Category: pyridine-derivatives

Abdallah el hadj, A. published the artcileAI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters, Product Details of C17H18N2O6, the publication is Fluid Phase Equilibria (2022), 113297, database is CAplus.

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state.

Fluid Phase Equilibria published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Appa, Rama Moorthy published the artcilePd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions, Recommanded Product: 2-Pyridinylboronic acid, the publication is Molecular Catalysis (2021), 111366, database is CAplus.

A quick and eco-friendly protocol for the synthesis of biaryls, e.g., I by an oxidative (aerobic) homocoupling of arylboronic acids RB(OH)₂ (R = C₆H₅, pyridin-2-yl, 2-thienyl, etc.) using Pd(OAc)₂ in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media is described. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result sym. biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.

Molecular Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wikaira, Jan L. published the artcileTetrahalocuprate salts of substituted 4-aminopyridines: Synthesis, structure and magnetic properties, Related Products of pyridine-derivatives, the publication is Polyhedron (2013), 770-780, database is CAplus.

The reaction of CuX₂ (X = Br or Cl) with 4-amino-2-chloropyridine or 4-amino-2-methylpyridine in aqueous acids (HX; X = Br or Cl) yields bis(4-amino-2-chloropyridinium) tetrachlorocuprate(II) 3, bis(4-amino-2-chloropyridinium) tetrabromocuprate(II) 4, bis(4-amino-2-methylpyridinium) tetrachlorocuprate(II) monohydrate 5, and bis(4-amino-2-methylpyridinium) tetrabromocuprate(II) monohydrate 6. These compounds were characterized by IR, powder x-ray diffraction, single crystal X-ray diffraction, combustion anal., and temperature dependent magnetic susceptibility. Compounds 3 and 4 both crystallize in the monoclinic space group C2/c, compounds 5 crystallizes in the monoclinic space group P2₁/c and compound 3 crystallizes in the triclinic space group P-1. Magnetic data were collected for the four synthesized compounds and their previously reported parent compounds of 4-aminopyridinium tetrachlorocuprate 1, or tetrabromocuprate 2. All compounds exhibit antiferromagnetic exchange via the two-halide exchange, with strongest exchange observed for compound 6. A number of potential magnetic exchange pathways are seen in these compounds, but fitting of the data to available anal. models suggests that the magnetic exchange constants are 2J/k_B approx. -0.14(2) K in 1, âˆ?0.812(5) K in 2, âˆ?0.173(6) K in 3, âˆ?0.82(1) K in 4, âˆ?2.123(6) K in 5, and âˆ?30.9(1) K in 6.

Polyhedron published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C4Br2N2O4S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Beng, Timothy K. published the artcileRegiocontrolled synthesis of (hetero)aryl and alkenyl dehydropyrrolidines, dehydropiperidines and azepenes by Ru-catalyzed, heteroatom-directed α-C-H activation/cross-coupling of cyclic enamides with boronic acids, Recommanded Product: 2-Pyridinylboronic acid, the publication is Organic & Biomolecular Chemistry (2016), 14(3), 830-834, database is CAplus and MEDLINE.

The synthesis of α-aryl and alkenyl pyrrolidine-, piperidine-, and azepane derivatives, through the intermediacy of cyclic enamides is described. The desired outcome is achieved through ruthenium-catalyzed, site-selective sp² C-H activation/cross-coupling with aryl and alkenyl boronic acids. The regioselectivity (α-sp²vs. α-sp³vs. β-sp² C-H functionalization) is governed by the rate differences between sp² and sp³ C-H activation and the necessity for chelation between the ruthenium metal and the carbonyl directing group.

Organic & Biomolecular Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cabalin, L. M. published the artcileSample illumination configurations for spatially resolved Raman spectrometry using a charge-coupled device detector, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1995), 42(10), 1379-83, database is CAplus and MEDLINE.

Two simple configurations for sample illumination using a CCD detectors are shown. The choice of an appropriate sample illumination can be crucial to obtain spatial and spectral information of complex samples. Simultaneous Raman spectra of a heterogeneous sample of 3 compounds can be obtained using a vertical sample illumination. Spatially resolved resonant Raman and surface-enhanced resonant Raman spectra of Ni 2-pyridinecarboxaldehyde 2-pyridylhydrazone complex were observed with a low integration time. Dividing the CCD in 2 regions and with horizontal multiline sample illumination (Ar-ion laser at 488 nm and He-Ne laser at 632.8 nm) spatially resolved fluorescence of a homogeneous mixture of dyes were obtained. The total image was acquired in only 1 s.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, R. published the artcileSpectrophotometric reaction-rate method for the determination of nitrite in waters with pyridine-2-aldehyde 2-pyridylhydrazone, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1987), 34(12), 1021-6, database is CAplus and MEDLINE.

A method for the kinetic determination of submicrogram amounts of NO₂^– was developed, based on the bromate oxidation of pyridine-2-aldehyde 2-pyridylhydrazone in an acidic medium by NO₂^–. The reaction is monitored spectrophotometrically at 372 nm. A comparative study with HCl and HClO₄ media shows that the anal. parameters are affected by the type of acid used. Within-day precision, based on 10 replicate determinations, was >0.011 μg/mL, which corresponds to 2.2-1.5% relative standard deviation at the concentrations examined Application of this method in the determination of NO₂^– in water is discussed. The recovery of NO₂^– from drinking waters was 90-117%, and the average relative standard deviation for NO₂^– determination is polluted river water was 3.2%. Large amounts of NO₂^– and NH₄⁺ do not interfere. However, there is interference by Cu²⁺, Pd²⁺, and electroactive substances. Major advantages for the method are simplicity, absence of a reagent blank, and the wide determination range.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, R. published the artcileKinetic determination of nitrite in drinking water by fluorometry, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytical Sciences (1991), 7(3), 467-71, database is CAplus.

A method for the kinetic determination of nanogram amounts of NO₂^– is based on its acceleration of the rate of bromination of pyridine-2-aldehyde 2-pyridylhydrazone in acidic medium. The reaction is followed by fluorometry while monitoring the formation of a fluorescent product using an excitation wavelength of 291 nm and an emission wavelength of 432 nm. The method was applied to drinking water anal., with a detection limit of 4.6 ng/mL and recoveries 92-105%. The relative standard deviation of the method is 2.4%. The major advantages of this method are simplicity, absence of a reagent blank, selectivity, and sensitivity.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, Rafael published the artcileCoupling of redox and complex formation processes for the kinetic determination of palladium, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analyst (Cambridge, United Kingdom) (1985), 110(11), 1339-41, database is CAplus.

A kinetic-spectrophotometric procedure for the determination of μg amounts of Pd(II) with pyridine-2-aldehyde 2-pyridylhydrazone (I) is described. The bromate oxidation of the dye is followed at 372 nm. The method is based on the decrease in the reaction rate produced by Pd complexation of I. A relative standard deviation of 2.5% was obtained in the range 0.5-3.2 μg/mL of Pd. Factors influencing the sensitivity and interferences from model solutions are discussed.

Analyst (Cambridge, United Kingdom) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oishi, Michio published the artcileEffect of L-cysteine on α-amylase production and nucleic acid metabolism in Bacillus subtilis, Product Details of C23H20BN, the publication is Journal of General and Applied Microbiology (1963), 9(3), 337-41, database is CAplus.

In B. subtilis, 10^-4M L-cysteine caused an almost complete inhibition of adenine incorporation into ribo- and DNAs and 2 × 10^-5M amounts suppressed α-amylase production to 80-90% of the controls. The latter inhibition was reversed by unidentified compounds in yeast extract

Journal of General and Applied Microbiology published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Product Details of C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fischer, E. published the artcileStereochemical studies of heterocyclic compounds. XII. Crystal and molecular structure of 1-(2-amino-1-cyano-2-thioethenyl)pyridinium ylides, Related Products of pyridine-derivatives, the publication is Journal fuer Praktische Chemie (Leipzig) (1983), 325(2), 261-8, database is CAplus.

E/Z Isomerization and hindered rotation of the pyridine ring were examined in I (R = Me, R¹ = Et). The former process had ΔG^* = 67 kJ/mol; the latter had ΔG^* = 46 kJ/mol. Crystallog. data, bond lengths, and bond angles were determined for I (R = H, R¹ = Ph); both E and Z isomers exists in the crystal. The C:C double bond is considerably longer than those in some olefins.

Journal fuer Praktische Chemie (Leipzig) published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem