Category: pyridine-derivatives

On October 20, 2010, Lamberto, Massimiliano; Rastede, Elizabeth E.; Decker, Justyne; Raymo, Francisco M. published an article.Computed Properties of 52243-87-5 The title of the article was Microwave-assisted synthesis of symmetric and asymmetric viologens. And the article contained the following:

Viologens are generally synthesized by N-alkylating 4,4′-bipyridine with alkyl halides. Under conventional heating conditions, however, their synthesis suffers from long reaction times and, often, low yields. In this work, sym. and asym. viologens were synthesized under the assistance of microwave irradiation in good to excellent yields and in short reaction times. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Computed Properties of 52243-87-5

The Article related to sym asym viologen microwave assisted synthesis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 30, 2007, Rao, Chepuri R. K.; Trivedi, D. C. published an article.Synthetic Route of 636-73-7 The title of the article was Tailoring the gold-polypyrrole nanostructures at water-toluene interphase. And the article contained the following:

A method is described to obtain gold-polypyrrole nanostructures by reacting gold chloride with pyrrole at toluene-water interphase. By adjusting the concentration of the stabilizer, namely, pyridine-3-sulfonate, the shape of the nanostructures formed at the interphase can be tailored. This novel method facilitates the fabrication of Au-Ppy composite material that gives wider scope for biosensing applications. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Synthetic Route of 636-73-7

The Article related to gold polypyrrole nanocomposite biosensor, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Synthetic Route of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1985, Tsiropoulos, G. J. published an article.Computed Properties of 636-73-7 The title of the article was Dietary administration of antivitamins affected the survival and reproduction of Dacus oleae. And the article contained the following:

Fifteen antivitamins were tested, at various concentrations, on the adult olive fruit fly, D. oleae. Fly survival was affected by the following antivitamins, indicating in parenthesis the antagonized vitamin: benzimidazole  [51-17-2] (B-12), α-picolinic acid  [98-98-6] (nicotinic acid), deoxypyridoxine  [61-67-6] (pyridoxine), neopyrithiamine  [534-64-5] (thiamin), and α-tocopherol quinone  [7559-04-8] (vitamin E). Egg production was significantly reduced by the same antivitamins, plus, dl-desthiobiotin  [636-20-4] (biotin), aminopterin  [54-62-6] (folic acid), isonicotinic acid  [55-22-1], nicotinic acid diethylamide  [59-26-7] (nicotinic acid), and dehydroascorbic acid  [490-83-5] (vitamin C). Fertility was significantly affected by: benzimidazole (B-12), dl-desthiobiotin (biotin), aminopterin (folic acid), isonicotinic acid (nicotinic acid), deoxypyridoxine (pyridoxine), neopyrithiamine (thiamin), tocopherol quinone (vitamin E), and dehydroascorbic acid (vitamin C). The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to dacus feed antivitamin reproduction, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 6, 1996, Suzuki, Masashi published a patent.Formula: C7H10N2 The title of the patent was Preparation of methylaminopyridine derivatives in high-yield. And the patent contained the following:

The title compounds (I; R = C1-4 alkyl, n = 1-2, X = NHMe) can be efficiently and economically produced by reaction of I (X = NH2, R, n = same as above) with a mixture of (HCO)2O and (AcO)2O or with HCO2H in the presence of (AcO)2O, followed by reduction of formyl group. I are useful intermediates in the production of drugs and pesticides. Thus, I (Rn = 4-Me and 6-Me, X = NH2) was reacted with HCO2H in the presence of (AcO)2O to give 85% I (Rn = 4-Me and 6-Me, X = NHCHO), which was reduced by LiAlH4 to give 97% I (Rn = 4-Me and 6-Me, X = NHMe). The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Formula: C7H10N2

The Article related to methylaminopyridine preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaji, Ayumi; Hashimoto, Yoshitaka; Sakai, Ryosuke; Okada, Hiroshi; Hamaguchi, Masahide; Ushigome, Emi; Majima, Saori; Yamazaki, Masahiro; Fukui, Michiaki published an article in 2019, the title of the article was Frequent usage of convenience stores is associated with low diet quality.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

In Japan, convenience stores are more common, and it is thus more important to assess whether people use convenience stores than the d. or availability of the convenience stores. In this cross-sectional study of patients with type 2 diabetes, the association between the usage of the convenience stores and dietary habits or the prevalence of hypertension was evaluated. Among the 206 men and 161 women in the study, 24 men and 9 women used convenience stores three or more times per wk. Fruit and vegetable intake (men, 132 (102-191) vs. 192 (128-267) g/1000 kcal, p = 0.019; and women, 178 (132-207) vs. 239 (172-313) g/1000 kcal, p = 0.063) of patients who frequently use convenience stores was lower compared to those who did not. Net endogenous acid production score (men, 55.2 (45.4-65.2) vs. 48.9 (42.3-56.8) mEq/day, p = 0.013; and women, 56.9 (52.6-59.8) vs. 46.3 (40.9-54.0) mEq/day, p = 0.050) and intake of carbohydrate to fiber ratio (men, 21.5 (20.0-29.3) vs. 19.9 (15.7-25.0), p = 0.052; and women, 21.0 (18.9-23.9) vs. 16.2 (13.8-20.3), p = 0.017) of patients who frequently use convenience stores were higher compared to those who did not. Addnl., frequent usage of convenience stores was associated with the prevalence of hypertension after adjusting for covariates (5.01; 95% confidence interval, 1.12-22.50; p = 0.035). In conclusion, frequent usage of convenience stores is associated with low diet quality and the prevalence of hypertension. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to diabetes convenience store low diet quality, convenience store, diet quality, food environment, habitual diet intake, lifestyle, type 2 diabetes, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhagat, Rakshanda; Sheikh, Amir Amin; Dar, Rouf Rashid; Dogra, Pooja; Islam, Sheikh Tajamul published an article in 2017, the title of the article was A clinical case of ear canker and alopecia in a rabbit.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

A two year old male rabbit was presented with history of itching; rough hair coat and hair fall from last 15 days with reddish brown crust formation on ears, paws and around eyes. Skin scraping revealed the presence of Psoroptes cuniculi (ear mite) thus diagnosing the case of ear canker. Treatment with Ivermectin (Ivomec) @ 0.02mg/kg S.c. weekly for 4 wk, Pheniramine maleate (Avil) @ 0.5 mg/kg I.m. and topical application of honey and turmeric mix daily for 1 wk was accomplished which resulted in substantial clin. improvement recorded in terms of decreased frequency of itching, regained smooth hair coat and lusture of hair and skin. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to ear canker alopecia rabbit, Mammalian Pathological Biochemistry: Skin Diseases and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, T. D.; Phillips, D. C.; Smith, J. D. B. published an article in 1977, the title of the article was Organoparticulate analysis of amine arenesulfonates.Formula: C5H5NO3S And the article contains the following content:

Thermal decompn of PhSO3H, p-MeC2H4SO3H, 3-pyridinesulfonic acid, and 1-naphthalenesulfonic acid and of 17 amine salt derivatives were studied by the title method. Vapor phase association of the end product was observed The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to organoparticulate analysis decomposition arenesulfonate, sulfonate amine decomposition, Physical Organic Chemistry: Degradation Reactions and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 23, 2017, Watanabe, Atsushi; Sato, Yuuki; Ogura, Keiji; Tatsumi, Yoshiyuki published a patent.Synthetic Route of 25813-24-5 The title of the patent was Preparation of biaryl derivatives as antifungal agents and medicine containing them. And the patent contained the following:

Biaryl derivatives represented by general formula I (ring A, X1, X2, X3, Y, Z, R2a, R3, and Q are defined below) or salts thereof having excellent antifungal activity against Trichophyton, which is a major causative organism of superficial mycoses. Ring A, X1, X2, X3, Y, Z, Q, and R3 are defined as [ring A = each (un)substituted Ph or 5- or 6-membered heteroaryl each optionally fused to form (un)substituted condensed ring; Q = CH2, CF2, S(O), SO2, C(O), NH, or S; X1, X2, X3 = CR1 or N; Y = CH or N; Z = CR2b or N; R1 = H, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, or C1-6 haloalkoxy; R3 = H, halo, or each (un)substituted C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-7 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, or aralkyl]. R2a and R2b are defined as [R2a, R2b = H, halo, HO, cyano, formyl, pentafluorosulfanyl, Q1, or each (un)substituted C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-4 alkoxy-C1-4 alkyl, C1-4 alkoxy-C1-4 haloalkyl, C1-6 alkyl carbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyloxy, C3-7 cycloalkyl, heterocycloalkyl, heterocycloalkyloxy, C2-6 alkenyl, C2-6 alkenyloxy, C2-6 alkenyl-C1-6 alkyl, C2-6 alkenyl-C1-6 alkoxy, C2-6 alkenyloxy-C1-4 alkoxy, C2-6 alkenyloxy-C1-4 haloalkyl, C2-6 alkenyloxy-C1-4 haloalkoxy, C2-6 alkynyl, C2-6 alkynyloxy, C2-6 alkynyl-C1-6 alkyl, C2-6 alkynyl-C1-6 alkoxy, C2-6 alkynyloxy-C1-4 alkyl, C2-6 alkynyloxy-C1-4 alkoxy, C2-6 alkynyloxy-C1-4 haloalkyl, C2-6 alkynyloxy-C1-4 haloalkoxy, NH2, C1-6 alkylthio, C1-6 haloalkylthio; ring B = each (un)substituted carbocyclic or heterocyclic ring; L = a single bond, (CH2)p, O(CH2)p, (CH2)pO, (CH2)pO(CH2)q, NRc(CH2)p , (CH2)pNRc, or (CH2)pNRc(CH2)q; p, q = 1, 2, or 3; one or a plural number of H atoms of each (CH2)p or (CH2)q is optionally substituted with halo, C1-4 alkyl, or C3-7 cycloalkyl; Rc = H or C1-6 alkyl; when Z = CR2b, R2a and R2b together with the carbon atoms to which they are bonded form each (un)substituted carbocyclic or heterocyclic ring]. The biaryl derivatives I include arylpyridine or heterocyclylpyridine derivatives, e.g. 3-phenyl-2-[(pyridin-3-yl)oxy]pyridine, 2-[(pyridin-3-yl)oxy]-3,3′-bipyridine, 5-[2-[(pyridin-3-yl)oxy]pyridin-3-yl]isoquinoline, 8-[2-[(pyridin-3-yl)oxy]pyridin-3-yl]quinoline, 3-(2,3-dihydrobenzofuran-7-yl)-2-[(pyridin-3-yl)oxy]pyridine, 5-[2-[(pyridin-3-yl)oxy]pyridin-3-yl]quinoxaline, and 3-(chroman-8-yl)-2-[(pyridin-3-yl)oxy]pyridine derivatives Thus, etherification of 3-bromo-2-chloropyridine with 6-(trifluoromethyl)pyridin-3-ol in the presence of Cs2CO3 in DMSO with stirring at 120° for 18 h gave 76% 3-[(3-bromopyridin-2-yl)oxy]-6-(trifluoromethyl)pyridine (II). Coupling of II with 2-methoxyphenylboronic acid in the presence of bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) and Cs2CO3 in aqueous dioxane solution with stirring at 120° for 30 min under microwave irradiation gave 76% 3-(2-methoxyphenyl)-2-[[6-(trifluoromethyl)pyridin-3-yl]oxy]pyridine (III). III showed min. inhibitory concentration of ≤0.1 μg/mL against Trichophyton mentagrophytes and T. rubrum. The experimental process involved the reaction of 3,5-Dibromo-4-methoxypyridine(cas: 25813-24-5).Synthetic Route of 25813-24-5

The Article related to bipyridine phenylpyridine pyridylquinoline pyrimidinylpyridine heterocyclylpyridine preparation antifungal, biaryl preparation antifungal agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Synthetic Route of 25813-24-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 17, 2016, Kato, Taku; Sakamoto, Toshiaki; Niwa, Yasuki; Sawamoto, Daisuke; Ohtani, Naohito; Kanbe, Misaki published a patent.HPLC of Formula: 39919-70-5 The title of the patent was Preparation of aromatic carboxylic acid amides having TRPM8 blocking effect. And the patent contained the following:

Disclosed are compounds I [ring A = benzene or thiophene; X1 = CR11 or nitrogen atom; R11 = H or (un)substituted alkyl; X2, X3 = independently CH or nitrogen atom; ring C = monocyclic ring; R1 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; R1 is substituted on the adjacent position to the point of attachment to ring B; R2 = H, (un)substituted alkyl or halo; R3 = cyano, -Ra, -N(Rb)(Rc), etc.; Ra = (un)substituted alkyl, (un)substituted non-aromatic heterocycle-methyl-, (un)substituted alkenyl, etc.; Rb = (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, etc.; Rc = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; R4 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; n = 0 or 1; R5 = H, (un)substituted alkyl, hydroxy, etc.; when n is 1, R4 and R5, together with ring C, may combine to form a bicyclic ring; or pharmacol. acceptable salts thereof]. For example, compound II was prepared from 5-bromo-3-fluoropyridine-2-carboxylic acid Et ester via conversion into 3-iodo-5-[2-(trifluoromethyl)phenyl]pyridine-2-carboxylic acid followed by amidation with 5-amino-2-trifluoromethylpyridine and reaction with 5-methyl-2-pyrrolidone. In TRPM8 blocking test, 361-example of I showed IC50 values (nmol/L) ranging from 0.2 to 2760, e.g., IC50 of II was 4 nmol/L. Of note, compounds I are useful for the treatment of chronic pain. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).HPLC of Formula: 39919-70-5

The Article related to aromatic carboxylic acid amide preparation trpm8 blocker, chronic pain treatment aromatic carboxylic acid amide trpm8 blocking, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 7, 2017, Kato, Taku; Sakamoto, Toshiaki; Niwa, Yasuki; Sawamoto, Daisuke; Otani, Naohito; Kanbe, Misaki published a patent.COA of Formula: C9H14N2 The title of the patent was Preparation of aromatic carboxylic acid amides having TRPM8 blocking effect. And the patent contained the following:

Disclosed are compounds I [ring A = benzene or thiophene; X1 = CR11 or nitrogen atom; R11 = H or (un)substituted alkyl; X2, X3 = independently CH or nitrogen atom; ring C = monocyclic ring; R1 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; R1 is substituted on the adjacent position to the point of attachment to ring B; R2 = H, (un)substituted alkyl or halo; R3 = cyano, -Ra, -N(Rb)(Rc), etc.; Ra = (un)substituted alkyl, (un)substituted non-aromatic heterocycle-methyl-, (un)substituted alkenyl, etc.; Rb = (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, etc.; Rc = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; R4 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; n = 0 or 1; R5 = H, (un)substituted alkyl, hydroxy, etc.; when n is 1, R4 and R5, together with ring C, may combine to form a bicyclic ring; or pharmacol. acceptable salts thereof]. For example, compound II was prepared from 5-bromo-3-fluoropyridine-2-carboxylic acid Et ester via conversion into 3-iodo-5-[2-(trifluoromethyl)phenyl]pyridine-2-carboxylic acid followed by amidation with 5-amino-2-trifluoromethylpyridine and reaction with 5-methyl-2-pyrrolidone. In TRPM8 blocking test, 361-example of I showed IC50 values (nmol/L) ranging from 0.2 to 2760, e.g., IC50 of II was 4 nmol/L. Of note, compounds I are useful for the treatment of chronic pain. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).COA of Formula: C9H14N2

The Article related to aromatic carboxylic acid amide preparation trpm8 blocker, chronic pain treatment aromatic carboxylic acid amide trpm8 blocking, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C9H14N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem