Category: pyridine-derivatives

Chen, Jinghu published the artcileFacile synthesis of highly porous hyper-cross-linked polymer for light hydrocarbon separation, HPLC of Formula: 971-66-4, the publication is Polymer Engineering & Science (2021), 61(3), 662-668, database is CAplus.

Light hydrocarbon separation is a crucial process associated with high energy expenditure in the petrochem. industry. The utilization of porous organic materials as solid porous adsorbents for light hydrocarbon separation has found widespread attention because of the advantages of low cost, excellent stability, and good recyclability. Here, we present the facile synthesis of a porous organic material, constructed from pyridine-triphenylborane by using a Friedel-Crafts alkylation coupling reaction, affording the hyper-crosslinked polymer, HCP-B. HCP-B features significant thermal stability, and high surface area. Gas adsorption experiments show that this material adsorbs much larger amounts of ethane, ethylene, and acetylene than that of methane. Ideal adsorbed solution theory (IAST) calculations also predict that HCP-B selectively adsorbs ethane, ethylene, and acetylene over methane. Both are indicative of the great potential of HCP-B in light hydrocarbon separation

Polymer Engineering & Science published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, HPLC of Formula: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vantomme, Ghislaine published the artcileAdaptation in Constitutional Dynamic Libraries and Networks, Switching between Orthogonal Metalloselection and Photoselection Processes, Formula: C11H10N4, the publication is Journal of the American Chemical Society (2014), 136(26), 9509-9518, database is CAplus and MEDLINE.

Constitutional dynamic libraries of hydrazones ^aA^bB and acylhydrazones ^aA^cC undergo reorganization and adaptation in response to a chem. effector (metal cations) or a phys. stimulus (light). The set of hydrazones [¹A¹B, ¹A²B, ²A¹B, ²A²B] undergoes metalloselection on addition of zinc cations which drive the amplification of Zn(¹A²B)₂ by selection of the fittest component ¹A²B. The set of acylhydrazones [E-¹A¹C, ¹A²C, ²A¹C, ²A²C] undergoes photoselection by irradiation of the system, which causes photoisomerization of E-¹A¹C into Z-¹A¹C with amplification of the latter. The set of acyl hydrazones [E-¹A¹C, ¹A³C, ²A¹C, ²A³C] undergoes a dual adaptation via component exchange and selection in response to two orthogonal external agents: a chem. effector, metal cations, and a phys. stimulus, light irradiation Metalloselection takes place on addition of zinc cations which drive the amplification of Zn(¹A³C)₂ by selection of the fittest constituent ¹A³C. Photoselection is obtained on irradiation of the acylhydrazones that leads to photoisomerization from E-¹A¹C to Z-¹A¹C configuration with amplification of the latter. These changes may be represented by square constitutional dynamic networks that display up-regulation of the pairs of agonists (¹A²B, ²A¹B), (Z-¹A¹C, ²A²C), (¹A³C, ²A¹C), (Z-¹A¹C, ²A³C) and the simultaneous down-regulation of the pairs of antagonists (¹A¹B, ²A²B), (¹A²C, ²A¹C), (E-¹A¹C,²A³C), (¹A³C, ²A¹C). The orthogonal dual adaptation undergone by the set of acylhydrazones amounts to a network switching process.

Journal of the American Chemical Society published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C15H21BO3, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Bing published the artcileSelf-Assembled Amphiphilic Water Oxidation Catalysts: Control of O-O Bond Formation Pathways by Different Aggregation Patterns, Name: Pyridine-3-sulfonic acid, the publication is Angewandte Chemie, International Edition (2016), 55(21), 6229-6234, database is CAplus and MEDLINE.

The oxidation of water to mol. oxygen is the key step to realize water splitting from both biol. and chem. perspective. In an effort to understand how water oxidation occurs on a mol. level, a large number of mol. catalysts have been synthesized to find an easy access to higher oxidation states as well as their capacity to make O-O bond. However, most of them function in a mixture of organic solvent and water and the O-O bond formation pathway is still a subject of intense debate. Herein, we design the first amphiphilic Ru-bda (H₂bda=2,2′-bipyridine-6,6′-dicarboxylic acid) water oxidation catalysts (WOCs) of formula [Ru^II(bda)(4-OTEG-pyridine)₂] (1, OTEG=OCH₂CH₂OCH₂CH₂OCH₃) and [Ru^II(bda)(PySO₃Na)₂] (2, PySO₃^–=pyridine-3-sulfonate), which possess good solubility in water. Dynamic light scattering (DLS), scanning electron microscope (SEM), critical aggregation concentration (CAC) experiments and product anal. demonstrate that they enable to self-assemble in water and form the O-O bond through different routes even though they have the same bda^2- backbone. This work illustrates for the first time that the O-O bond formation pathway can be regulated by the interaction of ancillary ligands at supramol. level.

Angewandte Chemie, International Edition published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C8H11NO, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lixia published the artcileCross coupling of arylboronic acids with imidazoles by sulfonatocopper(II)(salen) complex in water, HPLC of Formula: 197958-29-5, the publication is Chemistry Letters (2010), 39(7), 764-765, database is CAplus.

A mild and clean protocol for the cross coupling reactions between imidazoles and arylboronic acids has been developed in good to excellent yields up to 98% in the presence of sulfonatocopper(II)(salen) catalyst in water without addition of other additives and bases.

Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C8H11BO2, HPLC of Formula: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asuero, Agustin G. published the artcileSpectrophotometric evaluation of acidity constants of two-step overlapping equilibria from the inflexion points of the absorbance versus pH graphs with application to the dipyridylglyoxal mono-(2-pyridyl)hydrazone system, Product Details of C11H10N4, the publication is Acta Pharmaceutica Technologica (1988), 34(3), 164-8, database is CAplus.

Some pyridylhydrazone type derivatives are being currently studied from a pharmacol. point of view. In this respect, the knowledge of acidity constants of a drug is of great worth in solving fundamental problems of pharmaceutical interest. Thus, an extension of the method of Irving, Rossotti and Harris (1955) for the evaluation of acidity constants of diprotic acids is presented. A simple method of developing the final equations given by those authors in a more usual anal. form is also presented, thus providing a rapid and convenient desk method of calculation The methods devised were applied to the evaluation of acidity constants of dipyridylglyoxal mono-(2-pyridyl)-hydrazone (DMPH). Results obtained agree well with those obtained by applying a three equation procedure.

Acta Pharmaceutica Technologica published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gu, Lijun published the artcileSynthesis and antitumor activity of α-aminophosphonates containing thiazole[5,4-b]pyridine moiety, Related Products of pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2012), 10(35), 7098-7102, database is CAplus and MEDLINE.

A new procedure is developed for the synthesis of α-aminophosphonates containing thiazole[5,4-b]pyridine moiety from conveniently available starting materials. The target compounds were characterized by IR, ¹H NMR, ¹³C NMR, ³¹P NMR, mass spectrometry and elemental anal. The newly synthesized compounds were evaluated for their anticancer activities against PC-3, Bcap-37, H460 cells in vitro by the MTT method. Two compounds are highly effective against PC-3, Bcap-37 cells and good to H460 cells. Further study is necessary to find out the potential antitumor activities.

Organic & Biomolecular Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Niu, Nana published the artcileDesign and Synthesis of Tetrandrine Derivatives as Potential Anti-tumor Agents Against A549 Cell Lines, Category: pyridine-derivatives, the publication is ChemistrySelect (2019), 4(1), 196-201, database is CAplus.

Tetrandrine was converted to 5-bromotetrandrine using a mild oxidative system (DMSO/HBr). Suzuki-Miyaura and Sonogashira cross-coupling reactions were then employed to yield a set of 5-substituted tetrandrine derivatives I (R = 5-formylfuran-2-yl, pyrimidin-5-yl, 2-cyclopropylethynyl, etc.). Their antiproliferative activities against A549 cell lines in vitro were evaluated using the MTT assay. Most of the compounds were found to possess significant inhibitory activities and compound I (R = 2-methoxypyrimidin-5-yl) (A) had the highest (IC₅₀ = 3.04 μM). Further studies on the mechanism demonstrated by (A) showed that it promotes apoptosis of A549 cells in a dose-dependent manner and reduces the mitochondrial membrane potential. Western blot results showed that the compound up-regulated the levels of Bax protein and down-regulated the level of Bcl-2 protein. Compared to the control group, the expression of cleaved-caspase 3 and cleaved-PARP in cells was significantly increased.

ChemistrySelect published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gui, Yue published the artcileCrystal Energy Landscape of Nifedipine by Experiment and Computer Prediction, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Crystal Growth & Design (2022), 22(2), 1365-1370, database is CAplus.

The six polymorphs of nifedipine (NIF) known at present have been discovered over the past 50 years, and the most recent one (δ), discovered in 2020, came from an unusual route. This polymorph is ranked second in thermodn. stability but evaded all previous workers until its melt was seeded with the crystal of a foreign substance, felodipine, in which the mol. has a different conformation from all other NIF polymorphs known at that time. Given this unusual discovery in the lab, we investigated whether crystal structure prediction (CSP) can find this and other polymorphs in a “routine” search. We show that our CSP finds all ordered polymorphs of NIF known at present as low-energy structures (Ranks 1, 3, 4, and 43), including the most recent one unveiled by pseudoseeding (Rank 4). NIF being a flexible mol., it is of interest to learn which of its many conformers provides the best building block for crystals. An exptl. investigation of this question is limited by survival; i.e., information exists on the structures that are observed but not on those that are difficult to observe or not yet discovered. In this regard, our “computer experiments” access the full range of possibilities. We find that the synperiplanar (sp) conformer with respect to Ph torsion produces lower-energy crystals than the antiperiplanar (ap) conformer, with the most stable ap crystal being 4 kJ/mol higher in energy than the most stable sp structure. Exptl., the sp conformer dominates the ap in solution and is the only conformer observed in crystals. With respect to the ester torsions, the cis/trans conformer produces the lowest-energy crystals, followed by the cis/cis conformer and by the trans/trans conformer. Exptl., five of the six known polymorphs contain the cis/trans conformer, one contains the cis/cis conformer, and none contain the trans/trans conformer. Overall, the CSP is remarkably successful in predicting the polymorphs of NIF in spite of its complex conformational space and provides a quant. assessment of the relative costs of employing different conformers as units of crystal building.

Crystal Growth & Design published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Quan, Zheng-Jun published the artcilePalladium(II) catalyzed Suzuki/Sonogashira cross-coupling reactions of sulfonates: an efficient approach to C2-functionalized pyrimidines and pyridines, Synthetic Route of 89076-64-2, the publication is European Journal of Organic Chemistry (2013), 2013(31), 7175-7183, database is CAplus.

Pyrimidin-2-yl sulfonates, as a reaction partner, can be easily prepared from inexpensive com. materials and are efficiently cross-coupled with arylboronic acids and terminal alkynes by using Pd(OAc)₂-catalyzed Suzuki and Sonogashira reactions. A wide array of C2-functionalized pyrimidines have been prepared in good to excellent yields. 2-Arylpyridines and 2-(oct-1-ynyl)pyridine were also synthesized.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Synthetic Route of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nara, Susheel J. published the artcileDiscovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2022), 65(13), 8948-8960, database is CAplus and MEDLINE.

While several farnesoid X receptor (FXR) agonists under clin. investigation for the treatment of nonalcoholic steatohepatitis (NASH) have shown beneficial effects, adverse effects such as pruritus and elevation of plasma lipids have limited their clin. efficacy and approvability. Herein, we report the discovery and preclin. evaluation of compound 32 (BMS-986339), a nonbile acid FXR agonist with a pharmacol. distinct profile relative to our previously reported agonist BMS-986318. Compound 32 exhibited potent in vitro and in vivo activation of FXR, albeit with a context-dependent profile that resulted in tissue-selective effects in vivo. To our knowledge, this is the first report that demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo. Compound 32 demonstrated robust antifibrotic efficacy despite reduced activation of certain genes in the liver, suggesting that the addnl. pharmacol. of BMS-986318 does not further benefit efficacy, possibly presenting an opportunity for reduced adverse effects. Further evaluation in humans is warranted to validate this hypothesis.

Journal of Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem