Category: pyridine-derivatives

On December 31, 2011, Balhara, Yatan Pal Singh; Jain, Raka; Dhawan, Anju; Mehta, Manju published an article.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment. And the article contained the following:

Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiol. and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) – 2 mL, Pheniramine maleate – 45.5 mg, Lorazepam – 2 mg. The assessments were made at base line and then at 15 min, 120 min and 240 min. The subjects were assessed for the socio-demog. profile, drug use history, physiol. parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Anal. Used: Anal. was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiol. and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiol. and cognitive/psychomotor task performance. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pheniramine maleate lorazepam cognition psychomotor impairment drug addiction, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vyas, Bhavesh M.; Singh, Adarsh J.; Dhattiwala, Abdulkadir S.; Mansuri, Sabera M.; Patel, Varsha J. published an article in 2014, the title of the article was Comparative CNS activities of clinically employed antihistamines (H1 antagonist).SDS of cas: 132-20-7 And the article contains the following content:

Aim: H1 Antihistamines are classified into first generation and second generation agents. The main differences between the first and second generations of drugs are their propensity to cause central nervous system (CNS) side effects. Therefore, present study was aimed to analyze the effects of different H1 antihistamines (first and second generation) on CNS using different animal exptl. models. Materials & methods: H1 antihistamines such as pheniramine maleate (3 mg/kg, 6 mg/kg), cetirizine (0.6 mg/kg, 1.2 mg/kg), levocetirizine (0.6mg/kg, 1.2 mg/kg), loratadine (1 mg/kg, 2 mg/kg) and desloratidine (0.6 mg/kg, 1.2 mg/kg) are evaluated and compared for their effects on CNS using exptl. animal model (Pentobarbitone sleeping time, spontaneous motor activity, motor co-ordination) in Swiss albino mice. Results & Discussion: Desloratadine (0.6mg/kg, 1.2 mg/kg) and loratadine (1 mg/kg, 2 mg/kg) did not produce significant (P < 0.05) effect on sleeping time when compared to control. At 120 min time interval after treatment with cetirizine (1.2 mg/kg) and levocetirizine (1.2 mg/kg) was shown reduction in locomotor activity and remaining three drugs such as pheniramine (6 mg/kg), loratadine (2 mg/kg) and desloratadine did produced any effect on locomotor activity. Treatment with higher dose of pheniramine (6 mg/kg) and cetirizine (1.2 mg/kg) was shown significant (P<0.05) motor coordination while other drugs did not induce any motor in-coordination. First generation antihistamines were shown significant effect on CNS activity at low and high dose while only some second generation antihistamines showed significant effect on CNS at high dose. Conclusion: Numerous well-performed, sensitive measures of psychomotor and cognitive performances are needed to study to compare the effect of first generation and second generation antihistamines on CNS to avoid serious impairment of CNS function. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate cetirizine antihistamine motor activity coordination, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 1997, Kawano, Eiji; Nagai, Masashi; Inubushi, Atsurou; Shimada, Keiichi; Tobari, Hiroko published a patent.Category: pyridine-derivatives The title of the patent was Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient. And the patent contained the following:

A nitrogen monoxide synthetase (NOS) inhibitor which contains as the active ingredient 2-aminopyridines or pharmaceutically acceptable salts thereof. It has been found that 2-aminopyridines and pharmaceutically acceptable salts thereof have potent effects of inhibiting nitrogen monoxide synthetase. Namely, a medicinal composition containing 2-aminopyridines and pharmaceutically acceptable salts thereof is useful as a nitrogen monoxide formation inhibitor for treatment of NOS-related diseases e.g. septic shock, rheumatism, allergy, parkinsonism, cardiovascular diseases, obesity, and pain. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Category: pyridine-derivatives

The Article related to nitrogen monoxide synthetase inhibitor aminopyridine preparation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz; Nantka-Namirski, Pawel published an article in 1979, the title of the article was Bipyridines. XI. Synthesis of 4,5-diazacarbazole.Category: pyridine-derivatives And the article contains the following content:

3,3′-Dinitro-2,2′-bipyridine (I) was reduced with SnCl2 in concentrated HCl to give 71% 3,3′-diamino-2,2′-bipyridine (II), which was also prepared in 34% yield by heating 2-chloro-3-acetylaminopyridine with Cu in DMF and subsequently deacetylating the product in acidic medium. Hydrogenation of I (Pd/C, 2.5 atm) converted both NO2 groups into NHOH groups in 79% yield; subsequent cyclization in polyphosphoric acid at 300° gave 77% III. II with H2SO4-HNO3 gave 40% IV (R = NO2), with PhNCO, 94% IV (R = CONHPh), with Ac2O, 65% IV (R = Ac, V), with CS2, 25% VI, and with ZnCl2 at 350-400°, 55% VII. V was converted in 70% yield into the N,N’-dioxide by the action of 3-ClC6H4CO3H. in vivo Biol. tests with sarcoma 180 and leukemias were neg. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Category: pyridine-derivatives

The Article related to bipyridinediamine preparation reaction, diazacarbazole, dipyridopyrazine, dipyridodiazepinethione, dipyridopyrrole, neoplasm inhibitor bipyridinediamine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 29, 1984, Xiao, Xu Rui; Wang, Ching Bore; Tien, H. Ti published an article.COA of Formula: C16H22Br2N2 The title of the article was Photoreduction of alkyl viologens by zinc tetraphenylporphyrin in organic solvent-water systems. And the article contained the following:

Light-induced redox reactions between Zn meso-tetraphenylporphyrin (ZnTPP) and alkyl viologens (CnV2+) in organic solvent-surfactant-H2O solutions were studied as functions of the organic-solvent content of the solutions, the surfactant charge, and the alkyl viologen hydrophobicity. The best system was an oil-in-water emulsion containing 5 × 10-5 M ZnTPP and 10-3M C10V2+ stabilized by n-C16H33NMe3+ X- (X = Br, Cl) and 6% DMF, AcNMe2 or DMSO in H2O. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).COA of Formula: C16H22Br2N2

The Article related to photoreduction alkyl viologen zinc tetraphenylporphyrin, reduction photochem alkyl viologen, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.COA of Formula: C16H22Br2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 2, 2009, Yi, Chae S.; Kwon, Ki-Hyeok; Lee, Do W. published an article.Category: pyridine-derivatives The title of the article was Aqueous Phase C-H Bond Oxidation Reaction of Arylalkanes Catalyzed by a Water-Soluble Cationic Ru(III) Complex [(pymox-Me2)2RuCl2]+BF4-. And the article contained the following:

The cationic complex [(pymox-Me2)RuCl2]+BF4- was found to be a highly effective catalyst for the C-H bond oxidation reaction of arylalkanes in water. For example, the treatment of ethylbenzene (1.0 mmol) with t-BuOOH (3.0 mmol) and 1.0 mol % of the Ru catalyst in water (3 mL) cleanly produced PhCOCH3 at room temperature Both a large kinetic isotope effect (kH/kD = 14) and a relatively large Hammett value (ρ = -1.1) suggest a solvent-caged oxygen rebounding mechanism via a Ru(IV)-oxo intermediate species. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Category: pyridine-derivatives

The Article related to aqueous carbon hydrogen bond oxidation arylalkane cationic ruthenium complex, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 4, 2021, Behenna, Douglas; Deckhut, Charlotte; Rovira, Alexander; Goldberg, Steven; Kummer, David; Keith, John; Woods, Craig; Rhorer, Timothy; Tanis, Virginia; Martin, Connor; Meduna, Steven; McCarver, Stefan; Valdes, Alexander; Loskot, Steven; Xue, Xiaohua published a patent.Safety of 5-Isopropylnicotinic acid The title of the patent was Imidazopyridazines as modulators of IL-17 in the treatment of inflammatory disorders. And the patent contained the following:

The invention relates compounds of formula I, preparation and use in treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease. Compound I, wherein R1 is (un)substituted C1-6 alkyl, (un)substituted C0-2 alkyl-C3-6 cycloalkyl, and (un)substituted 5- and 6-membered heterocyclyl having 1 and 2 nitrogen atoms; R2 is H, C3-5 cycloalkyl and (un)substituted C1-4 alkyl; R3 is (un)substituted C0-1 alkyl-C3-6 cycloalkyl, (un)substituted C3-6 alkyl and (un)substituted C1-2 alkyl-O-C1-3 alkyl; R4 is (un)substituted C3-6 cycloalkyl, (un)substituted Ph and (un)substituted 5- and 6-membered heteroaryl having 1 to 4 heteroatoms selected from N, O and S; R5 is H and halo; and pharmaceutically acceptable salts thereof, are claimed. Compound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for IL-17A modulatory activity resulting in an IC50 of 0.18μM and 0.30μM using Eu-HTRF and NHK assays, resp. Compounds of the invention were evaluated for IL-17A modulatory activity (data given). The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Safety of 5-Isopropylnicotinic acid

The Article related to imidazopyridazine preparation modulator il 17 inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Safety of 5-Isopropylnicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 5, 2018, Groarke, Michelle; Shiomi, Takushi; Kawamura, Masahiro; Nagashima, Hideaki published a patent.Electric Literature of 75449-26-2 The title of the patent was Nitrogen-containing heterocyclic compounds for organic light emitting devices. And the patent contained the following:

A compound represented by a chem. formula I (A1, A2, A3 = (un)substituted C6-C30 ring aromatic hydrocarbon, (un)substituted C5-C30 heterocyclic group; Z1 = N, CR1; R1 = H, (un)substituted C1-C30 alkyl, (un)substituted C3-C30 cycloalkyl etc.; B1 = H, CN, (un)substituted C6-C30 ring aromatic hydrocarbon, etc.; L = single bond, (un)substituted alkylene having C1-C30; (un)substituted C3-C30 cycloalkylene; l = 1, 2 or 3), a material for an organic electroluminescence device comprising at least one compound of formula I; an organic electroluminescence device which comprises an organic thin film layer between a cathode and an anode, wherein the organic thin film layer comprises one or more layers and comprises a light emitting layer, and at least one layer of the organic thin film layer comprises at least one compound with formula I; an electronic equipment. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to nitrogen heterocyclic organic light emitting device electroluminescent material, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 15, 2011, Jung, Hyeon Cheol; Yoo, In Seon; Lee, Jeong Ae; Park, Seong Hui published a patent.Product Details of 39919-70-5 The title of the patent was Organic electroluminescent device having novel electron transport/injection materials comprising aromatic compound. And the patent contained the following:

The title organic electroluminescent device comprises stacked anode, hole injection layer, hole transport layer, host + dopant layer, electron transport layer, electron injection layer, and cathode. The compound shown in chem. formula I is used in the electron transport layer and the electron injection layer, wherein, R1, R2 and R3 are the same or not, and are substituted or unsubstituted aromatic groups, heterocyclic groups or aliphatic groups. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Product Details of 39919-70-5

The Article related to organic electroluminescent device electron injection transport aromatic, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Product Details of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 26, 2018, Kim, Jae Hyeon; Kim, Gi Han; Kim, Chung Hyo published a patent.Related Products of 52243-87-5 The title of the patent was Optical control device and transparent display device including the same with improved light transmittance. And the patent contained the following:

An optical control device and transparent display device including the same having improved light transmittance and quality is provided. The optical control device comprises a first and second substrate facing each other, a first and a second partition disposed between both the substrate, both the partition holds the gap between the two substrates, first electrode disposed on a side surface of the first partition facing the second partition, second electrode disposed on a side surface of the second partition facing the first partition, light control cell disposed between the first and the second electrode, and a light control cell including a light transmissive variable material that changes light transmittance according to a voltage applied to the first and second electrode. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Related Products of 52243-87-5

The Article related to optical control transparent display device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Related Products of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem