Category: pyridine-derivatives

On November 9, 2006, Kelly, Michael G.; Kincaid, John; Kaub, Carl J. published a patent.Related Products of 39919-70-5 The title of the patent was Preparation of fused heterocyclic compounds for preventing and treating various diseases. And the patent contained the following:

The title compounds I [A, B = (un)substituted CH2, CO or CS; Y = (un)substituted CH2; W = CR4, N; Z = O, NR2; L = (hetero)alkylene; R1 = carbocyclyl or heterocyclyl; R2 = H, alkyl, cycloalkyl; R3 = carbocyclyl or heterocyclyl; R4 = H, alkyl, acyl, etc.; R5 = R4, Z’-L’-R4 (wherein Z’ = a bond, O, S, etc.; L’ = alkylene)], useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others, were prepared and formulated. E.g., a multi-step synthesis of II, starting from Et 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride, was given. The exemplified compounds I were tested in calcium uptake assay (P2X2 and P2X3) and % inhibition data were given for representative compounds I. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Related Products of 39919-70-5

The Article related to fused heterocycle pyridopyrimidinamine preparation purinoceptor antagonist analgesic antiinflammatory anxiolytic, cognition enhancer pyridopyrimidinamine preparation purinoceptor antagonist, antidepressant pyridopyrimidinamine preparation purinoceptor antagonist and other aspects.Related Products of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mondal, Dipanjan; Sardar, Gopa; Kabra, Dinesh; Balakrishna, Maravanji S. published an article in 2022, the title of the article was 2,2′-Bipyridine derived doubly B- N fused bisphosphine-chalcogenides, [C5H3N(BF2){NCH2P(E)Ph2}]2 (E = O, S, Se): tuning of structural features and photophysical studies.Product Details of 75449-26-2 And the article contains the following content:

2,2′-Bipyridine based bisphosphine [C5H3N{N(H)CH2PPh2}]2 (1) and its bischalcogenide derivatives [C5H3N{N(H)CH2P(E)Ph2}]2 (2, E = O; 3, E = S; 4, E = Se) were synthesized, and further reacted with BF3·Et2O/Et3N to form doubly B-N fused compounds [C5H3N(BF2){NCH2P(E)Ph2}]2 (5, E = O; 6, E = S; 7, E = Se) in excellent yields. The influence of the P=E bonds on the electronic properties of the doubly B-N fused systems and their structural features were investigated in detail, supported by extensive exptl. and computational studies. Compound 6 exhibited a very high quantum yield of ϕ = 0.56 in CH2Cl2, whereas compound 7 showed a least quantum yield of ϕ = 0.003 in acetonitrile. D. functional theory (DFT) calculations demonstrated that the LUMO/HOMO of compounds 5-7 mostly delocalized over the entire π-conjugated frameworks. The involvement of PE bonds in the HOMO energy level of these compounds follows the order: PO < PS < PSe. Time-correlated single photon counting (TCSPC) experiments of compounds 5-7 revealed the singlet lifetime of 4.26 ns for 6, followed by 4.03 ns for 5 and a lowest value of 2.18 ns (τ1) and 0.47 ns (τ2) with a double decay profile for 7. The authors' findings provide important strategies for the design of highly effective B-N bridged compounds and tuning their photophys. properties by oxidizing phosphorus with different chalcogens. Compounds 5 and 6 have been employed as green emitters (λem = 515 nm) in fluorescent organic light-emitting diodes (OLEDs). For compound 5, doped into the poly(9-vinylcarbazole) (PVK) matrix with 5 wt% doping concentration, nearly 90 Cd m-2 luminance with 0.022% external quantum efficiency (EQE) was achieved. The best performance was observed for compound 6 doped into PVK by 1 wt% having a maximum luminance of 350 Cd m-2 and a similar EQE value. The experimental process involved the reaction of [2,2'-Bipyridine]-3,3'-diamine(cas: 75449-26-2).Product Details of 75449-26-2

The Article related to boron bipyridinylbisphosphinylchalcogenide complex preparation frontier mol orbital fluorescence lifetime, fluorescence oled redox potential boron bipyridinylbisphosphinylchalcogenide complex, crystal structure boron bipyridinylbisphosphinylchalcogenide complex and other aspects.Product Details of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Jianjun; Deming, Timothy J. published an article in 1999, the title of the article was Enantioselective polymerization of 5-benzyl glutamate N-carboxyanhydride using chiral nickel(0) initiators.Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine And the article contains the following content:

Enantioselective polymerization of 5-benzyl glutamate NCA was investigated using chiral bidentate nitrogen ligands in combination with a nickel zero initiation system. We found that ligands having mixed pyridine-oxazoline structures gave excellent control of mol. weight and narrow mol. weight distributions. Moderately high enantioselectivities were induced when chiral 2-pyridinyl oxazoline ligands were utilized. The highest enantioselectivity was found with (4S)-4-tert-butyl-(2-pyridinyl)-2-oxazoline. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to polybenzyl glutamate preparation catalyst nickel, benzyl glutamate carboxyanhydride polymerization nickel catalyst, enantioselective polymerization catalyst nickel, pyridine ligand nickel polymerization catalyst, oxazoline ligand nickel polymerization catalyst and other aspects.Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 10, 2021, Karges, Johannes; Kalaj, Mark; Gembicky, Milan; Cohen, Seth M. published an article.Reference of [2,2′-Bipyridine]-3,3′-diamine The title of the article was ReI tricarbonyl complexes as coordinate covalent inhibitors for the SARS-CoV-2 main cysteine protease. And the article contained the following:

Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CLpro), which is also known as the main protease, is considered among the most important pharmacol. targets. The vast majority of investigated 3CLpro inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. ReI tricarbonyl complexes were identified that demonstrate coordinate covalent enzymic inhibition of 3CLpro. Preliminary studies indicate the selective inhibition of 3CLpro over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CLpro cysteine protease. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Reference of [2,2′-Bipyridine]-3,3′-diamine

The Article related to rhenium tricarbonyl complex coordinate inhibitor main protease sars cov2, synthesis crystal structure rhenium tricarbonyl complex protease inhibitor 3clpro, sars-cov-2, antiviral agents, bioinorganic chemistry, medicinal inorganic chemistry, protease inhibitor and other aspects.Reference of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 1979, Sadikov, A. S.; Otroshchenko, O. S.; Yunusov, T. K. published an article.Category: pyridine-derivatives The title of the article was Sulfur-containing derivatives of anabasine and its analogs. And the article contained the following:

Treatment of anabasine, isoanabasine and 2,3′-dipiperidyl with SOCl2, SCl2, elemental S, concentrated H2SO4, and sulfoacids of N heterocyclic bases gave a series of biol. active S-containing derivatives, e.g. I and II, of anabasine and its analogs. Dependences between the structure of substrates and their chem. reactivity were discussed. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Category: pyridine-derivatives

The Article related to anabasine reaction sulfur compound, isoanabasine reaction sulfur, dipiperidyl reaction sulfur, sulfur reaction anabasine, thionyl chloride reaction anabasine, sulfur chloride reaction anabasine, sulfuric acid reaction anabasine, sulfo acid reaction anabasine and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2014, Ghaffari, Behnaz; Preshlock, Sean M.; Plattner, Donald L.; Staples, Richard J.; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R. published an article.Electric Literature of 1349171-28-3 The title of the article was Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis. And the article contained the following:

Ir catalysts supported by ortho-(diisopropylsilyl)(di-p-tolylphosphino)benzene bidentate ligand that contains P- or N-donors, effects ortho-borylations for a range of substituted aromatics E.g., reaction of C6H5CO2Me with bis(pinacolato)diboron (B2pin2) in the presence of 1.25 mol% [Ir(OMe)(cod)]2/ 2.5 mol% (p-tol)2PC6H4-2-(SiHiPr2) in THF at 80° to give 72% yield of Me 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Electric Literature of 1349171-28-3

The Article related to ortho silylphosphinylbenzene tethered iridium cyclooctadiene preparation catalyst orthoborylation, crystal structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene, mol structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene and other aspects.Electric Literature of 1349171-28-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 21, 2022, Rai, Roopa; Booth, Robert published a patent.COA of Formula: C9H14N2 The title of the patent was Preparation of 1H-pyrrolo[2,3-b]pyridine derivatives as PGDH inhibitors and inhalation formulations thereof. And the patent contained the following:

Disclosed are compounds that inhibit 15-hydroxy-prostaglandin dehydrogenase (PGDH) thus modulating prostaglandin levels which may be useful for the treatment of respiratory disorders such as COPD and idiopathic pulmonary fibrosis. Compounds of formula I [wherein R1 = (un)substituted C6-10aryl and 5- to 10-membered heteroaryl; R2 = H and R3 = CF3; R2 and R3 together = O; each R4 and R5 independently = halo, OH and derivatives, NH2 and derivatives, etc.; m = 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; n = 1, 2, 3, or 4; p = 0, 1, 2, or 3] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for PGDH inhibitory activity from which II demonstrated an IC50 of < 0.1μM. In some embodiments, the compounds disclosed herein are formulated for delivery via inhalation. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).COA of Formula: C9H14N2

The Article related to pyrrolopyridine carboxamide derivative preparation inhalant formulation, hydroxyprostaglandin dehydrogenase inhibitor preparation pulmonary fibrosis copd, benzimidazole azabenzimidazole indole benzoxazine carboxamide preparation prostaglandin inhibitor and other aspects.COA of Formula: C9H14N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 14, 2003, Adam, Geo; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes published a patent.Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine The title of the patent was Preparation of dihydrobenzodiazepin-2-ones as metabotropic glutamate receptor antagonists for the treatment of neurological disorders. And the patent contained the following:

This invention relates to dihydrobenzo[b][1,4]diazepin-2-ones (shown as I; variables defined below; e.g. 7,8-dichloro-4-[3-(pyridin-3-yl)phenyl]-1,3-dihydrobenzo[b][1,4]diazepin-2-one). The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurol. disorders, e.g. Alzheimer’s disease. Three examples of pharmaceutical compositions containing I are included. Ki values for 50 examples of I as metabotropic glutamate receptor antagonists are tabulated, e.g. 0.00135 μM for 7,8-dichloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydrobenzo[b][1,4]diazepin-2-one. More than 400 example preparations of I and many example preparations of intermediates are included. For example, 7,8-dichloro-4-[3-(pyridin-3-yl)phenyl]-1,3-dihydrobenzo[b][1,4]diazepin-2-one (310 mg) was prepared from 4,5-dichlorophenylenediamine (0.97 mmol) and 3-oxo-3-[3-(pyridin-3-yl)phenyl]propionic acid tert-Bu ester (0.97 mmol) by refluxing in xylene. For I: X is a single bond or an ethynediyl group; and wherein in case X is a single bond, R1 is H, cyano, halogen, lower alkyl, lower alkoxy, fluoro-lower alkyl, fluoro-lower alkoxy, pyrrol-1-yl, or Ph, which is (un)substituted by one or two substituents halogen, lower alkyl or fluoro-lower alkyl; or in case X is an ethynediyl group, R1 is Ph, which is (un)substituted by one or two substituents halogen, lower alkyl or fluoro-lower alkyl. R2 is H, lower alkyl, lower alkenyl lower alkoxy, halogen, -NR’R”, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, fluoro-lower alkyl, fluoro-lower alkoxy, or lower alkoxy(ethoxy)m; m = 1-4; R’ is H, lower alkyl or C3-C6-cycloalkyl; R” is H, lower alkyl or C3-C6-cycloalkyl; Y is -CH= or =N-; R3 is a six-membered aromatic heterocycle containing 1 to 3-N atoms or a pyridine N-oxide, which rings are (un)substituted by one or two substituents halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(O)-OR”, -(CH2)n-C(O)-NR’R”, -(CH2)n-SO2-NR’R”, -(CH2)n-C(NH2):NR”, hydroxy, lower alkoxy, lower alkylthio, C3-C6-cycloalkyl and lower alkyl, which is (un)substituted by fluoro, -NR’R”, hydroxy, lower alkoxy, pyrrolidin-1-yl, azetidin-1-yl, cyano or carbamoyloxy; n = 0-4. The experimental process involved the reaction of 4-Bromo-5-ethyl-2-methylpyridine(cas: 98488-99-4).Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine

The Article related to alzheimer disease, anti-alzheimer agents, antipsychotics, biological memory retention defect, cognition enhancers, cognitive disorders, drug delivery systems, homo sapiens, human, metabotropic glutamate receptors role: bsu (biological study, unclassified), biol (biological study) (antagonists), nervous system agents, nervous system disease, psychosis, schizophrenia and other aspects.Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Tao; Wang, Xiao-Xian; Zhang, Meng; Ou, Si-Meng; Hu, Tian-Ju published an article in 2017, the title of the article was Four new coordination polymers based on a pyridinetetracarboxylate ligand: syntheses, structures and high CO2/CH4 separation.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid And the article contains the following content:

Four new coordination polymers, [Zn(TPTA)0.5(BIBP)] (1), [Mn(TPTA)0.5(BIBP)0.5(DMF)] (2), [Zn1.5(TPTA)]·DMF·H2O (3), and [Cd1.5(TPTA)]·DMF·2H2O (4) (H4TPTA = 5,5′-(pyridine-2,5-diyl)diisophthalic acid, BIBP = 4,4′-bis(imidazol-1-yl)biphenyl), have been synthesized under solvothermal conditions and fully characterized. Single-crystal X-ray diffraction anal. revealed that complex 1 is a three-dimensional (3D) 3-fold interpenetrating architecture with (4·64·8)2(42·62·82) topol. Complex 2 possesses a 3D 2-fold interpenetrating framework based on binuclear Mn2 units with (412·63) topol. Both complexes 3 and 4 exhibit trinuclear 3D non-interpenetrating (4,8)-connected networks with (46)2(412·612·84) topol. The fluorescence properties of 1, 3 and 4 have been also measured. Importantly, gas adsorption studies for 1-4 show highly selective adsorption of CO2 over CH4. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

The Article related to zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex preparation thermal stability, crystal structure zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex, photoluminescence zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex, gas adsorption zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex and other aspects.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 8, 2015, Stoessel, Philipp; Joosten, Dominik; Koenen, Nils published a patent.Reference of 6-(tert-Butyl)pyridin-3-amine The title of the patent was Polycyclic nitrogen heterocyclic compounds as semiconducting materials for components of organic electronic devices. And the patent contained the following:

Polycyclic nitrogen heterocycles I (1, X = methyne, N; E = bivalent group, forming 5- or 6-membered condensed ring; Y = O, S, 1,2-ethenediyl, imino, borylene, silylene CO, alkenylidene, SO, SO2, 1,2-ethanediyl, phosphinidene, phosphinylidene; R = H, D, halo, amino, CN, NO2, OH, CO2H, carbamoyl, silyl, boryl, acyl, phosphinyl, sulfinyl, sulfonyl, sulfo, C1-20 alkyl, alkoxy, alkylthio, alkenyl, alkynyl; R1 = R or R1-R1 = bond) and their cyclometalated platinum and iridium complexes [M(L)n(L1)m] (2, M = Ir, Pd, Pt, Os, Re; L1 = auxiliary ligand), useful as organic semiconducting materials for manufacturing of charge-transporting and charge-injecting layers in organic semiconductor devices, preferably, in organic light-emitting devices (OLEDs) and featuring glass transition temperature at least 110°, were prepared by heterocyclization of aromatic aldehydes with aromatic amines and alkenes with optional subsequent cyclometalation and complexation with protonated ligands HpL1. In an example, Povarov reaction of 500 mmol of aniline with 550 mmol of benzaldehyde and 1 mol of norbornene in 1300 mL of CH2Cl2 catalyzed with 100 mmol of BF3·OEt2 for 40 h at reflux with subsequent oxidation by 5 mol of MnO2 for 16 h at reflux in 1000 mL of 1,2-dichlorobenzene under water separation gave the invented compound (1a, shown as I, E = CH:CHCH:CH, X = CH, Y = CH2, R = R1 = H) with 56% yield. The present invention relates to compounds having polycyclic structural units and to electronic devices, in particular organic electroluminescent devices, containing said compounds The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Reference of 6-(tert-Butyl)pyridin-3-amine

The Article related to nitrogen heterocyclic compound preparation povarov cyclization cycloalkene aldehyde amine, heterocyclic polycyclic aromatic nitrogen preparation component organic electronic device, organic semiconductor nitrogen heterocycle host hole electron transporter, metallacyclic complex iridium platinum nitrogen heterocycle preparation electroluminescence and other aspects.Reference of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem