Category: pyridine-derivatives

Mohamad, Ahmad Desoky M. published the artcileTemperature and salt effects of the kinetic reactions of substituted 2-pyridylmethylene-8-quinolyl iron (II) complexes as antimicrobial, anti-cancer, and antioxidant agents with cyanide ions, Product Details of C12H9NO, the publication is Canadian Journal of Chemistry (2021), 99(9), 763-772, database is CAplus.

Kinetics of substitution reaction of three high-spin pyridylmethylene-8-quinolyl iron (II) complexes by CN^– ions were studied spectrophotometrically in various ratios of aqueous-methanol binary mixtures at 298 ± 0.2 K. Kinetics of the substitution reaction follow the rate law (k₂[CN^–][complex]) on applying of the conditions of the pseudo first order reaction. Reactivity of the reaction was investigated in terms of ligand moiety and solvent effects. The rate of the reaction increased as the co-solvent methanol ratio increased. This reactivity trend is predominantly due to increases in the activity coefficient of those hydrophobic complexes in the organic methanol co-solvent, depending upon the hydrophobicity of the substituent groups (R) in the coordinated ligand in the complexes. Reactivity trends of the prepared complexes in the presence of the inserted hydrophobic salts such as tetrabutylammonium bromide (TBAB), tetraethylammonium bromide (TEAB), and tetramethylammonium bromide (TMAB) or hydrophilic salt potassium bromide (KBr) were studied. The observed decrease in the rate constants with increasing salt concentration was due to the cationic character of the reacting complexes. In addition, the synthesized compounds were tested for antimicrobial activity against selected strains of microbes. The results showed that the order of reactivity of the investigated complexes against the selected microbes were as follows: ppaqFe > paaqFe > pmaqFe. In addition, the investigated ligands and their Fe(II) complexes were screened for anticancer activities against several cell lines of cancer. The ppaqFe complex showed the best cytotoxic efficiency against the selected cancer lines (IC₅₀ = 8.75-21.50μg/μl), whereas the pmaq ligand showed the lowest cytotoxic efficiency (IC₅₀ = 58.25- 72.40). Furthermore, the antioxidant potential of the presented compounds was studied by applying DPPH assays and showed a potential activity compared with standard vitamin C. The excellent antimicrobial and anticancer activities of the investigated Fe(II) chelates compared with literature values are promising and deserve further study.

Canadian Journal of Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sayed, Ahmed M. published the artcileArylpyrazole as selective anti-enterococci; synthesis and biological evaluation of novel derivatives for their antimicrobial efficacy, HPLC of Formula: 197958-29-5, the publication is Journal of Heterocyclic Chemistry, database is CAplus.

Condensation of the 1-(1-[4-substituted aryl]phenyl-5-methyl-1H-pyrazol-4-yl)ethan-1-ones with the aminoguanidinehydrochloride gave target compounds 2-(1-(1-(4-[aryl or alkyl] phenyl)-5-methyl-1Hpyrazol-4-yl)ethylidene)hydrazine-1-carboximidamides I [R = Ph, Bn, 4-MeC₆H₄, etc.]. Exploring the structure-activity relationships (SAR) of a new set of phenylpyrazoles I [R = Ph, Bn, 4-MeC₆H₄, etc.] unveiled a potential anti-enterococcus lead compound I [R = benzofuran-2-yl]. The benzofuran moiety linked to the phenylpyrazole I [R = benzofuran-2-yl] was 32 times better than vancomycin against Enterococcus fecalis ATCC 51299. Besides, compound I [R = benzofuran-2-yl] is expected to have an excellent oral bioavailability according to the in silico studies. In SAR anal., it was found that the benzofuran side chain was essential for the activity. Changing the benzofuran with either benzothiophene, Ph, pyridinyl, tolyl, or naphthyl reduces/nullifies the pharmacol. action. Besides the anti-enterococcal activity, derivatives I [R = furan-2-yl, Ph] could be used to develop new broad-spectrum antibiotics as they exhibited activity against the wild-type highly virulent Escherichia coli isolate. Moreover, compound I [R = benzothiophen-2-yl] was proved to show antifungal activity (MIC = 4 μg/mL) against the Candida albicans SS5314 (wild type).

Journal of Heterocyclic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, HPLC of Formula: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rayder, Thomas M. published the artcileA Bioinspired Multicomponent Catalytic System for Converting Carbon Dioxide into Methanol Autocatalytically, Computed Properties of 338800-13-8, the publication is Chem (2020), 6(7), 1742-1754, database is CAplus.

Nature utilizes multicomponent catalyst systems to convert simple, abundant starting materials into complex mols. that are essential for life. In contrast, synthetic chem. transformations rarely adopt this strategy because it is difficult to replicate the sophisticated supramol. assemblies used by biol. for active-site separation and substrate trafficking. Here, we describe a method for multicomponent catalyst separation that involves encapsulating transition-metal complexes in nanoporous materials called metal-organic frameworks. The multicomponent catalyst system was highly active for converting hydrogen and carbon dioxide to methanol, and it could be formulated to be readily recyclable. Moreover, we uncovered an autocatalytic feature that was possible only when we utilized the multicomponent catalyst strategy. These results open avenues for obtaining fuel from abundant and renewable resources.

Chem published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Computed Properties of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saifuddin, Mohammad published the artcileWater-accelerated cationic π-(7-endo) cyclization: application to indole-based Peri-annulated polyheterocycles, Quality Control of 39856-58-1, the publication is European Journal of Organic Chemistry (2010), 5108-5117, S5108/1-S5108/27, database is CAplus.

An efficient and versatile method for the synthesis of indole-based polycyclic indolo-benzazepine and its derivatives e. g., I, II through water-accelerated cationic π-cyclization is described. The strategy involves condensation of arylamine moieties linked to C-4 in indole/azaindole systems with arylaldehydes in water containing catalytic amount of Bronsted acids. The C-C bond formation in water is complete within 10-30 min, furnishing the title compounds in excellent yields and purities, whereas in organic solvents 10-12 h are required. Furthermore, aldehydes both with electron-donating and-withdrawing substituents facilitate the π-cyclization equally.

European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Quality Control of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Duroux, Romain published the artcileAntagonists of the adenosine A_2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity, Application In Synthesis of 197958-29-5, the publication is European Journal of Medicinal Chemistry (2018), 151-163, database is CAplus and MEDLINE.

The authors have recently reported a series of 2-furoyl-benzoxazoles as potential A_2A adenosine receptor (A_2AR) antagonists. Two hits were identified with interesting pharmacokinetic properties but were find to bind the hA_2AR receptor in the micromolar-range. Herein, to enhance affinity toward the hA_2AR, the authors explored the C5- and C7-position of the hits based on docking studies. These modifications led to compounds with nanomolar-range affinity (e.g., 6a (2,7-di(furan-2-yl)benzoxazol-5-amine), Ki = 40 nM) and high antagonist activity (e.g., 6a, IC₅₀ = 70.6 nM). Selected compounds also exhibited interesting in vitro DMPK (Drug Metabolism and Pharmacokinetics) properties including high solubility and low cytotoxicity. Therefore, the benzoxazole ring appears as a highly effective scaffold for the design of new A_2A antagonists.

European Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Linxiao published the artcileSulfate promotion of selective catalytic reduction of nitric oxide by ammonia on ceria, SDS of cas: 636-73-7, the publication is Catalysis Science & Technology (2019), 9(8), 1802-1815, database is CAplus.

NO selective catalytic reduction by NH₃ (NH₃-SCR) is a promising technol. to control NO_x emissions. A recently discovered sulfate promotion effect in this reaction was thoroughly examined over CeO₂. Sulfates from different organic S precursors all exhibited a promoting effect. Mechanistic studies generated a reaction network which included Langmuir-Hinshelwood and Eley-Rideal mechanisms. Sulfates were shown to be versatile promoters with multiple functions: tuning reactant adsorption toward a more balanced intermediate coverage by creating strong Lewis acid sites; facilitating *NH₂ formation; and suppressing NH₃ ammonia oxidation via oxygen deactivation. A comparison between sulfates and the classic inorganic promoter, FeO_x, showed sulfates are more effective, particularly at high temperature This was mainly attributed to the high coverages of Eley-Rideal intermediates and low NH₃ oxidation activity on sulfated CeO₂. This work provided a fundamental understanding of the role of surface sulfates in NH₃-SCR; essential under actual operation conditions. This understanding presents an opportunity to design future catalysts with high durability and low cost.

Catalysis Science & Technology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Principe, Daniel R. published the artcileCalcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Proceedings of the National Academy of Sciences of the United States of America (2022), 119(18), e2200143119, database is CAplus and MEDLINE.

There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC). While palliative chemotherapy offers a survival benefit to most patients, nearly all will eventually progress on treatment and long-term survivability remains poor. Given the lack of subsequent line treatment options, in this study, we sought to identify novel strategies to prevent, delay, or overcome resistance to gemcitabine, one of the most widely used medications in PDAC. Using a combination of single-cell RNA sequencing and high-throughput proteomic anal., we identified a subset of gemcitabine-resistant tumor cells enriched for calcium/calmodulin signaling. Pharmacol. inhibition of calcium-dependent calmodulin activation led to the rapid loss of drug-resistant phenotypes in vitro, which addnl. single-cell RNA sequencing identified was due to impaired activation of the RAS/ERK signaling pathway. Consistent with these observations, calcium chelation or depletion of calcium in the culture media also impaired ERK activation in gemcitabine-resistant cells, and restored therapeutic responses to gemcitabine in vitro. We observed similar results using calcium channel blockers (CCBs) such as amlodipine, which inhibited prosurvival ERK signaling in vitro and markedly enhanced therapeutic responses to gemcitabine in both orthotopic xenografts and transgenic models of PDAC. Combined, these results offer insight into a potential means of gemcitabine resistance and suggest that select CCBs may provide a clin. benefit to PDAC patients receiving gemcitabine-based chemotherapy.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Iwasawa, Tetsuo published the artcileExperimental and Computational Probes of a Self-Assembled Capsule, Synthetic Route of 85237-71-4, the publication is Organic Letters (2006), 8(14), 2925-2928, database is CAplus and MEDLINE.

This research was undertaken to explore the interior surface of a synthetic receptor 1.1 with arylpyridines as guests. The interior surface differentiates the guests through the recognition of their nitrogen atoms. Exptl. and computational analyses revealed that there is a delicate balance of attractions and repulsions between the host and the lone pairs of guests.

Organic Letters published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Synthetic Route of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kiani, Adeleh published the artcileDirect synthesis of sulfonyl azides from sulfonic acids, Application In Synthesis of 636-73-7, the publication is Journal of Sulfur Chemistry (2014), 35(2), 119-127, database is CAplus.

A one-pot process for the synthesis of various sulfonyl azides (RSO₂N₃) by treating sulfonic acids with PPh₃-trichloroisocyanuric acid-sodium azide at room temperature was described. A wide range of arenesulfonyl and alkanesulfonyl azides was obtained in excellent yields under mild conditions.

Journal of Sulfur Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dropinski, James F. published the artcileSynthesis and biological activities of novel arylindole-2-carboxylic acid analogs as PPARγ partial agonists, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(22), 5035-5038, database is CAplus and MEDLINE.

A series of novel arylindole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chem. synthesis and in vitro activities are discussed. The indole I was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

Bioorganic & Medicinal Chemistry Letters published new progress about 870459-90-8. 870459-90-8 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, and the molecular formula is C6H5BF3NO2, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem