Category: pyridine-derivatives

On October 16, 2008, Beaton, Graham; Chen, Mi; Coon, Timothy Richard; Ewing, Todd; Jiang, Wanlong; Lowe, Richard; Moree, Willy; Smith, Nicole; Wade, Warren; Zhao, Liren; Zhu, Yun-Fei; Rowbottom, Martin; Ashweek, Neil published a patent.Synthetic Route of 156267-13-9 The title of the patent was Preparation of benzenecarboxamide derivatives as Gonadotropin-releasing hormone receptor antagonists. And the patent contained the following:

Title compounds represented by the formula I [wherein A = pyridyl, Ph, quinolinyl, etc.; R1a = H, halo, alkyl, etc.; R1b, R1c = independently H, halo, OH, etc.; R1d = F, Cl, Me, CF3 or cyano; R2 = alkyl-(R5)p; R2a = (un)substituted Ph, (hetero)aryl or alkyl; R5 = independently H, OH, amino, etc.; p = 1-3; and stereoisomers, esters, solvates, and pharmaceutically acceptable salts thereof] were prepared as Gonadotropin-releasing hormone receptor (GnRH) antagonists. For example, II was provided in a multi-step synthesis starting from 3-bromo-4-chlorobenzoic acid. I were tested in one or more of the peptide competitive human receptor binding assays and showed Ki values of 1 μM or less. Thus, I and their pharmaceutical compositions are useful for the treatment of a variety of sex-hormone related conditions in both men and women. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Synthetic Route of 156267-13-9

The Article related to benzenecarboxamide pyridinyl preparation gonadotropin releasing hormone receptor antagonist, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Synthetic Route of 156267-13-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 1974, Fleckenstein, Erwin; Heinrich, Ernst; Mohr, Reinhard published a patent.HPLC of Formula: 51566-22-4 The title of the patent was Pyridine derivatives. And the patent contained the following:

Pyridine derivatives I (R and R1 = amino, alkoxy, alkylthio, CN, Cl) (642 compounds) were prepared by substitution reactions on I (R = R1 = Cl). The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).HPLC of Formula: 51566-22-4

The Article related to pyridine dichloro substitution, substitution dichloropyridine, dye intermediate poridine, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2015, Lebedeva, O. V.; Chesnokova, A. N.; Badlueva, T. V.; Sipkina, E. I.; Rzhechitskii, A. E.; Pozhidaev, Yu. N. published an article.Reference of Pyridine-3-sulfonic acid The title of the article was Hybrid ion-exchange membranes based on heteroaromatic sulfonic acid derivatives. And the article contained the following:

Membranes exhibiting proton conductivity have been prepared by sol-gel synthesis using tetraethoxysilane and heteroaromatic sulfonic acid derivatives (2-phenyl-5-benzimidazolesulfonic acid and 3-pyridinesulfonic acid) in the presence of phosphoric acid and polyvinyl butyral. The membranes are gels composed of a polyvinyl butyral polymer matrix with uniformly distributed particles of silica containing mols. of heteroaromatic sulfonic acid derivatives mech. incorporated in its network structure. The membranes synthesized from 2-phenyl-5-benzimidazolesulfonic acid or 3-pyridinesulfonic acid exhibit a conductivity of 0.1X10-2 or 0.55X10-2 S/cm at 353 K, an ion-exchange capacity of 2.70 or 1.84 mequiv/g, and a proton-transfer activation energy of 24.93 or 21.73 kJ/mol, resp.; at a relative water content of 50%, the tensile strength is 4 or 6 MPa and the elastic modulus is 128 or 191 MPa, resp. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Reference of Pyridine-3-sulfonic acid

The Article related to tetraethoxysilane heteroaromatic sulfonic acid derivative membrane mech elec property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Reference of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 21, 2018, Wang, Xiaoqin; Zhao, Chuping; He, Minghua; Zhong, Zhiqian; Chen, Jiahe; Wang, Yanchun; Wang, Maoqin published a patent.Formula: C10H10N4 The title of the patent was Preparation of 3,3′-disubstituted bipyridine derivative as anti-Alzheimer’s disease drug. And the patent contained the following:

This invention provides 3,3′-disubstituted dipyridine derivatives I and II [wherein R = H, OH, halo, etc.; R1 = O(CH2)mCH3 or OH; m and n = independently 0-3; R2 = alkyl, one or more Me or Et substituted amino, etc.]. The title compounds can be used in preparing drugs for prevention and/or treatment of Alzheimer’s disease, vascular dementia or myasthenia gravis disease. The invention has the advantages of low biotoxicity, good safety, and broad application space in preparing anti-Alzheimer’s disease drugs. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Formula: C10H10N4

The Article related to bipyridine treatment alzheimer disease vascular dementia myasthenia gravis human, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C10H10N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van der Does, L.; Den Hertog, H. J. published an article in 1972, the title of the article was Didehydrohetarenes. XXV. Amination of alkyl substituted halopyridines with potassium amide in liquid ammonia.Quality Control of 6-(tert-Butyl)pyridin-3-amine And the article contains the following content:

The action of KNH2 in liquid NH3 on Me substituted 3- and 4-bromo(or chloro)pyridines, of 5-bromo-2-tert-butylpyridine and of 3-bromo(or chloro) and 4-bromo(or chloro)-2,6-dimethylpyridine was studied. The results of the reactions indicate the occurrence of derivatives of 3,4-didehydropyridine as intermediates. An interpretation is given of the influence of the substituent and the hetero atom on the course of the aminations. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Quality Control of 6-(tert-Butyl)pyridin-3-amine

The Article related to hetarene didehydro, amination alkylhalopyridine, pyridine alkylhalo amination, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 26, 1976, there was a patent about herbicides.Category: pyridine-derivatives The title of the patent was Herbicidal quaternary bipyridylium salts. And the patent contained the following:

The salts I (R, R1 = alkyl, alkenyl, alkynyl, substituted alkyl; X, X1 = Cl, Br, iodo, 4-MeC6H4SO3) (104 compounds) were prepared by quaternization. Thus 4,4′-bipyridine was treated with EtI and 4-(4-pyridyl)pyridinium ethiodide treated with CH2:CMeCH2I to give I (R = Et, R1 = CH2CMe:CH2, X = X1 = iodo). At 1 kg/ha I (R = Et, R1 = CH2CMe:CH2, X = X1 = iodo) post emergence gave ∼80% control of Avena fatua. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Category: pyridine-derivatives

The Article related to bipyridinium salt, quaternary bipyridinium salt, herbicide bipyridinium salt, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 2008, Glatthar, Ralf; Johns, Donald; Umbricht, Daniel published a patent.Application of 85614-89-7 The title of the patent was Preparation of pyridine derivatives as modulators of metabotropic glutamate receptors. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 – (un)substituted alkyl or benzyl; R2 = H, alkyl or (un)substituted benzyl; or R1R2N = (un)substituted heterocyclyl; R3 = halo, alkoxy, alkyl(amino) or dialkylamino; R4 = OH, halogen, alkyl or alkoxy; Q = CH, CR4 or N; V = CH, CR4 or N; W = CH, CR4 or N; X = CH or N; Y = CH, CR3 or N; Z = CH2, NH or O; provided that Q, V and W are not N at the same time; and in free base or acid addition salt form] were prepared as metabotropic glutamate receptors (mGluR) antagonist, especially mGluR5 antagonist,. For example, reaction of 6-chloro-N,N-diethylnicotinamide with 4-chloroaniline gave II in 56% yield. I were tested for inhibition of the glutamate induced elevation of intracellular Ca2+-concentration at a concentration of 10 μM, and I were also in clin. testing. Thus, I and their pharmaceutical compositions are useful as mGluR modulator for the treatment, prevention or delay of progression of cognitive dysfunction. The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application of 85614-89-7

The Article related to pyridine derivative preparation metabotropic glutamate receptor modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 85614-89-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 2013, Raghu, M. S.; Basavaiah, K.; Abdulrahaman, Sameer A. M.; Prashanth, K. N.; Vinay, K. B. published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite. And the article contained the following:

Two simple, selective and sensitive spectrophotometric methods for the determination of pheniramine maleate (PAM; H1 histamine receptor antagonist) in pharmaceutical pure and dosage forms are described. The methods are based on the reaction of PAM with Na hypochlorite in Kolthoff phosphate-borate buffer pH 7.0 leading to the PAM chloro derivative, subsequent decomposition of excess hypochlorite by Na nitrite (the PAM chloro derivative is not affected under optimized conditions), followed by the oxidation of K iodide with the PAM chloro derivative to iodine (I3-) colored product, which is measured either directly at 355 (method A; yellow product) or after reaction with starch at 590 nm (method B; blue product). The optimal conditions for the PAM-hypochlorite reaction were detd; under these conditions the linear relationship was found in the concentration ranges of 2-50 and 1-25 μg PAM/mL with methods A and B, resp. The calculated molar absorptivity values were 7.26 × 103 and 1.28 × 104 L/(mol cm) for methods A and B, resp. Sandell sensitivity values, limits of detection (LOD), and limits of quantification (LOQ) were calculated The proposed methods were used for the determination of PAM in tablets and injection solutions with good accuracy and precision and without interferences from common pharmaceutical additives. The obtained results compared favorably with those of the reference method. The accuracy and reliability of the proposed methods were further checked by recovery studies via standard addition procedure. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pharmaceutical analysis pheniramine maleate spectrophotometry sodium hypochlorite reagent, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Caglar, Hatice; Bueyuektuncel, Ebru published an article in 2014, the title of the article was HPLC method development and validation: simultaneous determination of active ingredients in cough and cold pharmaceuticals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Objective: This study aimed to develop a simple reversed-phase high performance chromatog. method for simultaneous determination of pseudoephdrine HCI, pheniramine maleate, acetaminophen, guaifenisin, pyrilamine maleate, chlorpheniramine maleate, triprolidine HCI, dextromethorphan HBr, diphenhydramine HCI in cough and cold pharmaceuticals. Methods: The separation of these compounds was achieved within 37.9 min on a Nucleodur gravity C18 column (250 x 4.0 mm, 5μm). The chromatog. separation of these compounds performed in a single run by using isocratic mobile phase consisting of methanol:buffer mixture (38:62, volume/volume) at room temperature, with flow rate of 0.75 mL.min-1. An UV absorption at 210 nm was monitored. 2,4,6-trimethoxybenzaldehyde was used as an internal standard (ISTD). The selectivity, linearity of calibration, accuracy, intraday and interday precision and forced degradation studies were examined as parts of the method validation. Results: The concentration-response relationship was linear over a concentration range of 0.2-250 μg.mL-1 for acetaminophen, 0.5-250 μg.mL-1 for pseudoephdrine HCI and pheniramine maleate, 1-250 μg.mL-1 for guaifenisin, 2.5-250 μg.mL-1 for chlorpheniramine maleate and triprolidine HCI, 5-250 μg.mL-1 for pyrilamine maleate and diphenhydramine HCI, 10-20 μg.mL-1 for dextromethorphan HBr with correlation coefficients better than 0.9993. The relative standard deviations of the intraday and interday were all less than 4%. Conclusion: The proposed liquid chromatog. method was successfully applied for the routine anal. of these compounds in different cough and cold pharmaceutical preparations such as syrups and tablets. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase high performance chromatog, cough cold pharmaceutical active ingredient, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Taomin; Chen, Nianzu; Wang, Donglei; Lai, Yonghua; Cao, Zhijuan published an article in 2014, the title of the article was A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.Computed Properties of 132-20-7 And the article contains the following content:

Background: A simple, rapid, and accurate stability-indicating reverse phase liquid chromatog. method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Results: Optimum chromatog. separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 min by using an Agilent zorbax eclipse XDB C18 column (150 mm × 4.6 mm, 5 μm) as the stationary phase with a mobile phase consisted of 10 mM phosphate buffer pH 2.8 containing 0.5% triethlamine and methanol (68:32, volume/volume) at a flow rate of 1 mL min-1. Detection was performed at 280 nm using a diode array detector. Theor. plates for pheniramine maleate and naphazoline hydrochloride were calculated to be 6762 and 6475, resp. The method was validated in accordance with ICH guidelines with respect to linearity, accuracy, precision, robustness, specificity, limit of detection and quantitation. Regression anal. showed good correlations (R2 > 0.999) for pheniramine maleate in the concentration range of 150-1200 μg mL-1 and naphazoline hydrochloride in 12.5-100 μg mL-1. The method results in excellent separation of both the analytes and degradation products. The peak purity factor is ≥980 for both analytes after all types of stress, indicating complete separation of both analyte peaks from the stress induced degradation products. Conclusions: Overall, the proposed stability-indicating method was suitable for routine quality control and drug anal. of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naphazoline hydrochloride pharmaceutical formulation quality control rphplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem