Category: pyridine-derivatives

Kaithal, Akash published the artcileCatalytic Hydrogenation of Cyclic Carbonates using Manganese Complexes, Synthetic Route of 338800-13-8, the publication is Angewandte Chemie, International Edition (2018), 57(41), 13449-13453, database is CAplus and MEDLINE.

Catalytic hydrogenation of cyclic carbonates to diols and methanol was achieved using a mol. catalyst based on earth-abundant manganese. The complex [Mn(CO)₂(Br)][HN(C₂H₄PⁱPr₂)₂] 1 comprising com. available MACHO ligand is an effective pre-catalyst operating under relatively mild conditions (T=120 °C, p(H₂)=30-60 bar). Upon activation with NaO^tBu, the formation of coordinatively unsaturated complex [Mn(CO)₂][N((C₂H₄PⁱPr₂)₂)] 5 was spectroscopically verified, which confirmed a kinetically competent intermediate. With the pre-activated complex, turnover numbers up to 620 and 400 were achieved for the formation of the diol and methanol, resp. Stoichiometric reactions under catalytically relevant conditions provide insight into the stepwise reduction form the CO₂ level in carbonates to methanol as final product.

Angewandte Chemie, International Edition published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Synthetic Route of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nappi, Manuel published the artcileSelective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis, Computed Properties of 89076-64-2, the publication is Journal of the American Chemical Society (2020), 142(51), 21484-21492, database is CAplus and MEDLINE.

Selective chem. that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp³)-H bond in the Me group of N6-Me deoxyadenosine and N6-Me adenosine, epigenetic modifications of emerging importance. A carefully orchestrated reaction combines reduction of a nitropyridine to form a nitrosopyridine spin-trapping reagent and an exquisitely selective tertiary amine-mediated hydrogen-atom abstraction at the N6-Me group to form an α-amino radical. Cross-coupling of the putative α-amino radical with nitrosopyridine leads to a stable conjugate, installing a label at N6-methyl-adenosine. We show that N6-Me deoxyadenosine-containing oligonucleotides can be enriched from complex mixtures, paving the way for applications to identify this modification in genomic DNA and RNA.

Journal of the American Chemical Society published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Computed Properties of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Olson, Kirk L. published the artcileNovel amide and imidazole compounds as potent hematopoietic prostaglandin D₂ synthase inhibitors, COA of Formula: C5H6BNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127759, database is CAplus and MEDLINE.

In seeking novel and potent small mol. hematopoietic prostaglandin D₂ synthase (H-PGDS) inhibitors as potential therapies for PGD₂-mediated diseases and conditions, we explored a series comprising multiple aryl/heteroaryl rings attached in a linear arrangement. Each compound incorporates an amide or imidazole “linker” between the pyrimidine or pyridine “core” ring and the “tail” ring system. We synthesized and screened twenty analogs by fluorescence polarization binding assay, thermal shift assay, glutathione S-transferase inhibition assay, and a cell-based assay measuring suppression of LPS-induced PGD₂ stimulation. Amide analogs show ten-fold greater shift in the thermal shift assay in the presence of glutathione (GSH) vs. the same assay run in the absence of GSH. The imidazole analogs did not produce a significant change in thermal shift between the two assay conditions, suggesting a possible stabilization effect of the amide linker in the synthase-GSH-inhibitor complex. Imidazole analog 23, (KMN-010034) demonstrates superior potency across the in vitro assays and good in vitro metabolic stability in both human and guinea pig liver microsomes.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhou, Min published the artcileFingerprinting pharmaceuticals of multiple sources at a provincial watershed scale, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Science of the Total Environment (2022), 153356, database is CAplus and MEDLINE.

Pharmaceutical residues in the aquatic environment have increasingly attracted public concerns but their fingerprint of sources remain unclear at a watershed scale. This study systematically explored pharmaceutical residues in effluent of 8 different type of sources in a provincial watershed in China using a multi-category protocol of pharmaceutical quantification. Seventy-seven out of 94 target compounds from 6 categories were quantified in effluent, up to 71,318 ng L^-1 in total from urban hospital sources with 20 antibiotics and 32 others. The spectrum of the quantified compounds in effluent significantly differentiated the urban (hospitals, domestic sewages, and WWTPs), rural (health centers and domestic sewages), and agricultural production sources (poultry and swine breeding yards, aquaculture ponds, and paddy fields). Compounds of non-steroidal anti-inflammation drugs (NSAIDs), cardiovascular drugs (CVs), and central nervous drugs (CNs) could fingerprint the three groups of sources. However, the three categories contributed 7 out of 10 compounds with high risk (risk quotient >1.0) to the aquatic environment identified by the eco-environmental risk assessment. No high-risk compounds were identified in effluent of urban WWTPs. Findings of this study suggest source identification and compound spectrum fingerprinting are crucial for studies on pharmaceutical residues in the aquatic environment, especially the complexity of pharmaceutical residues in source effluents for exploring source-sink dynamics at a watershed scale.

Science of the Total Environment published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C9H12O, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lei, Tao published the artcileDiscovery of the Potent Phosphoinositide 3-Kinase d (PI3 K d) Inhibitors, SDS of cas: 197958-29-5, the publication is ChemistrySelect (2020), 5(1), 196-200, database is CAplus.

The PI3Kd plays a pivotal role in regulating immune cell function and has recently emerged as a promising therapeutic target in treating various diseases, which draw more and more attention to discover potent PI3Kd inhibitors in recent years. Starting from structure-based drug design, a series of derivatives were designed and synthesized as new chemotypes of PI3Kd inhibitors. The potential compounds were structurally optimized by interaction showed in docking study. In cell-free kinase activity assays, Homogeneous Time-Resolved Fluorescence Assay (HTRF) method was performed for evaluating the inhibitory activities against PI3Kd. Interestingly, the representative compound 4 exhibited potent PI3Kd activity (IC₅₀=72 nM), which is comparable to that of pos. compound TGR1202. Furthermore, compound 4 showed 15-fold water solubility than TGR1202. In addition, the tests of compound 4 on anti-cancer activity against jeko-1 cancer cell line and cytotoxicity against peripheral blood mononuclear cell (PBMC) suggested high inhibition activity and low toxicity resp. A series of experiments indicated that compound 4 possessed novel chem. structure and high-efficiency PI3Kd inhibition activity, deserving further structural optimization to develop highly potent PI3Kd inhibitors.

ChemistrySelect published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, SDS of cas: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yamada, Masanori published the artcileProton conductivity of zwitterionic-type molecular solids under intermediate temperature and anhydrous conditions, HPLC of Formula: 636-73-7, the publication is Chemical Physics Letters (2005), 402(4-6), 324-328, database is CAplus.

Anhydrous proton conducting material for polymer electrolyte membrane fuel cell (PEFC) was prepared by the mixing of zwitterionic-type mol. solid 3-pyridinesulfonic acid (PS) and organic acid methylenediphosphonic acid (MP). As a result, PS mol., which has a sulfonic acid and a pyridine group in its structure, showed the proton conductivity of 4 × 10^-5 S cm^-1 at 160°C under anhydrous condition. Surprisingly, by the mixing of MP to PS material, the PS-MP composite material exhibited a conductivity of 2 × 10^-3 S cm^-1. Also, the conductivity of PS-MP composite material did not decrease under the heating at 160° for 50 h.

Chemical Physics Letters published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C11H14O4, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gyton, Matthew R. published the artcileA convenient method for the generation of {Rh(PNP)}⁺ and {Rh(PONOP)}⁺ fragments: reversible formation of vinylidene derivatives, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Dalton Transactions (2019), 48(9), 2877-2880, database is CAplus and MEDLINE.

The substitution reactions of [Rh(COD)₂][BAr^F₄] with PNP and PONOP pincer ligands 2,6-bis(di-tert-butylphosphinomethyl)pyridine and 2,6-bis(di-tert-butylphosphinito)pyridine in the weakly coordinating solvent 1,2-F₂C₆H₄ are an operationally simple method for the generation of reactive formally 14 VE rhodium(I) adducts in solution Application of this methodol. enables synthesis of known adducts of CO, N₂, H₂, previously unknown water complexes, and novel vinylidene derivatives [Rh(pincer)(CCHR)][BAr^F₄] (R = tBu, 3,5-tBu₂C₆H₃), through reversible reactions with terminal alkynes.

Dalton Transactions published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Renaud, Justin B. published the artcileNormalization of LC-MS mycotoxin determination using the N-alkylpyridinium-3-sulfonates (NAPS) retention index system, Category: pyridine-derivatives, the publication is Journal of Chromatography A (2021), 461901, database is CAplus and MEDLINE.

A major challenge for LC-MS anal. is the ability to compare data between laboratories and across instrument platforms. Currently, mycotoxin determination relies on dereplication strategies based on physicochem. properties such as the m/z of the precursor and product ions. Unlike these intrinsic properties, retention time (tR) is an extrinsic property impacted by LC conditions, including mobile phases and column chem., making exchange of data between groups difficult. To address this, we are introducing the concept of incorporating an electrospray compatible, retention index (RI) system based on a series of N-alkylpyridinium-3-sulfonates (NAPS) into routine mycotoxin determination These standards of differing alkyl chain length span RI units from 100 to 2000, are UV active and have fixed pos. and neg. charges for electrospray ionization in either mode. Using high resolution LC-MS/MS, the RIs of 96 mycotoxins and fungal secondary metabolites were normalized as a proof of concept with the NAPS RI system under multiple pH, column and gradient chromatog. conditions. This method was then applied to the anal. of a crude extract of Penicillium roqueforti, where we were able to decrease the number of false positives by implementing an RI filter as well as a secondary correction factor. Addnl., we developed software that allows users to convert published RIs to a predicted tR values. Integration of the NAPS RI system into routine LC-MS anal. will improve compound identifications and help facilitate ease of data sharing.

Journal of Chromatography A published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tsuruta, Keisuke published the artcileElectrochemical Condensation of Methylviologen on Specifically-adsorbed Anion Layers, Product Details of C22H18Cl2N2, the publication is Electroanalysis (2019), 31(6), 1150-1154, database is CAplus.

The adsorption of methylviologen dications (MV²⁺) on single-crystalline Au electrodes in both H₂SO₄ and HClO₄ was examined MV²⁺ strongly interacted with sulfate and bisulfate anions adsorbed on the Au(111) electrode surface in 0.05 M H₂SO₄ under a controlled potential of 1.25 V vs. the reversible hydrogen electrode (RHE). A characteristic non-Faradaic current was observed at 1.10 V vs. RHE. When adsorption of MV²⁺ was carried out in 0.1 M HClO₄, the electrochem. response of MV²⁺ was less than that obtained in H₂SO₄. The results show that the formation of a highly ordered sulfate/bisulfate adlayer plays an important role in the formation of condensed MV²⁺ layers. Examination of polycrystalline Au and Au(100) electrodes revealed a poor electrochem. response due to the surface roughness of the Au substrate, but the electrochem. detection was applicable to polycrystalline Au electrodes. A systematic investigation of the structural dependency of viologen derivatives showed that mol. size is important for electrostatic interactions with a highly ordered sulfate/bisulfate adlayer. The findings of the present study demonstrate successful detection of MV²⁺ at a concentration of â‰? pM with a non-Faradaic current.

Electroanalysis published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C6H9BN2O2, Product Details of C22H18Cl2N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Umemoto, Teruo published the artcileSyntheses and properties of N-fluoropyridinium salts, Safety of 1-Fluoropyridiniumtriflate, the publication is Bulletin of the Chemical Society of Japan (1991), 64(4), 1081-92, database is CAplus.

Various stable N-fluoropyridinium salts with a non- or weakly nucleophilic counter anion such as triflate, FSO₃^–, BF₄^–, SbF₆^–, ClO₄^–, CH₃SO₃^– etc., or with an electron-donating or -withdrawing substituent(s) on the pyridine ring were synthesized and their properties investigated. N-Fluoropyridinium-2-sulfonates, N-fluoroquinolinium triflate, and highly hindered N-fluoro-2,6-di-tert-butylpyridinium salts were also synthesized. They were synthesized by counter anion displacement reactions of unstable pyridine-F₂ compounds, fluorination of salts of pyridines with protonic acids or silyl esters with F, and/or fluorination of Lewis acid complexes of pyridines. The scope of each method was examined in detail. The stability of the N-fluoropyridinium salts depended on the nucleophilicity or basicity of the counter anions and electronic nature or position of the ring substituents. These results and NMR analyses clearly showed the unstable pyridine-F₂ compounds to have N-fluoropyridinium fluoride salt structure. Some N-fluoropyridinium triflates were hydrolyzed and the products were examined, suggesting a unique hydrolysis mechanism. The authors warn of the toxicity of fluorine.

Bulletin of the Chemical Society of Japan published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C9H12O, Safety of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem