Category: pyridine-derivatives

On March 13, 2003, Kajino, Masahiro; Kawada, Akira; Nakayama, Yutaka; Kimura, Haruhide published a patent.Quality Control of Ethyl 6-cyanopicolinate The title of the patent was Preparation of 2-heterocyclyl-1,3-benzothiazinone derivatives as inhibitors of apoptosis or cytoprotective agents. And the patent contained the following:

Compounds represented by the following general formula (I) or salts thereof (wherein R1 represents hydrogen, halogeno, hydroxy, nitro, optionally halogenated alkyl, optionally substituted alkoxy, acyl or optionally substituted amino; R2 represents pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each optionally substituted; and n is 1 or 2), which and have a high safety and favorable effects of inhibiting cell death and binding to macrophage migration inhibitory factor (MIF), are prepared Also disclosed are apoptosis inhibitors, cytoprotective agents, or myocardial cell death inhibitors, or preventives/remedies for diseases caused by apoptosis or MIF which contain the compounds of the general formula (I), in particular for the prevention and/or treatment of circulatory diseases, bone or joint diseases, infectious diseases, inflammatory bowel diseases, or kidney. They are also useful for the prevention and/or treatment of heart diseases, heart failure syndromes, neurodegenerative diseases, brain vascular diseases, central nerve infections, traumatic diseases, demyelinating diseases, liver diseases, myelodysplastic syndrome, AIDS, cancer, etc. Thus, a mixture of 0.67 g thiosalicylic acid Me ester, 2-cyano-6-propylthiopyridine, and 0.84 mL Et3N in 50 mL toluene was refluxed for 48 h to give 37% 2-(6-propylthio-2-pyridyl)-4H-1,3-benzothiazin-4-one which was oxidized by m-chloroperbenzoic acid in EtOAc at room temperature for 18 h to give 2-(6-propylsulfinyl-2-pyridyl)-4H-1,3-benzothiazin-4-one (II). II was further oxidized by m-chloroperbenzoic acid in EtOAc at room temperature for 18 h to give 41% 2-(6-propylsulfonyl-2-pyridyl)-4H-1,3-benzothiazin-4-one (III). II and III showed the minium effective concentration of 0.019 and 0.010 μM, resp., for inhibiting apoptosis of new born rat’s first generation myocardial cells. A tablet and a capsule formulation containing 2-(6-methylsulfonyl-2-pyridyl)-4H-1,3-benzothiezin-4-one were described. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Quality Control of Ethyl 6-cyanopicolinate

The Article related to heterocyclylbenzothiazinone preparation apoptosis inhibitor cytoprotective agent, myocardial cell death inhibitor heterocyclylbenzothiazinone preparation, circulatory disease prevention treatment heterocyclylbenzothiazinone preparation, bone joint disease prevention treatment heterocyclylbenzothiazinone preparation and other aspects.Quality Control of Ethyl 6-cyanopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 2, 2021, Lu, Dengfu; Cui, Jiajia; Yang, Sen; Gong, Yuefa published an article.Category: pyridine-derivatives The title of the article was Iron-catalyzed cyanoalkylation of glycine derivatives promoted by pyridine-oxazoline ligands. And the article contained the following:

An iron-catalyzed C(sp3)-H cyanoalkylation of glycine derivatives with cyclobutanone oxime esters was established for the incorporation of a cyano group into amino acids and peptides. In this reaction, Fe(NTf2)2 and pyridine-oxazoline ligands form highly active catalysts that could simultaneously and selectively activate both substrates. Preliminary mechanistic studies revealed the excellent chemo-selectivity may stem from an in situ formed imine intermediate and a consecutive radical addition The evidence suggested the interaction between glycinate substrate and the Fe-catalyst has a prominent impact on the catalytic activity, and the catalyst may also activate the imine intermediate as a Lewis acid. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Category: pyridine-derivatives

The Article related to nitrile amino acid diastereoselective synthesis cyclic voltammetry, glycine cyanoalkylation cyclobutanone oxime ester pyridine oxazoline iron catalyst, cyanoalkylation reaction mechanism imine intermediate radical addition lewis acid, aniline substitution bromide oxime acylation cyanoalkylation mechanism lewis acid and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 1996, Kim, Sung Hoon; Bae, Jin Seok; Hwang, Seok Hwan; Gwon, Tae Sun; Doh, Myung Ki; Park, Chul published an article.Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide The title of the article was Electrochromic properties of symmetric and asymmetric viologens. And the article contained the following:

Electrochromic properties of several viologen derivatives were examined by the cyclovoltametric and chronoamperometric methods. The electrochromic properties of 1,1′-diethyl-4,4′-bipyridinium dibromide(EV), 1,1′-dipropyl-4,4′-bipyridinium dibromide(PV), 1,1′-dibutyl-4,4′-bipyridinium dibromide(BV) and 1-butyl-1′-ethyl-4,4′-bipyridinium dibromide(EBV) were studied using an propylenecarbonate/methanol solution with Bu4NBF4 as supporting electrolyte. A monomer-dimer equilibrium might explain the observation that EV and EBV cation radical solutions shows violet under an applied voltage of 1.73̃.0 V but blue under open-circuit condition. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to viologen electrochromism cyclic voltammetry chronoamperometry, diethylbipyridinium dibromide electrochromism cyclic voltammetry chronoamperometry, dipropylbipyridinium dibromide electrochromism cyclic voltammetry chronoamperometry, dibutylbipyridinium dibromide electrochromism cyclic voltammetry chronoamperometry and other aspects.Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 5, 2018, Park, Hojoon; Chekshin, Nikita; Shen, Peng-Xiang; Yu, Jin-Quan published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Ligand-Enabled, Palladium-Catalyzed β-C(sp3)-H Arylation of Weinreb Amides. And the article contained the following:

Authors report the development of Pd(II)-catalyzed C(sp3)-H arylation of Weinreb amides. Both the inductive effect and the potential bidentate coordination mode of the Weinreb amides pose a unique challenge for this reaction development. A pyridinesulfonic acid ligand is designed to accommodate the weak, neutral-coordinating property of Weinreb amides by preserving the cationic character of Pd center through zwitterionic assembly of Pd/ligand complexes. D. functional theory (DFT) studies of the C-H cleavage step indicate that the superior reactivity of 3-pyridinesulfonic acid ligand, compared to Ac-Gly-OH and ligandless conditions, originates from the stabilization of overall substrate-bound Pd species. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

The Article related to ligand palladium catalyzed beta carbon hydrogen arylation weinreb amide, crystal mol structure methyl fluorobenzyl methoxymethylcarbamoylcyclopropyl benzoate, mol structure calculation palladium weinreb amide complex intermediate, c(sp3)–h activation, ligand design, palladium, pyridinesulfonic acid, weinreb amide and other aspects.Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 29, 2021, Rai, Roopa; Booth, Robert; Green, Michael J. published a patent.Name: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of substituted (aza)benzimidazole-, indole-, quinolinecarboxamides and analogs as PGDH inhibitors. And the patent contained the following:

The title compounds I [X = OCH2, C(O)NH, NHC(O), etc.; each Y = (independently) N and substituted CH; each R1 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; R2 = H and R3 = CF3; or R2 and R3 are taken together to form oxo or thio; each R4 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; each R5 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; n = 0-5; m = 0-4; and p = 0-10; with the proviso] or pharmaceutically acceptable salts thereof that can inhibit 15-hydroxyprostaglandin dehydrogenase, were prepared E.g., a multi-step synthesis of II, starting from 4-fluoro-3-nitrobenzoic acid, was described. Exemplified compounds I were evaluated in the hPGDH inhibitor screening biochem. assay (data given for representative compounds I). Compounds I may be administered to subjects that may benefit from modulation of prostaglandin levels. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Name: 6-(tert-Butyl)pyridin-3-amine

The Article related to benzimidazole azabenzimidazole indole quinoline carboxamide preparation pgdh inhibitor, prostaglandin level modulator benzimidazole azabenzimidazole indole quinoline carboxamide preparation, hydroxyprostaglandin dehydrogenase inhibitor benzimidazole azabenzimidazole indole quinoline carboxamide preparation and other aspects.Name: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 21, 1994, Schmuelling, Michael; Ryabov, Alexander D.; van Eldik, Rudi published an article.COA of Formula: C5H5NO3S The title of the article was To what extent can the Pt-C bond of a metallacycle labilize the trans position? A temperature- and pressure-dependent mechanistic study. And the article contained the following:

The orthoplatinated complexes [Pt{C6H3X(CH2NMe2)}(NC5H4SO3-3)(H2O)] (X = H 1a or 3-MeO 1b) were designed for mechanistic studies in H2O. The aqua ligand is located trans to the Pt-C bond of the Ph group which lies in the Pt(II) coordination plane. The rates of substitution of the aqua ligand by nucleophiles (Nu) (Cl-, Br-, I-, N3-, SCN-, thiourea, N,N’-dimethylthiourea or N,N,N’,N’-tetramethylthiourea) were studied as a function of concentration, pH, temperature, and pressure by using a stopped-flow technique. The pKa value of the aqua ligand in 1a is 9.75 ± 0.505 and the observed pseudo-first-order rate constants for the substitution reaction are given by kobs = k1[Nu] + k-1. The k-1 term arises from the reverse solvolysis reaction and is insignificant for stronger, S-donor nucleophiles. The values of k1 are ∼4 orders of magnitude higher than the corresponding rate constants for anation reactions of [Pt(dien)(H2O)]2+ (dien = diethylenetriamine) and close to the rate constants for anation of [Pd(dien)(H2O)]2+. The effect is largely due to a strong decrease in ΔH⧧, ΔS⧧ and ΔV⧧, clearly shows that the substantial rate increase is not associated with a changeover in mechanism and that the substitution process is still associative. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).COA of Formula: C5H5NO3S

The Article related to substitution kinetics nucleophile aminomethylplatinum complex, platinum aminomethyl substitution kinetics nucleophile, reactivity aminomethylplatinum complex nucleophile, reaction mechanism aminomethylplatinum complex nucleophile substitution, bond platinum carbon lability aminomethylplatinum metallacycle and other aspects.COA of Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 20, 2010, Soll, Mark David; Le Hir De Fallois, Loiec Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms; Beck, Brent Christopher published a patent.Synthetic Route of 1086838-13-2 The title of the patent was Preparation of enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds. And the patent contained the following:

The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives substantially enriched in an enantiomer of formula I (wherein P is C-R1 or N; Q is C-R2 or N; V is C-R8 or N; W is C-R9 or N; X is C-R10 or N; Y is C-R11 or N; R1, R2 R8, R9, R10 and R11 are independently H, NH2, amido, etc.; R3, R4 and R5 are independently H, halo, alkyl, etc., or R4 and R5 form part of a cycloalkyl ring; R6 is H, alkyl, alkoxyalkyl, etc. ; R7 is H, alkyl, cycloalkyl, etc.; Z is a direct bond, C(O), C(S) or S(O)p; a = 1-3; p = 0-2), compositions thereof, processes for their preparation, and their uses as pesticides, in particular for controlling endo- and ectoparasites that are harmful to mammals, fish and birds. Example compound II, prepared by reacting 4-trifluoromethoxybenzoyl chloride and (R)-2-amino-3-(6-bromopyrazolo[4,3-b]pyridin-2-yl)-2-methylpropionitrile (preparation given), showed 100% efficacy against ivermectin-resistant endoparasites at an oral dose of 1.5 mg/kg in sheep. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Synthetic Route of 1086838-13-2

The Article related to enantiomerically enriched aryloazolyl cyanoethylamino parasiticide preparation, benzotriazole cyanoethylamino preparation antiparasitic endoparasite ectoparasite, indazole cyanoethylamino preparation parasiticidal infection, endoparasite ectoparasite pesticidal pyrazolopyridine cyanoethylamino preparation and other aspects.Synthetic Route of 1086838-13-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem