic principle of the amide bond, R-NH-CO-R can be constructed in the porous frameworks to regulate the wettability. Herein, we report the construction of an amphiphilic and hierarchical porous Mn-N4 catalyst via the solvothermal copolymerization, in which N,N-methylenebisacrylamide is used as a hydrophilic monomer. This POP-based manganese catalyst can effectively promote the oxidation of secondary alc. to produce the ketone using aqueous hydrogen peroxide as the oxidant under mild conditions. Note that this amphiphilic catalyst displays high catalytic activity as its homogeneous counterpart in the selective oxidation of alcs. The present work has provided a successful approach for improving the catalytic activity by tuning the wettability of POP-based heterogeneous catalysts.

Journal of Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H15ClO3, Application of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lixian published the artcileManganese-catalyzed asymmetric transfer hydrogenation of hydrazones, COA of Formula: C12H9NO, the publication is Journal of Catalysis (2022), 487-497, database is CAplus.

The enantioselective reduction of C=N bonds constitutes an effective strategy for the production of chiral amines. Herein, manganese-catalyzed asym. transfer hydrogenation of hydrazones by employing a readily available chiral aminobenzimidazole manganese(I) complex under mild conditions was reported. The present protocol allows for the enantioselective transfer hydrogenation of a wide range of arylalkyl, dialkyl and diaryl hydrazones, providing the desired chiral hydrazines in excellent yields and enantioselectivities (65 examples, up to 99.9% ee). Of note, the current method is compatible with the challenging diaryl hydrazones without the requirement of an ortho-substitution on the Ph ring. A preliminary study of the mechanism suggests that a manganese-hydride pathway is involved, and the high enantiocontrol of the reaction is attributed to a π-π stacking interaction between substrate and catalyst.

Journal of Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C26H41N5O7S, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tam, Teck Lip Dexter published the artcileThermoelectric Performances of n-Doped Ladder-Type Conjugated Polymers Using Various Viologen Radical Cations, Quality Control of 47369-00-6, the publication is ACS Applied Polymer Materials (2021), 3(11), 5596-5603, database is CAplus.

Understanding the dopant-polymer interaction is of interest to the conducting polymer research community due to its influence on charge transport properties and also thermoelec. performance. However, studies on such interactions are often complicated by the change in polymer morphol. upon the addition of dopants. Here, we utilized sequential solution doping of a ladder-type poly(benzimidazobenzophenanthrolinedione) (BBL) via viologen radical cation salts. The strong interchain interaction in BBL prevents the infiltration of the viologen radical cations into individual BBL fibrils, thus minimizing the disruption of the polymer morphol. By changing the N-substitution (benzyl or hexyl) and counteranion (chloride or iodide) of the viologen radical cations, the dopant-polymer interaction in such a system was studied. Our results suggest that the anion-π (radical) interaction between the counteranion and BBL (BBL^–) is detrimental to the charge transport properties and thermoelec. performance of this system. This anion-π (radical) interaction between the counteranion and BBL (BBL^–) is governed by the solution state of the viologen radical cation (tightly bound anion or dimerized with loosely bound anion) during the doping process, which is controlled by the bulkiness of the N-substitution and the Lewis basicity of the counteranion. As a result, BBL doped with benzyl viologen monochloride showed the highest conductivities with reasonably high Seebeck coefficients while BBL doped with hexyl viologen monochloride showed inferior conductivities and Seebeck coefficients

ACS Applied Polymer Materials published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C11H10N4, Quality Control of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wolf, William J. published the artcileExamining the Effects of Monomer and Catalyst Structure on the Mechanism of Ruthenium-Catalyzed Ring-Opening Metathesis Polymerization, Product Details of C23H20BN, the publication is Journal of the American Chemical Society (2019), 141(44), 17796-17808, database is CAplus and MEDLINE.

The mechanism of Ru-catalyzed ring-opening metathesis polymerization (ROMP) is studied in detail using a pair of third generation ruthenium catalysts with varying sterics of the N-heterocyclic carbene (NHC) ligand. Exptl. evidence for polymer chelation to the Ru center is presented in support of a monomer-dependent mechanism for polymerization of norbornene monomers using these fast-initiating catalysts. A series of kinetic experiments, including rate measurements for ROMP, rate measurements for initiation, monomer-dependent kinetic isotope effects, and activation parameters were useful for distinguishing chelating and nonchelating monomers and determining the effect of chelation on the polymerization mechanism. The formation of a chelated metallacycle is enforced by both the steric bulk of the NHC and by the geometry of the monomer, leading to a ground-state stabilization that slows the rate of polymerization and also alters the reactivity of the propagating Ru center toward different monomers in copolymerizations The results presented here add to the body of mechanistic work for olefin metathesis and may inform the continued design of catalysts for ROMP to access new polymer architectures and materials.

Journal of the American Chemical Society published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C9H10O4, Product Details of C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ayesa, Susana published the artcileSolid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Bioorganic & Medicinal Chemistry (2009), 17(3), 1307-1324, database is CAplus and MEDLINE.

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relation of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Mol. modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.

Bioorganic & Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem