Category: pyridine-derivatives

On March 12, 1998, Daines, Robert A. published a patent.Name: N,3-Dimethylpyridin-2-amine The title of the patent was Preparation of 3,4-dinitrobenzamides as calcitonin gene related peptide receptor ligands.. And the patent contained the following:

Title compounds [I; R1 = H, Me, alkyl, phenylalkyl, heterocyclylalkyl, aminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, etc.; R2 = (substituted) aryl, heteroaryl, arylalkyl, heteroarylalkyl; R1R2N = (benzo-fused) 5-6 membered heterocyclyl], were prepared Thus, N-methylaniline in CH2Cl2 was treated with Et3N and then with 3,4-dinitrobenzoyl chloride and the mixture was shaken overnight to give N-methyl-N-phenyl-3,4-dinitrobenzamide. I antagonized CGRP receptors with IC50 = 0.001-100 μM. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Name: N,3-Dimethylpyridin-2-amine

The Article related to nitrobenzamide preparation cgrp related disease treatment, calcitonin gene related peptide antagonist dinitrobenzamide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Name: N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 17, 2019, Ahmad, Nadia; Anderson, Corey; Arumugam, Vijayalaksmi; Asgian, Iuliana Luci; Camp, Joanne Louise; Fanning, Lev Tyler Dewey; Hadida Ruah, Sara Sabina; Hurley, Dennis; Schmidt, Yvonne; Shaw, David; Sheth, Urvi Jagdishbhai; Thomson, Stephen Andrew published a patent.Recommanded Product: Methyl 5-amino-4-methylpicolinate The title of the patent was Preparation of (hetero)aromatic carboxamides as modulators of sodium channels for the treatment of diseases. And the patent contained the following:

The invention relates to preparation of aryl heteroaryl carboxamides and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The example compound I was prepared by multistep synthesis (procedure given). Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Recommanded Product: Methyl 5-amino-4-methylpicolinate

The Article related to aryl heteroaryl carboxamide preparation sodium channel modulator disease treatment, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: Methyl 5-amino-4-methylpicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 9, 2016, Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; Truong, Yen published a patent.Safety of Methyl 2-amino-5-chloroisonicotinate The title of the patent was Thio-substituted benzamides as antiviral agents for the treatment of treatment HBV infection and their preparation. And the patent contained the following:

The invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of formula I. Compounds of formula I wherein each R1, R2, and R3 are halo; R4 is (un)substituted C3-7 cycloalkyl (un)substituted C1-6 alkyl-C3-7 cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by thioetherification of N-(3,4,5-trifluoromethylphenyl)-4-fluoro-3-iodobenzamide with 1-(mercaptomethyl)cyclopropylacetic acid. The invention compounds were evaluated for their antiviral activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Safety of Methyl 2-amino-5-chloroisonicotinate

The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-amino-5-chloroisonicotinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 1, 2013, Zhao, Hong-Wu; Yue, Yuan-Yuan; Li, Hai-Long; Song, Xiu-Qing; Sheng, Zhi-Hui; Yang, Zhao; Meng, Wei; Yang, Ze published an article.Synthetic Route of 75449-26-2 The title of the article was Novel axially unfixed biaryl-based water-compatible organocatalysts: design, synthesis and their asymmetric catalysis in direct aldol reactions in water. And the article contained the following:

A family of novel axially unfixed biaryl-based, water-compatible bifunctional organocatalysts I [R = 4-MeC6H4, 4-MeC6H4, 1-naphthyl; X = CH, N] were designed and synthesized for asym. catalytic direct aldol reactions in water. These organocatalysts are comprised of prolinamide, aromatic sulfonamide and biaryl motifs. Under the optimal reaction conditions, one organocatalyst in particular delivered excellent stereocontrol (up to 99% ee and 99:1 dr) in direct aldol reactions of cyclohexanone with a variety of aromatic aldehydes in water. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to asym aldol addition biaryl catalyst preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tahara, Hironobu; Yonemura, Hiroaki; Harada, Satoko; Nakashima, Akio; Yamada, Sunao published an article in 2012, the title of the article was Photoinduced electron-transfer reactions and magnetic field effects on the decay rates of a photogenerated biradical from zinc porphyrin-viologen linked compounds in an ionic liquid.COA of Formula: C16H22Br2N2 And the article contains the following content:

Fluorescence and transient absorption spectra of zinc-porphyrin (ZnP)-viologen linked compounds with various methylene groups indicate that intramol. electron-transfer from the singlet or triplet excited state of ZnP to viologen occurred and a biradical was generated in the ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate) at various temperatures (283-343 K). The decay rate constants of the biradical decreased in 0-0.2∼0.5 T and became constant in 0.2∼0.5-1 T. Unique effects of temperature and methylene chain length on electron-transfer and magnetic field effects were observed and are probably due to the properties of the ionic liquid as compared with benzonitrile. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).COA of Formula: C16H22Br2N2

The Article related to photoinduced intramol electron transfer zinc porphyrin viologen dyad kinetics, magnetic field zinc porphyrin viologen dyad photochem ionic liquid, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.COA of Formula: C16H22Br2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1993, Kamogawa, Hiroyoshi; Nanasawa, Masato published an article.Related Products of 52243-87-5 The title of the article was Effect of temperature on the color developed by near ultraviolet light for 4,4′-bipyridinium salts (viologens) embedded in poly(1-vinyl-2-pyrrolidone) matrix. And the article contained the following:

Thermal stability of the colors developed by UV light for 4,4′-bipyridinium salts (viologens) embedded in the glass-sandwiched poly(1-vinyl-2-pyrrolidone) is dominated by the kind of counter anion. Temperature increase resulted in either no or slight changes of the colors developed for the major viologens, whereas it resulted in bleaching for some viologen sulfonates. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Related Products of 52243-87-5

The Article related to bipyridinium salt photochromism vinylpyrrolidone polymer, thermal stability color photoproduct viologen polyvinylpyrrolidone, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Related Products of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kato, Chuzo; Kuroda, Kazuyuki; Sugawara, Yoshiyuki; Miyata, Hirokatsu published an article in 1987, the title of the article was Synthesis of montmorillonite-viologen intercalation compounds and photochromism.HPLC of Formula: 52243-87-5 And the article contains the following content:

Photochromic behavior of viologen I (R = Pr, n-heptyl, benzyl, phenethyl) intercalated into the layers of montmorillonite with poly(vinylpyrrolidone) (PVP) and poly(vinyl alc.) (PVA) was studied. When irradiated with a Hg lamp, the intercalation compounds turned blue to give radical cations, whereupon PVP and PVA served as electron donors for reduction of I. The radical cations generated in montmorillonite were more stable than those in the PVP matrix. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).HPLC of Formula: 52243-87-5

The Article related to photoreduction viologen montmorillonite polymer matrix, intercalation compound viologen montmorillonite photochromism, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.HPLC of Formula: 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pop, Flavia; Melan, Caroline; Danila, Ion; Linares, Mathieu; Beljonne, David; Amabilino, David B.; Avarvari, Narcis published an article in 2014, the title of the article was Hierarchical Self-Assembly of Supramolecular Helical Fibres from Amphiphilic C3-Symmetrical Functional Tris(tetrathiafulvalenes).Name: [2,2′-Bipyridine]-3,3′-diamine And the article contains the following content:

The preparation and self-assembly of the enantiomers of C3-sym. compounds incorporating three tetrathiafulvalene (TTF) residues is reported. The chiral citronellyl and dihydrocitronellyl alkyl chains lead to helical one dimensional stacks in solution Mol. mechanics and dynamics simulations combined with exptl. and theor. CD support the observed helicity in solution These stacks self-assemble to give fibers that have morphologies that depend on the nature of the chiral alkyl group and the medium in which the compounds aggregate. An inversion of macroscopic helical morphol. of the citronellyl compound is observed when compared to analogous 2-methylbutyl chains, which is presumably a result of the stereogenic center being further away from the core of the mol. This composition still allows both morphologies to be observed, whereas an achiral compound shows no helicity. The morphol. of the fibers also depends on the flexibility at the chain ends of the amphiphilic components, as there is not such an apparently persistent helical morphol. for the dihydrocitronellyl derivative as for that prepared from citronellyl chains. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Name: [2,2′-Bipyridine]-3,3′-diamine

The Article related to hierarchical self assembly supramol helix amphiphilic c3 sym tetrathiafulvalene, c3 symmetry, circular dichroism, electronic microscopy, supramolecular chirality, tetrathiafulvalene and other aspects.Name: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 1982, McPheat, W. L.; Wardlaw, A. C. published an article.Related Products of 636-73-7 The title of the article was Inhibition of nicotinic acid and nicotinamide uptake into Bordetella pertussis by structural analogs. And the article contained the following:

The nicotinic acid (I) and nicotinamide (II) structural analogs, 3-pyridinecarboxaldehyde (III) and 3-pyridinealdoxime (IV) (both 500 and 50 μM), but not isonicotinamide, isonicotinic acid, 6-aminonicotinic acid, 6-aminonicotinamide, isoniazid, 3-acetylpyridine, 3-pyridylacetic acid, N,N-diethylnicotinamide, or 3-pyridinesulfonic acid, were effective and specific inhibitors of the uptake of I and II by B. pertussis, although neither compound inhibited the growth of the bacteria in liquid medium or the oxidation of glutamate by washed suspensions. 3-Pyridylcarbinol, at the same dose, was inhibitory, but less so than III and IV. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Related Products of 636-73-7

The Article related to nicotinate nicotinamide transport metabolism bordetella, pyridinecarboxaldehyde bordetella nicotinamide uptake inhibition, pyridinealdoxime bordetella nicotinamide uptake inhibition and other aspects.Related Products of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1990, Kaczmarek, Lukasz; Nantka-Namirski, Pawel published an article.Name: [2,2′-Bipyridine]-3,3′-diamine The title of the article was Synthesis of N-monosubstituted [2,2′-bipyridyl]-3,3′-diamines. And the article contained the following:

The cyclocondensation reaction of 2,2′-bipyridiyl-3,3′-diamine with PhC(:NH)OEt.HCl gave 6-phenyl-5H-dipyrido[3,2-d:2′,3′-f][1,3]diazepine. Alkylation of the latter gave N-benzoyl-N’-alkyl-2,2′-bipyridiyl-3,3′-diamines which upon hydrolysis gave N-alkyl-2,2′-bipyridiyl-3,3′-diamines I [R = Bu, Me2NCH2CH2CH2, [3-(4-chlorophenyl-1-piperazinyl)propyl]]. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Name: [2,2′-Bipyridine]-3,3′-diamine

The Article related to bipyridiyldiamine cyclocondensation benzimidate, dipyridodiazepine phenyl alkylation, diazepine phenyldipyrido alkylation, alkylation phenyldipyridodiazepine, alkylbipyridiyldiamine and other aspects.Name: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem